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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian li Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting li qiang su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

Optimization of the Test of Tartrazine and sunset Yellow in Cereals by Means of HPLC

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Chinese Food Science 2012年第1期1卷 43-46页

作者： CHU Hong-tao ZHANG Hui WANG Jun JIN Feng-long su li-qiang Qiqihar University Qingdao University of Science and Technology Qiqihaer Bureau of Quality and Technical supervision

[Objective] The aim was to explore an optimized method to measure the artificial pigment by means of high performance liquid chroma- tograph. [Method] The gradient elution technique of HPLC was used to isolate and analyze tartrazine and sunset yellow in the cereals. The pre- treatment temperature, ultrasonic time, the column temperature and the elution conditions were studied, and the best expedmental conditions were confirmed. [ Result] At 40 ℃, the optimum chromatography analysis condition was moving phase, with pH （6.8）, methanol/water of acetic acid- ammonium acetate （0.02 mol/L）, and column temperature （35 ℃）. Gradient elution condition was 20% -35% methanol, 3%/rain; 35% -98%, 6%/min; 98%, 8 min. The content of tartrazine and sunset yellow in cereal was tested precisely by the means of HPLC. The average recoveries of standard addition were 97.9% and 100.2%, and the detection limit were 0.02 mg/kg and 0.03 mg/kg. [ Conclusion] This method shortened the a- nalysis time, improved the detection sensitivity and the resolution of artificial color.

关键词： Cereals Tartrazine sunset Yellow High Performance liquid Chromatography Optimization China

Recent development in electrode design for wide-temperature supercapacitors

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Science China Chemistry 2025年第1期68卷 96-117页

作者： Jianhong liu qiang Zhou Yuxiao lin Xinsheng Zhao Guangmin Zhou Xiaoxiao li School of Physics and Electronic Engineering Jiangsu Normal University Tsinghua-Berkeley Shenzhen Institute & Tsinghua Shenzhen International Graduate School Tsinghua University

An ever-increasing market demand has stimulated the soaring enthusiasm of researchers to develop wide-temperature supercapacitors(SCs). The active electrode is one of the most important parts of SC, which is directly related to the energy density,power transmission and long-term cyclability of the device in the wide-temperature environment. Compared with the SC electrodes aimed for room-temperature application, the SC electrodes for operating at wide-temperature scene often face greater challenges. In this review, the main challenges of SC electrodes under various temperature conditions, including low, high and cross-fade temperatures, are summarized. The relevant performance decay and failure mechanisms of wide-temperature SC electrodes are analyzed. In addition, this review deals with the recent studies and developments in robust wide-temperature SC electrodes with respect to the rational design of electrode structures and the exploitation of advanced active materials. Finally, the future directions for exploring reliable wide-temperature SCs are also proposed.

关键词： supercapacitor wide-temperature electrode design active materials

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： qiang liu Xiang li Shen Du Ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei li Jian-Hong Shi Tan li Wan-su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

Effect of Progressive substitution of Cement and lime by Powdered Shells Used as a Curing Agent for Dredged Soil in a Port Area

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 88-102页

作者： suN Yang WANG Faxin su Yaying li Yiwei HE Feng College of Harbour Coastal and Offshore EngineeringHohai UniversityNanjing 210098China Huai'an Research Institute Hohai UniversityHuai'an 223025China Jiangsu Fangyang Industrial Investment Corp.Ltd. Lianyungang 210098China

This study aimed to address the challenges of solid waste utilization,cost reduction,and carbon reduction in the treatment of deep-dredged soil at Xuwei Port in lianyungang city of *** research in this area was ***,a curing agent made from powdered shells was used to solidify the dredged soil in *** employed laboratory orthogonal tests to investigate the physical and mechanical properties of the powdered shell-based curing *** was collected by conducting experiments to assess the role of powdered shells in the curing process and to determine the optimal ratios of powdered shells to solidified soil for different *** development of strength in solidified soil was studied in both seawater and pure water *** study revealed that the strength of the solidified soil was influenced by the substitution rate of powdered shells and their interaction with *** cement content had a positive effect on *** high-strength solidified soil,the recommended ratio of wet soil:cement:lime:powdered shells were 100:16:4:4,while for low-strength solidified soil,the recommended ratio was 100:5.4:2.4:***,under appropriate conditions,improved short-term strength by promoting the formation of expansive ettringite minerals that contributed to cementation and *** findings suggest that the combination of cement and powdered shells is synergistic,positively affecting the strength of solidified *** recommended ratios provide practical guidance for achieving desired strength levels while considering factors such as cost and carbon *** role of seawater in enhancing short-term strength through crystal formation is noteworthy and can be advantageous for certain *** conclusion,this research demonstrates the potential of using a powdered shell-based curing agent for solidifying dredged soil in an environmentally friendly and cost-effective *** recommended ratios for different str

关键词： carbon reduction and solidification dredged soil abandoned shells orthogonal test chemical additives(lime and cement) unconfined compressive strength(UCS)

磺胺类复合模板分子印迹聚合物的制备及其应用

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分析试验室 2016年第5期35卷 590-595页

作者：秦世丽苏立强王鹏哈尔滨工业大学理学院哈尔滨150006 齐齐哈尔大学化学与化学工程学院齐齐哈尔161006

以磺胺甲基嘧啶和磺胺甲恶唑为复合模板分子，2-乙烯基吡啶为功能单体，二甲基丙烯酸乙二醇酯为交联剂，制备了对磺胺类抗生素（SAs）具有组选择吸附性能的印迹聚合物。通过紫外光谱法分析双模板分子印迹效应产生的机制，静态吸附实验... 详细信息

以磺胺甲基嘧啶和磺胺甲恶唑为复合模板分子，2-乙烯基吡啶为功能单体，二甲基丙烯酸乙二醇酯为交联剂，制备了对磺胺类抗生素（SAs）具有组选择吸附性能的印迹聚合物。通过紫外光谱法分析双模板分子印迹效应产生的机制，静态吸附实验研究聚合物对SAs的结合与识别性能。结果表明，双模板-功能单体分子间的多位点协同作用优化了聚合物的印迹孔穴，使其对SAs体现出良好的组选择吸附性。同时，以该印迹聚合物为固相萃取材料，建立分子印迹一固相萃gz／HPLC方法，对污水处理厂进、出水中的SAs进行分离、富集、检测，方法回收率为86．1％～98．0％，相对标准偏差低于6．5％，检测限为4．46～12．34ng／L，可以满足环境水样中痕量SAs的确证和多残留分析的要求。

关键词：磺胺类抗生素复合模板分子印迹聚合物分子印迹一固相萃取

有机磷阻燃剂气相色谱-四极杆飞行时间质谱裂解机理研究

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质谱学报 2021年第1期42卷 36-47,I0002页

作者：杨吉双张庆合苏立强齐齐哈尔大学化学与化学工程学院黑龙江齐齐哈尔161006 中国计量科学研究院化学计量与分析科学研究所北京100029

利用气相色谱-四极杆飞行时间质谱法(GC-QTOF MS),在全扫描模式下,采用电子轰击离子源(EI)对烷基类、氯化类和芳香类等17种有机磷阻燃剂(OPFRs)的质谱裂解机理进行探究。结果表明,在50 eV电离能下,各化合物碎片离子丰度较高且相对稳定... 详细信息

利用气相色谱-四极杆飞行时间质谱法(GC-QTOF MS),在全扫描模式下,采用电子轰击离子源(EI)对烷基类、氯化类和芳香类等17种有机磷阻燃剂(OPFRs)的质谱裂解机理进行探究。结果表明,在50 eV电离能下,各化合物碎片离子丰度较高且相对稳定。烷基类和氯化类OPFRs通常会发生3次γ-H重排,C—O键断裂后分别形成[M-R+2H]^+、[M-2R+3H]^+、[M-3R+4H]^+碎片离子,支链氯化类OPFRs易失去—CH2Cl;芳香类OPFRs更易断裂P—O键得到相应碎片;同时发现,邻、间、对磷酸三甲苯酯碎片离子种类基本相似,但碎片丰度却存在明显差异。这3类OPFRs在碎裂过程中均伴随失水现象。本研究通过探究OPFRs各化合物质谱裂解机理,建立了全扫描模式下OPFRs精确质量数据库,为此类化合物的结构鉴定提供了依据。

关键词：有机磷阻燃剂气相色谱-四极杆飞行时间质谱(GC-QTOF MS) 裂解机理

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang Lei Xiao Zhiyong Kan Jing Guo qiang li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms