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Synthesis of Hydroxylated Sterols(Ⅱ)——Synthesis of 24-Methylenecholest-4-en-3β,6α-diol

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Chemical Research in Chinese Universities 2000年第3期16卷 271-272页

作者： ZENG Long mei CUI Jian guo su jing yu Department of Chemistry Zhongshan UniversityGuangzhou 510275P.R.China Department of Chemistry Guangxi Teachers CollegeNaning 530001P.R.China

In a study on the soft coral, Alcyonuim patagonicum, a new hydroxylated sterol, 24-methylenecholest-4-en-3β,6α-diol exhibiting a potent activity to murine leukemia cells (IC50 = 1 μg/mL) was isolated and synthesized. The relationship between the chemical structure and the biological activity of the hydroxylated sterols, the synthesis of 24-methylenecholest-4-en-3β,6α-diol were presented. The melting point were determined on a X4 apparatus and were uncorrected. The infrared spectra were measured with a Nicolet 205 FT-IR and Nicolet FT-360 spectrophotometer. The H NMR spectra were recorded on a Varian Unity Inova 500 NB spectrometer in CDCl3 using tetramethylsilane (TMS) as the internal standard.

关键词： Synthesis Reduction 24-Methylenecholest-4-en-3u,6T-diol

Tricyclic Sesquiterpene from Laurencia Majuscula

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Chemical Research in Chinese Universities 1997年第2期13卷 84-86页

作者： XU Xiao Hua ZENG Long Mei su jing yu Department of Chemistry Zhongshan UniversityGuangzhou510275

ＴｒｉｃｙｃｌｉｃＳｅｓｑｕｉｔｅｒｐｅｎｅｆｒｏｍＬａｕｒｅｎｃｉａＭａｊｕｓｃｕｌａ＊ＸＵＸｉａｏ－Ｈｕａ，ＺＥＮＧＬｏｎｇ－ＭｅｉａｎｄＳＵＪｉｎｇ－Ｙｕ＊＊（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙ，Ｚｈｏ... 详细信息

ＴｒｉｃｙｃｌｉｃＳｅｓｑｕｉｔｅｒｐｅｎｅｆｒｏｍＬａｕｒｅｎｃｉａＭａｊｕｓｃｕｌａ＊ＸＵＸｉａｏ－Ｈｕａ，ＺＥＮＧＬｏｎｇ－ＭｅｉａｎｄＳＵＪｉｎｇ－Ｙｕ＊＊（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙ，ＺｈｏｎｇｓｈａｎＵｎｉｖｅｒｓｉｔｙ，...

关键词： Tricyclic sesquiterpene Laurencia majuscula Terpenoid Majusin

Regio-and Stereo-selective Reductions of Steroidal 4-en-3,6-dione

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Chemical Research in Chinese Universities 2002年第4期18卷 400-404页

作者： CUI Jian-guo ZENG Long-mei su jing-yu LIN Cui-wu School of Chemistry and Chemical Engineering Zhongshan UniversityGuangzhou 510275P.R.China Department of Chemistry Guangxi Teachers CollegeNanning 530001P.R.China Department of Chemistry Guangxi UniversityNanning 530001P.R.China

The different regioselective and stereoselective products were obtained by the reduction of stigmast-4,22-dien-3,6-dione with NaBH_4-CH_3OH when different kinds of metal ions was added to the reaction.

关键词： Steroids Stigmast-4 22-dien-3 6-dione Regioselective reduction Metal ion

In vivo anti-tumor effect of hybrid vaccine of dendritic cells and esophageal carcinoma cells on esophageal carcinoma cell line 109 in mice with severe combined immune deficiency

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World Journal of Gastroenterology 2008年第8期14卷 1167-1174页

作者： Guang-Hua Guo su-Zuan Chen jing yu Juan Zhang Li-Li Luo Li-Hua Xie Zhong-jing su Hong-Mei Dong Hong Xu Li-Biao Wu Department of Gastroenterology The First Affiliatecl Hospital of Shantou University Medical College Shantou 515041Guangdong Province China

AIM： To develop a fusion vaccine of esophageal carcinoma cells and dendritic cells （DC） and observe its protective and therapeutic effect against esophageal carcinoma cell line 109 （EC109）. METHODS： The fusion vaccine was produced by fusing traditional polyethyleneglycol （PEG）, inducing cytokine, sorting CD34＋ magnetic microbead marker and magnetic cell system （MACS）. The liver, spleen and lung were pathologically tested after injection of the fusion vaccine. To study the therapeutic and protective effect of the fusion vaccine against tumor EC109, mice were divided immune group and therapeutic group. The immune group was divided into P, E, D and ED subgroups, immunized by phosphate buffered solution （PBS）, inactivated EC109, DC and the fusion vaccine respectively, and attacked by EC109 cells. The tumor size, weight, latent period and mouse survival period were recorded and statistically analyzed. The therapeutic group was divided into four subgroups： P, inactivated EC109, D and ED subgroups, which were attacked by EC109 and then treated with PBS, inactivated EC109, DC, and EC109-DC respectively. Pathology and flow cytometry were also used to study the therapeutic effect of the fusion vaccine against EC109 cells.REsuLTS： Flow cytometry showed that the expression of folate receptor （FR）, EC109 （C）, Des （D） in human nasopharyngeal carcinoma cell line （HNE1）（B） was 78.21%, 89.50%, and 0.18%, respectively. The fusion cells （C） were highly expressed. No tumor was found in the spleen, lung and liver after injection of the fusion vaccine. Human IgG was tested in peripheral blood lymphocytes （PBL）. In the immune group, the latent period was longer in EC109-DC subgroup than in other subgroups, while the tumor size and weight were also smaller than those in ED subgroup. In the therapeutic group, the tumor size and weight were smaller in ED subgroup than in P, inactivated EC109 and DC subgroups. CONCLUSION： Fusion cells are highly expressed not only in FR but also in CD8

关键词： Dendritic cells Esophageal carcinoma cells Cell fusion Immune protection Immunotherapy

A New Furanolactam from the Chinese Sponge Phacellis Fusca

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Chemical Research in Chinese Universities 1998年第4期14卷 78-79页

作者： ZENG Long mei, ZHU Ye, YAN su jun and su jing yu (Department of Chemistry, Zhongshan University, Guangzhou, 510275) Zhongshan Univ Dept Chem Guangzhou 510275 Peoples R China

Ｉｎｔｈｅｃｏｕｒｓｅｏｆｏｕｒｃｏｎｔｉｎｕｉｎｇｓｅａｒｃｈｆｏｒｂｉｏａｃｔｉｖｅｓｕｂｓｔａｎｃｅｓｆｒｏｍｍａｒｉｎｅｏｒｇａｎｉｓｍｓ，ｗｅｈａｖｅｓｔｕｄｉｅｄｔｈｅｓｅｃｏｎｄａｒｙｍｅｔａｂｏｌｉｔ... 详细信息

Ｉｎｔｈｅｃｏｕｒｓｅｏｆｏｕｒｃｏｎｔｉｎｕｉｎｇｓｅａｒｃｈｆｏｒｂｉｏａｃｔｉｖｅｓｕｂｓｔａｎｃｅｓｆｒｏｍｍａｒｉｎｅｏｒｇａｎｉｓｍｓ，ｗｅｈａｖｅｓｔｕｄｉｅｄｔｈｅｓｅｃｏｎｄａｒｙｍｅｔａｂｏｌｉｔｅｓｏｆｍａｒｉｎｅｓｐｏｎｇｅＰ...

关键词： Fuscain Furanolactam Sponge Phacellis fusca Cytotoxicity

Two new diterpenoids from the marine Soft coral Clavularia viridis

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Chinese Journal of Chemistry 1992年第2期10卷 155-160页

作者： su,jing-yu ZHONG,Yong-Li ZENG,Long-Mei Department of Chemistry,Zhongshan University,Guangzhou 510275 Department of Chemistry Zhongshan University Guangzhou 510275

Two new dolabellane diterpenoids named clavudiol B(2)and clavirolide F(5),have been iso- lated from the soft coral Clavularia viridis,collected from Xisha Islands in the South China *** structures have been determined... 详细信息

关键词： Two new diterpenoids from the marine Soft coral Clavularia viridis ppm

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(±)-耳壳藻内酯的全合成研究(Ⅱ)

高等学校化学学报 2006年第6期27卷 1055-1057页

作者：晏日安苏镜娱暨南大学食品科学与工程系广州510632 中山大学化学系广州510275

以2,6,6-三甲基环己-2-烯-1,4-二酮为原料,经选择性羰基保护、W ittig反应、脱保护基、腈基水解和还原等5步反应合成了目标化合物,总产率可达6.0%.

关键词：耳壳藻内酯 2,6,6-三甲基环己-2-烯-1,4-二酮 Wittig反应合成

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碟形弹簧竖向减震装置的性能试验研究

重庆建筑大学学报 2008年第6期30卷 51-55页

作者：张玉敏苏幼坡苏经宇河北理工大学建筑工程学院唐山063009 北京工业大学建筑工程学院北京100044

基础隔震技术是目前应用最广泛的结构控制方法,但是,目前这种技术只是最大限度地减少或隔离水平地震作用,而对竖向地震作用几乎没有影响。为改善隔震技术在隔离竖向地震中的限制,研制了一种由碟形弹簧和粘弹性阻尼器组合而成的碟形弹簧... 详细信息

基础隔震技术是目前应用最广泛的结构控制方法,但是,目前这种技术只是最大限度地减少或隔离水平地震作用,而对竖向地震作用几乎没有影响。为改善隔震技术在隔离竖向地震中的限制,研制了一种由碟形弹簧和粘弹性阻尼器组合而成的碟形弹簧竖向减震装置,并对其进行了在静载和动载作用下的力学性能试验研究,给出了该装置在竖向静力和动力作用下的等效刚度和阻尼比,建立了恢复力模型,试验研究表明,碟形弹簧竖向减震装置能有效的解决竖向大承载力和竖向阻尼的难题,力学性能优良且稳定,加工制作容易,是一种比较理想的竖向减震装置。

关键词：碟形弹簧粘弹性阻尼器竖向地震等效刚度等效阻尼比恢复力特性

Studies on the Steroids of Marine Sponge

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Chemical Research in Chinese Universities 1995年第2期11卷 174-177页

作者： ZENG Long-mei,ZENG Zhi and su jing-yu (Department of Chemistry,Zhongshan University,Guangzhou 510275)

Sterols are essential components of all eukaryotic cells and were the first group of marine sponge natural products used in the taxonomic characterization of marine sponges. Thus, in the past decade there has been an increasing interest in sterols of marine sponge, which has led to the discovery of a large number of novel compounds. The use of a variety of separation techniques has demonstrated the complexity of the sterol components of marine extracts, up to 50 sterols from one species of organism. However, the quantity of each sterol

关键词： Marine sponge Sterol GC-MS