检索结果-南通市图书馆

Metabolic disorders in prediabetes:From mechanisms to therapeutic management

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第3期15卷 361-377页

作者： Wen-Xin Ping Shan Hu Jing-qian su Song-Ying Ouyang Biomedical Research Center of South China College of Life SciencesFujian Normal UniversityFuzhou 350117Fujian ProvinceChina

Diabetes,one of the world's top ten diseases,is known for its high mortality and complication rates and low cure rate.Prediabetes precedes the onset of diabetes,during which effective treatment can reduce diabetes risk.Prediabetes risk factors include high-calorie and high-fat diets,sedentary lifestyles,and stress.Consequences may include considerable damage to vital organs,including the retina,liver,and kidneys.Interventions for treating prediabetes include a healthy lifestyle diet and pharmacological treatments.However,while these options are effective in the short term,they may fail due to the difficulty of long-term implementation.Medications may also be used to treat prediabetes.This review examines prediabetic treatments,particularly metformin,glucagon-like peptide-1 receptor agonists,sodium glucose cotransporter 2 inhibitors,vitamin D,and herbal medicines.Given the remarkable impact of prediabetes on the progression of diabetes mellitus,it is crucial to intervene promptly and effectively to regulate prediabetes.However,the current body of research on prediabetes is limited,and there is considerable confusion surrounding clinically relevant medications.This paper aims to provide a comprehensive summary of the pathogenesis of prediabetes mellitus and its associated therapeutic drugs.The ultimate goal is to facilitate the clinical utilization of medications and achieve efficient and timely control of diabetes mellitus.

关键词： Prediabetes Glucagon-like peptide agonists Sodium–glucose cotransporter 2 inhibitors Vitamin D Chinese herbal medicines

Stability analysis of loose accumulation slopes under rainfall:case study of a high‑speed railway in Southwest China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Railway Engineering Science 2024年第1期32卷 95-106页

作者： Xin Wang qian su Zongyu Zhang Feihu Huang Chenfang He School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China Key Laboratory of High‑Speed Railway Engineering Ministry of Education School of Civil EngineeringSouthwest Jiaotong UniversityChengdu 610031China CCCC Second Highway Consultants Co. Ltd.Wuhan 430056China

The high and steep slopes along a high-speed railway in the mountainous area of Southwest China are mostly composed of loose accumulations of debris with large internal pores and poor stability,which can easily induce adverse geological disasters under rainfall conditions.To ensure the smooth construction of the high-speed railway and the subsequent safe operation,it is necessary to master the stability evolution process of the loose accumulation slope under rainfall.This article simulates rainfall using the finite element analysis software’s hydromechanical coupling module.The slope stability under various rainfall situations is calculated and analysed based on the strength reduction method.To validate the simulation results,a field monitoring system is established to study the deformation characteristics of the slope under rainfall.The results show that rainfall duration is the key factor affecting slope stability.Given a constant amount of rainfall,the stability of the slope decreases with increasing duration of rainfall.Moreover,when the amount and duration of rainfall are constant,continuous rainfall has a greater impact on slope stability than intermittent rainfall.The setting of the field retaining structures has a significant role in improving slope stability.The field monitoring data show that the slope is in the initial deformation stage and has good stability,which verifies the rationality of the numerical simulation method.The research results can provide some references for understanding the influence of rainfall on the stability of loose accumulation slopes along high-speed railways and establishing a monitoring system.

关键词： High-speed railway Loose accumulation slope Slope stability analysis Rainfall effect Strength reduction

Computer vision-aided DEM study on the compaction characteristics of graded subgrade filler considering realistic coarse particle shapes

在线全文

学校读者我要写书评

暂无评论

Railway Engineering Science 2024年第2期32卷 194-210页

作者： Taifeng Li Kang Xie Xiaobin Chen Zhixing Deng qian su Railway Engineering Research Institute China Academy of Railway Sciences Corporation LimitedBeijing 100081China Department of Civil Engineering Central South UniversityChangsha 410075China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China

The compaction quality of subgrade filler strongly affects subgrade settlement.The main objective of this research is to analyze the macro-and micro-mechanical compaction characteristics of subgrade filler based on the real shape of coarse particles.First,an improved Viola-Jones algorithm is employed to establish a digitalized 2D particle database for coarse particle shape evaluation and discrete modeling purposes of subgrade filler.Shape indexes of 2D subgrade filler are then computed and statistically analyzed.Finally,numerical simulations are performed to quantitatively investigate the effects of the aspect ratio(AR)and interparticle friction coefficient(μ)on the macro-and micro-mechanical compaction characteristics of subgrade filler based on the discrete element method(DEM).The results show that with the increasing AR,the coarse particles are narrower,leading to the increasing movement of fine particles during compaction,which indicates that it is difficult for slender coarse particles to inhibit the migration of fine particles.Moreover,the average displacement of particles is strongly influenced by the AR,indicating that their occlusion under power relies on particle shapes.The dis-placement and velocity of fine particles are much greater than those of the coarse particles,which shows that compaction is primarily a migration of fine particles.Under the cyclic load,the interparticle friction coefficientμhas little effect on the internal structure of the sample;under the quasi-static loads,however,the increase inμwill lead to a significant increase in the porosity of the sample.This study could not only provide a novel approach to investigate the compaction mechanism but also establish a new theoretical basis for the evaluation of intelligent subgrade compaction.

关键词： subgrade filler particles Deep learning particle Shape analysis Particle library Compaction characteristics Discrete element method(DEM)

Prospects in the application of ultrasensitive chromosomal aneuploidy detection in precancerous lesions of gastric cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal surgery 2024年第1期16卷 6-12页

作者： su-Ting qian Fei-Fei Xie Hao-Yu Zhao Qing-Sheng Liu Dan-Li Cai Department of Digestive Hangzhou Hospital of Traditional Chinese MedicineHangzhou 310007Zhejiang ProvinceChina Science and Education Section Hangzhou Hospital of Traditional Chinese MedicineHangzhou 310007Zhejiang ProvinceChina Intensive Care Unit The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 311122Zhejiang ProvinceChina

Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in China.Despite advancements in treatment modalities,such as surgery supplemented by adjuvant radiotherapy or chemotherapeutic agents,the prognosis for GC remains poor.New targeted therapies and immunotherapies are currently under invest-igation,but no significant breakthroughs have been achieved.Studies have indicated that GC is a heterogeneous disease,encompassing multiple subtypes with distinct biological characteristics and roles.Consequently,personalized treatment based on clinical features,pathologic typing,and molecular typing is crucial for the diagnosis and management of precancerous lesions of gastric cancer(PLGC).Current research has categorized GC into four subtypes:Epstein-Barr virus-positive,microsatellite instability,genome stability,and chromosome instability(CIN).Technologies such as multi-omics analysis and gene sequencing are being employed to identify more suitable novel testing methods in these areas.Among these,ultrasensitive chromosomal aneuploidy detection(UCAD)can detect CIN at a genome-wide level in subjects using low-depth whole genome sequencing technology,in conjunction with bioinformatics analysis,to achieve qualitative and quantitative detection of chromosomal stability.This editorial reviews recent research advancements in UCAD technology for the diagnosis and management of PLGC.

关键词： Gastric cancer Precancerous lesions of gastric cancer Molecular typing Ultrasensitive chromosomal aneuploidy detection Adjuvant therapy Application prospects

存在停售第三方卖家的复合型电商平台定价模型

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

管理工程学报 2024年第2期38卷 139-151页

作者：张凯苏倩上海理工大学管理学院上海200093 西安电子科技大学经济与管理学院陕西西安710126

数量众多的第三方卖家是一种战略资源,对复合型电商平台发展有重要意义。然而,观察发现:很多销量为零的第三方卖家(称之为停售第三方卖家)长期停留在复合型电商平台上。这些停售第三方卖家除了缴纳技术服务费外,无法给电商平台带来扣点... 详细信息

数量众多的第三方卖家是一种战略资源,对复合型电商平台发展有重要意义。然而,观察发现:很多销量为零的第三方卖家(称之为停售第三方卖家)长期停留在复合型电商平台上。这些停售第三方卖家除了缴纳技术服务费外,无法给电商平台带来扣点收入,却会增加消费者筛选产品的成本,进而降低交易效率。基于这一现象,本文构建了一个包含停售第三方卖家的复合型电商平台模型,分析停售第三方卖家数量对均衡结果的影响,探讨他们对复合型电商平台的策略价值。研究发现:由于均衡解所处区域不同,停售第三方卖家的存在可能加剧也可能缓解平台自营和在售第三方卖家之间的竞争;与不存在停售第三方卖家情形相比,适当数量的停售第三方卖家可以同时提高复合型电商平台和在售第三方卖家的利润;控制第三方卖家总数量总是对在售第三方卖家有利,是否有利于复合型电商平台取决于单位交易成本获得的基本效用和技术服务费;当消费者更偏好平台自营时,在售第三方卖家利润会减少,复合型电商平台利润可能增加也可能减少。

关键词：复合型电商平台第三方卖家 Spokes模型定价策略

在线全文

学校读者我要写书评

暂无评论

基于RBF的油气水段塞流流型超声识别方法

化工进展 2024年第2期43卷 628-636页

作者：苏茜夏志飞刘振兴武汉科技大学信息科学与工程学院/人工智能学院湖北武汉430081 武汉科技大学冶金自动化与检测技术教育部工程研究中心湖北武汉430081

石油管道内的多相流流型识别主要集中在气液两相流和油水两相流方向且准确识别流型范围有限,为了解决油气水段塞流流型识别问题,本文提出一种基于RBF神经网络和超声传播规律的油气水段塞流流型识别方法。根据油气水段塞流的相分布特点,... 详细信息

石油管道内的多相流流型识别主要集中在气液两相流和油水两相流方向且准确识别流型范围有限,为了解决油气水段塞流流型识别问题,本文提出一种基于RBF神经网络和超声传播规律的油气水段塞流流型识别方法。根据油气水段塞流的相分布特点,建立了流型识别超声测试仿真模型。采用超声透射衰减技术和反射回波技术研究水平管道油气水三相段塞流超声响应特性,提取透射衰减信号区分段塞流液膜区、气泡夹带区和稳定液塞区。利用反射信号时间序列数据中的回波能量等统计特征,通过RBF神经网络对油气水段塞流进行流型识别。结果表明,基于超声传播机理以及RBF神经网络三相段塞流流型识别率为95.7%。基于RBF神经网络的流型识别算法研究为超声技术实现水平管油气水段塞流流型识别提供了理论基础。

关键词：多相流瞬态响应油气水段塞流超声衰减 RBF网络流型识别

在线全文

学校读者我要写书评

暂无评论

油气水三相流相含率超声测试模型优化

化工进展 2024年第2期43卷 791-799页

作者：苏茜邓翔天刘振兴武汉科技大学信息科学与工程学院(人工智能学院) 湖北武汉430081 武汉科技大学冶金自动化与检测技术教育部工程研究中心湖北武汉430081

油气水多相流广泛存在于油气工业过程。针对现有油气水多相流相含率模型对超声换能器测量信息利用有限这一问题,提出了一种水基分散分层流相含率超声测试模型的优化方法。利用最大粒径模型,研究了水基分散分层流中分散相粒径变化规律,... 详细信息

油气水多相流广泛存在于油气工业过程。针对现有油气水多相流相含率模型对超声换能器测量信息利用有限这一问题,提出了一种水基分散分层流相含率超声测试模型的优化方法。利用最大粒径模型,研究了水基分散分层流中分散相粒径变化规律,确定粒径-波长比的范围处于中波长区。根据超声脉冲回波法,采用“一发三收”超声换能器测试系统,提出了水基分散分层流中超声扩散衰减的测试方法。在此基础上,结合Faran弹性散射理论,建立了油水分散流含油率超声测试模型。利用换能器渡越时间测量信息,提出了声程波动修正参数,改进了油水分散流中混合声速测试模型,并进一步优化了含气率测试模型。仿真结果表明,水基分散分层流含气率预测平均相对误差和均方根误差分别为0.43%和0.23%,含油率预测平均相对误差和均方根误差分别为3.30%和0.28%,验证了所提出的基于混合声速的相含率测试优化模型的有效性和准确性,为油气水多相流超声测试方法提供理论依据。

关键词：分散系相含率模型优化脉冲回波法

在线全文

学校读者我要写书评

暂无评论

叙事结构理论视角下数据故事模型构建研究

现代情报 2024年第7期44卷 13-21页

作者：宿倩纪雪梅山东理工大学信息管理学院山东淄博255049

[目的/意义]数据故事是数据与故事的结合,具有叙事性和结构性,从叙事结构理论视角可以厘清数据故事的结构要素,进而构建数据故事模型,指导数据故事创作。[方法/过程]首先,基于叙事结构理论从故事点、叙事意图、叙事逻辑、视觉效果4个层... 详细信息

[目的/意义]数据故事是数据与故事的结合,具有叙事性和结构性,从叙事结构理论视角可以厘清数据故事的结构要素,进而构建数据故事模型,指导数据故事创作。[方法/过程]首先,基于叙事结构理论从故事点、叙事意图、叙事逻辑、视觉效果4个层次剖析数据故事结构,得到数据故事模型框架;其次,从原料层、目标层、结构层和呈现层4个层次构建数据故事模型,对数据故事构建的生命周期进行阐释;最后,通过制作山东省农业碳排放数据故事对构建的数据故事模型进行实例分析。[结果/结论]该模型能够指导数据故事的生成和结构要素的呈现,对于提升数据的可读性、可理解性和逻辑性具有一定的理论与实践意义。

关键词：叙事结构叙事要素数据故事数据叙事山东省农业碳排放

基于协同降噪与IGWO-SVR的高填方路基沉降预测

在线全文

学校读者我要写书评

暂无评论

铁道学报 2024年第3期46卷 87-98页

作者：苏谦张棋张宗宇牛云彬陈德西南交通大学土木工程学院四川成都610031 西南交通大学高速铁路线路工程教育部重点实验室四川成都610031

高填方路基沉降影响山岭重丘区重载铁路运营安全。为克服实测沉降数据掺杂随机噪声、现有预测模型适用性差的不足,提出基于协同降噪算法与IGWO-SVR模型的沉降预测方法。运用互补集合经验模态分解法(CEEMD)与小波包变换法(WPT)对含噪沉... 详细信息

高填方路基沉降影响山岭重丘区重载铁路运营安全。为克服实测沉降数据掺杂随机噪声、现有预测模型适用性差的不足,提出基于协同降噪算法与IGWO-SVR模型的沉降预测方法。运用互补集合经验模态分解法(CEEMD)与小波包变换法(WPT)对含噪沉降数据进行协同降噪处理;提出基于佳点集初始化均布、非线性收敛控制与自身历史最优记忆位置更新的改进灰狼优化(IGWO)算法,并结合支持向量回归模型(SVR),构建IGWO-SVR沉降预测模型。进一步地,利用大准铁路工点及现有文献研究成果,验证IGWO-SVR模型的优越性。结果表明:协同降噪法可有效消除原数据中噪声项的干扰波动;在小样本数据集上,IGWO-SVR模型较传统沉降预测模型与现有文献所述预测模型,具有更高的预测精度与稳定性。研究成果为重载铁路高填方路基沉降预测提供了新途径。

关键词：重载铁路高填方路基沉降预测协同降噪改进灰狼优化支持向量回归