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Chinese Science Bulletin 2010年第31期55卷 3556-3561页

作者： MICHALSKI Oskar BIDZINSKA Ewa BOROWSKI Micha DYREK Krystyna OLKO Pawe stolarczyk liliana SWAKON Jan TOMASIK Piotr WENDA ElZbieta Department of Chemistry and Physics University of Agriculture in Krakow Faculty of Chemistry Jagiellonian University Institute of Nuclear Physics of the Polish Academy of Sciences

Cornstarch heated in the range of 230-280°C depolymerized into pyrodextrins characterized by two-component EPR signals of relatively stable free *** thermally generated radicals could serve as efficient scavengers for free radicals generated from pyrodextrins with the 200 Gy dose of γ-*** most efficient traps/scavengers were produced from cornstarch at 250-280°*** data indicated incorporation of the OH groups to the *** groups most probably originated from the OH· radicals formed by the radiolysis of *** spectra provided evidence for trapping free radicals generated by γ-irradiation and for their subsequent annihilation on contact with *** affected radical processes occurring in pyrodextrins caused by γ-irradiation.

关键词：自由基清除剂玉米淀粉生产 EPR谱信号特征相对稳定双组分拾荒者数据表

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Ti/WO_(3),a nanothermite for special purposes:An experimental study

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Defence Technology（防务技术） 2024年第11期41卷 1-12页

作者： Mateusz Polis Agnieszka stolarczyk Konrad Szydlo Tomasz Jarosz Marcin Procek Sebastian Slawski Lukasz Hawelek Łukasiewicz Research Network-Institute of Industrial Organic Chemistry Explosive Techniques Research GroupKrupski Młyn 42-693Poland Department of Physical Chemistry and Technology of Polymers Silesian University of TechnologyGliwice 44-100Poland Department of Optoelectronics Silesian University of TechnologyGliwice 44-100Poland Department of Theoretical and Applied Mechanics Silesian University of TechnologyGliwice 44-100Poland Lukasiewicz Research Networkd Institute of Non-Ferrous Metals Gliwice 44-100Poland

A new nanothermite system,composed of titanium and tungsten trioxide is *** investigations show that it has low-average sensitivity to mechanical stimuli(friction,impact),but that its sensitivity to laser irradiation can be controlled in a moderately wide *** combustion of this nanothermite system takes place at a very high apparent temperature(>3695 K)and it follows the key predictions of the established reactive sintering mechanism,as supported by SEM-EDS and XRD analyses.

关键词： Nanothermite Combustion Energetic material Laser initiation Sensitivity

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Novel opioid-neurotensin-based hybrid peptide with spinal long-lasting antinociceptive activity and a propensity to delay tolerance development

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Acta Pharmaceutica Sinica B 2020年第8期10卷 1440-1452页

作者： Karolina Fra˛czek Mattia Ferraiolo Emmanuel Hermans Magdalena Bujalska-Zadrozny Kaja Kasarello Anna Erdei Kamila Kulik Agnieszka Kowalczyk Piotr Wojciechowski Dorota Sulejczak Piotr Sosnowski Sebastian Granica Sandor Benyhe Katarzyna Kaczynska Lukasz Nagraba Artur stolarczyk Agnieszka Cudnoch-Jedrzejewska Patrycja Kleczkowska Department of Pharmacodynamics Centre for Preclinical Research(CBP)Medical University of WarsawWarsaw 02-097Poland Laboratory of Neuropharmacology Institute of NeurosciencesUniversite´Catholique de LouvainBrussels B-1200Belgium Department of Experimental and Clinical Physiology Centre for Preclinical Research(CBP)Medical University of WarsawWarsaw 02-097Poland Institute of Biochemistry Biological Research CentreHungarian Academy of SciencesSzeged H-6701Hungary Doctoral School of Therotecical Medicine University of SzegedSzeged H-6720Hungary Department of Respiration Physiology Mossakowski Medical Research CentrePolish Academy of SciencesWarsaw 02-106Poland Department of Experimental Pharmacology Mossakowski Medical Research CenterPolish Academy of SciencesWarsaw 02-106Poland Department of Neuropeptides Mossakowski Medical Research CentrePolish Academy of SciencesWarsaw 02-106Poland Department of Pharmacognosy and Molecular Basis of Phytotherapy Faculty of PharmacyMedical University of WarsawWarsaw 02-097Poland Department of Orthopaedics and Rehabilitation Medical University of WarsawWarsaw 04-749Poland

The behavioral responses exerted by spinal administration of the opioid-neurotensin hybrid peptide, PK23, were studied in adult male rats. The antinociceptive effect upon exposure to a thermal stimulus, as well as tolerance development, was assessed in an acute pain model. The PK23 chimera at a dose of 10 nmol/rat produced a potent pain-relieving effect, especially after its intrathecal administration. Compared with intrathecal morphine, this novel compound was found to possess a favourable side effect profile characterized by a reduced scratch reflex, delayed development of analgesic tolerance or an absence of motor impairments when given in the same manner, though some animals died following barrel rotation as a result of its i.c.v. administration(in particular at doses higher than 10 nmol/rat). Nonetheless, these results suggest the potential use of hybrid compounds encompassing both opioid and neurotensin structural fragments in pain management. This highlights the enormous potential of synthetic neurotensin analogues as promising future analgesics.

关键词： opioid neurotensin doses

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Inter-observer variability in histopathological assessment of liver biopsies taken in a pediatric open label therapeutic program for chronic HBV infection treatment

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World Journal of Gastroenterology 2006年第11期12卷 1713-1717页

作者： Marek Woynarowski Joanna Cielecka-Kuszyk Andrzej Ka■u■y(n|')ski Aleksandra Omulecka Maria Sobaniec-■otowska Julian stolarczyk Wojciech Szczepa(n|')ski Department of Gastroenterology Hepatology and Immunology Children's Health Memorial InstituteWarsawPoland Department of Pathology Children's Health Memorial Institute WarsawPoland Department of Pathology Polish Mother Memorial Research Institute ■ód(z|')Poland Department of Pathology Medical University of ■ód(z|') Poland Department of Clinical Pathology Medical University of Bialystok Poland Department of Pathology Medical Academy of Gda(n|')sk Poland Department of Pathology Jagiellonian University Medical College KrakówPoland

AIM： To our knowledge, the inter-observer variability of the liver biopsy findings in HBV-infected children have not been studied as yet. Hence, we aimed to compare different pathologist＇s assessment of grading and staging in liver biopsies obtained from children prior to interferon treatment. METHODS： We collected 920 biopsies from 11 medical centers. The biopsies were independently reviewed by 6 pathologists from academic centers who assessed Batts-Ludwig score for grading and staging. Satisfactory agreement among observers was defined as at least 60% of observers having the same opinion. Satisfactory dispersion between maximal and minimal score for the same biopsy specimen was defined as a maximum 1 point. RESULTS： Satisfactory inter-observer agreement for grading was obtained in 51.6% and for staging in 75.7% of biopsies. Satisfactory dispersion for grading scores was observed in 44.5% and for staging in 72.7% of cases. CONCLUSION： Our study demonstrates that：（1） pathologists differ in their assessment of grading and staging of liver biopsies; （2） inter-observer variability for staging is lower than that for grading; and （3） regardless of the inter-observer variability of assessments, the majority of children with chronic HBV infection have mild to moderate inflammation and mild to moderate fibrosis.

关键词： Grading Staging Type B Hepatitis Children

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Ti/WO 3 , a nanothermite for special purposes: An experimental study

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Defence technology 2024年第11期 1页

作者： Mateusz Polis Agnieszka stolarczyk Konrad Szydlo Tomasz Jarosz Marcin Procek Sebastian Slawski Lukasz Hawelek

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