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Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis

World Journal of Gastroenterology 2024年第15期30卷 2143-2154页

作者： Sen Li Qian-Jun Ren Can-Hao Xie Yang Cui Li-Tao Xu Yi-Dan Wang su Li Xing-Qiu Liang Bin wen Ming-Kun Liang Xiao-Fang Zhao Department of Basic Science Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Department of Science and Technology Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Traditional Chinese Medicine Specialty Office Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina

BACKGROUND Liver fibrosis is a compensatory response during the tissue repair process in chronic liver injury,and finally leads to liver cirrhosis or even hepatocellular *** pathogenesis of hepatic fibrosis is associated with the progressive accumulation of activated hepatic stellate cells(HSCs),which can transdiffer-entiate into myofibroblasts to produce an excess of the extracellular matrix(ECM).Myofibroblasts are the main source of the excessive ECM responsible for hepatic ***,activated hepatic stellate cells(aHSCs),the principal ECM producing cells in the injured liver,are a promising therapeutic target for the treatment of hepatic *** To explore the effect of taurine on aHSC proliferation and the mechanisms *** Human HSCs(LX-2)were randomly divided into five groups:Normal control group,platelet-derived growth factor-BB(PDGF-BB)(20 ng/mL)treated group,mmol/L,respectively)with PDGF-BB(20 ng/mL)treated *** Counting Kit-8 method was performed to evaluate the effect of taurine on the viability of ***-linked immunosorbent assay was used to estimate the effect of taurine on the levels of reactive oxygen species(ROS),malondialdehyde,glutathione,and iron *** electron microscopy was applied to observe the effect of taurine on the autophagosomes and ferroptosis features in *** real-time polymerase chain reaction and Western blot analysis were performed to detect the effect of taurine on the expression ofα-SMA,Collagen I,Fibronectin 1,LC3B,ATG5,Beclin 1,PTGS2,SLC7A11,and *** Taurine promoted the death of aHSCs and reduced the deposition of the *** with taurine could alleviate autophagy in HSCs to inhibit their activation,by decreasing autophagosome formation,downregulating LC3B and Beclin 1 protein expression,and upregulating p62 protein ***,treatment with taurine triggered ferroptosis and ferritinophagy to eliminate aHSCs characterized b

关键词： Hepatic stellate cells Autophagy Ferroptosis Molecular docking Taurine

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液舱运动与流体晃荡耦合运动数值模拟与试验验证

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船舶力学 2024年第10期28卷 1516-1525页

作者：刘文夫周素素杨旭陈磊中国船舶及海洋工程设计研究院

本文针对液舱运动与流体晃荡耦合运动问题，采用基于Hilber-Hughes-Taylor(HHT)格式的隐式直接积分法求解液舱运动，应用VOF法捕捉流体晃荡自由表面运动，建立液舱运动与流体晃荡双向耦合迭代算法。将算法应用到某转动液舱系统的模型试... 详细信息

本文针对液舱运动与流体晃荡耦合运动问题，采用基于Hilber-Hughes-Taylor(HHT)格式的隐式直接积分法求解液舱运动，应用VOF法捕捉流体晃荡自由表面运动，建立液舱运动与流体晃荡双向耦合迭代算法。将算法应用到某转动液舱系统的模型试验中，通过数值计算结果与试验结果的比较验证算法的有效性。本文建立的分析方法可为液舱运动与流体晃动耦合运动问题提供一种有效的分析方法。

关键词：液舱运动流体晃荡 HHT方法 VOF方法

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Imaging of human parafoveal area with large field of view in adaptive optics line scanning ophthalmoscope

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 41-51页

作者： wen Kong Yiwei Chen Guohua Shi Yi He Department of Biomedical Engineering University of Science and Technology of ChinaHefei 230041P.R.China Jiangsu Key Laboratory of Medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163P.R.China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031P.R.China Key Laboratory of Myopia of State Health Ministry and Key Laboratory of Visual Impairment and Restoration of ShanghaiShanghai 200003P.R.China

The parafoveal area,with its high concentration of photoreceptors andfine retinal capillaries,is crucial for central vision and often exhibits early signs of pathological *** current adaptive optics scanning laser ophthalmoscope(AOSLO)provides an excellent tool to acquire accurate and detailed information about the parafoveal area with cellular ***,limited by the scanning speed of two-dimensional scanning,thefield of view(FOV)in the AOSLO system was usually less than or equal to 2,and the stitching for the parafoveal area required dozens of images,which was time-consuming and ***,almost half of patients are unable to obtain stitched images because of their *** solve this problem,we integrate AO technology with the line-scan imaging method to build an adaptive optics line scanning ophthalmoscope(AOLSO)system with a larger *** the AOLSO,afocal spherical mirrors in pairs are nonplanar arranged and the distance and angle between optical elements are optimized to minimize the aberrations,two cylinder lenses are orthogonally placed before the imaging sensor to stretch the point spread function(PSF)for su±ciently digitizing light *** human retinal images show the whole parafoveal area with 55FOV,60 Hz frame rate and cellular *** advantage of the 5FOV of the AOLSO,only 9 frames of the retina are captured with several minutes to stitch a montage image with an FOV of 99,in which photoreceptor counting is performed within approximately 5*** AOLSO system not only provides cellular resolution but also has the capability to capture the parafoveal region in a single frame,which offers great potential for noninvasive studying of the parafoveal area.

关键词： Adaptive optics line scanning retinal imaging system parafoveal capillary vasculature.

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2001-2016年广州市登革3型病毒E基因序列及系统进化树分析

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中国人兽共患病学报 2018年第5期34卷 487-491页

作者：刘远蒋力云景钦隆苏文哲蔡文锋狄飚杨智聪广州市疾病预防控制中心广州510440

目的了解2001-2016年广州市登革3型病毒的流行情况,掌握毒株的进化情况和趋势。方法将登革热确诊病例的血清用荧光PCR检测,阳性血清用C6/36细胞进行病毒分离,测定分离毒株的E基因序列,与NCBI的毒株序列相比较,利用Mega 4.0软件构建系统... 详细信息

目的了解2001-2016年广州市登革3型病毒的流行情况,掌握毒株的进化情况和趋势。方法将登革热确诊病例的血清用荧光PCR检测,阳性血清用C6/36细胞进行病毒分离,测定分离毒株的E基因序列,与NCBI的毒株序列相比较,利用Mega 4.0软件构建系统进化树。结果 2001-2016年共分离到登革3型病毒24株,从基因型上分类属于基因亚型Ⅰ、Ⅱ、Ⅲ和Ⅴ型,基因亚型Ⅲ在流行年份和分离毒株数上稍占优势。流行病学调查和序列分析均显示与东南亚国家流行的登革热相关度较高。结论广州市登革3型病毒以输入为主,随着输入压力增大、基因亚型增多和转换,可能会使广州市登革热流行传播更为复杂,流行风险进一步增高。

关键词：登革3型病毒 E基因系统进化树

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Signature of superconductivity in Pressurized La_(4)Ni_(3)O_(10)

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Chinese Physics Letters 2024年第1期41卷 77-84页

作者：李庆张英杰项浙宁张宇航祝熙宇闻海虎 National Laboratory of Solid State Microstructures and Department of Physics Center for Superconducting Physics and MaterialsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

The discovery of high-temperature superconductivity near 80K in bilayer nickelate La_(3)Ni_(2)O_(7)under high pressures has renewed the exploration of superconducting nickelate in bulk *** extension of superconductivity in other nickelates in a broader family is also ***,we report the experimental observation of superconducting signature in trilayer nickelate La_(4)Ni_(3)O_(10)under high *** using a modified solgel method and post-annealing treatment under high oxygen pressure,we successfully obtained polycrystalline La_(4)Ni_(3)O_(10)samples with different transport behaviors at ambient *** we performed high-pressure electrical resistance measurements on these samples in a diamond-anvil-cell ***,the signature of possible superconducting transition with a maximum transition temperature(T_(c))of about 20K under high pressures is observed,as evidenced by a clear drop of resistance and the suppression of resistance drops under magnetic *** the resistance drop is sample-dependent and relatively small,it appears in all of our measured *** argue that the observed superconducting signal is most likely to originate from the main phase of La_(4)Ni_(3)O_(10).Our findings will motivate the exploration of superconductivity in a broader family of nickelates and shed light on the understanding of the underlying mechanisms of high-T_(c) superconductivity in nickelates.

关键词： materials superconductivity signature

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中国医学影像技术 2024年第9期40卷 1351-1356页

作者：蔺楠任超童冠圣文哲首都医科大学附属北京世纪坛医院核医学科北京100038 中国医学科学院北京协和医院核医学科核医学分子靶向诊疗北京市重点实验室北京100730

目的观察乳腺癌相关淋巴水肿(BCRL)治疗前淋巴显像分期与脂肪抽吸术联合淋巴管-静脉吻合术(LVA)疗效的相关性。方法回顾性分析67例接受脂肪抽吸术并于术后3个月接受LVA的BCRL患者,依据治疗前淋巴显像分为患侧上肢淋巴部分梗阻(P期)与完... 详细信息

目的观察乳腺癌相关淋巴水肿(BCRL)治疗前淋巴显像分期与脂肪抽吸术联合淋巴管-静脉吻合术(LVA)疗效的相关性。方法回顾性分析67例接受脂肪抽吸术并于术后3个月接受LVA的BCRL患者,依据治疗前淋巴显像分为患侧上肢淋巴部分梗阻(P期)与完全梗阻(T期)组;记录联合治疗后3及6个月双上肢淋巴水肿指数(UELi)、患侧UELi超额百分比(UPE)、治疗后与治疗前患侧UPE比值(rUPE)及术后上肢淋巴水肿功能、残疾与健康问卷调查表(Lymph-ICF-UL)评分,对比不同分期患者治疗后临床参数及上肢淋巴水肿改善情况。结果治疗前淋巴显像显示P期组29例、T期组38例。组间治疗前蜂窝织炎发生率、术中吸出脂肪体积差异均有统计学意义(P均<0.05)。联合治疗后3及6个月,67例患侧UELi、UPE及Lymph-ICF-UL评分均低于治疗前,差异均有统计学意义(P均<0.05)。结论BCRL治疗前淋巴显像分期与脂肪抽吸术联合LVA疗效相关。

关键词：乳腺肿瘤淋巴水肿放射性核素显像

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Broadband and fabrication-tolerant 3-dB couplers with topological valley edge modes

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Light(Science & Applications) 2024年第8期13卷 1623-1630页

作者： Guo-Jing Tang Xiao-Dong Chen Lu sun Chao-Heng Guo Meng-Yu Li Zhong-Tao Tian Hou-Hong Chen Hong-Wei Wang Qi-Yao sun Ying-Di Pan Xin-Tao He Yi-Kai su Jian-wen Dong School of Physics&State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Electronic EngineeringShanghai Jiao Tong UniversityShanghai 200240China

3-dB couplers,which are commonly used in photonic integrated circuits for on-chip information processing,precision measurement,and quantum computing,face challenges in achieving robust performance due to their limited 3-dB bandwidths and sensitivity to fabrication *** address this,we introduce topological physics to nanophotonics,developing a framework for topological 3-dB *** couplers exhibit broad working wavelength range and robustness against fabrication dimensional *** leveraging valley-Hall topology and mirror symmetry,the photonic-crystal-slab couplers achieve ideal 3-dB splitting characterized by a wavelength-insensitive scattering *** analysis confirms the superiority on broad bandwidth of 48 nm and robust splitting against dimensional errors of 20 *** further propose a topological interferometer for on-chip distance measurement,which also exhibits robustness against dimensional *** extension of topological principles to the fields of interferometers,may open up new possibilities for constructing robust wavelength division multiplexing,temperature-drift-insensitive sensing,and optical coherence tomography applications.

关键词： topological splitting insensitive

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水滑石基Ni/Al_(2)O_(3)催化剂催化玉米秸秆加氢裂解制二元醇和芳香族单体性能研究

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低碳化学与化工 2024年第6期49卷 63-72页

作者：马泽暐温哲中石化石油化工科学研究院有限公司北京100083 常州大学石油化工学院江苏常州213164

生物质是化石能源最有前景的可再生替代品之一,由生物质制备高附加值化学品是实现生物质多元化应用的有效途径。采用尿素沉淀法和程序升温还原法制备了水滑石基Ni/Al_(2)O_(3)催化剂,通过X射线衍射(XRD)分析了催化剂及其前驱体的物相组... 详细信息

生物质是化石能源最有前景的可再生替代品之一,由生物质制备高附加值化学品是实现生物质多元化应用的有效途径。采用尿素沉淀法和程序升温还原法制备了水滑石基Ni/Al_(2)O_(3)催化剂,通过X射线衍射(XRD)分析了催化剂及其前驱体的物相组成,并考察了Ni/Al_(2)O_(3)催化剂对玉米秸秆在水-甲醇混合溶剂中加氢裂解反应的催化性能。结果表明,Ni/Al_(2)O_(3)催化剂表现出较好的催化活性,在最优反应条件(V(H_(2)O):V(CH_(3)OH)=7:3、240℃和3.0 MPa H_(2))下,玉米秸秆转化率接近100%,二元醇产率为38.8%,芳香族单体产率为13.6%。V(H_(2)O):V(CH_(3)OH)和反应温度显著影响了玉米秸秆转化率和小分子产物产率,Ni/Al_(2)O_(3)催化剂和反应气氛主要影响了小分子产物产率和分布。对经过一次循环后的催化剂进行循环性测试发现,二元醇产率和芳香族单体产率分别下降至10.8%和5.4%。根据拉曼光谱分析结果推测,催化剂活性下降可能是因为催化剂表面形成了积炭。分析二元醇和芳香族单体的生成路径发现,Ni/Al_(2)O_(3)催化剂对活性中间体的稳定起到了重要作用。

关键词：玉米秸秆加氢裂解 Ni/Al_(2)O_(3)催化剂二元醇芳香族单体

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Proxitome profiling reveals a conserved SGT1- NSL1 signaling module that activates NLRmediated immunity

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Molecular Plant 2024年第9期17卷 1369-1391页

作者： Dingliang Zhang Xinxin Yang Zhiyan wen zhen Li Xinyu Zhang Chenchen Zhong Jiajie She Qianshen Zhang He Zhang wenli Li Xiaoyun Zhao Mingliang Xu zhen su Dawei Li Savithramma P.Dinesh-Kumar Yongliang Zhang State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBejing 100193China Department of Plant Biology and The Genome Center College of Biological SciencesUniversity of CaliforniaDavisDavisCA 95616USA State Key Laboratory of Plant Environmental Resilience College of Agronomy and BiotechnologyChina Agricultural UniversityBejing 100193China

suppressor of G2 allele of skp1(SGT1)is a highly conserved eukaryotic protein that plays a vital role in growth,development,and immunity in both animals and *** some SGT1 interactors have been identified,the molecular regulatory network of SGT1 remains ***1 serves as a co-chaperone to stabilize protein complexes such as the nucleotide-binding leucine-rich repeat(NLR)class of immune receptors,thereby positively regulating plant ***1 has also been found to be asso-ciated with the SKP1-Cullin-F-box(SCF)E3 ubiquitin ligase ***,whether SGT1 targets im-mune repressors to coordinate plant immune activation remains *** this study,we constructed a toolbox for TurbolD-and split-TurbolD-based proximity labeling(PL)assays in Nicotiana benthamiana and used the PL toolbox to explore the SGT1 interactome during pre-and post-immune *** comprehensive SGT1 interactome network we identified highlights a dynamic shift from proteins associ-ated with plant development to those linked with plant immune *** found that SGT1 interacts with Necrotic Spotted Lesion1(NSL1),which negatively regulates salicylic acid-mediated defenseby inter-fering with the nucleocytoplasmic trafficking of non-expressor of pathogenesis-related genes 1(NPR1)during N NLR-mediated response to tobacco mosaic ***1 promotes the SCF-dependent degrada-tion of NSL1 to facilitate immune activation,while salicylate-induced protein kinase-mediated phosphory-lation of SGT1further potentiates this *** NNLR,NSL1also functions in several other NLR-mediated ***,our study unveils the regulatory landscape of SGT1 and reveals a novel SGT1-NSL1 signaling module that orchestrates plant innate immunity.

关键词： suppressor of G2 allele of skp1 SGT1 proximity labeling N NLR immune receptor Necrotic Spotted Lesion 1 NSL1 salicylic acid ubiquitination

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Analysis of status and influencing factors of mental health in patients with systemic lupus erythematosus

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World Journal of Psychiatry 2024年第6期14卷 829-837页

作者： Xuan Zhang zhe Wang Gui-Ling Lin Fang-Zhi Wei Yan-Ping Zhuang wen-Lu Xu Qi Zhang Hui-Tao Wu Zi-Man He Xi-Yu Yin Ying Liu Long Mi Ai-Min Gong School of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571101Hainan ProvinceChina Department of Rheumatology and Immunology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311Hainan ProvinceChina Department of Radiology The First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikou 570100Hainan ProvinceChina

BACKGROUND Systemic lupus erythematosus(SLE)is a heterogeneous autoimmune disorder with varied clinical courses and prognoses,not only did the patients suffer from physical impairment,but also various physical and psychiatric *** evidence have suggested that mental disorders in SLE patients,can lead to various adverse *** To explored the features and influencing factors of mental health in patients with SLE and clarifying the correlations between mental health and personality characteristics and perceived social *** results would provide a basis for psychological intervention in patients with *** The clinical data of 168 patients with SLE admitted at the First Affiliated Hospital of Hainan Medical University between June 2020 and June 2022 were *** assessment and correlation analysis were conducted using the Symptom Checklist-90(SCL-90)and Perceived Social support Scale,and the collected data were compared with the national norms in *** relevant factors influencing mental health were identified by statistical analysis.A general information questionnaire,the Revised Life Orientation Test,and Short-Form 36-Item Health survey were employed to assess optimism level and quality of life(QoL),*** Patients with SLE obtained higher scores for the somatization,depression,anxiety,and phobic anxiety subscales than national norms(Psupport and total SCL-90 score or each subscale(P<0.05).The factors significantly affecting patients’mental health were hormone dosage and disease activity index(DAI)(P<0.05).The average optimism score of patients with SLE was 14.36±4.42,and 30 cases were in the middle and lower levels.A positive correlation was found between optimism level and QoL *** Patients with SLE develop psychological disorders at varying degrees,which are significantly influenced by hormone dosage and ***’menta

关键词： Systemic lupus erythematosus Mental health Quality of life Influencing factors

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