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Gene Expression Changes in the Pituitary Gland of Rats Exposed to Electromagnetic Pulses

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Biomedical and Environmental Sciences 2011年第5期24卷 560-568页

作者： QI YuHong LIANG Jun HIM YanPing DING GuiRong LIU JunYe su xiaoming GUO GuoZhen Department of Radiotherapy Tangdu HospitalFourth Military Medical UniversityXi＇an 710038ShaanxiChina Department of Radiotion Medicine Faculty of Preventive MedicineFourth Military Medical UniversityXi＇an 710032ShaanxiChina Department of Pathology Faculty of Preclinical MedicineFourth Military Medical UniversityXi＇an 710032ShaanxiChina

Objective We examined alterations in the expression of tumorigenesis‐related genes in the pituitary gland of rats exposed to electromagnetic pulses （EMP）.Methods The global gene expression profiles of the pituitary gland in EMP‐exposed and control groups were detected by cDNA microarray *** then validated and further investigated the reduced expression of two tumorigenesis‐related genes,Pten,and Jund,by assessing their mRNA and protein expression by quantitative real‐time‐PCR,western blotting,and immunohistochemistry in the pituitary gland of rats 6 months after exposure to *** EMP exposure induced genome‐wide gene expression changes in the rat pituitary *** was decreased expression of the Pten and Jund mRNAs and proteins in EMP‐exposed rats compared with in unexposed control *** EMP exposure alters the expression of tumorigenesis‐related genes in the pituitary *** tumorigenesis‐related genes are potentially involved in the development of pituitary gland tumors in rats.

关键词： Tumorigenesis Electromagnetic pulses Pituitary gland Pten Jund

具有避难所和Ornstein-Uhlenbeck过程的随机三种群捕食模型的持久与灭绝

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复杂系统与复杂性科学 2024年第2期21卷 89-103页

作者：苏晓明陈波沈阳工业大学理学院沈阳110870

目前大多数的捕食模型都是用白噪声描述环境的随机性,针对真实情境下,模型中的参数可能满足Ornstein-Uhlenbeck过程的问题,提出具有避难所和Ornstein-Uhlenbeck过程的随机三种群捕食模型。利用伊藤公式、微分不等式及随机分析理论对模... 详细信息

目前大多数的捕食模型都是用白噪声描述环境的随机性,针对真实情境下,模型中的参数可能满足Ornstein-Uhlenbeck过程的问题,提出具有避难所和Ornstein-Uhlenbeck过程的随机三种群捕食模型。利用伊藤公式、微分不等式及随机分析理论对模型进行动力学行为分析。证明了模型全局正解的存在唯一性,分别得到了每个种群平均持久生存和灭绝的充分条件,最后利用python进行数值模拟,验证了定理中所得到的结论,并进一步研究了避难所对种群数量的影响。

关键词： Ornstein-Uhlenbeck过程避难所平均持久性灭绝性

Analysis of isolation of cerebral cortical neurons in rats by different methods

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BIOCELL 2020年第2期44卷 209-215页

作者： JIANHUA LI YAOGANG ZHANG TAO ZHANG MEIYUAN TIAN JING HOU DENGLIANG HUANG YAN CHENG ZHU MAN xiaoming su ZHIQIN LI SIXIAN TONG XUAN ZHANG JUN DENG YUN DONG YANYAN MA Central Laboratory of Qinghai University Affiliated Hospital Qinghai UniversityXining810000China Qinghai Research Key Laboratory for Echinococcosis Xining810000China Qinghai University Xining810000China

The aim of this study was to find a way to efficiently separate neuronal cells from the cerebral cortex of adult rats,providing a reference method for rapid acquisition of neuronal cells from the adult rat *** SD rats were randomly divided into three groups,with five SD rats in each ***,neuron cells were isolated from the adult rat cerebral cortex by the grinding method,the trypsin method,and the collagenase II method,*** expression of anti-NeuN in the neurons of each group was analyzed by flow *** acquisition rates and morphology of neurons of each group were observed by immunofluorescence *** grinding or collagenase II method is more suitable for rapid acquisition of neuronal cells from an adult rat’s cerebral *** number of neuron cells obtained by the trypsin method were very few,so it is not convenient for later experiments.

关键词： Neurons Grinding method Collagenase II method Trypsin method Flow cytometry

An a-L∞ stability Small-Gain Theorem for Nonlinear Interconnection Systems

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An a-L∞ stability Small-Gain Theorem for Nonlinear Intercon...

第43届中国控制会议

作者： su xiaoming LI Jiamei BAO Adiya WANG Zhanxiu Shenyang University of Technology School of Science School of Information Engineering Yancheng Teachers University

This paper presents a small-gain result for interconnected large-scale system based on a-L stability. It is assumed that the output of the subsystem satisfies the a-L stability bound and the small gain condition holds, then the composite output of the interconnected system can be proved to satisfy an a-L stability bound. Comparing with the input-output stability, the a-L stability only requires that the system state is bounded and the output converges. This theorem expounds the stability problem of a more general nonlinear system with less restrictive conditions.

关键词： a-L_∞ stability small-gain theorem nonlinear interconnected systems observer output feedback

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cnki会议

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论科学发展观的理论品质

江汉论坛 2007年第1期 28-31页

作者：苏晓明浙江林学院人文学院教授临安311300

本文以“科学发展观是指导发展的世界观和方法论的集中体现”这一重大理论问题为主线,提升对于科学发展观的世界观和方法论意义的深刻认识和领会,提炼和概括科学发展观具有的理论品质特色。以此证实科学发展观与马克思主义的世界观、方... 详细信息

本文以“科学发展观是指导发展的世界观和方法论的集中体现”这一重大理论问题为主线,提升对于科学发展观的世界观和方法论意义的深刻认识和领会,提炼和概括科学发展观具有的理论品质特色。以此证实科学发展观与马克思主义的世界观、方法论具有内在一致性,是马克思主义关于发展的世界观和方法论的集中体现。

关键词：科学发展观世界观和方法论理论品质

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科学发展观的价值意蕴

江汉论坛 2008年第11期 66-69页

作者：苏晓明浙江林学院人文学院教授临安311300

科学发展观基于理论和实践的结合,深刻揭示了中国特色社会主义所面临的一系列发展问题,生动体现了对于人和社会的现实境遇与未来发展的价值关怀,内在蕴涵着丰富的价值哲学思想。科学发展观的价值意蕴主要彰显为以人民群众为本位的价值... 详细信息

科学发展观基于理论和实践的结合,深刻揭示了中国特色社会主义所面临的一系列发展问题,生动体现了对于人和社会的现实境遇与未来发展的价值关怀,内在蕴涵着丰富的价值哲学思想。科学发展观的价值意蕴主要彰显为以人民群众为本位的价值主体确立、以发展为第一要务的价值评价标准、以全面协调可持续发展为目标的价值实现途径、以统筹兼顾为方法的价值实施手段等方面内容。

关键词：科学发展观价值主体价值评价价值实现

基于四元数卷积神经网络的移动机器人闭环检测

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中国惯性技术学报 2019年第3期27卷 357-365页

作者：仉新张禹苏晓明沈阳工业大学机械工程学院

为提高复杂环境下移动机器人闭环检测的准确性,减少视觉里程计的累积误差,提出了四元数卷积神经网络的闭环检测算法。首先,利用超像素分割,提取多尺度路标,提升图像描述的视角和外观不变性;然后,扩展卷积神经网络的卷积层为四元数卷积层... 详细信息

为提高复杂环境下移动机器人闭环检测的准确性,减少视觉里程计的累积误差,提出了四元数卷积神经网络的闭环检测算法。首先,利用超像素分割,提取多尺度路标,提升图像描述的视角和外观不变性;然后,扩展卷积神经网络的卷积层为四元数卷积层,增加红绿蓝三通道的关联性,提取彩色图像的深层信息,更好地体现彩色图像的整体性;最后,在图像相似度度量中,不仅计算路标距离,还考虑路标形状和空间分布信息,提高相似性度量的准确性。在卡内基梅隆大学和昆士兰大学公开数据集上对算法有效性进行了验证。实验结果表明,相比传统闭环检测算法,所提算法在保证较高召回率的同时,提高了闭环检测的准确率,在数据集上分别取得87.64%和90.12%的平均准确率,显著提高了光照、视角和季节变化等复杂环境中移动机器人闭环检测的准确性。

关键词：同时定位与地图构建闭环检测四元数卷积神经网络超像素分割

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基于启发式算法的移动机器人SLAM

中国惯性技术学报 2018年第1期26卷 45-50页

作者：仉新张禹苏晓明沈阳工业大学机械工程学院沈阳110870

为了实现GPS信号缺失下的移动机器人自主导航,解决传统粒子滤波中的粒子退化以及粒子贫乏引起的移动机器人定位和导航精度下降问题,提出了基于小生境理论的启发式蝙蝠优化粒子滤波的同时定位与地图构建算法。首先,在启发式蝙蝠优化算法... 详细信息

为了实现GPS信号缺失下的移动机器人自主导航,解决传统粒子滤波中的粒子退化以及粒子贫乏引起的移动机器人定位和导航精度下降问题,提出了基于小生境理论的启发式蝙蝠优化粒子滤波的同时定位与地图构建算法。首先,在启发式蝙蝠优化算法的速度和位置更新过程中,引入惯性权重,加快了算法寻优精度,提高了收敛速度;然后,利用小生境理论进一步优化启发式蝙蝠算法,利用排挤机制和惩罚函数,有效地保证了种群的多样性,提高了算法的全局寻优能力;最后,将基于小生境理论的启发式蝙蝠优化算法用于传统粒子滤波采样中,使得粒子能够智能、快速地向高似然区域运动,同时提高了传统粒子滤波算法的全局寻优能力和寻优精度。实验结果表明:该算法显著提高了移动机器人导航和定位的精度和实时性。

关键词：同时定位与地图构建粒子滤波启发式算法蝙蝠算法

Home Blood Pressure Monitoring and Its Association With Blood Pressure Control Among Hypertensive Patients With High Cardiovascular Risk in China

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Cardiology Discovery 2024年第1期4卷 15-22页

作者： Jiaying Li Aoxi Tian Jiamin Liu Jinzhuo Ge Yue Peng xiaoming su Jing Li National Clinical Research Center for Cardiovascular Diseases National Health Commission Key Laboratory of Clinical Research for Cardiovascular MedicationsState Key Laboratory of Cardiovascular DiseaseFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNational Center for Cardiovascular DiseasesBeijing 100037China

Objective:Home blood pressure monitoring(HBPM)is viewed as a facilitating factor in the initial diagnosis and long-term management of treated ***,evidence remains scarce about the effectiveness of HBPM use in the real *** study aimed to examine the associations of HBPM use with blood pressure(BP)control and medication ***:This prospective cohort study included hypertensive patients with high cardiovascular risk who were aged≥50 *** baseline,information about types of BP monitor,frequency of HBPM,perception of anti-hypertensive treatment,and measured office BP were *** the 1-year follow-up(visits at 1,2,3,6,and 12 months),information on medication adherence was collected at each *** 2 major outcomes were BP control at baseline and medication adherence during the 1-year follow-up.A log-binomial regression model was used to examine the association between frequency of HBPM and outcomes,stratified by the perceptions of anti-hypertensive ***:A total of 5,363 hypertensive patients were included in the *** age was(64.6±7.2)years,and 41.2%(2,208)were *** the total patients,85.9%(4,606)had a home BP monitor and 47.8%(2,564)had an incorrect perception of anti-hypertensive ***,24.2%(1,299)of patients monitored their BP daily,37.6%(2,015)weekly,17.3%(926)monthly,and 20.9%(1,123)less than *** baseline,the systolic BP and diastolic BP were(146.6±10.8)mmHg and(81.9±10.6)mmHg,respectively,and 28.5%(1,527)of patients had their BP *** of whether the patients had correct or incorrect perceptions of anti-hypertensive treatment,there is no significant association between HBPM frequency and BP control at *** the 1-year follow-up,23.9%(1,280)of patients had non-adherence to medications at least *** patients with an incorrect perception of anti-hypertensive treatment,those monitoring BP most frequently(daily)had the highest non-adherence rate(29.

关键词： Hypertension Home blood pressure monitoring Blood pressure control Medication adherence