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Nonlinear optical imaging by detection with optical parametric amplification(invited paper)

Journal of Innovative Optical Health Sciences 2023年第1期16卷 5-14页

作者： Yi Sun Haohua Tu stephen a.boppart Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaIL 61801USA Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign UrbanaIL 61801USA Carle Illinois College of Medicine University of Illinois at Urbana-Champaign UrbanaIL 61801USA

Nonlinear optical imaging is a versatile tool that has been proven to be exceptionally useful in various research ***,due to the use of photomultiplier tubes(PMTs),the wide application of nonlinear optical imaging is limited by the incapability of imaging under am-bient *** this paper,we propose and demonstrate a new optical imaging detection method based on optical parametric amplification(OPA).As a nonlinear optical process,OPA in-trinsically rejects ambient light photons by coherence *** poled lithium niobate(PPLN)crystals are used in this study as the media for *** to bulk nonlinear optical crystals,PPLN crystals support the generation of OPA signal with lower pump ***,this characteristic of PPLN crystals is particularly beneficial when using high-repetition-rate lasers,which facilitate high-speed optical signal detection,such as in spec-troscopy and imaging.A PPLN-based OPA system was built to amplify the emitted imaging signal from second harmonic generation(SHG)and coherent anti-Stokes Raman scattering(CARS)microscopy imaging,and the amplified optical signal was strong enough to be detected by a biased photodiode under ordinary room light *** OPA detection,ambient-light-on SHG and CARS imaging becomes possible,and achieves a similar result as PMT detection under strictly dark *** results demonstrate that OPA can be used as a substitute for PMTs in nonlinear optical imaging to adapt it to various applications with *** ing conditions.

关键词： Nonlinear optical microscopy optical parametric amplification optical detection

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DYNAMIC OPTICAL COHERENCE ELASTOGRAPHY:A REVIEW

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Journal of Innovative Optical Health Sciences 2010年第4期3卷 221-233页

作者： XING LIANG VASILICA CRECEA stephen a.boppart Department of Electrical and Computer Engineering Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaIL61801USA Department of Physics Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaIL61801USA Departments of Electrical and Computer Engineering Bioengineering and Internal MedicineBeckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaIL61801USA Biophotonics Imaging Laboratory Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaIL61801USA

With the development of optical coherence tomography,the application optical coherence elastography(OCE)has gained more and more attention in biomechanics for its unique features including micron-scale resolution,real-time processing,and non-invasive *** this review,one group of OCE techniques,namely dynamic OCE,are introduced and discussed including external dynamic OCE mapping and imaging of ex vivo breast tumor,external dynamic OCE measurement of in vivo human skin,and internal dynamic OCE including acoustomotive OCE and magnetomotive *** techniques overcame some of the major drawbacks of traditional static OCE,and broadened the OCE application *** by scientific needs to engineer new quantitative methods that utilize the high micron-scale resolution achievable with optics,results of biomechanical properties were obtained from biological *** results suggest potential diagnostic and therapeutic clinical *** from these studies also help our understanding of the relationship between biomechanical variations and functional tissue changes in biological systems.

关键词： Optical coherence tomography optical coherence elastography biomechanics tissue characterization scattering phase measurements

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Fluorescent nanodiamonds for characterization of nonlinear microscopy systems

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Photonics Research 2021年第12期9卷 2309-2318页

作者： MANTASŽURAUSKAS ANEESH ALEX JAENA PARK STEVE RHOOD stephen a.boppart Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-ChampaignUrbanaIllinois 61801USA GSK Center for Optical Molecular Imaging University of Illinois at Urbana-ChampaignUrbanaIllinois 61801USA GlaxoSmithKline CollegevillePennsylvania 19426USA GlaxoSmithKline StevenageHertfordshire SG12NYUK Department of Electrical and Computer Engineering University of Illinois at Urbana-ChampaignUrbanaIllinois 61801USA Department of Bioengineering University of Illinois at Urbana-ChampaignUrbanaIllinois 61801USA Cancer Center at Illinois University of Illinois at Urbana-ChampaignUrbanaIllinois 61801USA Carle Illinois College of Medicine University of Illinois at Urbana-ChampaignUrbanaIllinois 61801USA

Characterizing the performance of fluorescence microscopy and nonlinear imaging systems is an essential step required for imaging system optimization and quality control during longitudinal experiments. Emerging multimodal nonlinear imaging techniques require a new generation of microscopy calibration targets that are not susceptible to bleaching and can provide a contrast across the multiple modalities. Here, we present a nanodiamond-based calibration target for microscopy, designed for facilitating reproducible measurements at the object plane. The target is designed to support day-to-day instrumentation development efforts in microscopy laboratories. The images of a phantom contain information about the imaging performance of a microscopy system across multiple spectral windows and modalities. Since fluorescent nanodiamonds are not prone to bleaching, the proposed imaging target can serve as a standard, shelf-stable sample to provide rapid reference measurements for ensuring consistent performance of microscopy systems in microscopy laboratories and imaging facilities.

关键词： nonlinear system diamond

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Nonlinearity-tailored fiber laser technology for low-noise, ultra-wideband tunable femtosecond light generation

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Photonics Research 2017年第6期5卷 262-273页

作者： XIAOMIN LIU JESPER LAEGSGAARD ROMAN IEGOROV ASK S.SVANE F.OMER ILDAY HAOHUA TU stephen a.boppart DMITRY TURCHINOVICH DTU Fotonik Technical University of Denmark Max Planck Institute for Polymer Research Department of Physics Bilkent University National Research Tomsk Polytechnic University Institute of Power Engineering Department of Electrical and Electronics Engineering Bilkent University Biophotonics Imaging Laboratory University of Illinois at Urbana-Champaign Fakultat fur Physik Universitat Duisburg-Essen

The emission wavelength of a laser is physically predetermined by the gain medium used. Consequently, arbitrary wavelength generation is a fundamental challenge in the science of light. Present solutions include optical parametric generation, requiring complex optical setups and spectrally sliced supercontinuum, taking advantage of a simpler fiber technology: a fixed-wavelength pump laser pulse is converted into a spectrally very broadband output, from which the required resulting wavelength is then optically filtered. Unfortunately, this process is associated with an inherently poor noise figure, which often precludes many realistic applications of such supercontinuum sources. Here, we show that by adding only one passive optical element—a tapered photonic crystal fiber—to a fixed-wavelength femtosecond laser, one can in a very simple manner resonantly convert the laser emission wavelength into an ultra-wide and continuous range of desired wavelengths, with very low inherent noise, and without mechanical realignment of the laser. This is achieved by exploiting the double interplay of nonlinearity and chirp in the laser source and chirp and phase matching in the tapered fiber. As a first demonstration of this simple and inexpensive technology, we present a femtosecond fiber laser continuously tunable across the entire red–green–blue spectral range.

关键词： length PCF Nonlinearity-tailored fiber laser technology for low-noise ultra-wideband tunable femtosecond light generation

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Video-rate multimodal multiphoton imaging and three-dimensional characterization of cellular dynamics in wounded skin

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Journal of Innovative Optical Health Sciences 2020年第2期13卷 70-80页

作者： Joanne Li Madison N.Wilson Andrew J.Bower Marina Marjanovic Eric J.Chaney Ronit Barkalifa stephen a.boppart Department of Bioengineering University of Illinois at Urbana-Champaign Urbana ILU.S.A Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign Urbana ILU.S.A Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign Urbana ILU.S.A Carle Illinois College of Medicine University of Illinois at Urbana-Champaign Urbana ILU.S.A

To date,numerous studies have been performed to elucidate the complex cellular dynamics in skin diseases,but few have attempted to characterize these cellular events under conditions similar to the native *** address this challenge,a three-dimensional(3D)multimodal analysis platform was developed for characterizing in vivo cellular dynamics in skin,which was then utilized to process in vivo wound healing data to demonstrate its *** attention is focused on in vivo biological parameters that are difficult to study with ex vivo analysis,including 3D cell tracking and techniques to connect biological information obtained from different imaging *** results here open new possibilities for evaluating 3D cellular dynamics in vivo,and can potentially provide new tools for characterizing the skin microenvironment and pathologies in the future.

关键词： Cellular dynamics multimodal imaging multiphoton microscopy

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FC-DIRECTED ANTIBODY CONJUGATION OF MAGNETIC NANOPARTICLES FOR ENHANCED MOLECULAR TARGETING

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Journal of Innovative Optical Health Sciences 2009年第4期2卷 387-396页

作者： ROBABEH REZAEIPOOR RENU JOHN STEVEN G.ADIE ERIC J.CHANEY MARINA MARJANOVIC AMY L.OLDENBURG STEPHANIE A.RINNE stephen a.boppart Biophotonics Imaging Laboratory Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaILUSA Departments of Electrical and Computer Engineering Bioengineeringand Internal Medicine University of Illinois at Urbana-Champaign UrbanaILUSA

In this study, we report the fabrication of engineered iron oxide magnetic nanoparticles (MNPs)functionalized with anti-human epidermal growth factor receptor type 2 (HER2) antibody totarget the tumor antigen HER2. The Fc-directed conjugation of antibodies to the MNPs aidstheir efficient immunospecific targeting through free Fab portions. The directional specificity ofconjugation was verified on a macrophage cell line. Immunofluorescence studies on macrophagestreated with functionalized MNPs and free anti-HER2 antibody revealed that the antibodymolecules bind to the MNPs predominantly through their Fc portion. Different cell lines with different HER2 expression levels were used to test the specificity of our functionalized nanoprobe formolecular targeting applications. The results of cell line targeting demonstrate that these engineered MNPs are able to differentiate between cell lines with different levels of HER2 expression.

关键词： Nanoprobe molecular imaging cancer

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SEGMENTATION AND CORRELATION OF OPTICAL COHERENCE TOMOGRAPHY AND X-RAY IMAGES FOR BREAST CANCER DIAGNOSTICS

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Journal of Innovative Optical Health Sciences 2013年第2期6卷 71-81页

作者： JONATHAN G.SUN STEVEN G.ADIE ERIC J.CHANEY stephen a.boppart Beckman Institute for Advanced Science and Technology 405 North Mathews Avenue UrbanaIllinois 61801USA Department of Bioengineering Beckman Institute for Advanced Science and Technology 405 North Mathews Avenue UrbanaIllinois 61801USA Departments of Electrical and Computer Engineering and Internal Medicine University of Illinois at Urbana-Champaign UrbanaIllinoisUSA

Pre-operative X ray mammography and int raoperative X-ray specimen radiography are routinely used to identify breast cancer *** advances in optical coherence tomography(OCT)have enabled its 1use for the intraoperative assessment of surgical margins during breast cancer *** each modality offers distinct contrast of normal and pathological features,there is an essential need to correlate image based features between the two modalities to take adv antage of the diagnostic capabilities of each *** compare OCT to X-ray images of resected human breast tissue and correlate different tissue features between modalities for future use in real-tine intraoperative OCT imaging.X ray imaging(specimen radiography)is currently used during surgical breast cancer procedures to verify tumor margins,but cannot image tissue in *** has the potential to solve this problem by providing intrao-perative imaging of the resected specimen as well as the in situ tumor *** and micro-CT(X-ray)images are automatically segmented using different computational approaches,and quantitatively compared to determine the ability of these algorithms to automat ically differentiate regions of adipose tissue from ***,two-dimensional(2D)and three-dimensional(3D)results are *** correlations,combined with real-time intraoperative OCT,have the potential to identify possible regions of tumor within breast tissue which correlate to tumor regions identified previously on X-ray imaging(mammography or specimen radiography).

关键词： Optical imaging mammography specimen radiography segmentation breast cancer intraoperative imaging

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