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Interactions of drug-metabolizing enzymes with the Chinese herb Psoraleae Fructus

Chinese Journal of Natural Medicines 2019年第11期17卷 858-870页

作者： ZHOU Qi-Hang ZHU Ya-Di ZHANG Feng song yun-qing JIA Shou-Ning ZHU Liang FANG Sheng-Quan GE Guang-Bo Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 200000China Translational Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200000China qinghai Hospital of Traditional Chinese Medicine Xining 810000China

Psoraleae Fructus(the dried fruits of Psoralea corylifolia), one of the most frequently used Chinese herbs in Asian countries, has a variety of biological activities. In clinical settings, Psoraleae Fructus or Psoraleae Fructus-related herbal medicines frequently have been used in combination with a number of therapeutic drugs for the treatment of various human diseases, such as leukoderma, rheumatism and dysentery. The use of Psoraleae Fructus in combination with drugs has aroused concern of the potential risks of herb-drug interactions(HDI) or herb-endobiotic interactions(HEI). This article reviews the interactions between human drug-metabolizing enzymes and the constituents of Psoraleae Fructus;the major constituents in Psoraleae Fructus, along with their chemical structures and metabolic pathways are summarized, and the inhibitory and inductive effects of the constituents in Psoraleae Fructus on human drug-metabolizing enzymes(DMEs), including target enzyme(s), its modulatory potency, and mechanisms of action are presented. Collectively, this review summarizes current knowledge of the interactions between the Chinese herb Psoraleae Fructus and therapeutic drugs in an effort to facilitate its rational use in clinical settings, and especially to avoid the potential risks of HDI or HEI through human DMEs.

关键词： Psoraleae Fructus Cytochrome P450 enzymes(CYPs) Uridine diphosphate-glucuronosyltransferases(UGTs) Herb-drug interactions(HDI) Herb-endobiotic interactions(HEI)

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CAI在体育专业术科教学中应用的研究

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浙江体育科学 2000年第5期22卷 20-22页

作者：宋允清韶关大学体育系广东韶关512005

通过对计算机辅助教学在体育专业技术课教学中应用的实验分析论证 ,揭示其特点 ,即在体育专业技术课教学中 ,通过计算机这一高科技产物 ,集中优秀教师的共同智慧 ,形象生动地向学习者实施教育。

关键词：计算机辅助教学术科教学教学质量

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粤北山区农村居民健身活动的现状及发展对策

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体育学刊 2013年第4期20卷 75-77页

作者：吴建逊宋允清韶关学院体育学院广东韶关512005

对粤北山区10个县农村居民健身活动的现状进行分析。结果表明:粤北山区农村居民对健身意识的认识水平相对较低;近年来参与健身活动人数比例有所提高,随年龄增长参加健身活动人口比例下降;健身活动内容表现出现代与传统交融;健身活动形... 详细信息

对粤北山区10个县农村居民健身活动的现状进行分析。结果表明:粤北山区农村居民对健身意识的认识水平相对较低;近年来参与健身活动人数比例有所提高,随年龄增长参加健身活动人口比例下降;健身活动内容表现出现代与传统交融;健身活动形式和活动场所呈随意性。基于现状,提出发展粤北少数民族特色的大众健身活动,以"节日"体育比赛和表演为龙头,实施以"乡镇为重点,以村队为切入点"等对策。

关键词：社会体育全民健身粤北山区农村

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Transmission line model and field analysis of metamaterial absorber：ideal concentrator of electromagnetic waves

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中国光学与应用光学 2010年第1期3卷 79-84页

作者： WEN Qi-ye ZHANG Huai-wu XIE yun-song YANG qing-hui LI Yuan-xun State Key Laboratory of Electronic Films and Integrated Devices University of Electronic Science and Technology of China Chengdu 610054 China

Arising from the proposed Transmission Line(TL) model for ERR and wire structure, a TL model for a metamaterial absorber is proposed. The S-parameters obtained by this TL model demonstrate the same shapes as the simulation. An investigation of the TL model and average absorption power densities shows that the metamaterial absorber does not simply convert the electromagnetic wave into thermal energy, but concentrate the electromagnetic wave into a small space where it is finally absorbed. This suggests that the metamaterial absorber can be applied to solar cells for the purpose of light trapping.

关键词：热释光吸收功率电磁波吸收器

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粤北山区全民健身活动现状及对策研究

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中国体育科技 2005年第4期41卷 119-121,129页

作者：张黎平宋允清韶关学院体育系广东韶关512005

通过对粤北山区城、乡居民对全民健身的认识与参与现状的调查,较全面地了解了该地区群众体育活动状况,发现问题,并提出了合理的发展对策。

关键词：全民健身发展对策粤北山区

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Differential expression of a novel colorectal cancer differentiation-related gene in colorectal cancer

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World Journal of Gastroenterology 2001年第4期7卷 551-554页

作者： Xing-Guo Li Jin-Dan song yun-qing Wang Key Laboratory of Cell Biology,Ministry of Public Health of China,China Medical University,Shenyang 110001,Liaoning Province,China Key Laboratory of Cell Biology Ministry of Health of China China Medical University Shenyang 110001 Liaoning Province China.

AIM: To investigate SBA2 expression in CRC cell lines and surgical specimens of CRC and autologous healthy mucosa. METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) was used for relative quantification of SBA2 mRNA levels in 4 human CRC cell lines with different grades of differentiation and 30 clinical samples. Normalization of the results was achieved by simultaneous amplification of beta-actin as an internal control. RESULTS: In the exponential range of amplification, fairly good linearity demonstrated identical amplification efficiency for SBA2 and beta-actin (82%). Markedly lower levels of SBA2 mRNA were detectable in tumors, as compared with the coupled normal counterparts PP P<0.05). CONCLUSION: SBA2 gene might be a promising novel biomarker of cell differentiation in colorectal cancer and its biological features need further studies.

关键词： Gene Expression Regulation, Neoplastic Cell Differentiation Colorectal Neoplasms DNA, Complementary Humans Molecular Sequence Data Neoplasm Proteins Polymerase Chain Reaction Tumor Cells, Cultured Tumor Markers, Biological

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青少年跳高赛前的控制训练

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体育学刊 2002年第2期9卷 104-106页

作者：宋允清韶关学院体育系广东韶关512005

为了探讨跳高赛前控制训练这一课题 ,运用运动训练学的基本原理 ,采用随训跟踪的方法 ,对其进行了实验探讨 ,旨在摸索跳高赛前控制训练的一般规律。

关键词：青少年跳高赛前训练

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粤北少数民族传统体育资源产业化发展的研究

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韶关学院学报 2010年第12期31卷 88-92页

作者：宋允清韶关学院体育学院广东韶关512005

在深入调查的基础上,运用逻辑分析的方法,探讨粤北少数民族传统体育这一地域性文化资源优势如何推向市场,探讨其向商业化、产业化方向发展的经济价值要素,以期构建其产业化发展的基本理论及其发展运行机制,发现其特色和发展趋势,研发相... 详细信息

在深入调查的基础上,运用逻辑分析的方法,探讨粤北少数民族传统体育这一地域性文化资源优势如何推向市场,探讨其向商业化、产业化方向发展的经济价值要素,以期构建其产业化发展的基本理论及其发展运行机制,发现其特色和发展趋势,研发相关的扶持政策和措施,从而为确立粤北少数民族传统体育资源的开发与合理布局提供依据.

关键词：粤北少数民族传统体育资源产业化

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