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Repeated measurement of growth-differentiation factor-15in Chinese Han patients with post-myocardial infarction chronic heart failure

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Journal of Geriatric Cardiology 2018年第10期15卷 618-627页

作者： Ji-Xuan LIU Yan-Ping LI Bo-Han LIU Xiao-Jing ZHAO Ze-Yu ZHANG Jin-Da WANG Qian JIA Chun-lei LIU Xiao-jian GAO Zhen-Guo XU Hua-Wei ZHANG Lin-Nan song Zhi-Jun SUN Kun-Lun HE Beijing Key Laboratory of Chronic Heart Failure Precision Medicine Chinese PLA General HospitalBeijingChina Transformation Medicine Centre Chinese PLA GeneraI HospitalBeijingChina Department of Cardiovascular Chinese PLA General HospitalBeijingChina Department of Geriatric Cardiology Chinese PLA General HospitalBeijingChina Outpatient Department of North China Military Materials Procurement Bureau TianjinChina Queen Mary College of Nanchang University NanchangChina

Background Growth-differentiation factor-15(GDF-15)is a promising prognostic biomarker in patients with chronic heart failure (CHF).Comparatively little is known about the value of repeated measurement of GDF-15with CI-IF in Chinese Han *** study sought to identify the clinical value of repeated measurement of GDF-15in Chinese Han patients with post-myocardial infarction CHF. Methods In total,232consecutive Chinese Hart patients with post-myocardial infarction CHF were enrolled prospectively from January 2014to June *** plasma concentration of GDF-15was determined on admission and over *** were followed up for all-cause death and a composite outcome of major adverse cardiac events (MACE)included all-cause death,myocardial infarction and first heart failure (HF)*** with other clinical variables and adverse outcomes of repeated measurement of GDF-15 was *** The median baseline GDF-15level was 2025ng/*** GDF-15was moderately associated with baseline N-terminal pro-B type nalriuretic peptide (NT-proBNP)(coefficient 0.561,P <0.001).During a median follow-up of 20months,there were 53deaths and ***-I5remained an independent predictor of all-cause death (adjusted hazard ratio 1.826per 1Ln U,95%CI: 1.037-8.360;P =0.037)and MACE (adjusted hazard ratio 2.243per I Ln U,95%CI:1.181-1.775;P <0.001)adjusted for established risk *** measurement of GDF-15was performed in 173survivals over *** of GDF-15over 12months was associ- ated with dilatation of left ventricle and acted as an independent predictor of subsequent all-canse death (adjusted HR =3.164,95%CI: 1.245~.041;P =0.015).In the joint model,GDF-15was also shown to be a risk factor for all-cause death (HR =2.749,95%CI: 1.667-3.831;P <0.001)and MACE (FIR =2.434,95%CI:1.425-3.443;P <0.001).Conclusions Repeated measurements of GDF-15 have promising prognostic value of the risk of all-cause death in Chinese Han patients

关键词： Chronic heart failure Growth-differentiation factor-15 Left ventricular remodeling Myocardial infarction Prognosis

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三维可视化技术在复杂腹壁切口疝中的应用:48例患者的临床经验总结

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中国普外基础与临床杂志 2024年第8期31卷 928-932页

作者：彭雪峰杨华李慧宋应寒张雨晨雷文章四川大学华西医院普通外科胃肠外科病房成都610041 自贡市第四人民医院普外科四川自贡643000 四川大学华西医院全科医学中心日间手术中心成都610041 四川大学华西天府医院胃肠外科成都610213

目的评价三维可视化(three-dimensional visualization,3DV)技术在复杂腹壁缺损重建中的应用价值。方法回顾性收集2021年9月至2022年9月期间四川大学华西医院收治的复杂腹壁切口疝患者的临床资料。采用3DV技术重建并用Medraw软件分析... 详细信息

目的评价三维可视化(three-dimensional visualization,3DV)技术在复杂腹壁缺损重建中的应用价值。方法回顾性收集2021年9月至2022年9月期间四川大学华西医院收治的复杂腹壁切口疝患者的临床资料。采用3DV技术重建并用Medraw软件分析腹壁缺损面积,据此进行腹壁缺损分类和分区,计算疝囊/腹腔容积比,预估补片大小,记录术后24 h及48 h时的腹腔内压力值以及手术时间和术后并发症情况。结果本研究共收集到48例复杂腹壁切口疝患者,其中正中线腹壁切口疝30例,其他部位18例。中型疝13例、大型疝19例、巨大疝16例。48例患者通过3DV技术测量的腹壁缺损面积为(92.11±60.25)cm^(2),疝囊/腹腔容积比为(7.7±5.2)%,术中实际测量的腹壁缺损面积为(89.20±57.38)cm^(2),Pearson相关性分析结果显示术前3DV技术测量和术中实际测量的腹壁缺损面积值呈正相关(r=0.959,P<0.001)。手术时间为(73.5±8.2)min,术后肛门排气时间为(31.66±15.32)h,术后24 h和48 h时的腹腔内压力分别为(13.50±2.12)mmHg、(11.39±1.42)mmHg,住院时间为(7.12±1.21)d。48例患者中术后共有7例(14.6%)患者发生并发症,均经保守治疗后痊愈,无非计划再次手术。所有患者均获得随访,随访时间18~32个月、中位时间为26个月,均未见远期疝复发。结论从本组资料分析结果看,应用3DV技术评估复杂腹壁切口疝可以辅助疝外科医师作出正确抉择,安全而有效。

关键词：三维可视化技术复杂腹壁切口疝

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Subacute Toxicity of High-Dose Resveratrol and its Effect on Gut Microbiota in Healthy Male and Female Sprague-Dawley Rats

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Biomedical and Environmental Sciences 2021年第7期34卷 587-591页

作者： LU Wei song Yan Hua XIA Yong ZHANG Shi Xin YAN Jun CAI De lei XU Cai Ju Zhejiang Provincial Centre for Disease Control and Prevention Hangzhou 310051ZhejiangChina

Resveratrol,3,5,4-trihydroxystilbene,is a natural polyphenol phytoalexin found in various plant species and red *** this compound has been widely used and extensively investigated,there are still uncertainties regarding the applicable dose range and relevant toxicities in experimental animals and *** fact,disparate doses(5-5,000mg/day)and variable experimental settings related to the bioactivity studies of resveratrol have been used and investigated,which might lead to variations in readouts.

关键词： applicable hough bioactivity

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Inflammatory myofibroblastic tumor diagnosed due to high intraocular pressure

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 147-150页

作者： Juan Zhu Hong-lei Liu Hui Liu Gang Li jian-Rong Liu Wei-Wei Wang Shaanxi Eye Hospital Xi’an People’s Hospital(Xi’an Fourth Hospital)Affiliated People’s Hospital Northwest UniversityXi’an 710004Shaanxi ProvinceChina Department of Pathology Xi’an People’s Hospital(Xi’an Fourth Hospital)Affiliated People’s Hospital Northwest UniversityXi’an 710004Shaanxi ProvinceChina

Dear Editor,I am writing this letter to present an unusual case of orbital inflammatory myofibroblastic tumor(IMT)diagnosed due to high intraocular pressure(IOP).IMT is a rare mesenchymal,low-grade malignant or borderline tumor,composed of differentiated myofibroblastic spindle cells,often accompanied by plasma cells and lymphocyte infiltration[1].The onset in most patients is insidious.

关键词： intraocular letter high

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2022年达州市家畜O型口蹄疫免疫抗体监测与分析

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动物医学进展 2024年第2期45卷 123-127页

作者：张蕾欧云文刘俐君赵小波唐慧伦杨青李成高嵩李清竹达州市动物疫病预防控制中心四川达州635000 开江县动物疫病预防控制中心四川达州636250 中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室甘肃兰州730046

为准确掌握2022年达州市家畜O型口蹄疫(Foot-and-mouth disease, FMD)免疫效果,从辖区180个场(点)随机采集猪、牛和羊血清2 879份,采用酶联免疫吸附试验(ELISA)进行O型FMD免疫抗体检测。结果显示,家畜O型FMD免疫抗体场(点)阳性率为88.8... 详细信息

为准确掌握2022年达州市家畜O型口蹄疫(Foot-and-mouth disease, FMD)免疫效果,从辖区180个场(点)随机采集猪、牛和羊血清2 879份,采用酶联免疫吸附试验(ELISA)进行O型FMD免疫抗体检测。结果显示,家畜O型FMD免疫抗体场(点)阳性率为88.89%,样品阳性率为88.78%,均达到农业农村部规定标准。在不同种类家畜方面,牛场(点)阳性率和样品阳性率均最高,分别为93.94%和93.41%;在场(点)类型方面,屠宰环节的场(点)阳性率显著低于养殖环节(P<0.05),规模场(存栏量≥500头/只)的场(点)阳性率、样品阳性率均高于适度规模场(存栏量<500头/只)和散养户;在不同区域方面,通川区场(点)阳性率和样品阳性率均最高,渠县最低;在不同季节方面,场(点)阳性率最高为夏季(92.31%),而样品阳性率最高为冬季(90.76%);从不同生长阶段来看,种畜场(点)阳性率和样品阳性率均最高,分别为96.72%和92.62%。监测结果表明,达州市家畜O型FMD免疫效果较好,建立了有效的免疫保护屏障,可为进一步做好FMD科学防控提供数据参考。

关键词：家畜 O型口蹄疫免疫抗体

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《诗学梯航》诗学研究

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洛阳师范学院学报 2024年第6期43卷 49-52页

作者：何建邱美琼云南师范大学文学院云南昆明650500

《诗学梯航》是明代一部诗法著作,其体例完备、论述细致,基本涉及了诗歌创作的各个方面。作者群受台阁文学背景影响,《诗学梯航》具有明显的儒家文学倾向,基本诗学立场是崇唐抑宋,体现出明初儒士对于历代诗歌史的构建逻辑。《诗学梯航... 详细信息

《诗学梯航》是明代一部诗法著作,其体例完备、论述细致,基本涉及了诗歌创作的各个方面。作者群受台阁文学背景影响,《诗学梯航》具有明显的儒家文学倾向,基本诗学立场是崇唐抑宋,体现出明初儒士对于历代诗歌史的构建逻辑。《诗学梯航》反映出明代初期诗坛习诗的路径和取式,在品藻方面,侧重划分历代同类诗风而不是分析内在差异;在命题观上,又以“纯”的范畴要求命题准确明晰;在学诗态度上,主张细细推敲、久久为功。

关键词：《诗学梯航》诗法研究习诗路径诗学价值

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Chinese Physics Letters 1998年第9期15卷 677-679页

作者： ZHAO Yi-guang CHENG lei HUANG Xian-ling ZHANG Guo-yi LI Jing YANG Zhi-jian Department of Physics Peking UniversityBeijing 100871 National Laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083 Department of Physics Mesoscopic Physics LaboratoryPeking UniversityBeijing 100871

Using solid-phase regrowth technique,Pd/Ge contact has been made on the GaN layer,and very good ohmic behavior was observed for the *** Photoluminescence(PL)spectra for different structures formed by the Pd/Ge contact,GaN layer,sapphire substrate,and mirror were studied,and a defect-assisted transition was found at 450nm related to Ge *** results show that the microcavity effect strongly influences the PL spectra of the band-gap and defect-assisted transitions.

关键词： GaN sapphire ohmic

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Three-dimensional Simulation of Reverberation Chamber Using Finite-element Time-domain Method

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高电压技术 2013年第12期39卷 2889-2893页

作者： DU lei WANG song CUI Yaozhong WANG Qingguo PAN Yun Research Institute of Electrostatic and Electromagnetic Protection Mechanical Engineering College Shijiazhuang 050003 China Department of Computer Science Xinyang College of Agricultyure and Forestry Xinyang 453007 China

Three-dimensional (3D) finite-element time-domain (FETD) method is used for the first time to simulate the low frequency response of a reverberation chamber (RC). The application of FETD algorithm for RC modeling is described. A dipole antenna, a vertical stirrer, and a horizontal stirrer are located in the RC, where the FETD method with its flexibility in geometrical modeling, helps to model the stirrers of the RC explicitly. The rotation angles of the stirrers are set arbitrarily, and each stirrer is independently rotated step-by-step five times. This gives 25 stirrer positions. Applying modulated Gaussian pulse with the bandwidth of 30 ?80 MHz in the modeled RC, eight observations of low frequency response are made in the simulations. The standard deviations from 30 MHz to 40 MHz are above 4 while having some oscillation, and from 40 MHz to 80 MHz they vary smoothly between 2 and 8. These standard deviation agree with the theoretical analyses described by IEC 61000-4-21-2011 standard within the given frequency range, which varifies the accuacy and efficacy of the proposed 3D FETD method simulations of RC. Therefore, this method could be utilized for further designing and optimizing RCs.

关键词：三维模拟时域法有限元混响室几何建模标准偏差雷达散射截面低频响应

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Evaluation of therapeutic effectiveness of 131I-antiEGFR-BSA-PCL in a mouse model of colorectal cancer

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World Journal of Gastroenterology 2016年第14期22卷 3758-3768页

作者： Wei Li Yan-hui Ji Cheng-xia Li Zhong-Yun Liu Ning Li lei Fang Jin Chang jian Tan Department of Nuclear Medicine Tianjin Medical University General Hospital Tianjin 300052 China Yantai Institute of Coastal Zone Research Chinese Academy of Sciences Yantai 264003 Shandong Province China Institute of Nanobiotechnology School of Materials Science and Engineering Tianjin Key Laboratory of Composites and Functional Materials Tianjin University Tianjin 300072 China

AIM: To investigate the biological effects of internal irradiation, and the therapeutic effectiveness was assessed of ^(131)I-labeled anti-epidermal growth factor receptor(EGFR) liposomes, derived from cetuximab, when used as a tumor-targeting carrier in a colorectal cancer mouse ***: We described the liposomes and characterized their EGFR-targeted binding and cellular uptake in EGFR-overexpressing LS180 colorectal cancer cells. After intra-tumor injections of 74 MBq(740 MBq/m L) ^(131)I-anti EGFR-BSA-PCL, we investigated the biological effects of internal irradiation and the therapeutic efficacy of ^(131)I-anti EGFR-BSA-PCL on colorectal cancer in a male BALB/c mouse model. Tumor size, body weight, histopathology, and SPECT imaging were monitored for 33 d ***: The rapid radioiodine uptake of ^(131)I-antiEGFR-BSA-PCL and ^(131)I-BSA-PCL reached maximum levels at 4 h after incubation, and the ^(131)I uptake of ^(131)I-anti EGFR-BSA-PCL was higher than that of ^(131)I-BSAPCL in vitro. The ^(131)I tissue distribution assay revealed that ^(131)I-anti EGFR-BSA-PCL was markedly taken up by the tumor. Furthermore, a tissue distribution assay revealed that ^(131)I-anti EGFR-BSA-PCL was markedly taken up by the tumor and reached its maximal uptake value of 21.0 ± 1.01 %ID/g(%ID/g is the percentage injected dose per gram of tissue) at 72 h following therapy; the drug concentration in the tumor was higher than that in the liver, heart, colon, or spleen. Tumor size measurements showed that tumor development was significantly inhibited by treatments with ^(131)I-anti EGFR-BSA-PCL and ^(131)I-BSA-PCL. The volume of tumor increased, and treatment rate with ^(131)I-anti EGFR-BSA-PCL was 124% ± 7%, lower than that with ^(131)I-BSA-PCL(127% ± 9%), ^(131)I(143% ± 7%), and normal saline(146% ± 10%). The percentage losses in original body weights were 39% ± 3%, 41% ± 4%, 49% ± 5%, and 55% ± 13%, respectively. The best survival and cure rates were obtained in t

关键词： Radioiodine therapy Colorectal cancer Liposome Epidermal growth factor receptor mouse

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Laser-Generated Transient Lamb Wave in Thin Plates

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Chinese Physics Letters 1996年第1期13卷 24-27页

作者： WU lei CHENG jian-chun ZHANG Shu-yi Institute of Acoustics and Laboratory of Modern Acoustics Nanjing UniversityNanjing 210093

The laser-generated transient Lamb wave in thin isotropic plates is studied theoretically by employing the method of eigenfunction *** thermoelastic displacement field is expressed by symmetric and antisymmetnc Lamb wave modes,so that it is convenient to investigate thg transient excitation of the lowest and higher order Lamb wave *** characteristics of transient Lamb waves in thin materials with different thicknesses are discussed in details.

关键词： expansion transient wave

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