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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-qing Liu Li-Fei song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Influence of carbon-partitioning treatment on the microstructure, mechanical properties and wear resistance of in situ VCp-reinforced Fe-matrix composite

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International Journal of Minerals,Metallurgy and Materials 2020年第1期27卷 100-111页

作者： Ping-hu Chen yun Zhang Rui-qing Li Yan-xing Liu song-sheng Zeng School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhen 518055China Light Alloy Research Institutes and State Key Laboratory of High Performance Complex Manufacturing Central South UniversityChangsha 410083China School of Mechanical Engineering DongGuan University of TechnologyDongguan 523808China Valin ArcelorMittal Automotive Steel Co. Ltd.Loudi 417000China

The wear resistance of iron(Fe)-matrix materials could be improved through the in situ formation of vanadium carbide particles(VCp)with high ***,brittleness and low impact toughness limit their application in several industries due to addition of higher carbon ***-partitioning treatment plays an important role in tuning the microstructure and mechanical properties of in situ VCp-reinforced Fe-matrix *** this study,the influences of carbon-partitioning temperatures and times on the microstructure,mechanical properties,and wear resistance of in situ VCp-reinforced Fe-matrix composite were *** experimental results indicated that a certain amount of retained austenite could be stabilized at room temperature through the carbon-partitioning *** of in situ VCp-reinforced Fematrix composite under carbon-partitioning treatment could be decreased,but impact toughness was improved accordingly when wear resistance was *** addition,the enhancement of wear resistance could be attributed to transformation-induced plasticity(TRIP)effect,and phase transformation was caused fromγ-Fe(face-centered cubic structure,fcc)toα-Fe(body-centered cubic structure,bcc)under a certain load.

关键词： carbon-partitioning treatment retained austenite phase transformation mechanical properties wear resistance

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Biomaterial-based platforms for cancer stem cell enrichment and study

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Cancer Biology & Medicine 2021年第2期18卷 458-469页

作者： Chunhua Luo Zhongjie Ding yun Tu Jiao Tan qing Luo Guanbin song Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Institute of Pathology and Southwest Cancer Center Southwest HospitalThird Military Medical University(Army Medical University)Key Laboratory of Tumor ImmunopathologyMinistry of Education of ChinaChongqing 400038China School of Pharmacy Chongqing Medical and Pharmaceutical CollegeChongqing 401331China

Cancer stem cells(CSCs)are a relatively rare subpopulation of tumor cell with self-renewal and tumorigenesis *** are associated with cancer recurrence,progression,and chemoradiotherapy *** a reliable platform for CSC enrichment and study is a prerequisite for understanding the characteristics of CSCs and discovering CSC-related therapeutic *** strategies for CSC enrichment have been used in laboratory,particularly fluorescence-activated cell sorting(FACS)and mammosphere ***,these methods fail to recapitulate the in vivo chemical and physical conditions in tumors,thus potentially decreasing the malignancy of CSCs in culture and yielding unreliable research *** research suggests the promise of a biomaterial-based three-dimensional(3 D)strategy for CSC enrichment and *** strategy has an advantage over conventional methods in simulating the tumor microenvironment,thus providing a more effective and predictive model for CSC laboratory *** this review,we first briefly discuss the conventional methods for CSC enrichment and *** then summarize the latest advances and challenges in biomaterial-based 3 D CSC *** strategies for materials,morphology,and chemical and physical cues are highlighted to provide direction for the future construction of platforms for CSC enrichment and study.

关键词： Cancer stem cell biomaterial CSC enrichment and study three-dimensional culture platform

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian Hu Siying Kang song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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Nonlocal stress gradient formulation for damping vibration analysis of viscoelastic microbeam in thermal environment

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Applied Mathematics and Mechanics(English Edition) 2023年第5期44卷 773-786页

作者： Hai qing Huidiao song State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

An integral nonlocal stress gradient viscoelastic model is proposed on the basis of the integral nonlocal stress gradient model and the standard viscoelastic model,and is utilized to investigate the free damping vibration analysis of the viscoelastic BernoulliEuler microbeams in thermal ***'s principle is used to derive the differential governing equations and corresponding boundary *** integral relations between the strain and the nonlocal stress are converted into a differential form with constitutive *** size-dependent axial thermal stress due to the variation of the environmental temperature is derived *** Laplace transformation is utilized to obtain the explicit expression for the bending deflection and *** the boundary conditions and constitutive constraints,one can get a nonlinear equation with complex coefficients,from which the complex characteristic frequency can be determined.A two-step numerical method is proposed to solve the elastic vibration frequency and the damping *** effects of length scale parameters,viscous coefficient,thermal stress,vibration order on the vibration frequencies,and critical viscous coefficient are investigated numerically for the viscoelastic Bernoulli-Euler microbeams under different boundary conditions.

关键词： damping vibration size effect integral nonlocal stress gradient model standard viscoelastic model Laplace transformation

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Discovery of four W UMa type eclipsing binaries in the field of open cluster ASCC 5

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Research in Astronomy and Astrophysics 2013年第9期13卷 1052-1062页

作者： Xiang-song Fang Sheng-Hong Gu Li-yun Zhang qing-Feng Pi National Astronomical Observatories/yunnan Observatory Chinese Academy of Sciences Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences University of Chinese Academy of Sciences College of Science/Department of Physics & NAOC-GZU-Sponsored Center for Astronomy Research Guizhou University

We carried out time-series photometric observations in the Re-band of the young, poorly studied open cluster ASCC 5 during November and December, 2012, to search for magnetically active stars, and discovered four eclipsing binary stars in this field. In order to characterize these four newly discovered binaries, we derived their orbital periods by their times of light minimum, estimated their effective tem- peratures based on their （J - H） colors and analyzed their light curves using the Wilson-Devinney light curve modeling technique. Our analyses reveal that all of them are contact binaries with short orbital periods of less than 0.5 d, with spectral types from late-F to mid-K. Among them, one is a typical A subtype contact binary with a mass ratio around 0.5 and a period of 0.44 d, and one is an H subtype contact binary with a high mass ratio around 0.9 and a short period of about 0.27 d. The other two systems show low amplitudes of light variation （Ant 〈0.11m）; their actual photomet- ric mass ratios could not be determined by the light curve modelings, probably due to their attributes of being partially eclipsing stars. A preliminary analysis for these two systems indicates that both of them are likely to be W subtype contact binaries with low orbital inclinations. In addition, both of these two low amplitude variables show asymmetric distorted light curves （e.g., O＇Connell effect of ARc --~0.02m） during the observing runs, suggesting the presence of starspots on these two systems. More inter- estingly, the one showing a large case of the O＇Connell effect presented a remarkable variation in the shape of the light curve on a time scale of one day, indicating that this star is in a very active state. Therefore, these two stars need spectroscopic observations to precisely determine their parameters, as well as further photometric observations to understand the properties of their magnetic activity, e.g., the evolution of starspots.

关键词： stars:binaries: close -- stars:binaries: eclipsing -- stars: spots

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Existence of Three HMOLS of Type 2~nu^1

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Acta Mathematica Sinica,English Series 2009年第8期25卷 1325-1336页

作者： yun qing XU Mathematics Department Ningbo University Ningbo 315211 P. R. Uhina

A Latin squares of order v with ni missing sub-Latin squares （holes） of order hi （1 〈= i 〈 k）, which are disjoint and spanning （i.e. ∑k i=l1 nihi = v）, is called a partitioned incomplete Latin squares and denoted by PILS. The type of PILS is defined by （h1n1 h2n2…hknk ）. If any two PILS inaset of t PILS of type T are orthogonal, then we denote the set by t-HMOLS（T）. It has been proved that 3-HMOLS（2n31） exist for n ≥6 with 11 possible exceptions. In this paper, we investigate the existence of 3-HMOLS（2nu1） with u ≥ 4, and prove that 3-HMOLS（2~u1） exist if n ≥ 54 and n ≥7/4u ＋ 7.

关键词： holey Latin square mutually orthogonal Latin square group divisible design

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On the Spectrum of Mutually r-orthogonal Idempotent Latin Squares

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Acta Mathematicae Applicatae Sinica 2015年第3期31卷 813-822页

作者： yun-qing XU Mathematics Department Ningbo University

Two Latin squares of order v are r-orthogonal if their superposition produces exactly r distinct ordered pairs. The two squares are said to be r-orthogonal idempotent Latin squares and denoted by r-MOILS（v）if they are all idempotent. In this paper, we show that for any integer v≥28, there exists an r-MOILS（v） if and only if r∈[v, v^2]／ {v ＋ 1, v^2-1}.

关键词： Latin square r-orthogonal idempotent

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Cyclical Deformations of Quadrangles in S^(2)_(κ)and Defining Properties of Alexandrov Spaces

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Acta Mathematica Sinica,English Series 2021年第4期37卷 597-640页

作者： qing song CAI Colledge of Science Tianjin University of TechnologyTianjin 300384P.R.China

This paper is mainly devoted to proving the four equivalent defining properties of a CBA(κ)*** proof is based on an interesting tool we established which describes the cyclical five-step deformation procedure for quadrangles in the model 2-plane S^(2)_(κ),including the limit shape of each *** a byproduct we give a complete list of cyclical deformation procedures for all kinds of quadrangles on *** last we make a contrast of geometric properties of CBA with CBB spaces,including a comparison between their defining properties and a discussion about Alexandrov’s Lemma.

关键词： Spherical quadrangle Alexandrov spaces CBA spaces CBB spaces

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河南奶山羊体尺与体重的相关性分析

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山东农业科学 2009年第6期41卷 96-98页

作者：田亚磊高腾云宋云青孙宇李改英潘军王笑笑河南农业大学牧医工程学院河南郑州450002 郑州市畜牧局河南郑州450052

为探讨河南奶山羊体尺指标与体重的相关关系,更好地服务于选种、育种工作,本研究运用SPSS软件对119只河南奶山羊体尺、体重的测定结果进行了相关分析和通径分析,并建立了最优回归方程。结果表明:河南奶山羊的体重(Y)与体高(X1)、体长(X2... 详细信息

为探讨河南奶山羊体尺指标与体重的相关关系,更好地服务于选种、育种工作,本研究运用SPSS软件对119只河南奶山羊体尺、体重的测定结果进行了相关分析和通径分析,并建立了最优回归方程。结果表明:河南奶山羊的体重(Y)与体高(X1)、体长(X2)、胸围(X3)、胸宽(X4)、胸深(X5)、管围(X6)呈极显著正相关(P<0.01)。体高、体长、胸围、胸宽的直接作用和间接作用对体重的影响极大,得到最优回归方程为Y=0.317X1+0.326X2+0.181X3+0.121X4。

关键词：体重体长胸宽直接作用间接作用相关性分析

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