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一种基于元胞自动机的自适应网络病毒传播模型

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物理学报 2011年第12期60卷 110-119页

作者：宋玉蓉蒋国平徐加刚南京邮电大学自动化学院南京210003

自适应网络是节点动力学和网络动力学相互作用和反馈的演化网络.基于元胞自动机建立自适应网络中易感-感染-易感(susceptible-infected-susceptible)的病毒传播模型,研究节点为了规避病毒传播所采取的多种网络重连规则对病毒传播及网络... 详细信息

自适应网络是节点动力学和网络动力学相互作用和反馈的演化网络.基于元胞自动机建立自适应网络中易感-感染-易感(susceptible-infected-susceptible)的病毒传播模型,研究节点为了规避病毒传播所采取的多种网络重连规则对病毒传播及网络统计特征的影响.结果表明:自适应网络中的重连规则可以有效减缓病毒传播速度,降低病毒传播规模;随机重连规则使得网络统计特征趋于随机网络;基于元胞自动机建立的传播模型清晰地表达了病毒在传播过程中的双稳态现象.

关键词：自适应网络传播动力学网络动力学元胞自动机

Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： song jiang Congwen Zhu Ning jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： song He Li Li Sai Wang Shao-jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Epidemic spreading on scale-free networks with diversity of node anti-attack abilities

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The Journal of China Universities of Posts and Telecommunications 2010年第1期17卷 73-76,126页

作者： song yu-rong jiang guo-ping Center for Control and Intelligence Technology Nanjing University of Posts and Telecommunications Nanjing 210003 China College of Automation Nanjing University of Posts and Telecommunications Nanjing 210003 China

In this article, a modified susceptible-infected-removed （SIR） model is proposed to study the influence of diversity of node anti-attack abilities on the threshold of propagation in scale-free networks. In particular, a vulnerability function related to node degree is introduced into the model to describe the diversity of a node anti-attack ability. Analytical results are derived using the mean-field theory and it is observed that the diversity of anti-attack of nodes in scale-free networks can increase effectively the threshold of epidemic propagation. The simulation results agree with the analytical results. The results show that the vulnerability functions can help adopt appropriate immunization strategies.

关键词： epidemic spreading scale-free network SIR model anti-attack vulnerability function

Epidemic spreading in scale-free networks including the effect of individual vigilance

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Chinese Physics B 2012年第1期21卷 41-45页

作者： Gong Yong-Wang song yu-rong jiang guo-ping College of Computer Nanjing University of Posts and TelecommunicationsNanjing 210003 China School of Information Engineering Yancheng Institute of TechnologyYancheng 224051China College of Automation Nanjing University of Posts and TelecommunicationsNanjing 210003 China

In this paper, we study the epidemic spreading in scale-flee networks and propose a new susceptible-infected- recovered （SIR） model that includes the effect of individual vigilance. In our model, the effective spreading rate is dynamically adjusted with the time evolution at the vigilance period. Using the mean-field theory, an analytical result is derived. It shows that individual vigilance has no effect on the epidemic threshold. The numerical simulations agree well with the analytical result. Purthermore, we investigate the effect of individual vigilance on the epidemic spreading speed. It is shown that individual vigilance can slow the epidemic spreading speed effectively and delay the arrival of peak epidemic infection.

关键词： scale-free network susceptible-infected-recovered model individual vigilance epidemicthreshold

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期 369-376页

作者： song-Meng Wang Hao Nian Yan-Fang Wang Li-Shuo Zheng yu-Tao Zheng Yi-Wei Dong Liping Huang Xiaoping Wang Wei jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Prediction of epidemics dynamics on networks with partial differential equations:A case study for COVID-19 in China

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Chinese Physics B 2021年第12期30卷 19-27页

作者： Ru-Qi Li yu-rong song guo-ping jiang School of Computer Science Nanjing University of Posts and TelecommunicationsNanjing 210003China College of Automation and College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjing 210023China

Since December 2019,the COVID-19 epidemic has repeatedly hit countries around the world due to various factors such as trade,national policies and the natural *** closely monitor the emergence of new COVID-19 clusters and ensure high prediction accuracy,we develop a new prediction framework for studying the spread of epidemic on networks based on partial differential equations(PDEs),which captures epidemic diffusion along the edges of a network driven by population flow *** this paper,we focus on the effect of the population movement on the spread of COVID-19 in several cities from different geographic regions in China for describing the transmission characteristics of *** results show that the PDE model obtains relatively good prediction results compared with several typical mathematical ***,we study the effectiveness of intervention measures,such as traffic lockdowns and social distancing,which provides a new approach for quantifying the effectiveness of the government policies toward controlling COVID-19 via the adaptive parameters of the *** our knowledge,this work is the first attempt to apply the PDE model on networks with Baidu Migration Data for COVID-19 prediction.

关键词： partial differential equations intervention measures Baidu Migration Data COVID-19 prediction

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui jiang Hui-Li Kang Yi jiang Hua-Wei Zhang Xiao-Mei song yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing Zhao Yan song Yahong Cheng Tong Li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species