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The impact of COVID-19 on clinical outcomes of burn patients

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Burns & Trauma 2023年第1期11卷 792-799页

作者： Elliot T.Walters Alen Palackic Camila Franco-Mesa Nikhil R.Shah Michael j.erickson Steven E.Wolf Department of Surgery University of Texas Medical Branch301 UniversityGalvestonTXUSA Division of Plastic Aesthetic and Reconstructive SurgeryDepartment of SurgeryMedical University of GrazGrazAustria

Background:Multiple studies have shown the SARS-CoV-2 virus(COVID-19)to be associated with deleterious outcomes in a wide range of *** impact of COVID-19 has not been well investigated among burned *** suspect that patients will have worsened respiratory and thrombotic complications,ultimately leading to increased *** objective of this study is to determine the impact a concurrent infection of COVID-19 has on clinical outcomes after a burn ***:This is a retrospective,propensity matched,cohort *** examined a de-identified database of electronic medical records of over 75 million patients across 75 health care associations in the United States for patients treated for thermal burns from 1 january 2020,to 31 july 2021,and those who also were diagnosed with COVID-19 infection within one day before or after injury based on International Classification of Disease,tenth revision(ICD-10)*** participants included adults who were treated for a burn injury during the study ***:We included 736 patients with burn injury and concomitant COVID-19 infection matched to 736 patients with burn injury and no concurrent COVID-19 infection(total 1472 patients,mean age 36.3±24.3).We found no significant increase in mortality observed for patients with concurrent COVID-19(OR 1.203,95%CI 0.517-2.803;p=0.6675).We did observe significant increase in infections(OR 3.537,95%CI 2.798-4.471;p=0.0001),thrombotic complications(OR 2.342,95%CI 1.351-4.058;p=0.0018),as was the incidence of hypertrophic scarring(OR 3.368,95%CI 2.326-4.877;p=0.0001).Conclusions:We observed that concurrent COVID-19 infection was associated with an increase in infections,thrombosis and hypertrophic scarring but no increase in mortality in our cohort of burn patients.

关键词： COVID-19 infection mortality burn thrombosis scarring

Monitoring the geospace response to the Great American Solar Eclipse on 21 August 2017

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Earth and Planetary Physics 2017年第1期1卷 72-76页

作者： Shun-Rong Zhang Philip j.erickson Larisa P.Goncharenko Anthea j.Coster Nathaniel A.Frissell Haystack Observatory Massachusetts Institute of Technology Center for Solar-Terrestrial Research New Jersey Institute of Technology

Since ancient times,solar eclipses have fascinated—and sometimes terrified—*** eclipses are direct sensory *** the sun vanishes from the sky,birds fall silent during the midday *** instrumentation has enabled resear... 详细信息

关键词： solar eclipse geospace effect ionospheric observations ionospheric radio citizen science

Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro

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Asian journal of Andrology 2016年第4期18卷 620-626页

作者： Mark j McCabe Caroline FH Foo Marcel E Dinger Peter M Smooker Peter G stanton Male Fertility Regulation Laboratory Hudson Institute of Medical Research Monash Medical Centre Clayton Victoria 3168 Australia School of Applied Sciences Royal Melbourne Institute of Technology University Bundoora Victoria 3088 Australia Kinghorn Centre for Clinical Genomics Garvan Institute of Medical Research Darlinghurst New South Wales 2010 Australia St Vincent's Clinical School UNSW Sydney New South Wales 2052 Australia.

The Sertoli cell tight junction （T j） is the key component of the blood-testis barrier, where it sequesters developing germ cells undergoing spermatogenesis within the seminiferous tubules. Hormonally regulated claudin-11 is a critical transmembrane protein involved in barrier function and its murine knockout results in infertility. We aimed to assess quantitatively the significance of the contribution of claudin-11 to Tj function, in vitro, using siRNA-mediated gene silencing. We also conducted an analysis of the contribution of occludin, another intrinsic transmembrane protein of the Tj. Silencing of claudin-11 and/or occludin was conducted using siRNA in an immature rat Sertoli cell culture model. Transepithelial electrical resistance was used to assess quantitatively Tj function throughout the culture. Two days after siRNA treatment, cells were fixed for immunocytochemical localization of junction proteins or lyzed for RT-PCR assessment of mRNA expression. Silencing of claudin-11, occludin, or both resulted in significant decreases in Tj function of 55% （P 〈 0.01）, 51% （P 〈 0.01）, and 62% （P 〈 0.01）, respectively. Data were concomitant with significant decreases in mRNA expression and marked reductions in the localization of targeted proteins to the Sertoli cell Tj. We provide quantitative evidence that claudin-11 contributes significantly （P 〈 0.01） to Sertoli cell Tj function in vitro. Interestingly, occludin, which is hormonally regulated but not implicated in infertility until late adulthood, is also a significant （P 〈 0.01） contributor to barrier function. Our data are consistent with in vivo studies that clearly demonstrate a role for these proteins in maintaining normal Tj barrier structure and function.

关键词： blood-testis barrier claudin-11 occludin Sertoli cell tight junction siRNA

Zinc in plants:Integrating homeostasis and biofortification

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Molecular Plant 2022年第1期15卷 65-85页

作者： Camilla stanton Dale Sanders Ute Krämer Dorina Podar john Innes Centre Colney LaneNorwichNR47UHUK Molecular Genetics and Physiology of Plants Ruhr University Bochum44801 BochumGermany Department of Molecular Biology and Biotechnology and Centre for Systems Biology Biodiversity and BioresourcesBabes-Bolyai University400084 Cluj-NapocaRomania

Zinc plays many essential roles in *** a strong Lewis acid that lacks redox activity under environ-mental and cellular conditions,the Zn2+cation is central in determining protein structure and catalytic function of nearly 10%of most eukaryotic *** specific functions of zinc have been elucidated at a molecular level in a number of plant proteins,wider issues abound with respect to the acquisition and distribution of zinc by *** important challenge is to understand how plants balance between Zn supply in soil and their own nutritional requirement for zinc,particularly where edaphic factors lead to a lack of bioavailable zinc or,conversely,an excess of zinc that bears a major risk of *** are the ultimate source of zinc in the human diet,and human Zn deficiency accounts for over 400000 deaths ***,we review the current understanding of zinc homeostasis in plants from the molecular and physiological *** provide an overview of approaches pursued so far in Zn biofortification of ***,we outline a"push-pull"model of zinc nutrition in plants as a simplifying *** summary,this review discusses avenues that can potentially deliver wider bene-fits for both plant and human Zn nutrition.

关键词： zinc biofortification Zn homeostasis cereals Arabidopsis barley wheat rice

Rehabilitation and return to sport after hamstring strain injury

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journal of Sport and Health Science 2017年第3期6卷 262-270页

作者： Lauren N.erickson Marc A.Sherry Sports Rehabilitation University of Wisconsin Hospital and ClinicsMadisonWI 53718USA

Hamstring strain injuries are common among sports that involve sprinting,kicking,and high-speed skilled movements or extensive muscle lengthening-type maneuvers with hip flexion and knee *** injuries present the challenge of significant recovery time and a lengthy period of increased susceptibility for recurrent *** one third of hamstring strains recur within the first year following return to sport with subsequent injuries often being more severe than the *** high re-injury rate suggests that athletes may be returning to sport prematurely due to inadequate return to sport *** this review article,we describe the epidemiology,risk factors,differential diagnosis,and prognosis of an acute hamstring *** on the current available evidence,we then propose a clinical guide for the rehabilitation of acute hamstring strains and an algorithm to assist clinicians in the decision-making process when assessing readiness of an athlete to return to sport.

关键词： Acute Muscle Performance Physical therapy Recurrence Re-injury Thigh

Heat Shock Protein 90.1 Plays a Role in Agrobacterium- Mediated Plant Transformation

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Molecular Plant 2014年第12期7卷 1793-1796页

作者： So-Yon Park Xiaoyan Yin Kaixuan Duan stanton B. Gelvin Zhanyuan j. Zhang Plant Transformation Core Facility University of Missouri Columbia MO 65211 USA Department of Plant Pathology Physiology and Weed Science Virginia Tech Blacksburg VA 24061 USA Department of Biological Sciences Purdue University West Lafayette IN 47907–1392 USA

Dear Editor, ManybacterialproteinsareinvolvedinAgrobacterium- mediated plant transformation. By contrast, relatively little is known about plant proteins that play key roles in transformation. Some of these host proteins interact with Virulence effector proteins, including VirE2, that are transferred from Agrobacterium to plants （Gelvin, 2010; Pitzschke and Hirt, 2010）. A recent study indicated that the plant protein SUPPRESSOR OF G2 ALLELE OF SKP1 （SGT1）, a co-chaperone of heat shock protein 90 （HSP90）, is required for Agrobacterium-mediated transformation （Anand et al., 2012）. These studies suggested the involvement of HSPg0 in Agrobacterium-mediated transformation.

关键词： BACTERIA -- Heat shock proteins PLANT genetic transformation AGROBACTERIUM

在K/T界线的全球微量元素生物地球化学——对假想的陨石碰撞的海洋和生物的响应

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宝石和宝石学杂志(中英文) 1989年第2期 55-58页

作者： David j.ericksonⅢ Stephen M.Dickson 汪东波

对于与假想的一直径10km的C1球粒陨石有关海洋的微量元素通量计算表明,陨星中包含的某些元素的质量,如Fe,Co,Mn,Al,Zn,Ni,Ge,Cr,Sn,Cd,Pb,Ag,Cu,Hg和Se,相当于或大于世界海洋的储量.所以,在一个大的陨石碰撞后。以大气雾微粒形式的陨石... 详细信息

对于与假想的一直径10km的C1球粒陨石有关海洋的微量元素通量计算表明,陨星中包含的某些元素的质量,如Fe,Co,Mn,Al,Zn,Ni,Ge,Cr,Sn,Cd,Pb,Ag,Cu,Hg和Se,相当于或大于世界海洋的储量.所以,在一个大的陨石碰撞后。以大气雾微粒形式的陨石元素进入到表层海洋,同时各种特定元素的溶解性能,能迅速改变一些海洋微量元素的地球化学平衡.我们确信这种假想的微量元素涌入量足以扰乱66.4Ma前,即陨石可能的碰撞时间的生物地球化学循环、通过直接暴露和生物堆积,这些陨石元素将对海洋食物链的很多营养水平产生不利的影响。这些生存于表层海洋的生物将暴露在有毒元素的长期高浓度下。当海洋中微量元素含量较高时,由于不同种属对高含量的微量元素忍耐程度不同,就可能发生选择性的灭绝。K/T界线处与火山作用有联系的微量元素雾的通量对世界海洋的微量元素高含量也作出了贡献。微量元素中毒说推测这一机制在中生代末海洋生物选择性灭绝的事件中起了作用。

关键词：陨石天空石 K/T 微量元素痕量元素界线

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香港大蹄蝠出飞时间及其季节变化（英文）

兽类学报 2017年第3期37卷 251-255页

作者： David j.stanton aec Ltd 127 Commercial Centre

于2014年5月至2015年4月,对香港低海拔栖息地的大蹄蝠夜晚出飞活动时间进行了研究。结果显示大蹄蝠出飞时间平均为日落后(14.6±6.1)min。初飞时间与民用曙暮光呈强正相关(r=0.968,P<0.0001),而出飞结束时刻同样与民用曙暮光时间呈现显... 详细信息

于2014年5月至2015年4月,对香港低海拔栖息地的大蹄蝠夜晚出飞活动时间进行了研究。结果显示大蹄蝠出飞时间平均为日落后(14.6±6.1)min。初飞时间与民用曙暮光呈强正相关(r=0.968,P<0.0001),而出飞结束时刻同样与民用曙暮光时间呈现显著相关(r=0.977,P<0.0001)。在一年中较冷的12月和1月则没有蝙蝠出飞记录。大蹄蝠虽然在亚洲分布广泛,但是相对于温带地区的蝙蝠物种来说,关于该物种的基础生态学研究较少。本文对大蹄蝠的季节性出飞行为开展研究工作,以利有关长远保育的深入研究。

关键词：民用曙暮光香港蝙蝠保育大蹄蝠出飞时间

太阳紫外线辐射增加对生物地球化学循环的影响

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人类环境杂志 1995年第3期24卷 180-186页

作者： Richard G.Zepp Terry V.Callaghan David j.erickson 吴持政 United States Environmental Protection Agency Environmental Research Laboratory 960 College Station Road Athens. Georgia 30605-2720 USA University of Manchester Centre of Arctic Ecology Williamson Building Oxford Road Manchester M13 GP1 UK National Center for Atmospheric Research 1850 Table Mesa Drive P. O. Box 3000 Boulder Colorado 80307 USA

太阳的紫外线(UV)辐射增加可影响陆地和水生生态系统的生物地球化学循环,从而改变两者的温室和具化学重要性痕量气体如二氧化碳(CO_2)、一氧化碳(CO)、羰基硫化物(COS)的源和汇。在陆地生态系统中,增加了的UV-B辐射可以修正植物物质的... 详细信息

太阳的紫外线(UV)辐射增加可影响陆地和水生生态系统的生物地球化学循环,从而改变两者的温室和具化学重要性痕量气体如二氧化碳(CO_2)、一氧化碳(CO)、羰基硫化物(COS)的源和汇。在陆地生态系统中,增加了的UV-B辐射可以修正植物物质的生产与分解,并使具大气重要性的痕量气体的吸收和释放产生变化。当UV-B对落叶层表面产生光致降解时,分解过程被加速;当其主要影响包含了活组织的化学组成变化,使被埋落叶的生物降解性降低时,分解过程被延缓。分解过程的这些变化能影响微生物的二氧化碳和其他痕量气体的生产,也会影响植物生长必不可少的养分供应。初级生产力可因增强了的UV-B而下降,但这种作用随物种甚至某些作物的栽培品种不同而异。与此类似,高UV-B辐射对植物物质的CO光致生成的影响也依赖于物种,并有从枯死物质的生成比从有生命物质的生成更有效的现象。对几个不同地区水生生态系统的研究表明,降低现有太阳的UV-B辐射水平可提高初级生产力,而南极臭氧洞下的实验证明增强了的UV-B辐射抑制初级生产。大阳的UV辐射除了对初级生产有影响外还能减慢海洋上层浮游细菌的生长,这可能会对海洋的生物地球化学循环产生重要影响。当细菌的活动受高UV-B辐射的抑制时,分解过程被延缓,而当太阳的UV辐射对水中的溶解有机质(DOM)产生光致降解时,分解过程被加速。DOM的光致降解引起对UV吸收的减弱并生成溶解无机碳(DIC)、CO和有机底层物质,而这些物质容易矿化或被水生微生物吸收。UV-B辐射可以影响海洋的硫循环,并有可能改变海洋向大气的COS和二甲硫(DMS)的散发过程,而这两种气体都能在平流层和对流层中被降解成硫酸盐气溶胶。

关键词：太阳紫外线辐射生物地球化学