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Biomedical and Environmental Sciences 2014年第11期27卷 858-871页

作者： WU Jing NORRIS Jessie LIU Hui Xin LI Zheng su ying ying ZHU Lin WANG Ning National Center for AIDS/STD Control and Prevention China Center for Disease and Prevention School of Agroforestry & Medicine the Open University of China

Objective To understand drug resistance prevalence among treatment-failure and treatment-nave HIV-positive individuals in *** We searched five electronic databases（Wanfang,CNKI,CQVIP,SinoMed,and Pubmed） for studies of HIV drug ***-effects models were carried out to estimate the prevalence of drug resistance among treatment-failure and treatment-nave individuals,*** The estimated nationwide rates of HIV drug resistance to any-class drugs among treatment-failure and treatment-nave individuals were 57%（95% CI：49%-65%） and 3.23%（95% CI：2.47%-4.07%）,*** the drug classes,the prevalence of resistance to PIs was low（1.45%;95% CI：0.73%-2.33%） in treatment-failure individuals,although high rates of resistance to NNRTIs（54%;95% CI：45%-63%） and NRTIs（40%;95% CI：32%-49%） were *** to any-class drugs,NNRTIs and NRTIs manifested regional differences,but resistance to PIs did *** correlations were observed between resistance to NNRTIs and NRTIs among treatment-failure and treatment-nave individuals,*** The prevalence of HIV drug resistance to NNRTIs and NRTIs among treatment-failure individuals was *** contrast,the prevalence of drug resistance among treatment-nave individuals was *** epidemics of drug resistance matched current treatment strategies and interventions in *** for HIV drug resistance is necessary to assess the sustainability and durability of current treatment regimens.

关键词： HIV Drug resistance Meta-analysis China

Recommendations for Electroencephalography Monitoring in Neurocritical Care Units

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Chinese Medical Journal 2017年第15期130卷 1851-1855页

作者： su, ying-ying Hong, Zhen Neurocritical Care Commitlee of the Chinese Society of Neurology (NCC/CSN)

INTRODUCTION Since the 1950s, electroencephalography （EEG） has been used extensively in Neurocritical Care Units （NCUs）. At the beginning of this century, China＇s NCUs underwent rapid development. According to an... 详细信息

关键词： Electroencephalography Neurocritical Care Recommendation

Evaluation of coma patients after cardiopulmonary resuscitation

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Chinese Medical Journal 2005年第21期118卷 1808-1811页

作者： su ying-ying YANG Qing-lin PANG ying LV Xiang-ping Department of Neurology Xuanwu Hospital Capital University of Medical Sciences Beijing 100053 China

Background Coma after cardiopulmonary resuscitation （CPR） is commonly seen in daily clinical practice. How to objectively evaluate brain function after CPR is essential to the following treatment. Coma patients after CPR had been studied prospectively at the Neuro-Intensive Care Unit of Xuanwu Hospital since 2002. In this study, we focused on the topic of how to evaluate the severity of coma after CPR . Methods From April 2002 to November 2004, patients in coma 24 hours after CPR were monitored, the evaluation methods included Glasgow coma score （GCS） , brain stem reflection, and spinal reflection. Laboratory evaluation included electroencephalography （EEG）, brainstem auditory evoked potential （BAEP）, short latency somatosensory evoked potential （SLSEP）, and transcranial Doppler （TCD） .Results Twenty-four of 35 patients（68.57% ）were in deep coma. The GCS was 3 except for 2 patients;EEG was evaluated not less than grade Ⅳ except for 4 patients, BAEP was evaluated as grade Ⅲ except for 3 patients, and SLSEP was evaluated as grade Ⅲ except for 1 patient. Twenty-four patients died within 1 month and 11 of them （ 45. 83% ） were determined as brain death. Glasgow outcome score （GOS） was evaluated as grade Ⅰ. Eleven of the 35 patients survived and their consciousness changed from deep coma to coma vigil. EEG was evaluated as grade Ⅰ in 5 patients, BAEP and SLSEP were evaluated as grade Ⅰ in 3 patients, and GOS was all evaluated as grade Ⅱ among the 11 patients. Two patients（ 18.18% ）regained consciousness in 35 and 90 days after cardiopulmonary resuscitation and GOS was evaluated as grade Ⅳ and Ⅲ, respectively. Conclusion objectively Combined or continuous evaluation of clinical examinations and laboratory tests can accurately determine brain function after CPR.

关键词： cardiopulmonary resuscitation coma brain death electroencephalography evoked potentials ultrasonography Doppler transcranial

HIV-infected Female Sex Workers High Risk Behavior and Attitude Changes in Kaiyuan City, Yunnan Province, China

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Biomedical and Environmental Sciences 2014年第6期27卷 444-452页

作者： DING Guo Wei HSI Jenny H LIU Hui Xin su ying ying WANG Jun Jie BAI Jun WANG Gui Xiang WANG Hai Bo DONG Rui Ling WANG Ning National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Kaiyuan City Center for Disease Control and Prevention Chinese Center for Disease Control and Prevention Shenzhen International Travel Healthcare Center

Objective To investigate the attitude and sexual behavior status and change among HIV positive female workers in entertainment sites in Kaiyuan city, Yunnan province, China. The key information should be applied in the integrated intervention program in future. Methods A cohort survey among HIV positive female workers was conducted during 12 months, between 2010 and 2012. All the risk sexual behavior and attitude were collected for assessment for the potential secondary transmission to sexual partners. Results Of 99 HIV positive women who sell sex in Kaiyuan city, 99 participated in the survey at baseline, 80, 80, 75, and 75 at 3-, 6-, 9-, and 12-month follow-ups. The percentage of participants who reported consistently used condoms in the last one month ranged between 94.5% and 95.5%. The client volume in the last one month, income per sex and age group were significant related with non-insistent condom use with their clients. Conclusion It was suggested that integrated intervention program package should include 100 percent condom use promotion for the HIV positive FSW with all sexual partners, and also, include socially support involved.

关键词： HIV-infected Female sex workers Sexual behavior Change

A case of limbic encephalitis with positive antibody to the GABAB receptor

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Chinese Medical Journal 2013年第18期126卷 3599-3600页

作者： ZHANG Yan su ying-ying GAO Yuan Department of Neurology Xuanwu Hospital of Capital Medical University Beijing 100053 China Melbourne Medical School Melbourne University Melbourne Australia

To the editor： The number of studies of antibodies against neuronal surface antigens in patients with idiopathic orparaneoplastic limbic encephalitis （LE） has increased significantly.＇ But 7-aluinobutyric acid-B receptor antibodies （GABABR-ab） in patients with LE are rare. Detailed characteristics and responses to treatment remain unclear so far. Herein, we present a case of a female patient affected with LE and GABABR-ab positive in cerebrospinal fluid （CSF）.

关键词： GABAB受体抗体阳性边缘性脑炎病例抗原抗体神经细胞 CSF

The Chinese Expert Consensus on Evaluation of Coma after Cardiopulmonary Resuscitation

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Chinese Medical Journal 2016年第17期129卷 2123-2127页

作者： su, ying-ying Huang, Xu-Sheng Pan, su-Yue Peng, Bin Jiang, Wen Capital Med Univ Xuanwu Hosp Dept Neurointens Care Unit Beijing 100053 Peoples R China Chinese Peoples Liberat Army Gen Hosp Dept Neurol Beijing 100853 Peoples R China Southern Med Univ Nanfang Hosp Dept Neurol Guangzhou Guangdong Peoples R China Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Neurol Beijing Peoples R China Peking Union Med Coll Beijing Peoples R China Fourth Mil Med Univ Xijing Hosp Dept Neurol Xian Peoples R China

INTRODUCTIONThe prognosis of patients who suffer from coma after cardiopulmonary resuscitation （CPR） may be poor （defined as cerebral performance categories scores from 3 to 5） Thus, an accurate prediction of their neurological outcomes is an essential component of post-cardiac arrest evaluation, especially for decisions to limit or withdraw life-sustaining care. Since the 1960s, a series of domestic and foreign studies began to focus on the evaluation of coma patients after CPR, and considerable progress has been achieved in this field.

关键词： Cardiopulmonary Resuscitation Coma Consensus Electrophysiological Examination Neuroimaging Neurological Biomarkers Clinical Examination

Trans-cranial Doppler predicts early neurologic deterioration in anterior circulation ischemic stroke after successful endovascular treatment

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Chinese Medical Journal 2020年第14期133卷 1655-1661页

作者： Yan-Bo He ying-ying su Gary BRajah ying-Bo Zhang Un-Lin Fan Gang Liu Hong-Bo Chen Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurology The Beijing Moslem People's HospitalBeijing 100054China Department of Neurosurgery Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNY 14201USA Department of Neurosurgery Gates Vascular Institute at Kaleida HealthBuffaloNY 14201USA.

Background:Early neurologic deterioration(END)may occur in patients with anterior circulation ischemic stroke(ACIS)after receiving endovascular treatment(EVT).Hemodynamic insufficiency,re-occlusion,and post-re-canalization hyper-perfusion are likely to play a critical role in *** hypothesized that hemodynamic changes can predict END in patients with ACIS postsuccessful EVT using trans-cranial Doppler(TCD).Methods:We utilized a prospectively maintained database of ACIS patients treated with EVT between September 2016 and June 2018 in the Xuanwu Hospital,Capital Medical *** parameters including peak systolic velocity(PSV),bilateral mean flow velocity(MFV),and pulse index(PI)were determined via the middle cerebral arteries within 72 h post-EVT.A logistic regression model was applied to detect independent predictors for ***:Totally,112 EVT patients were included in this study and 80/112 patients experienced successful re-canalization withsuffered END,for which vasogenic cerebral edema(11/17)was considered as a leading role and followed by symptomatic intra-cranial hemorrhage(4/17)and ischemia progression(2/17).For the 80 patients,the PSV(median:127 cm/s vs.116 cm/s,P=0.039),the ratio of ipsilateral-MFV/contra-lateral-MFV(iMFV/cMFV)(median:1.29 vs.1.02,P=0.036)and iMFV/mean blood pressure(MBP)(median:0.97 vs.0.79,P=0.008)in END patients were higher than those of *** the receiver-operating characteristic curve to obtain cut-off values for PSV,PI,iMFV/cMFV,and iMFV/MBP for END,we found that PI≥0.85(odds ratio:11.03,95%confidence interval:1.92–63.46,P=0.007)and iMFV/MBP≥0.84(odds ratio:9.20,95%confidence interval:2.07–40.84,P=0.004)were independent predictors of END in a multivariate logistic regression model,with a sensitivity of 82.4%and 76.5%and a specificity of 42.9%and 66.7%,respectively,and had the positive predictive values of 29.0%and 38.2%,and negative predictive values of 90.0%and 91.

关键词： Cerebrovascular disease/acute ischemic stroke Endovascular treatment Thrombectomy Diagnostic methods Transcranial Doppler

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多模式诱发电位对缺氧性脑病的研究

中华神经科杂志 2005年第8期38卷 491-494页

作者：庞英宿英英首都医科大学宣武医院神经内科北京100053

目的应用多模式诱发电位评估缺氧性脑病脑功能损伤程度和预测预后的准确性。方法对44例心肺复苏后、低血压和(或)低血氧导致的昏迷患者进行体感诱发电位、脑干听觉诱发电位监测,并根据Judson、Hall、Cant、Haupt标准进行单模式、多模式... 详细信息

目的应用多模式诱发电位评估缺氧性脑病脑功能损伤程度和预测预后的准确性。方法对44例心肺复苏后、低血压和(或)低血氧导致的昏迷患者进行体感诱发电位、脑干听觉诱发电位监测,并根据Judson、Hall、Cant、Haupt标准进行单模式、多模式以及单模式与多模式之间的比较。结果单模式和多模式各分级标准与预后均有显著相关性,级别越高,预后越差。体感诱发电位预测准确性(Judson标准为84.1%)高于脑干听觉诱发电位(Hall标准为79.5%)。多模式诱发电位预测准确性(Cant标准为88.4%)高于单模式诱发电位。结论多模式诱发电位能更好地反映缺氧性脑病的脑功能损伤程度,Cant标准简便易行,预测准确性高,适于临床推广应用。

关键词：诱发电位心肺复苏术缺氧,脑预后体感诱发电位缺氧性脑病多模脑干听觉诱发电位预测预后分级标准

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膜融合的研究进展及其在药物运输方面的应用

分析化学 2019年第12期47卷 1871-1877页

作者：苏莹莹李春艳李迪华东师范大学化学与分子工程学院吉林大学第一医院呼吸医学科

膜融合对于生物体的生命活动具有重要的调控作用。细胞内的膜融合在生物体的整个生命周期中发挥了促进细胞内物质运转的作用,病毒和细胞膜的融合可能标志着生物体生命的终结。然而,由于活细胞的复杂性,对细胞内膜融合过程的认识仅局限... 详细信息

膜融合对于生物体的生命活动具有重要的调控作用。细胞内的膜融合在生物体的整个生命周期中发挥了促进细胞内物质运转的作用,病毒和细胞膜的融合可能标志着生物体生命的终结。然而,由于活细胞的复杂性,对细胞内膜融合过程的认识仅局限于少数细胞膜上的蛋白结构,如可溶性N-乙基马来酰亚胺敏感性因子附着型的蛋白受体(Soluble N-ethyl maleimide sensitive factor attachment protein receptors,SNARE)及其在促进膜融合中的作用。为更好地研究膜融合的机理,常用相关人工模型系统模拟生物膜融合。本文对SNARE促进膜融合的机理、DNA及卷曲螺旋多肽介导的膜融合研究进展,以及膜融合在药物运输等方面的应用进行了概述。

关键词：膜融合 N-乙基马来酰亚胺敏感性因子附着型的蛋白受体 DNA 评述

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重症脑卒中患者并发高渗血症的危险因素

中华神经科杂志 2006年第11期39卷 762-765页

作者：朱海英宿英英首都医科大学北京宣武医院神经内科 100053

目的探讨重症脑卒中患者并发高渗血症的危险因素,为制定干预措施提供依据。方法重症脑卒中患者80例,根据评价生存与死亡的血浆渗透压界值分为高渗组(>310mmol/L,34例)和非高渗组(≤310mmol/L,46例)。监测可能影响血浆渗透压的危险因素... 详细信息

目的探讨重症脑卒中患者并发高渗血症的危险因素,为制定干预措施提供依据。方法重症脑卒中患者80例,根据评价生存与死亡的血浆渗透压界值分为高渗组(>310mmol/L,34例)和非高渗组(≤310mmol/L,46例)。监测可能影响血浆渗透压的危险因素。结果大剂量甘露醇(>100g/d)、高钠血症和高血糖症是导致高渗血症的3个主要危险因素。高渗组4周生存率(47·1%)明显低于非高渗组(78·3%),两组比较差异有统计学意义(P<0·01)。结论引起高渗血症的主要危险因素是大剂量甘露醇、高钠血症和高血糖症,高渗血症患者预后差,生存率低。

关键词：脑血管意外高钠血症危险因素