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Constrictive pericarditis as a cause of refractory ascites after liver transplantation:A case report

World Journal of Clinical Cases 2019年第20期7卷 3266-3270页

作者： Miran Bezjak Branislav Kocman Stipislav Jadrijevic Hrvoje Gasparovic Anna Mrzljak Tajana Filipec Kanizaj Darko Vujanic tomislav Bubalo Danko Mikulic Division of Abdominal Surgery and Organ Transplantation Department of SurgeryUniversity Hospital MerkurZagreb 10000Croatia Division of Cardiology Department of Internal MedicineUniversity Hospital Centre ZagrebZagreb 10000Croatia Division of Gastroenterology Department of Internal MedicineUniversity Hospital MerkurZagreb 10000Croatia Division of Cardiology Department of Internal MedicineUniversity Hospital MerkurZagreb 10000Croatia

BACKGROUND Refractory ascites is a rare complication following orthotopic liver transplantation(OLT).The broad spectrum of differential diagnosis often leads to delay in *** depends on recognition and treatment of the underlying *** pericarditis is a condition characterized by clinical signs of right-sided heart *** the advanced stages of the disease,hepatic congestion leads to formation of *** patients after OLT,cardiac etiology of ascites is easily overlooked and it requires a high degree of clinical *** SUMMARY We report a case of a 55-year-old man who presented with a refractory ascites three months after liver transplantation for alcoholic *** to transplantation the patient had a minimal amount of *** transplant procedure and the early postoperative course were *** posttransplant work up failed to reveal any typical cause of refractory post-transplant *** function of the graft was *** from atrial fibrillation,cardiac status was *** months post transplantation the patient developed dyspnea and severe fatigue with peripheral *** was still *** presenting signs of right-sided heart failure were highly suggestive of cardiac *** paracentesis was suggestive of cardiac ascites,and further cardiac evaluation showed typical signs of constrictive *** was performed followed by complete resolution of *** the follow-up the patient remained symptom-free with no signs of recurrent ascites and with normal function of the liver *** Refractory ascites following liver transplantation is a rare complication with many possible *** differential diagnosis needs to be considered.

关键词： Constrictive pericarditis Liver transplantation Refractory ascites Case report

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The Study of Supply and Demand of Organic Products in the European Union and Serbia

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Journal of Food Science and Engineering 2013年第1期3卷 40-46页

作者： Lj ubomir Pupovac tomislav Sudarevic Suzana Salai Faculty of Economics University of Novi Sad Segedinski Subotica 24000 Serbia

One of the phenomena that marked 20th century is rapid technology progress. This process did not avoid food production and processing. Thanks to rapid development of technology, there has been a development of conventional food production, as well as appearance of genetically modified food. As a consequence of this trend, as well as the concern among some part of human population for their health, we had the return to natural food production in the form of the development of organic food production. One of the characteristics of organic food market in the European Union is the constant growth of demand for this product group, and insufficient quantities of organic products available in this market. These information led to the conclusion that organic food represents an opportunity for less developed countries, i.e., that countries like Serbia can manufacture and sale these products on the market with the highest purchasing power in the world--the European Union market. In this paper, the characteristics of demand for organic foods in the European Union were presented, then it was explained in detail why are these products export chance of Serbia, as well as reasons why is the export of organic food from Serbia to the EU very low at the time being. At the end, some recommendations that could help Serbia to increase export of organic product to EU countries were proposed.

关键词： Organic products supply and demand European Union Serbia.

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Electromagnetic Fields and Induced Voltages on Underground Pipeline in the Vicinity of AC Traction System

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Journal of Energy and Power Engineering 2014年第7期8卷 1333-1340页

作者： Bosko Milesevic Bozidar Filipovic-Grcic tomislav Radosevic Faculty of Electrical Engineering and Computing University of Zagreb Zagreb 10000 Croatia Ravel Ltd. Brajkovikev prilaz 13 Zagreb 10000 Croatia

Various regulations, aimed at the protection of human beings and electrical equipment against possible adverse effects resulting from exposure to electromagnetic fields, have been issued in many countries. Most of them are based on safety guidelines published by international expert groups. In this paper, electric and magnetic fields are calculated in the vicinity of 25 kV traction line supplying railway traction systems. Calculation results are compared to exposure limits specified by safety guidelines and regulations. Possible countermeasures for reduction of electromagnetic fields are proposed. Also, this paper presents a method for calculation of the induced voltages to an underground gas pipeline from a neighbouring 25 kV electric traction overhead line in case of short circuit. Calculations are performed with EMTP-ATP software. Possible countermeasures for reduction of induced voltages are proposed.

关键词： Electric and magnetic fields electric traction system induced voltages underground gas pipeline.

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Labor Induction with Transcervical Catheter versus Oral Misoprostol in Primiparous Women and Women with an Unripe Cervix

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Open Journal of Obstetrics and Gynecology 2015年第14期5卷 819-826页

作者： Anna Thorbiornson tomislav Vladic Ylva Vladic Stjernholm Medical Educational Programme in Gynecology and Obstetrics Karolinska University Hospital and Karolinska Institute Stockholm Sweden Department of Women’s and Children’s Health Karolinska University Hospital Stockholm Sweden

Objective: To compare labor induction with transcervical catheter to oral misoprostol treatment in primiparous women and women with an unripe cervix, who are at high risk for unsuccessful labor induction. Study Design: A retrospective study was carried out in a university hospital in Sweden. Primary outcomes were vaginal birth within 24 hours and the cesarean section rate. Secondary outcomes were the induction to vaginal delivery interval, chorioamnionitis and neonatal asphyxia. Results: Vaginal birth within 24 hours was obtained more frequently after catheter compared with misoprostol in primiparous women (p 0.05). The induction to vaginal delivery interval was 8 - 12 hours shorter after catheter (p < 0.001). The rates of chorioamnionitis and newborns with an Apgar score 0.05). Conclusion: Labor induction with transcervical catheter resulted in a higher rate of vaginal birth within 24 hours and an 8 - 12 hour shorter induction to vaginal delivery interval compared to treatment with oral misoprostol. This was obtained without increasing the rates of cesarean section, chorioamnionitis or neonatal asphyxia.

关键词： Cervical Ripening Transcervical Catheter Oral Misoprostol Vaginal Birth Cesarean Section

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Rectal cancer and Fournier's gangrene- current knowledge and therapeutic options

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World Journal of Gastroenterology 2015年第30期21卷 9002-9020页

作者： tomislav Bruketa Matea Majerovic Goran Augustin Department of Surgery University Hospital Center Zagreb Department of Internal Medicine University Hospital Center Zagreb Department of Surgery Division of Gastroin- testinal SurgeryUniversity Hospital Center Zagreb School of Medicine University of Zagreb

Fournier's gangrene(FG) is a rapid progressive bacterial infection that involves the subcutaneous fascia and part of the deep fascia but spares the muscle in the scrotal,perianal and perineal region. The incidence has increased dramatically,while the reported incidence of rectal cancer-induced FG is unknown but is extremely low. Pathophysiology and clinical presentation of rectal cancer-induced FG per se does not differ from the other causes. Only rectal cancer-specific symptoms before presentation can lead to the diagnosis. The diagnosis of rectal cancer-induced FG should be excluded in every patient with blood on digital rectal examination,when urogenital and dermatological causes are excluded and when fever or sepsis of unknown origin is present with perianal symptomatology. Therapeutic options are more complex than for other forms of FG. First,the causative rectal tumor should be removed. The survival of patients with rectal cancer resection is reported as 100%,while with colostomy it is 80%. The preferred method of rectal resection has not been defined. Second,oncological treatment should be administered but the timing should be adjusted to the resolution of the FG and sometimes for the healing of plastic reconstructive procedures that are commonly needed for the reconstruction of large perineal,scrotal and lower abdominal wall defects.

关键词： Fournier's gangrene Necrotizing fasciitis Proctological examination Necrotizing soft tissueinfections Oncological treatment Rectal cancer Surgical treatment Reconstructive surgery

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Overhauling the assessment of agrochemical-driven interferences with microbial communities for improved global ecosystem integrity

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Environmental Science and Ecotechnology 2020年第4期4卷 12-17页

作者： Mengcen Wang tomislav Cernava Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects Institute of Pesticide and Environmental ToxicologyZhejiang UniversityHangzhou310058China Institute of Environmental Biotechnology Graz University of TechnologyGraz8010Austria

Recent studies have shown that various agrochemicals can substantially affect microbial communities;especially those that are associated with cultivated *** certain circumstances,up to 50% of the naturally occurring microorganisms can be negatively affected by common agricultural practices such as seed coating with fungicide-based ***,the off-target effects of commonly applied agrochemicals are still understudied in terms of their interferences with microbial *** the same time,agrochemical inputs are steadily increasing due to the intensification of agriculture and the increasing pathogen pressure that is currently observed *** this article,we briefly reflect on the current knowledge related to pesticide interference with microbial communities and discuss negative implications for the plant holobiont as well as such that are spanning beyond local system *** effects of pesticide inputs that cause alterations in microbial functioning likely have unforeseen implications on geochemical cycles that should be addressed with a high priority in ongoing research.A holistic assessment of such implications will allow us to objectively select the most suitable means for food production under the scenario of a growing global population and aggravating climatic *** present three hypothetical solutions that might facilitate a more sustainable and less damaging application of pesticides in the future.

关键词： Pesticides Sustainable agriculture Microbiome Microbial ecology Agrochemicals

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Glucagon-like-1 receptor agonists and sodium/glucose cotransporter-2 inhibitors combination—are we exploiting their full potential in a real life setting?

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World Journal of Diabetes 2020年第11期11卷 540-552页

作者： Maja Cigrovski Berkovic Ines Bilic-Curcic tomislav Bozek Davorka Herman Mahecic Sanja KlobucarMajanovic Silvija Canecki-Varzic Jelena Andric Srecko Marusic Anna Mrzljak Faculty of Medicine J.J.Strossmayer University OsijekOsijek 31000Croatia Department for Endocrinology Diabetes and Clinical PharmacologyClinical Hospital DubravaZagreb 10000Croatia Department of Kinesiological Anthropology and Methodology Faculty of KinesiologyUniversity of ZagrebZagreb 10000Croatia Department of Endocrinology and Metabolism Disorders Clinical Hospital CenterOsijek 31000Croatia University Clinic for Diabetes“Vuk Vrhovac” Merkur University HospitalZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department for Endocrinology Diabetes and MetabolismUniversity Hospital Centre“Sestre milosrdnice”Zagreb 10000Croatia Department for Endocrinology Diabetes and MetabolismUniversity Hospital Centre RijekaSchool of MedicineUniversity of Rijeka51000 RijekaCroatia Department of Medicine Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia

BACKGROUND The sodium/glucose cotransporter-2 inhibitors(SGLT-2i)and glucagon-like-1 receptor agonists(GLP-1RA)are antidiabetic agents effective both in hemoglobin A1c(HbA1c)reduction(with a low risk of hypoglycemia)and cardiovascular event *** patients with type 2 diabetes,the add-on value of combination therapy of GLP-1RA and an SGLT-2i seems *** To investigate whether the efficacy of GLP-1RA and SGLT-2i combination observed in randomized controlled trials translates into therapeutic benefits in the Croatian population during routine clinical practice and *** We included 200 type 2 diabetes patients with poor glycemic control and analyzed the effects of treatment intensification with(1)GLP-1RA on top of SGLT-2i,(2)SGLT-2i on top of GLP-1RA compared to(3)simultaneous addition of both *** primary study endpoint was the proportion of participants with HbA1c<7.0%and/or 5%bodyweight *** outcomes included changes in fasting plasma glucose(FPG),prandial plasma glucose,lowdensity lipoprotein cholesterol,estimated glomerular filtration rate(eGFR),and cardiovascular(CV)incidents assessment over a follow-up period of 12 *** The majority of patients were over 65-years-old,had diabetes duration for more than 10 *** initial body mass index was 39.41±5.49 kg/m2 and HbA1c 8.32±1.26%.Around half of the patients in all three groups achieved target HbA1c below 7%.A more pronounced decrease in the HbA1c seen with simultaneous SGLT-2i and GLP-1RA therapy was a result of higher baseline HbA1c and not the effect of initiating combination *** number of patients achieving FPG below 7.0 mmol/L was significantly higher in the SGLT-2i group(P=0.021),and 5%weight loss was dominantly achieved in the simultaneous therapy group(P=0.044).A composite outcome(reduction of HbA1c below 7%(53 mmol/mol)with 5%weight loss)was achieved in 32.3%of total patients included in the *** 18.2%of patients attained composite outc

关键词： Sodium/glucose cotransporter-2 inhibitors Glucagon-like-1 receptor agonists Type 2 diabetes mellitus Body weight Glycemic control Cardiovascular complications

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Ileus Caused by Large Diverticulum of Postbulbar Duodenum: Case Report

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Open Journal of Gastroenterology 2015年第9期5卷 115-118页

作者： Grgi? Dora Zovak Mario Brkic Marina Brkic tomislav Division of Gastroenterology and Hepatology Department of Internal Medicine University Hospital Rebro Zagreb Croatia Clinic of Surgery University Hospital Sestre Milosrdnice Zagreb Croatia Apnea Diagnostic Clinic of Internal Medicine Neurology and Anesthesiology Reanimation and Intensive Care Zagreb Croatia

Duodenal diverticula are common and are usually found in patients undergoing roentgenographic investigation of the upper gastrointestinal tract. The majority of these cases are asymptomatic and rarely require operative intervention. Occasionally they can result in the obstruction of the biliary and/or pancreatic ducts, haemorrhage or perforation. Symptomiatic cases may require endoscopic or surgical intervention. Herein, we present a case report of a female patient who underwent surgical procedure due to repetitive obstructive symptoms.

关键词： Duodenal Diverticulum Obstruction Upper Endoscopy Diverticulectomy

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G-Phenomena as a Base of Scalable Distributed Computing—G-Phenomena in Moore’s Law

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International Journal of Internet and Distributed Systems 2014年第1期2卷 1-4页

作者： Karolj Skala Davor Davidovic tomislav Lipic Ivan Sovic Centre for Informatics and Computing Ruder Boskovic InstituteZagrebCroatia

Today we witness the exponential growth of scientific research. This fast growth is possible thanks to the rapid development of computing systems since its first days in 1947 and the invention of transistor till the present days with high performance and scalable distributed computing systems. This fast growth of computing systems was first observed by Gordon E. Moore in 1965 and postulated as Moore’s Law. For the development of the scalable distributed computing systems, the year 2000 was a very special year. The first GHz speed processor, GB size memory and GB/s data transmission through network were achieved. Interestingly, in the same year the usable Grid computing systems emerged, which gave a strong impulse to a rapid development of distributed computing systems. This paper recognizes these facts that occurred in the year 2000, as the G-phenomena, a millennium cornerstone for the rapid development of scalable distributed systems evolved around the Grid and Cloud computing paradigms.

关键词： Historical Development of Computing G-Phenomena Moore’s Law Distributed Computing Scalability Grid Computing Cloud Computing Component

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Bacterial-fungal interactions under agricultural settings:from physical to chemical interactions

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Stress Biology 2022年第1期2卷 411-427页

作者： Yaqi Zhou Hongkai Wang Sunde Xu Kai Liu Hao Qi Mengcen Wang Xiaoyulong Chen Gabriele Berg Zhonghua Ma tomislav Cernava Yun Chen State Key Laboratory of Rice Biology and Key Laboratory of Molecular Biology of Crop Pathogens and InsectsInstitute of BiotechnologyZhejiang University866 Yuhangtang RoadHangzhou 310058China Key Laboratory of Molecular Biology of Crop Pathogens and Insects Ministry of AgricultureInstitute of Pesticide and Environmental ToxicologyZhejiang UniversityHangzhouChina Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of EducationGuizhou UniversityGuiyang 550025China Institute of Environmental Biotechnology Graz University of Technology8010 GrazAustria Leibniz-Institute for Agricultural Engineering and Bioeconomy PotsdamGermany University of Potsdam PotsdamGermany.

Bacteria and fungi are dominant members of environmental *** bacterial-fungal interactions(BFIs)and their mutual regulation are important factors for ecosystem functioning and *** interactions can be highly dynamic,and often require spatiotemporally resolved assessments to understand the interplay which ranges from antagonism to *** of these interactions are still poorly understood,especially in terms of the underlying chemical and molecular interplay,which is crucial for inter-kingdom communication and *** are highly relevant under agricultural settings;they can be determinative for crop *** our knowledge related to mechanisms underpinning the interactions between bacteria and fungi will provide an extended basis for biological control of pests and pathogens in ***,it will facilitate a better understanding of complex microbial community networks that commonly occur in *** will allow us to determine factors that are crucial for community assembly under different environmental conditions and pave the way for constructing synthetic communities for various biotechnological ***,we summarize the current advances in the field of BFIs with an emphasis on agriculture.

关键词： Bacterial-fungal interactions Biological control Synthetic communities Secondary metabolites

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