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中华糖尿病杂志 2023年第S2期15卷 257-260页

作者：苏娇隋国良烟台市烟台山医院内分泌与代谢病科，烟台264000

回顾性分析1例在山东省烟台市烟台山医院内分泌与代谢病科就诊的2型糖尿病合并动脉粥样硬化性心血管疾病患者使用利拉鲁肽的诊疗过程并进行文献复习。患者为47岁男性,因“口干、多饮、多尿15年”入院,入院后完善相关检查,明确诊断为2型... 详细信息

回顾性分析1例在山东省烟台市烟台山医院内分泌与代谢病科就诊的2型糖尿病合并动脉粥样硬化性心血管疾病患者使用利拉鲁肽的诊疗过程并进行文献复习。患者为47岁男性,因“口干、多饮、多尿15年”入院,入院后完善相关检查,明确诊断为2型糖尿病合并动脉粥样硬化性心脏病,予利拉鲁肽(1.8 mg,1次/d)联合达格列净(10 mg,1次/d)控制血糖,联合抗血小板聚集、调脂、降压等综合治疗,患者血糖、血压、血脂、体重控制良好,胰岛功能改善。作为临床中常用的胰高糖素样肽-1受体激动剂,利拉鲁肽在发挥降糖作用的同时亦可降低体重、血压、血脂等代谢指标,实现糖尿病患者综合管理达标。

关键词：糖尿病,2型利拉鲁肽动脉粥样硬化性心血管疾病

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Factors affecting meibomian gland area loss in symptomatic adults

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1036-1041页

作者： Si-Cheng Ding Jing-Jing su Qing Zhan jiao-Man Wang Fang Zheng Xu-Xuan Fang Dan Cheng Ping Guo The Second Clinical Medical College Jinan UniversityShenzhen 518000Guangdong ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina Department of Ophthalmology Jinzhou Medical UniversityJinzhou 121000Liaoning ProvinceChina

AIM:To characterize the distribution of meibomian gland(MG)area loss(MGL)and its relationship with demographic characteristics,mites,and ***:This retrospective observational study included patients who visited the Dry Eye Clinic of Shenzhen Eye Hospital between June 2020 and August *** patient characteristics,ocular symptoms,Demodex test results of the eyelid edges,and the results of a comprehensive ocular surface analysis were *** was analyzed using Image J ***:This study enrolled 1204 outpatients aged 20-80(40.70±13.44)y,including 357 males(29.65%)and 847 females(70.35%).The patients were classified into mild(n=155;12.87%),moderate(n=795;66.03%),severe(n=206;17.11%),and extremely severe(n=48;3.99%)MGL *** was significantly larger in female than in male(P=0.006).The degree of MGL also significantly differed in age(P<0.001)and the more numbers of mites with severity(P<0.001).Multivariate disordered multinomial logistic regression analysis identified that female sex,older age,secretory symptoms,and a large number of mites were risk factors for MGL(P<0.05).CONCLUSION:Patients with MGL are more likely to be older,female,more numbers of mites,and increased secretion.

关键词： meibomianglands aging sex symptomatology Demodex

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基于耦合动力学模型的围岩-支架相互作用分析

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煤炭学报 2015年第11期40卷 2534-2539页

作者：周凯李明瑞焦素娟上海交通大学机械系统与振动国家重点实验室上海200240

液压支架处于与围岩相互作用的工作环境中,因此掌握其耦合作用规律,对于液压支架的抗冲击、自调适设计具有十分重要的意义。以ZY12000/28/64支顶掩护式液压支架为研究对象,运用拉格朗日第二类动力学理论建立6自由度围岩-支架耦合动力学... 详细信息

液压支架处于与围岩相互作用的工作环境中,因此掌握其耦合作用规律,对于液压支架的抗冲击、自调适设计具有十分重要的意义。以ZY12000/28/64支顶掩护式液压支架为研究对象,运用拉格朗日第二类动力学理论建立6自由度围岩-支架耦合动力学方程。应用该动力学方程,分析了基本顶质量、基本顶初始高度及断裂点位置对液压支架动力学响应的影响。结果表明,立柱千斤顶、平衡千斤顶的受力随着基本顶质量和基本顶初始高度的增加呈线性增大;随着断裂点位置的前移,立柱千斤顶受力增大、平衡千斤顶受力减小。

关键词：液压支架围岩-支架耦合动力学模型动力学响应

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Editing of eIF(iso)4E.c confers resistance against Turnip mosaic virus in Brassica rapa

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Horticultural Plant Journal 2024年第4期10卷 1020-1034页

作者： Yujia Liu Xiaoyun Xin Peirong Li Weihong Wang Yangjun Yu Xiuyun Zhao Deshuang Zhang jiao Wang Fenglan Zhang Shujiang Zhang Shuancang Yu Tongbing su State Key Laboratory of Vegetable Biobreeding Beijing Vegetable Research CenterBeijing Academy of Agriculture and Forestry ScienceBeijing 100097China National Engineering Research Center for Vegetables Beijing Key Laboratory of Vegetable Germplasms ImprovementKey Laboratory of Biology and Genetics Improvement of Horticultural Crops(North China)Key Laboratory of Urban Agriculture(North)of Ministry of AgricultureBeijing Vegetable Research CenterBeijing Academy of Agriculture and Forestry ScienceBeijing 100097China Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesBeijing 100081China

Turnip mosaic virus(TuMV)constitutes one of the primary diseases affecting Brassica rapa,severely impacting its production and resulting in crop failures in various regions *** research has demonstrated the significance of plant translation initiation factors,specifically the eIF4E and eIF4G family genes,as essential recessive disease resistance *** our study,we conducted evolutionary and gene expression studies,leading us to identify e IF(iso)4E.c as a potential TuMV-resistant *** CRISPR/Cas9 technology,we obtained mutant *** plants with edited eIF(iso)4E.c *** confirmed eIF(iso)4E.c confers resistance against TuMV through phenotypic observations and virus content ***,we employed ribosome profiling assays on eif(iso)4e.c mutant seedlings to unravel the translation landscape in response to ***,we observed a moderate correlation between the fold changes in gene expression at the transcriptional and translational levels(R^(2)=0.729).Comparative analysis of ribosome profiling and RNA-seq data revealed that plant-pathogen interaction,and MAPK signaling pathway-plant pathways were involved in eIF(iso)4E.c-mediated TuMV *** analysis revealed that sequence features,coding sequence length,and normalized minimal free energy,influenced the translation efficiency of *** study highlights that the loss of e IF(iso)4E.c can result in a highly intricate translation mechanism,acting synergistically with transcription to confer resistance against TuMV.

关键词： Brassica rapa eIF(iso)4E.c TuMV Ribo-seq

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