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Asian Pacific Journal of Tropical Biomedicine 2020年第7期10卷 316-324页

作者： Amin FMajdalawieh Jenna F.Farraj Ronald I.carr Department of Biology Chemistryand Environmental SciencesFaculty of Arts and SciencesAmerican University of SharjahSharjahP.O.Box 26666United Arab Emirates Department of Microbiology and Immunology Faculty of MedicineSir Charles Tupper Medical BuildingDalhousie UniversityHalifaxNova ScotiaCanada B3H 4R2

Objective:To evaluate the potential immunomodulatory effects of an aqueous extract of Sesamum indicum seeds with regard to splenocyte proliferation,Th1/Th2 balance,macrophage function,and the cytotoxic activity of natural killer(NK)***:Splenocyte proliferation was measured by[~3H]-thymidine *** assay was performed to evaluate the production of nitric oxide by *** levels of cytokines secreted by splenocytes and macrophages were measured by *** assay was performed to examine the cytotoxic activity of NK cells against YAC-1 tumor ***:Sesamum indicum significantly enhanced splenocyte proliferation in a dose-dependent *** indicum also increased and suppressed the secretion of Th1 and Th2 cytokines,respectively,by *** secretion of key pro-inflammatory mediators(IL-6,TNFα,and nitric oxide)by primary macrophages was significantly inhibited by Sesamum ***,Sesamum indicum increased the cytotoxic activity of NK cells against YAC-1 tumor ***:Sesamum indicum shows potent immunomodulatory,anti-inflammatory,and anti-cancer *** of Sesamum indicum may be used as effective therapeutic agents in regulating immune reactions implicated in various infectious and noninfectious conditions including cancer.

关键词： Sesamum indicum Anti-cancer Inflammation Immunomodulation Macrophages NK cells

Deadly case of Pasteurella multocida aortitis and mycotic aneurysm following a cat bite

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World Journal of Clinical Cases 2016年第6期4卷 142-145页

作者： Dennis Dane Cho Yaniv Berliner David carr Division of Emergency Medicine Department of Medicine University of Toronto Department of Emergency Medicine University Health Network

Animal bites are frequently encountered in the emergency department(ED). Aortitis leading to mycotic abdominal aortic aneurysm is a rare and potentially deadly complication of Pasteurella multocida(P. multocida) following an animal bite. We present the case of a 68-year-old male who presented to the ED after falling at home. He complained of weakness and abdominal pain. He was in septic shock and was treated empirically with broad-spectrum antibiotics and intravenous fluids. He reported previous antibiotic treatment of a cellulitis secondary to a cat bite injury to his right thumb four weeks prior. Abdominal ultrasound and subsequent computed tomography scan revealed a leaking mycotic abdominal aneurysm that was surgically repaired. Blood cultures and aortic wall tissue cultures grew P. multocida. Given how common animal bite presentations are in the ED, this case highlights the need to consider aortitis and mycotic abdominal aortic aneurysm in an unwell patient with an animal bite.

关键词： Mycotic aneurysm Emergency department Cat bite Pasteurel a multocida Aortitis

The power of a healthy lifestyle for cancer prevention:the example of colorectal cancer

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Cancer Biology & Medicine 2022年第11期19卷 1586-1597页

作者： Xuechen Chen Jie Ding Hengjing Li Prudence R.carr Michael Hoffmeister Hermann Brenner Division of Clinical Epidemiology and Aging Research German Cancer Research Center(DKFZ)Heidelberg 69120Germany Medical Faculty Heidelberg Heidelberg UniversityHeidelberg 69120Germany School of Public Health and Preventive MedicineMonash UniversityMelbourneVIC 3004Australia German Cancer Consortium(DKTK) German Cancer Research Center(DKFZ)Heidelberg 69120Germany Division of Preventive Oncology German Cancer Research Center(DKFZ)and National Center forTumorDiseases(NCT)Heidelberg 69120Germany

Objective:We aimed to directly compare the estimated effects of adherence to a healthy lifestyle with those of risk predisposition according to known genetic variants affecting colorectal cancer(CRC)risk,to support effective risk communication for cancer ***:A healthy lifestyle score(HLS)was derived from 5 lifestyle factors:smoking,alcohol consumption,diet,physical activity,and body *** association of lifestyle and polygenic risk score(PRS)(based on 140 CRC-associated risk loci)with CRC risk was assessed with multiple logistic regression and compared through the genetic risk equivalent(GRE),a novel approach providing an estimate of the effects of adherence to a healthy lifestyle in terms of percentile differences in ***:A higher HLS was associated with lower CRC risk(4,844 cases,3,964 controls).Those adhering to all 5 healthy lifestyle factors had a 62%(95%CI 54%-68%)lower CRC risk than those adhering to≤2 healthy lifestyle *** estimated effect of adherence to all 5 compared with≤2 healthy lifestyle factors was as strong as the effect of having a 79 percentile(GRE 79,95%CI 61-97)lower *** association between a healthy lifestyle and CRC risk was independent of PRS level but was particularly pronounced among those with a family history of CRC in≥1 first-degree relative(P-interaction=0.0013).Conclusions:A healthy lifestyle was strongly inversely associated with CRC *** large GRE indicated that CRC risk determined by polygenic risk may be offset to a substantial extent by adherence to a healthy lifestyle.

关键词： Colorectal cancer healthy lifestyle score polygenic risk score family history genetic risk equivalent

Macroscopic superposition states of ultracold bosons in a double-well potential

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Frontiers of physics 2012年第1期7卷 131-145页

作者： M.A.Garcia-March D.R.Dounas-Frazer Lincoln D.carr Department of Physics Colorado School of MinesGoldenCO80401USA Department of Physics University College CorkCorkIreland Department of Physics University of CaliforniaBerkeleyCA94720USA Universitat Heidelberg Physikalisches InstitutPhilosophenweg 12D-69120HeidelbergGermany

We present a thorough description of the physical regimes for ultracold bosons in double wells, with special attention paid to macroscopic superpositions （MSs）. We use a generalization of the Lipkin-Meshkov-Glick Hamiltonian of up to eight single particle modes to study these MSs, solving the Hamiltonian with a combination of numerical exact diagonalization and high-order perturbation theory. The MS is between left and right potential wells; the extreme case with all atoms simulta- neously located in both wells and in only two modes is the famous NOON state, but our approach encompasses much more general MSs. Use of more single particle modes brings dimensionality into the problem, allows us to set hard limits on the use of the original two-mode LMG model com- monly treated in the literature, and also introduces a mixed Josephson-Fock regime. Higher modes introduce angular degrees of freedom and MS states with different angular properties.

关键词： macroscopic superposition states ultracold bosons in double-well potentials

Analysis of aggressiveness factors in hepatocellular carcinoma patients undergoing transarterial chemoembolization

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World Journal of Gastroenterology 2018年第15期24卷 1641-1649页

作者： Yossi Ventura Brian I carr Issac Kori Vito Guerra Oren Shibolet Liver Unit Department of Gastroenterology and Hepatology Tel-Aviv Medical Center Sackler faculty of Medicine Tel-Aviv University Izmir Biomedicine and Genome Center Dokuz Eylul University Interventional Radiology Division of Imaging TelAviv Medical Center Department of Clinical Trials and Epidemiology IRCCS de Bellis

AIM To investigate novel predictors of survival in hepatocellular carcinoma(HCC) patients following transarterial chemoembolization(TACE).METHODS One hundred sixty seven patients with un-resectable HCC were retrospectively analyzed to identify factors that might contribute to their HCC biology and aggressiveness. We correlated routine laboratory results(total bilirubin, AST, ALKP, GGTP, albumin etc.) to maximum tumor diameter, number of tumor nodules, portal vein thrombosis and blood alpha-fetoprotein levels. These 4 parameters were previously combined to form an aggressiveness index(AgI). We used The Wilcoxon ranksum(Mann-Whitney), to test the correlation between the AgI categories and liver function parameters. The Cox proportional hazards model was applied to evaluate the categories of AgI associated with overall survival. RESULTS The AgI was strongly correlated with survival in this novel patient population. Three year survival probability for AgI > or 4 had HR for mortality of 2.18(95%CI: 1.108-4.310, P 4 had a HR for mortality of 2.26(95%CI: 1.184-4.327, P < 0.016). GGTP had a HR of 1.003(95%CI: 1.001-1.004, P < 0.001).CONCLUSION Our study validates the AgI in a new population with un-

关键词： Hepatocellular carcinoma Aggressiveness index Liver function Transarterial chemoembolization survival

Review of pharmacological inhibition of thyroid cancer metabolism

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 640-658页

作者： Cole D.Davidson Frances E.carr Department of Pharmacology Larner College of MedicineBurlingtonVT 05405USA University of Vermont Cancer Center BurlingtonVT 05405USA

Thyroid cancer(TC)is the most common malignancy of the endocrine system and has been rapidly increasing in incidence over the past few *** TCs metastasize quickly and often levy poor prognoses,as they are frequently resistant to first-line treatment *** diagnosed with aggressive,dedifferentiated TC have a prognosis of under a year with the most current treatment *** many cancers,TCs also exhibit altered cell metabolism,which enhances the cell’s ability to generate energy,protect against reactive oxygen species,and synthesize macromolecules such as lipids,proteins,and nucleotides for *** and enzyme profiling of TC tissues and cell lines have uncovered several dysregulated metabolic pathways such as glycolysis,the pentose phosphate pathway,glutamine metabolism,and pyrimidine *** aberrations are most often due to overexpression of rate-limiting enzymes or metabolite *** pathways pose attractive therapeutic targets in aggressive TC and may serve to work in tandem with standard therapeutics such as kinase inhibitors depending on the genetic,metabolic,and signaling backgrounds of individual *** studies are needed to clearly delineate altered metabolic targets across TC subtypes for implementing therapeutic metabolic inhibitors that have shown success in other aggressive tumors.

关键词： Thyroid cancer tumor metabolism metabolic inhibitors Warburg effect cell signaling

Near-Earth bursty bulk flows and AE index

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Science China(Technological Sciences) 2008年第10期51卷 1704-1712页

作者： W BAUMJOHANN M. W. DUNLOP C. carr H. RME Space Research Institute Austrian Academy of Sciences Graz Austria Space Sciences Division Rutherford Appleton Laboratory Chilton Didcot UK Imperial College London United Kingdom Centre d'Etude Spatiale des Rayonnements Toulouse France

With the 4-s resolution data of the magnetometer and the ion plasma analyzer on TC-1 from June to November of each year during the period of 2004―2006, we statistically analyzed the occurrence rate of both convective and field-aligned bursty flows (FABFs). A near-Earth bursty bulk flow (NEBBF) occurred during both the quiet time and substorm process. In general, the magnetic field and the plasma density began oscillating with the appearance of the NEBBF associated with a distinct increase of the AE index. The increase of AE index during the NEBBF was more than 100 nT in both quiet time and substorm process. The statistical analysis indicated that the occurrence rates of the FABFs were nearly the same in the dif-ferent stages of the AE index, but the occurrence rate of the NEBBFs was much higher in the growth stage of the AE index, indicating that the NEBBFs were di-rectly related to the growth and expansion phases of the substorm. The observa-tions suggested that the quite large number of BBFs from the mid magnetotail could enter into the near-Earth tail and play important role in triggering the sub-storm onset.

关键词： BBF near-Earth AE index substorm onset

The Asian Lineage of Zika Virus: Transmission and Evolution in Asia and the Americas

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Virologica Sinica 2019年第1期34卷 1-8页

作者： Tao Hu Juan Li Michael J.carr Sebastián Duchêne Weifeng Shi Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong Taishan Medical College Global Station for Zoonosis Control Global Institution for Collaborative Research and Education (GI-CoRE)Hokkaido University National Virus Reference Laboratory School of MedicineUniversity College Dublin Department of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology InstituteUniversity of Melbourne

Since first isolation in 1947 from the Zika forest in Uganda, Zika virus(ZIKV) has been principally known as a benign agent associated with sporadic human infections in a restricted number of African countries. However, during 2015–2016,an Asian lineage of ZIKV caused an unprecedentedly large outbreak in the Americas and sizeable numbers of exported cases across the globe. In this review, we critically appraise the recent advances in molecular epidemiological studies of ZIKV performed to date, and we highlight the pivotal role played by genomic surveillance in elucidating the origins,dissemination and evolution of the Asian lineage of ZIKV in Asia and in the Americas.

关键词： Zika virus(ZIKV) Asian lineage Transmission Evolution Re

Cross-Linguistic Influence in Hong Kong ESL Learners' Acquisition of Conjunctions

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Fudan Journal of the Humanities and Social Sciences 2023年第4期16卷 515-539页

作者： Ming Sum Kong Mary carr Sin Wang Chong International Education Institute University of St.AndrewsKinessburn Kennedy GardensSt Andrews KY169DJUK Student Services University of DundeeDundee DD14HNUK

Language transfer is one of the most significant aspects of cross-linguistic *** can be divided into two types:positive and negative,the beneficial and det-rimental use of one language's acquired characteristics in *** study aims to investigate the L1(Chinese)influence on Hong Kong ESL learners'acquisition of conjunctions and whether the use of L1 has an impact on this *** online questionnaire combining questions about students'English learning experience and a grammatical judgement task was sent to a government-funded secondary school in Hong Kong and completed by 79 *** of both positive and negative transfer from Chinese to English was found by testing six conjunctions or conjunc-tion pairs:although...but,because...so,not only...but also,either...or,neither...nor,.and *** results suggest that Chinese is likely to have an impact on students'acquisition of conjunctions,and the use of Chinese in English classes can worsen negative transfer and boost positive *** degree of transfer might increase when more Chinese is used in *** alleviate the impact of Chinese transfer and to provide more effective L2 teaching,monitoring the use of L1 and regular evalua-tion might be *** can also adjust the amount of Chinese used according to the students'English proficiency level.

关键词： Cross-linguistic influence Language transfer Conjunctions Hong Kong ESL learners

Aseismic smart building isolation systems under multi-level earthquake excitations： Part II, energy-dissipation and damage reduction

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Frontiers of Structural and Civil Engineering 2015年第3期9卷 297-306页

作者： Min-Ho CHEY J. Geoffrey CHASE John B. MANDER Athol J. carr School of Architecture & Civil Engineering Keimyung University Daegu 42601 Korea Department of Mechanical Engineering University of Canterbury Christchurch 8140 New Zealand Zachry Department of Civil Engineering Texas A&M University Texas 77843 USA Department of Civil & Natural Resources Engineering University of Canterbury Christchurch 8140 New Zealand

Based on the performance results of the previously suggested smart building isolation systems （lst companion paper）, this following study verifies the control effects of the systems from the view point of energy dissipation and damage level metrics. Several different model cases of the strategically isolated multi-story building structures utilizing passive dampers and semi-active resettable devices are analyzed and the energy-based target indices are compared. Performance comparisons are conducted on statistically calculated story/structural hysteretic energy and story/structural damage demands over realistic suites of earthquake ground motion records, representing seismic excitations of specific return period probability. Again, the semi-active solutions show significant promise for applications ofresettable device, offering advantages over passive systems in the consistent damage reductions. The specific results of this study include the identification of differences in the mechanisms by which smart building isolation systems remove energy, based on the differences in the devices used. Less variability is also seen for the semi-active isolation systems, indicating an increased robustness.

关键词： smart building isolation story and structural energy-dissipation damage assessment

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