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inflammatory myofibroblastic tumor from molecular diagnostics to current treatment

Oncology research 2024年第7期32卷 1141-1162页

作者： PAULiNA CHMiEL ALEKSANDrA SŁOWiKOWSKA ŁUKASZ BANASZEK ANNA SZUMErA-CiEĆKiEWiCZ BArTŁOMiEJ SZOSTAKOWSKi MATEUSZ J.spaŁEK TOMASZŚWiTAJ PiOTr rUTKOWSKi ANNA M.CZArNECKA Department of Soft Tissue/Bone Sarcoma and Melanoma Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland Faculty of Medicine Medical University of WarsawWarsaw02-091Poland Department of Pathology Maria Sklodowska Curie National Research Institute of OncologyWarsaw02-781Poland Department of radiotherapy Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland

inﬂammatory myoﬁbroblastic tumor(iMT)is a rare neoplasm with intermediate malignancy characterized by a propensity for recurrence but a low metastatic *** challenges arise from the diverse pathological presentation,variable symptomatology,and lack of different imaging ***,iMT is identiﬁed by the fusion of the anaplastic lymphoma kinase(ALK)gene,which is present in approximately 70%of cases,with various fusion partners,including ran-binding protein 2(rANBP2),which allows conﬁrmation of the *** surgery is the preferred approach for localized tumors,the optimal long-term treatment for advanced or metastatic disease is difﬁcult to deﬁ*** therapies are crucial for achieving sustained response to treatment within the context of genetic alteration in ***,an ALK tyrosine kinase inhibitor(TKi),was ofﬁcially approved by the US Food and Drug Administration(FDA)in 2020 to treat iMT with ALK ***,most patients face resistance and disease progression,requiring consideration of sequential *** radiotherapy with targeted therapy appears to be beneﬁcial in this *** promising results have also been achieved with immunotherapy,indicating potential for combined therapy ***,deﬁned recommendations are still *** review analyzes the available research on iMT,including genetic disorders and their impact on the course of the disease,data on the latest targeted therapy regimens and the possibility of developing immunotherapy in this indication,as well as summarizing general knowledge about prognostic and predictive factors,also in terms of resistance to systemic therapy.

关键词： inﬂammatory myoﬁbroblastic tumor(iMT) Epithelioid inﬂammatory myoﬁbroblastic sarcoma Tyrosine kinase inhibitors(TKi) Anaplastic lymphoma kinase(ALK)

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Blue Cap is Effective and Safe for the Treatment of Atopic Dermatitis in Children

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Open Journal of Pediatrics 2024年第3期14卷 609-622页

作者： Mirjana Gajić-Veljić Biljana Marenović Margita Mijušković Vesna reljić Danica Tiodorović Danijela Popović Sanja Zorić-Blagojević Milica Vučinić David Marquez-Soriano Jovan Lalošević University of Belgrade Faculty of Medicine Department of Dermatology and Venereology University Clinical Center of Serbia Beograd Serbia University of Niš Faculty of Medicine Department of Dermatology and Venereology University Clinical Center of Ni&#353 Ni&#353 Serbia City institute for Skin and Venereal Diseases Beograd Serbia Scientific Department Catalysis S.L. Madrid Spain

Background: Atopic dermatitis (AD) is the most common inflammatory skin disease in children. Treatment of AD is based on skin barrier repair and reduction of inflammation. We analyzed the efficacy and safety of activated piroctone olamine (APO)—Blue Cap—in children with AD. Materials and Methods: An open-label interventional clinical study was carried out at three clinical centers in Serbia. A total of 58 patients with AD, aged between 3 and 18 years were included and treated with Blue Cap Foam (100 ml;CATALYSiS S.L. Madrid)—Activated Piroctone Olamine—applied twice a day in the affected areas with eczema for 30 days and final assessment at 45 days from baseline. Photographic documentation, clinical evaluation, therapy effectiveness and safety questionnaires were assessed at baseline, 15, 30 and 45 days. results: Our results demonstrated a significant reduction in signs (erythema, scaling, infiltration, excoriations, xerosis) and symptoms (pruritus) at weeks 2 and 4 of the study. At the end of the study, most patients had moderate (28.6%) to great (62.5%) disappearance of manifestations and moderate (25%) to great (71.4%) skin quality improvement. The effect and tolerability of the therapy were evaluated as very good in 66.1 % and 67.9% and good in about 14.3% and 17.9%, assessed by the investigator and patient, respectively. Three patients experienced a burning sensation at the beginning of the study, the side-effects were resolved as the patients continued applying the foam. After two weeks of cessation of the investigated foam, a significant percentage of patients experienced worsening in the final assessment done by the investigator as well as the participant. in the final assessment, a significantly high percentage (57.1%) of patients had a total reduction of manifestation, and a significant number of participants considered the applied product as treatment success, assessed by the investigator (62.5%) as well as the participants (66.4%). Conclusions: Blue Cap

关键词： Pediatric Dermatology Atopic Dermatitis Piroctone Olamine Skin Care

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Effect of residual dissolved oxygen on the corrosion behavior of low carbon steel in 0.1 M NaHCO3 solution

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Journal of Materials Science & Technology 2018年第8期34卷 1349-1358页

作者： Fang Xue Xin Wei Junhua Dong ini-ibehe Nabuk Etim Changgang Wang Wei Ke institute of Metal research Chinese Academy of SciencesShenyang 110016China University of Science and Technology of China Hefei 230026China

The effect of residual dissolved oxygen （DO） on the corrosion behavior of carbon steel in 0.1 M NaHCO3 solution was investigated by electrochemical measurements, corrosion mass loss test, scanning electron microscopy （SEM） and X-ray diffraction （XrD）. in the initial immersion stage, the increase of the dissolved oxygen concentration led to the change of from a reductive state of active dissolution to an oxidizing state of pseudo passivation in low carbon steel. While in the final stage, all the steels transformed into the steady state of pseudo passivation. in the anaerobic solution, the formation of c^-FeOOH was attributed to the chemical oxidization of the ferrous corrosion products and the final cathodic process only included the reduction of c^-FeOOH, while in the aerobic solution, it included the reduction of oxygen and （x-FeOOH simultaneously. As the main corrosion products, the content of （x-FeOOH was increased while that of Fe6（OH）12CO3 was decreased with increasing concentration of dissolved oxygen. The total corrosion mass loss of the steel was promoted with the increase of dissolved oxygen concentration.

关键词： Low carbon steel residual dissolved oxygen Electrochemical characterization Anodic dissolution state Pseudo passivation

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Evolution of Viral Load in Patients infected with HiV-1 at Point G University Hospital

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Open Journal of Medical Microbiology 2024年第1期14卷 66-76页

作者： A. Maiga D. Kone D. M. Coulibaly Ag M. Baraika A. Traore S. S. Diakite i. i. Maiga i. Konate A. i. Maiga Faculty of Medicine and Odontostomatology of Bamako (FMOS) University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of Medical Biology and Hospital Hygiene of Point-G University Hospital Bamako Mali Faculty of Pharmacy of Bamako (FaPh) University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of the Luxembourg Mother-Child Hospital Bamako Mali National institute of Public Health Bamako Mali National institute for Training in Health Sciences Bamako Mali Laboratory of the Kati University Hospital Center Bamako Mali infectious and Tropical Diseases Department of Point-G University Hospital Bamako Mali Laboratory of CHU Gabriel Touré Bamako Mali

introduction: HiV, the human immunodeficiency virus, is the etiological agent of acquired immunodeficiency syndrome (AiDS). The aim of this study was to assess the evolution of the viral load in patients under treatment. Methodology: This was a study carried out from July 2017 to June 2022 at the Point G University Hospital laboratory. The determination of the viral load of patients was carried out by PCr on the ABOTT M2000sp/rt platform. results: A total of 129 patients infected with HiV-1, aged 19 to 72 years with a mean age of 40.05 years ± 10.71;all on antiretroviral chemotherapy. The female gender predominated among our patients. The most common treatment regimen was 2iNTi + 1iNNTi with 72.9% followed by 2iNTi + 1ini with 13.2%. As for the combinations of molecules, the combination TDF + 3TC + EFV and TDF + 3TC + DTG predominated, respectively 65.1% and 13.2%. 89.9% of our patients had undetectable viremia after 12 months of treatment (p ith an average viral load which had evolved from 681315.65 copies/ml ± 1616908.484 to M0 at 5742.36 copies /ml ± 35756.883 at M12 (p Conclusion: Generally speaking, antiretroviral treatment had contributed to controlling viral loads, however the therapeutic combination TDF + 3TC + DTG had made it possible to obtain more patients with undetectable viremia instead.

关键词： HiV-1 Treatment Viral Load Point G University Hospital

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Hepatocellular carcinoma treated with transarterial chemoembolization: Dynamic perfusion-CT in the assessment of residual tumor

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World Journal of Gastroenterology 2010年第47期16卷 5993-6000页

作者： Davide ippolito Pietro Andrea Bonaff ini Laura ratti Laura Antolini rocco Corso Ferruccio Fazio Sandro Sironi Department of Diagnostic radiology School of Medicine University of Milano-BicoccaH S. Gerardo Department of Clinical Medicine Prevention and Biotechnology Section of Medical Statistics H S. Gerardo Department of Clinical Medicine School of Medicine University of Milano-Bicocca H S. Gerardo Department of interventional radiology H S. Gerardo

AiM: To asses the value of computed tomography (CT)-perfusion in the detection of residual hepatocellular carcinoma (HCC) vascularization after transarterial chemoembolization (TACE). METHODS: Thirty-two consecutive patients were pro-spectively included in this study. All patients had liver cirrhosis and a conf irmed HCC lesion which was treated with TACE. One month after treatment, perfusion measurements of treated lesions were carried out. The CTperfusion (CT-p) protocol was performed with 16 slice multidetector computed tomography which included the following parameters: 8 dynamic slices/scan per 40 scans after iv injection of 50 mL of iodinated contrast (350 mg/mL) at a flow rate of 6 mL/s. Treated lesions were evaluated using dedicated perfusion software, which generated a quantitative colour map of perfusion. The following parameters were considered: hepatic perfusion (HP), arterial perfusion (AP), blood volume (BV), hepatic perfusion index (HPi), and time to peak (TTP). Perfusion parameters were described with quartile values of their distribution and statistically analyzed. rESULTS: Perfusion parameters of the treated lesions could be quantitatively assessed using CT-p analysis. The presence of residual tumor tissue was observed in 13 of the 32 patients. The values of the perfusion parameters measured within the relapse tissue were: HP (mL/100 g per minute): median = 44.4 (1stqt = 31.3, 3rdqt = 55.8); BV (mL/100 g): median = 18.7 (1stqt = 11.5, 3rdqt = 22.5); AP (mL/min): median = 39.0 (1stqt = 36.5, 3rdqt = 61.3); HPi (%): median = 34.0 (1stqt = 30.4, 3rdqt = 38.9); TTP (s): median = 17.3 (1stqt = 15.8, 3rdqt = 26.5). With the use of the univariate paired Wilcoxon signed rank test, HP, AP and HPi were shown to be significantly higher (Pin the relapse site than in the primary lesion. The BV and TTP parameters showed a tendency to be greater and lower, respectively, in the relapse site than in the primary lesion. CONCLUSiON: in patients with HCC treat

关键词： Computed tomography-perfusion Functional-computed tomography Hepatocellular carcinoma Trans-arterial chemoembolization Tumour neo-angiogenesis

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Electrochemical noise analysis on the pit corrosion susceptibility of biodegradable AZ31 magnesium alloy in four types of simulated body solutions

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Journal of Materials Science & Technology 2018年第10期34卷 1876-1884页

作者： changgang wang liping wu fang xue rongyao ma ini-ibehe nabuk etim xuehui hao junhua dong wei ke institute of Metal research Chinese Academy of Sciences Shenyang 110016 China

Magnesium alloys have been investigated as biodegradable implant materials since the last century. Non-uniform degra.a.ion caused by local corrosion limits their application, and no appropriate technology has been used in the research. in this study, electrochemical noise has been used to study the pit corrosion on magnesium alloy AZ31 in four types of simulated body solutions, and the data have been analyzed using wavelet analysis and stochastic theory. Combining these with the conventional polarization curves, mass loss tests and scanning electron microscopy, the electrochemical noise results implied that AZ31 alloy in normal saline has the fastest corrosion rate, a high pit initiation rate, and maximum pit growth probability. in Hanks＇ balanced salt solution and phosphate-buffered saline, AZ31 alloy has a high pit initiation rate and larger pit growth probability, while in simulated body fluid, AZ31 alloy has the slowest corrosion rate, lowest pit initiation rate and smallest pit growth probability.

关键词： Biodegradable magnesium alloy Electrochemical noise (EN) Pit corrosion susceptibilities Wavelet analysis Stochastic model

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Effect of applied potential on the microstructure, composition and corrosion resistance evolution of fluoride conversion film on AZ31 magnesium alloy

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Journal of Materials Science & Technology 2018年第11期34卷 2084-2090页

作者： Liping Wu Changgang Wang Durga Bhakta Pokharel ini-ibehe Nabuk Etim Lin Zhao Junhua Dong Wei Ke Nan Chen Environmental Corrosion Center Institute of Metal ResearchChinese Academy of Sciences

AZ31 magnesium（Mg） alloy was potentiostatic polarized in 0.1 M deaerated KF solution with pH 7.5 from-0.4 V to-1.4 V with an interval of-0.2 V. The polarization process was described by the potentiostatic current decay. The resultant film was analyzed by scanning electron microscopy（SEM）, X-ray diffraction（XrD）, X-ray photoelectron spectroscopy（XPS） and electrochemical impedance spectroscopy（EiS）. The results demonstrated that the deposited film included a Mg（OH）2/MgF2 containing inner layer and a Mg（OH）-2/MgF2/KMgF3 comprising outer layer. The high polarized potential produced high content of MgF2 but low content of KMgF3 and thin film. Conversely, the low polarized potential produced small content of MgF2 but high content of KMgF3 and thick film. The optimal corrosion resistance of the deposited film was obtained at-1.4 V, which was closely related with the content of MgF2 and KMgF3 and the film thickness.

关键词： Potentiostatic Fluoride conversion film AZ33 magnesium alloy KF solution Corrosion

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Effect of D-fructose on the in-vitro corrosion behavior of AZ31 magnesium alloy in simulated body fluid

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Journal of Materials Science & Technology 2021年第7期66卷 202-212页

作者： Durga Bhakta Pokharel Liping Wu Junhua Dong Xin Wei ini-ibehe Nabuk Etim Dhruba Babu Subedi Aniefiok Joseph Umoh Wei Ke Shenyang National Laboratory for Materials Science(SYNL) Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Material Science and Engineering University of Science and Technology of ChinaHefei230026China Department of Marine Biology Akwa Ibom State UniversityUyoNigeria

The effect of addingd-fructose to simulated body fluid(SBF) on the corrosion behavior of AZ31 magnesium(Mg) alloy at 37.C and at a pH of 7.4 was studied by potentiodynamic polarization(PDP), electrochemical impedance spectroscopy(EiS), potentiostatic polarization and hydrogen(H2) collecting techniques,raman spectroscopy technique, scanning electron microscopy(SEM), energy dispersive spectroscopy(EDS), X-ray diffraction(XrD), X-ray photoelectron spectroscopy analysis(XPS) and Fourier transformed infrared(FTir). The results demonstrated that the addition of fructose enhanced the deposition of phosphates forming thick and compact corrosion products, which inhibited the transmission of aggressive ions into the Mg substrate. As a result, both the anodic dissolution of Mg and negative difference effect(NDE) were suppressed. Thus, the corrosion resistance of AZ31 Mgalloy in SBF was significantly improved.

关键词： AZ31 Mg alloy D-Fructose SBF EiS Hydroxya.a.ite

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Corrosion Behaviour of Carbon Steel Fasteners in Neutral Chloride Solution

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Acta Metallurgica Sinica(English Letters) 2022年第4期35卷 563-576页

作者： Enobong Felix Daniel Junhua Dong Xiaofang Li ini-ibehe Nabuk Etim inime ime Udoh rongyao Ma Lei Chen Changgang Wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China School of Environmental and Chemical Engineering Shenyang Ligong UniversityShenyang 110159China Department of Marine Biology Akwa Ibom State UniversityP.M.B 1167UyoNigeria

An experimental model for simulating the corrosion of carbon steel fasteners(bolt and nut) composed of a contact carbon steel electrode(CCSE) and an exposed bare carbon steel plate electrode(BCSE) was designed. The effect of coupling on the corrosion process of the galvanically coupled carbon steel electrode was evaluated and compared with the self-corrosion process observed independently at the exposed and contact regions. results obtained indicated that at an equal area ratio and uncoupled conditions, the corrosion rate is accelerated in the surface directly exposed to bulk solution compared to the bolt surface in contact with the nut. A coupling current was recorded when the exposed surface(BCSE) was electrically connected with the contact surface(CCSE);with the CCSE acting as the anode thereby suppressing the corrosion process in the exposed surface. By implication, the galvanic coupling between CCSE and BCSE increased the corrosion rate of CCSE. The diff erence in oxygen supply was responsible for the coupling effect observed in the system as there was no decrease in the solution pH. Moreover, varying the cathode-to-anode area( S c/S a) ratio significantly influenced the corrosion current density as increased S c/S a ratio resulted in an accelerated galvanic corrosion process. The corroded surfaces and interfaces were analysed using stereomicroscopy and scanning electron microscopy. X-ray diff ractometry was adopted for corrosion product characterization. The results obtained showed supportive evidence of the corrosion behaviour in carbon steel fasteners.

关键词： Bolt and nut Galvanic current density Zero resistance ammetry(ZrA) Coupling potential Differential aeration cell Carbon steel fasteners

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Effect of organic silicon quaternary ammonium salts on mitigating corrosion of reinforced steel induced by SrB in mild alkaline simulated concrete pore solution

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Journal of Materials Science & Technology 2021年第5期64卷 126-140页

作者： ini-ibehe Nabuk Etim Junhua Dong Jie Wei Chen Nan Durga Bhakt Pokharel Aniefiok Joseph Umoh Dake Xu Mingzhong Su Wei Ke Environmental Corrosion Centre Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China University of Chinese Academy of Sciences 19A Yuquan road Shijingshan DistrictBeijing 100049China Department of Marine Biology Akwa Ibom State UniversityP.M.B.1167UyoNigeria School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Sani-care Salon Products Inc.USA

The corrosion damage of 20 SiMn steel by sulphate-reducing bacteria(SrB)and the mitigation effect of organic silicon quaternary ammonium salt(OSA)were studied in sterilized mild alkaline simulated concrete pore solution(STr)with different additions of SrB and OSA at pH 9.35 for 28 *** corrosion occurs in STr medium while slight localized corrosion is observed in STr+OSA medium,and localized pitting corrosion occurs in STr+SrB and STr+SrB+OSA *** largest pit depth reduces from 36.70μm in STr+SrB medium to 3.31μm in STr+SrB+OSA medium due to the mitigation effect of *** corrosion rate reflected by weight loss and electrochemical impedance spectroscopy(EiS)results presents the order of STrr+OSAr+SrB+OSAr+SrB,which also proves that the presence of SrB can accelerate corrosion in a carbonated ***,OSA as an efficient bacteriostatic agent can reduce the excessive growth of SrB and thus reduce corrosion.

关键词： Steel reinforced concrete Microbial corrosion Biocide EiS

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