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Effect of Nitric Oxide on the Interaction Between Mitochondrial Malate Dehydrogenase and Citrate Synthase

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Journal of Integrative Agriculture 2014年第12期13卷 2616-2624页

作者： LIU Yu-chen WANG Juan su pei-ying MA Chun-mei ZHU Shu-hua College of Chemistry and Material Science Shandong Agricultural University Department of Horticultural and Forest Engineer Heze University Tai’an Tumor Prevention and Treatment Hospital

Mitochondrial malate dehydrogenase （mMDH） and citrate synthase （CS） are sequential enzymes in Krebs cycle. mMDH, CS and the complex between mMDH and CS （mMDH＋CS） were treated with nitric oxide solution. The roles of notric oxide （NO） on the secondary structures and the interactions between mMDH and CS were studied using circular diehroism （CD） and Fourier transform surface plasmon resonance （FT-SPR）, respectivley. The effects of NO on the activities of mMDH, CS and mMDH＋CS were also studied. And the regulations by NO on mMDH and CS were simulated by PyMOL software. The results of SPR conifrmed that strong interaction between mMDH and CS existed and NO could signiifcantly regulate the interaction between the two enzymes. NO reduced the mass percents ofα-helix and increased that of random in mMDH, CS and mMDH＋CS. NO increased the activities of CS and mMDH＋CS, and inhibited the activity of mMDH. Graphic simulation indicated that covalent bond was formed between NO and Asn242 in active site of CS. However, there was no direct bond between NO and mMDH. The increase in activity of mMDH＋CS complex depended mostly on the interaction between NO and CS. All the results suggested that the regulations by NO on the activity and interaction between mMDH and CS were accord with the changes in mMDH, CS and mMDH＋CS caused by NO.

关键词： Krebs cycle nitric oxide surface plasmon resonance protein-protein interaction citrate synthase malate dehydrogenase

Pathogenic genes and clinical prognosis in hypertrophic cardiomyopathy

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World Journal of Cardiology 2025年第1期17卷 47-54页

作者： ying Hong Hu-Tao Xi Xin-Yi Yang Wilber W su Xiao-Ping Li Institute of Cardiovascular Diseases&Department of Cardiology Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina Department of Cardiology Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Department of Cardiology Banner-University Medical CenterPhoenixAZ 85006United States

Hypertrophic cardiomyopathy(HCM)is an autosomal dominant inherited cardiomyopathy characterized by left ventricular *** is one of the chief causes of sudden cardiac death in younger people and ***-genetic studies have confirmed that the vast majority of HCM is caused by mutations in genes encoding sarcomere *** has a relatively wide phenotypic heterogeneity,varying from asymptomatic to sudden cardiac death,because of the many different mutations and pathogenic genes underlying *** studies have explored the clinical symptoms and prognosis of HCM,emphasizing the importance of genotype in evaluating patient prognosis and guiding the clinical management of *** elaborate the main pathogenic genes and phenotypic prognosis in HCM to promote a better understanding of this genetic *** analysis of literature to evaluate the association between underlying gene mutations and clinical phenotypes in HCM *** sequencing technology advances,the pathogenic gene mutation spectrum and phenotypic characteristics of HCM are gradually becoming *** is a widespread inherited disease with a highly variable clinical *** precise mechanisms linking known pathogenic gene mutations and the clinical course of this heterogeneous condition remain elusive.

关键词： Hypertrophic cardiomyopathy Genotype Phenotype Pathogenic genes Prognosis

Impact of dietary nutrition regimens based on body composition analysis on bone metabolism in Alzheimer’s disease patients

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World Journal of Psychiatry 2025年第2期15卷 59-68页

作者： Xue-Lian Wang Yi-Ran Zhao ying Yu Zhi-Fang Mao su-Xian Tan Shan-Shan Yu Department of Clinical Nutrition The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Rehabilitation Treatment Group The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Geriatrics The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Rehabilitation Medicine The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Psychiatry The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Geriatric Psychiatry The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Body composition analysis(BCA)is primarily used in the management of conditions such as obesity and endocrine ***,its potential in providing nutritional guidance for patients with Alzheimer’s disease(AD)remains relatively *** To explore the clinical efficacy of BCA-based dietary nutrition scheme on bone metabolism in AD *** This retrospective study included 96 patients with AD complicated by osteoporosis who were admitted to The Third Hospital of Quzhou between January 2023 and December *** on data from previous similar studies,the patients were randomly assigned to either a routine diet(RD)group(n=48)or a personalized nutrition(PN)group(n=48).The RD group received conventional dietary guidance,while the PN group received individualized diet intervention measures based on human *** intervention period lasted for 12 *** mineral density(BMD),body mass index(BMI),muscle mass,mineral content,osteocalcin,25-hydroxyvitamin D,procollagen type I N-terminal propeptide(PINP),beta C-terminal telopeptide of type I collagen(β-CTX),and serum calcium were measured and compared between the two groups before and 12 weeks after the *** No significant differences were observed between groups in terms of age,sex,height,BMI,or other baseline data(P>0.05).In both groups,BMI did not show significant changes after the intervention(P>0.05),whereas muscle mass and mineral content were significantly increased(P-1 compared to the RD group(P<0.05).The mini-mental state examination(MMSE)score was similar in both groups before the ***,12 weeks after the intervention,the MMSE score in the PN group was significantly higher than

关键词： Alzheimer’s disease Bone metabolism disorders Human body composition analysis Dietary nutrition Bone homeostasis Dietary management

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新时代人文经济学理论构建的三重维度

苏州大学学报(哲学社会科学版) 2025年第1期46卷 10-18页

作者：苏培君苏州大学哲学系/人文经济学研究院江苏苏州215021

站在中华民族伟大复兴之战略全局和世界百年未有之大变局的历史方位,构建新时代人文经济学既是对西方经济学的价值反思,也是对中国经济发展实践的自觉审视,更是对构筑中国经济学自主知识体系的学术期许。新时代人文经济学作为一个崭新... 详细信息

站在中华民族伟大复兴之战略全局和世界百年未有之大变局的历史方位,构建新时代人文经济学既是对西方经济学的价值反思,也是对中国经济发展实践的自觉审视,更是对构筑中国经济学自主知识体系的学术期许。新时代人文经济学作为一个崭新的概念,它的构建不是在“文化沙漠”中的自然生长,而是有着丰富的思想资源作为理论支撑。鉴于此,本文尝试从马克思经典文本中的人文经济思想、中华优秀传统文化中的人文底蕴及其经济伦理思想,以及西方经济思想中的人文元素等三个维度出发,总结与提炼新时代人文经济学的思想资源,试图打破以西方经济学为主导的学科定式思维的同时,深化新时代人文经济学的理论基底与文化底蕴,继而为新时代人文经济学的理论构建培育系统而深厚的理论根基。

关键词：新时代人文经济学根脉魂脉人文元素思想资源

Multi-Scenario Probabilistic Load Flow Calculation Considering Wind Speed Correlation

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Energy Engineering 2025年第2期122卷 667-680页

作者： Xueqian Wang Hongsheng su School of Automation and Electrical Engineering Lanzhou Jiaotong UniversityLanzhou730070China

As the proportion of newenergy increases,the traditional cumulant method(CM)produces significant errorswhen performing probabilistic load flow(PLF)calculations with large-scale wind power *** the wind speed correlation,a multi-scenario PLF calculation method that combines random sampling and segmented discrete wind farm power was ***,based on constructing discrete scenes of wind farms,the Nataf transform is used to handle the correlation between wind ***,the random sampling method determines the output probability of discrete wind power scenarios when wind speed exhibits ***,the PLF calculation results of each scenario areweighted and superimposed following the total probability formula to obtain the final power flow calculation *** in the IEEE standard node system,the absolute percent error(APE)for the mean and standard deviation(SD)of the node voltages and branch active power are all within 1%,and the average root mean square(AMSR)values of the probability curves are all less than 1%.

关键词： Wind speed correlation probabilistic load flow multi-scenario piecewise cumulant method

Geographical Engineering and Its Role in Promoting Integrated Geography Research

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Chinese Geographical Science 2025年第1期35卷 1-23页

作者： LIU Yansui su Sixin LI Xuhong Institute of Geographic Science and Natural Resources Research Chinese Academy of SciencesBeijing 100101China Faculty of Geographical Science and Engineering Henan UniversityZhengzhou 450046China College of Resource and Environment University of Chinese Academy of SciencesBeijing 100049China

Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific *** possesses its distinct ontological basis and value orientation,rendering it inseparable from being merely a derivative of geographical science or *** paper defines geographical engineering and introduces its development history through the lens of Chinese geographical engineering ***,it is highlighted the logical and functional consistency between the theory of human-earth system and the praxis of geographical *** modern cases of geographical engineering projects are presented in detail to demonstrate the points and characteristics of different types of modern geographical *** engineering serves as an engine for promoting integrated geography research,and in response to the challenge posed by fragmented geographies,this paper advocates for an urgent revitalization of geographical *** feasibility of revitalizing geographical engineering is guaranteed because it aligns with China’s national strategies.

关键词： geographical engineering geographical science and engineering integrated geography research human-earth system Chinese geography

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A mitochondria targeting Ir(Ⅲ)complex triggers ferroptosis and autophagy for cancer therapy:A case of aggregation enhanced PDT strategy for metal complexes

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Chinese Chemical Letters 2025年第1期36卷 374-380页

作者： Panpan Wang Hongbao Fang Mengmeng Wang Guandong Zhang Na Xu Yan su Hongke Liu Zhi su Jiangsu Collaborative Innovation Center of Biomedical Functional Materials College of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China

Metal complexes hold significant promise in tumor diagnosis and ***,their potential applications in photodynamic therapy(PDT)are hindered by issues such as poor photostability,low yield of reactive oxygen species(ROS),and aggregation-induced ROS *** address these challenges,we present a molecular self-assembly strategy utilizing aggregation-induced emission(AIE)conjugates for metal *** a proof of concept,we synthesized a mitochondrial-targeting cyclometalated Ir(Ⅲ)photosensitizer *** approach significantly enhances the photodynamic effect while mitigating the dark toxicity associated with AIE ***-TPE readily self-assembles into nanoaggregates in aqueous solution,leading to a significant production of ROS upon light *** Ir-TPE triggers multiple modes of death by excessively accumulating ROS in the mitochondria,resulting in mitochondrial DNA *** damage can lead to ferroptosis and autophagy,two forms of cell death that are highly cytotoxic to cancer *** aggregation-enhanced photodynamic effect of Ir-TPE significantly enhances the production of ROS,leading to a more pronounced cytotoxic *** vitro and in vivo experiments demonstrate this aggregation-enhanced PDT approach achieves effective in situ tumor *** study not only addresses the limitations of metal complexes in terms of low ROS production due to aggregation but also highlights the potential of this strategy for enhancing ROS production in PDT.

关键词： Metal complex AIEgens Mitochondria targeting Enhanced photodynamic therapy Anticancer agent

Distributed State and Fault Estimation for Cyber-Physical Systems Under DoS Attacks

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IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 261-263页

作者： Limei Liang Rong su Haotian Xu the School of Control Science and Engineering Shandong University IEEE the School of Electrical and Electronic Engineering Nanyang Technological University

Dear Editor,The letter deals with the distributed state and fault estimation of the whole physical layer for cyber-physical systems(CPSs) when the cyber layer suffers from DoS attacks. With the advancement of embedded computing, communication and related hardware technologies, CPSs have attracted extensive attention and have been widely used in power system, traffic network, refrigeration system and other fields.

关键词： Observers Estimation error Sensors Physical layer Sensor systems Security Power system stability

Bluish-green emission of novel BaAl_(2)Ge_(2)O_(8):Eu^(2+) phosphors under near-ultraviolet excitation

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Journal of Rare Earths 2025年第1期43卷 30-38,I0002页

作者： Sk.Khaja Hussain Jae su Yu Department of Electronic Engineering Institute for Wearable Convergence ElectronicsKyung Hee University1 Seocheon-dongGiheung-guYongin-sGyeonggi-do446-701Republic of Korea Nanosensor Research Institute Hanyang University55 Hanyangdaehak-roSangnok-guAnsanGyeonggi-do15588Republic of Korea

A new class of phosphor samples,denoted as Ba_(1-x)Al_(2)Ge_(2)O_(8):xEu^(2+)(BAGO:xEu^(2+))was synthesized using a Pechini-type sol-gel technique and subsequent thermal reduction in CO *** morphology and structural characteristics of both the BAGO host lattice and the Eu^(2+)ions activated BAGO phosphors were investigated through field-emission scanning electron microscopy and X-ray diffractometry analyses,*** BAGO host lattice has micro-sized particles and the Rietveld refinement reveals the presence of a monoclinic crystal phase,characterized by the space group I2/c(No.15).Introducing Eu^(2+)ions into Ba^(2+)sites under CO condition reduces the particle size,switching from microscale to *** the near-ultraviolet spectrum(353 nm),the BAGO:xEu^(2+)phosphors exhibit a broadband bluish-green photoluminescence(PL)emission characterized by a peak band at 492 *** phenomenon is attributed to the 4f^(6)5d^(1)→4f^(7) electronic *** BAGO:0.02Eu^(2+)phosphor shows the strongest bluish-green PL emission,and a co mprehensive description of the concentration quenching mechanism between Eu^(2+)ions is ***,the thermal stability of the optimized BAGO:0.02Eu^(2+)phosphor was investigated,and its activation energy was ***,the synthesized bluish-green BAGO:0.02Eu^(2+)phosphor holds the promise of being a novel and potential candidate for utilization in white light-emitting diode applications.

关键词： Broadband bluish-green Ba1Al_(2)Ge_(2)O_(8):Eu^(2+) Near-ultraviolet excitation cothermal reduction White light-emitting diodes Rare earths