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Patient-Reported Outcomes of Postoperative NSCLC Patients with or without Staged Chinese Herb Medicine Therapy during Adjuvant Chemotherapy(NALLC 2): A Randomized, Double-Blind, Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第11期30卷 963-973页

作者： ZHANG Yi-lu JIAO Li-jing GONG Ya-bin XU Jian-fang NI Jian SHEN Xiao-yong ZHANG Jie ZHOU Di qiAN Cheng-xin WANG qin YAO Jia-lin yang wen-xiao su Ling-zi WANG Li-yu LI Jia-qi YAO Yi-qin ZHANG Yuan-hui WANG Yi-chao CHEN Zhi-wei XU Ling Oncology Department Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Institute of Traditional Chinese Medicine Oncology Shanghai University of Traditional Chinese Medicine Oncology Department Shanghai Pulmonary Hospital Shanghai Tongji University Thoracic surgery Department Huadong Hospital Shanghai Fudan University Thoracic surgery Department Shanghai Cancer Hospital Shanghai Fudan University Oncology Department Shanghai Chest Hospital Shanghai Jiao Tong University

Objective:To investigate whether the combination of chemotherapy with staged Chinese herbal medicine(CHM) therapy could enhance health-related quality of life(QoL) in non-small-cell lung cancer(NSCLC)patients and prolong the time before deterioration of lung cancer symptoms,in comparison to chemotherapy ***:A prospective,double-blind,randomized,controlled trial was conducted from December 14,2017 to August 28,2020.A total of 180 patients with stage ⅠB-ⅢA NSCLC from 5 hospitals in Shanghai were randomly divided into chemotherapy combined with CHM(chemo+CHM) group(120 cases) or chemotherapy combined with placebo(chemo+placebo) group(60 cases) using stratified blocking *** European Organization for Research and Treatment of Cancer(EORTC) Quality-of-Life-Core 30 Scale(QLQ-C30) was used to evaluate the patient-reported outcomes(PROs) during postoperative adjuvant chemotherapy in patients with early-stage *** events(AEs) were assessed in the safety ***:Out of the total 180 patients,173 patients(116in the chemo+CHM group and 57 in the chemo+placebo group) were included in the PRO *** initial mean QLQ-C30 Global Health Status(GHS)/QoL scores at baseline were 57.16±1.64 and 57.67±2.25 for the two respective groups(P>0.05).Compared with baseline,the chemo+CHM group had an improvement in QLQ-C30GHS/QoL score at week 18 [least squares mean(LSM) change 17.83,95% confidence interval(CI) 14.29 to 21.38].Conversely,the chemo+placebo group had a decrease in the score(LSM change-13.67,95% CI-22.70 to-4.63).A significant between-group difference in the LSM GHS/QoL score was observed,amounting to 31.63 points(95% CI25.61 to 37.64,P<0.001).The similar trends were observed in physical functioning,fatigue and appetite *** week 18,patients in the chemo+CHM group had a higher proportion of improvement or stabilization in GHS/QoL functional and symptom scores compared to chemo+placebo group(P<0.001).The median time to deterioration

关键词： Chinese herbal medicine adjuvant chemotherapy health-related quality of life non-small-cell lung cancer patient-reported outcome

Bio-MOF-11(Co)活化过一硫酸盐去除废水中的罗丹明B和Cu^(2+)

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中国环境科学 2024年第2期44卷 755-767页

作者：张霞玲苏冰琴宋鑫峂赵文博林嘉伟卫月星太原理工大学环境科学与工程学院山西晋中030600 山西省市政工程研究生教育创新中心山西晋中030600

采用Bio-MOF-11(Co)活化过一硫酸盐(PMS)同步去除废水中的罗丹明B(RhB)和Cu^(2+).考察了Bio-MOF-11(Co)投加量、PMS浓度、初始pH值、反应温度、RhB初始浓度和Cu^(2+)浓度对RhB降解和Cu^(2+)去除的影响,并采用响应面分析法优化了降解RhB... 详细信息

采用Bio-MOF-11(Co)活化过一硫酸盐(PMS)同步去除废水中的罗丹明B(RhB)和Cu^(2+).考察了Bio-MOF-11(Co)投加量、PMS浓度、初始pH值、反应温度、RhB初始浓度和Cu^(2+)浓度对RhB降解和Cu^(2+)去除的影响,并采用响应面分析法优化了降解RhB的反应条件.结果表明,RhB的降解符合伪一级反应动力学.Cu^(2+)最大吸附量为22.98mg/g.在RhB初始浓度为20mg/L、Cu^(2+)浓度为2.5mg/L、Bio-MOF-11(Co)浓度为80mg/L、PMS浓度为1.0mmol/L、初始pH值为7的条件下,反应15min后,RhB降解率达到98.72%,Cu^(2+)去除率为73.53%,.自由基淬灭实验证实,RhB的降解通过非自由基(~1O_(2))和自由基(SO_(4)^(-)·、·O_(2)^(-)和·OH)氧化的途径共同完成,Cu^(2+)主要通过Bio-MOF-11(Co)的吸附作用被去除.紫外可见吸收光谱分析结果推测了RhB可能的降解路径.Bio-MOF-11(Co)活化PMS高级氧化工艺可实现同步去除有机污染物和重金属.

关键词： Bio-MOF-11(Co) 过一硫酸盐罗丹明B 铜离子反应机制

Heavy metal pollution in tidal zones of Bohai Bay using the dated sediment cores

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Journal of Environmental Sciences 2006年第3期18卷 610-615页

作者： qin Yan-wen MENG Wei ZHENG bing-hui su Yi-bin River and Coastal Environment Research Center Chinese Research Academy of Environmental Sciences Beijing 100012 China

Three sediment cores were collected in November 2003 from Dagu estuary to qikou estuary. The main polluted heavy metals in the sediment of tidal zones for the Bohai Bay have been found by analyzing the relationship among the contents of heavy metals, the contents of geochemical elements （Fe, AI and Mn） and the size of grain. The dominating contaminative elements in tidal sediments of Bohai Bay are Pb, Zn and Cd. Their contents are higher than the corresponding upper limit of environmental background values and they have very faint correlation with the corresponding contents of geochemical elements and the size of grain, indicating the anthropogenic enrichment. Especially, the preliminary study on the pollution sources and the history of heavy metals in the Dagu estuary has been done using the dated results. The contamination by Zn and Cd also started in the middle 1950s, while the contamination by Pb appeared in the early 1940s. The pollution by Zn and Cd mainly originate from sewage discharge, while the pollution by Pb has many sources, like atmosphere deposition and industrial discharRe.

关键词： Bohai Bay tidal zone the dated sediment core heavy metal pollution

Rumen fermentation and bacterial communities in weaned Chahaer lambs on diets with different protein levels

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Journal of Integrative Agriculture 2016年第7期15卷 1564-1574页

作者： yang Chun-tao SI bing-wen DIAO qi-yu JIN Hai ZENG Shu-qin TU Yan Feed Research Institute Chinese Academy of Agricultural Sciences/Key Laboratory of Feed BiotechnologyMinistry of AgricultureBeijing 100081P.R.China Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences Huhhot 010000P.R.China

We evaluatedthe effects of diets with different crude protein （CP） levels on growth performance, rumen fermentation and bacterial communities in weaned Chahaer lambs. 128 weaned Chahaer lambs （（20.56±1.43） kg body weight; ram：ewe 1：1） aged （61±1.85） d were randomly alotted to one of four diets with CP content of 11.17% （T1）, 12.06% （T2）, 13.40% （T3） or 14.36% （T4）.Ruminal fermentation parameters were measured and bacterial communities were analysed using PCR-dena-turing gradient gel electrophoresis （PCR-DGGE） and quantitative PCR. The average daily gain and feed utilization efifciency in T3 were higher than those in the other groups （P〈0.05）, although the dry matter intake and metabolizable energy intake were similar. Total volatile fatty acid concentration in the ruminal lfuid of T3 was lower than that of T1 （P=0.011）, T2 （P=0.008） or T4 （P=0.309）. The ammonia nitrogen concentration and acetate/propionate ratio of ruminal lfuid were signiifcantly higher in lambs fed the higher CP diets, whereas the molar concentrations of propionate and butyrate of ruminal lfuid were lower. The rumen bacterial community was similar in T2 and T3 which shown more stable and diverse rumen microbes ecosystem compared with the other groups. The DGGE proifles and phylogenetic tree indicated thatBacteroides uniformis,Clostrid-iumalkalicellulosi,Alkalibaculum *** common bacterium of Chahaer lamb rumen. B. uniformis,***,Saccharofermentanssp. andGracilibacter thermotolerans,which belong to the Bacteroidetes and Firmicutesphyla,were the dominant species in the rumen of lambs fed 13.40% ***,Ruminococcus albus, Ruminococcus lfavefaciensand Butyrivibrio ifbrisolvenswerenot differentin lambs fed different CP diets. Therefore, it could be concluded thatB. uniformis,***,A. *** common bacteria of Chahaer lamb rumen. Furthermore, the dietary CP of 13.04% could improve performance and change rumen fermentati

关键词： dietary crude protein rumen fermentation bacterial diversity weaned lamb PCR-DGGE

Malignant histiocytosis associated with mediastinal germ cell tumor:A case report

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World Journal of Clinical Cases 2022年第20期10卷 7116-7123页

作者： Pei-Yi yang Xiao-Li Ma wen Zhao Li-bing Fu Rui Zhang qi Zeng Hong qin Tong Yu Yan su Department of Medical Oncology Pediatric Oncology CenterBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Pathology Beijing Children’s HospitalCapital Medical UniversityNational Center of Children’s HealthBeijing 100045China Hematology Center Beijing Children’s HospitalCapital Medical UniversityNational Center of Children’s HealthBeijing 100045China Department of Thoracic surgery Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of surgical Oncology Capital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Image Center Beijing Children’s HospitalCapital Medical UniversityNational Center of Children’s HealthBeijing 100045China

BACKGROUND Germ cell tumors(GCTs)account for 2%of human malignancies but are the most common malignant tumors among males aged *** 1983,an association between mediastinal GCT(MGCT)and hematologic malignancies has been *** suMMARY We report a case in which malignant histiocytosis was associated with mediastinal *** clinical data of a male patient with MGCT admitted to Beijing Children's Hospital were collected *** patient was first diagnosed according to imaging and pathological features as having MGCT,and was treated with surgery and *** year after stopping chemotherapy,imaging showed metastases in the right supraclavicular,mediastinum,hilar region and retroperitoneal lymph node,right pleura,right lung,and right para-cardiac *** diagnosis of the liver nodular and hilar lymph nodes included systemic juvenile xanthogranuloma and Rosai-Dorfman lesions with malignant transformation(i.e.,morphological characteristics and immunophenotype of histiocytic sarcoma).Following diagnosis,the patient accepted chemotherapy with vindesine,cytarabine and *** emission tomography–computed tomography showed partial *** patient was followed-up for 10 mo after the diagnosis of malignant histiocytosis,and no sign of progression or relapse was *** Physicians should recognize the possibility of hematologic malignancies being associated with *** sites should be selected for pathological examination.

关键词： Germ cell tumor Mediastinal Malignant histiocytosis Histiocytic sarcoma Hematologic malignancies Case report

Fabrication of azobenzene-functionalized porous polymers for selective CO_(2) capture

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Chinese Journal of Chemical Engineering 2022年第3期35卷 24-30页

作者： Ding-Ming Xue wen-Juan Zhang Xiao-qin Liu Shi-Chao qi Lin-bing sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China

Many solid adsorbents have been prepared for the CO_(2)*** particular,the photoresponsive adsorbents have attracted extensive interests because of their tunable pore structure and variable responsive behaviors provoked by the external ***,it is challenging to fabricate the photoresponsive adsorbents featured the big CO_(2)capacity and high CO_(2)***,copolymerized between 4-phenylazobenzoyl chloride,2,4,6-trichloro-1,3,5-triazine and melamine,a series of azobenzenefunctionalized porous polymers(PTM-AZOs)are successfully *** PTM-AZOs are verified in possession of proper pore structures,large surface area and photoconductive properties through a series of *** PTM-AZO-2 with the trans-isomerization exhibits the best CO_(2)adsorption amount of 2.7 mmol·g^(-1)(273 K and 0.1 MPa),while the CO_(2)/N_(2)selectivity can reach 2459 and 607 on the trans-and cis-isomerization,*** regulatable pore structures controlled by the photoresponsive azobenzene groups affect the CO_(2)capture performance of the PTM-AZOs.

关键词： Adsorption CO_(2)capture Selectivity Azobenzene Photoresponse

Active flow control of S-duct by plasma synthetic jet

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2022年第8期23卷 652-668页

作者： Ru-bing LIU Xiao-yin MEI Sheng-hui XUE Yu-wen LU Zhe-zhe su qi LIN School of Aerospace Engineering Xiamen UniversityXiamen 361102China Fujian Key Laboratoryof Plasmaand Magnetic ResonanceResearch Xiamen 361102China

Flow separation and secondary flow in the S-duct of an aircraft engine cause severe pressure loss and airflow distortion at the outlet,lowering engine ***,a serial two-electrode plasma synthetic jet(PSJ)actuator array is used to actively control the flow field in the duct and improve its *** results show that the PSJ significantly increases the wall pressure recovery coefficient,suppresses flow separation,and improves the outlet pressure *** primary and secondary orders of the influencing factors are as follows:control position>jet momentum coefficient>excitation frequency>jet *** best jet control position is near the separation location,and the best jet configuration is the‘Λ’*** higher the jet momentum coefficient and excitation frequency,the better the flow *** wall pressure coefficient increases by up to 127.8%,and the outlet steady pressure distortion index decreases by 9.15%.The control mechanism is the direct energy injection into the flow boundary layer through a high-speed jet and the indirect control effect of the induced streamwise *** the one hand,the PSJ suppresses flow separation by improving the ability of the boundary layer to resist the inverse pressure *** the other hand,it reduces pressure distortion by decreasing the intensity of the secondary flow and weakening the *** study thus provides a new technology for the active control of the flow-field characteristics in an S-duct and has significance for guiding the application of synthetic jet technology in S-ducts.

关键词： S-duct Flow control Plasma synthetic jet(PSJ) Flow separation Pressure distortion

使用血管活性药物重症病人肠内营养实施的进展

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肠外与肠内营养 2024年第3期31卷 176-183页

作者：张宏宇江利冰王海龙许永安王承妃阮峰齐文旗左素敏徐善祥浙江大学医学院附属第二医院急诊医学科/全省严重烧创伤诊治与应急救援重点实验室/浙江省急危重症临床医学研究中心浙江杭州310009

营养治疗是重症病人管理的核心内容之一,肠内途径因其营养及非营养双重作用成为了营养治疗的首选方式。血管活性药物的使用使得这部分病人肠内营养的决策更具挑战性。本综述系统回顾了血管活性药物对重症病人胃肠道的病理生理学影响、... 详细信息

营养治疗是重症病人管理的核心内容之一,肠内途径因其营养及非营养双重作用成为了营养治疗的首选方式。血管活性药物的使用使得这部分病人肠内营养的决策更具挑战性。本综述系统回顾了血管活性药物对重症病人胃肠道的病理生理学影响、目前肠内营养在此部分病人中应用的价值及安全性,总结了在此部分病人中实施肠内营养的最佳策略以供临床参考。

关键词：肠内营养血管活性药物重症病人实施策略

2022年汉江流域中游“汛期反枯”背景下的区域地下水化学特征

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地下水 2024年第2期46卷 26-30页

作者：张奥奇杨文兵何贞竹付文进苏召帝湖北省地质局第八地质大队湖北襄阳441000

2022年6月份,长江流域由于大气环流异常等因素而爆发大面积的严重干旱,产生了“汛期反枯”的异常现象,这种现象一直持续到当年冬季。汉江是长江第一大支流,选取汉江中游襄阳段岸线带周边地下水为研究对象开展研究,采用多元统计分析、Pi... 详细信息

2022年6月份,长江流域由于大气环流异常等因素而爆发大面积的严重干旱,产生了“汛期反枯”的异常现象,这种现象一直持续到当年冬季。汉江是长江第一大支流,选取汉江中游襄阳段岸线带周边地下水为研究对象开展研究,采用多元统计分析、Piper三线图、主成分分析、Gibbs图等方法对该地区地下水水化学特征及动态变化进行分析。结果表明:研究区地下水水化学类型主要为低矿化度偏碱性水,地下水组分中的阳离子以Ca^(2+)和Na^(+)为主,阴离子以HCO_(3)^(-)为主,9月地下水pH偏高,地下水咸度有所下降;6月汉江流域襄阳段周边的地下水类型主要为HCO_(3)·SO_(4)-Ca·Mg型,9月地下水存在向HCO_(3)-Na型转化的趋势,离子浓度变化大多是整体变化,可能与周边含水层的侧向补给有关;地下水水化学特征受到周边碳酸盐岩和硅酸盐岩风化溶解共同控制,靠近下游区域的地下水阳离子交替吸附作用较强,受到干旱少雨的影响,导致该区域阳离子吸附作用明显减弱。

关键词：汉江中游汛期反枯地下水水化学特征因子分析