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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang yi Jiang Hua-Wei Zhang Xiao-Mei song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

Supnorm Estimates for ā on Product Domains in C^(n)

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2307-2323页

作者： Martino FASSINA yi fei PAN Department of Mathematics University of Illinois at Urbana-Champaign1409 West Green StreetUrbanaIL 61801USA Department of Mathematical Sciences Purdue University Fort Wayne2101 East Coliseum BoulevardFort WayneIN 46805USA

Using methods from complex analysis in one variable,we define an integral operator that solves ā with supnorm estimates on product domains in C^(n).

关键词： Supnorm estimates product domains Cauchy Riemann equation

影响尿激酶静脉溶栓治疗急性脑梗死预后因素的初步分析

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现代生物医学进展 2016年第19期16卷 3687-3691页

作者：宋亦飞朱丹丛林聂雪丹丁思文梁庆成哈尔滨医科大学附属第二医院黑龙江哈尔滨150080

目的:对影响急性缺血性脑卒中患者应用尿激酶溶栓治疗预后的相关危险因素进行初步分析及研究,为今后选择适宜应用尿激酶溶栓的患者打下基础。方法:以2015年1月1日至2015年10月31日入院且应用尿激酶静脉溶栓的38例急性缺血性脑卒中患者,... 详细信息

目的:对影响急性缺血性脑卒中患者应用尿激酶溶栓治疗预后的相关危险因素进行初步分析及研究,为今后选择适宜应用尿激酶溶栓的患者打下基础。方法:以2015年1月1日至2015年10月31日入院且应用尿激酶静脉溶栓的38例急性缺血性脑卒中患者,根据治疗3个月后的预后情况将患者分为A组(24例,预后良好)和B组(14例,预后不良),对两组患者的预后影响因素进行分析。结果:预后良好组患者的溶栓前NIHSS评分低于预后不良组,差异具有统计学意义(P<0.05)。多因素的Logistic回归分析显示,吸烟和HINSS评分与急性脑梗死尿激酶溶栓预后不良有关,差异具有统计学意义(P<0.05),且NIHSS评分是预后的独立预测因素。结论:尿激酶静脉溶栓治疗脑梗死的患者,溶栓前较高的NIHSS评分可能与溶栓预后不良有关。吸烟的患者溶栓后出现预后不良的几率是不吸烟患者溶栓后预后不良的8.83倍,溶栓前NIHSS评分每增加1分,溶栓预后不良的几率增加1.76倍。

关键词：尿激酶急性缺血性脑卒中预后

2010—2013年357种中药配方颗粒的临床使用分析

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现代药物与临床 2014年第9期29卷 1050-1053页

作者：鹿岩李妮段梦雅孙世光刘健郭琳琳宋毅斐山东中医药大学第二附属医院山东省中西医结合医院药学部山东济南250001

目的评价山东中医药大学第二附属医院中药配方颗粒的临床使用情况。方法对山东中医药大学第二附属医院2010年9月1日—2013年12月31日门诊中药配方颗粒的用量、金额和处方进行回顾性、描述性分析。结果中药配方颗粒的发展大体经历了导入... 详细信息

目的评价山东中医药大学第二附属医院中药配方颗粒的临床使用情况。方法对山东中医药大学第二附属医院2010年9月1日—2013年12月31日门诊中药配方颗粒的用量、金额和处方进行回顾性、描述性分析。结果中药配方颗粒的发展大体经历了导入期、增长期和成熟期3个阶段;中药配方颗粒品种数(357种)仅为中药饮片(489种)的73.01%;从药物经济学的角度去评价,中药配方颗粒的价格并不像公众认为的那样高;单品种前10位合计27.42%,功效分类前10位合计92.19%;中药配方颗粒实际应用中更多的还是依赖处方医师的个人经验。结论中药配方颗粒因自身优势而取得了发展,但也存在等效性和价格等突出问题,开拓灵活的使用思路将是未来进一步发展的重点。

关键词：中药配方颗粒临床使用数据挖掘加权价格医师行为等效性

Microstructural evolution and mechanical properties of Ni-45Ti-5Al-2Nb-1Mo alloy subjected to different heat treatments

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Rare Metals 2023年第8期42卷 2774-2780页

作者： Xiao-Yun song Yan Li fei Zhang State Key Laboratory of Nonferrous Metals and Processes GRIMAT Engineering Institute Co.LtdBeijing 101407China School of Materials Science and Engineering Beihang UniversityBeijing 100191China

The effects of solution and aging heat treatment on microstructural evolution and room temperature tensile properties for as-forged Ni-45Ti-5Al-2Nb-1Mo alloy were investigated through scanning electron microscopy(SEM),transmission electron microscopy(TEM)and tensile *** results show that the microstructure of solution-treated alloy comprises NiTi matrix,Ti_(2)Ni and(Nb,Ti)ss *** aging treatment at 700℃for 6 and100 h,the distribution of Ti_(2)Ni and(Nb,Ti)ss precipitates increases in *** new type of precipitate is observed in the specimen aged at 700℃.After aging at800℃for 100 h,numerous nanosized Ni_(2)TiAl phases are precipitated within the *** and aging treatments improve the tensile properties at room *** strength and ductility are improved after solution treatment at 1100℃plus aging treatment at 800℃for 6 h or 700℃for 100 *** aging time prolonging to 100 h at 800℃,the precipitation of fine Ni2TiAl particles leads to the improvement in tensile strength and deterioration of elongation.

关键词： NiTi-Al-based alloy Intermetallics Microstructure Mechanical properties Heat treatment

Effects of HNO_3 concentration on the pit morphologies of aluminum foil etched in HNO_3–HCl and HNO_3–H_2SO_4–HCl solutions

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International Journal of Minerals,Metallurgy and Materials 2016年第1期23卷 70-76页

作者： Quan-xiu yi Ye-dong He Ning Peng Hong-zhou song Xiao-fei Yang Xiao-yu Cai Beijing Key Laboratory for Corrosion Erosion and Surface Technology University of Science and Technology Beijing Institute of Technology Research and Development of Electronic Aluminum Foil Guangxi Hezhou Guidong Electronics Technology Co. Ltd.

In this work, the effects of HNO3 concentration on the pit morphologies of high-cubic-texture aluminum foil etched in HNO3-HCl and HNO3-H2SO4-HCl solutions were investigated. When the aluminum foil was etched in HNO3-HCl solutions, the morphologies of pits transformed from irregular tunnels to typical tunnels （as inverted pyramids） and shallow cuboids as the HNO3 concentration in the etchant solution was increased. However, as the HCl concentration in the etchant solution was increased, the morphologies of pits transformed from shallow cuboids to typical tunnels （as inverted pyramids） and irregular tunnels. When the aluminum foil was etched in n N HNO3-（7.2-n） N H2SO4-0.8 N HCl solutions, the morphologies of the pits transformed from typical tunnels （i.e., the number of sub-tunnels formed on the main tunnels increased） to irregular tunnels （corrugated tnnnels and polyline tunnels） as the HNO3 concentration in the etchant solution was increased. These effects are attributed primarily to corrosion on the （100） and （010） faces of pits being accelerated and to the （001） faces be- ing prone to passivation to different degrees when various concentrations of HNO3 are added to the etchant solutions.

关键词： aluminum foil pitting corrosion morphology passive films

Prediction of mechanical properties of cold rolled strip based on improved extreme random tree

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Journal of Iron and Steel Research International 2023年第2期30卷 293-304页

作者： Yun-bao Zhao Yong song fei-fei Li Xian-le Yan Institute of Engineering Technology University of Science and Technology BeijingBeijing100083China

Taking the 2130 cold rolling production line of a steel mill as the research object,feature dimensionality reduction and decoupling processing were realized by fusing random forest and factor analysis,which reduced the generation of weak decision trees while ensured its *** base learner used a weighted voting mechanism to replace the traditional average method,which improved the prediction ***,the analysis method of the correlation between steel grades was proposed to solve the problem of unstable prediction accuracy of multiple steel *** experimental results show that the improved prediction model of mechanical properties has high accuracy:the prediction accuracy of yield strength and tensile strength within the error of±20 MPa reaches 93.20%and 97.62%,respectively,and that of the elongation rate under the error of±5%has reached 96.60%.

关键词： Cold strip rolling Mechanical property prediction Extreme random tree Factor analysis Random forest Correlation analysis Steel grade

Observations of nodal lines in the topological semimetal ZrSnTe

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Science China(Physics,Mechanics & Astronomy) 2020年第2期63卷 111-116页

作者： Bo Chen Bo Zhang JiHai Yu FuCong fei Muhammad Naveed yi Zhang Zhe Sun XianGang Wan FengQi song National Laboratory of Solid State Microstructure School of PhysicsNanjing UniversityNanjing 210093China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

Performing angle-resolved photoemission spectroscopy(ARPES) and theoretical calculations for ZrSnTe, we find a nodal line in the kx-ky plane with a tiny gap and two nodal lines without gaps along the kzdirection. The constant energy contours are plotted in the kx-ky plane at a photon energy of 30 e V to examine the gapping feature of the nodal line. In addition, we depict the band dispersions along the Γ-M and Γ-X directions from the ARPES images at photon energies ranging from 24 to 40 e V. The kz mapping confirms the presence of stable Dirac points with obvious kzdependences along the M-A and X-R directions. In this paper, we report the two types of nodal lines associated with the theoretical local-density approximation calculations, broadening the horizons of nodal-line semimetal research.

关键词： nodal-line semimetals ZrSnTe ARPES

Mobile crowd sensing task optimal allocation： a mobility pattern matching perspective

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Frontiers of Computer Science 2018年第2期12卷 231-244页

作者： Liang WANG Zhiwen YU Bin GUO fei yi fei XIONG School of Computer Science Northwestern Polytechnical University Xi'an 710072 China School of Electrical and Control Engineering Xi'an University of Science and Technology Xi'an 710054 China School of Electronic and Information Engineering Beijing Jiaotong University Beijing 100044 China

With the proliferation of sensor-equipped portable mobile devices, Mobile CrowdSensing （MCS） using smart devices provides unprecedented opportunities for collecting enormous surrounding data. In MCS applications, a crucial issue is how to recruit appropriate participants from a pool of available users to accomplish released tasks, satisfying both resource efficiency and sensing quality. In order to meet these two optimization goals simultaneously, in this paper, we present a novel MCS task allocation framework by aligning existing task sequence with users＇ moving regularity as much as possible. Based on the process of mobility repetitive pattern discovery, the original task allocation problem is converted into a pattern matching issue, and the involved optimization goals are transformed into pattern matching length and support degree indicators. To determine a trade-off between these two competitive metrics, we propose greedy- based optimal assignment scheme search approaches, namely MLP, MDP, IU1 and IU2 algorithm, with respect to matching length-preferred, support degree-preferred and integrated utility, respectively. Comprehensive experiments on real- world open data set and synthetic data set clearly validate the effectiveness of our proposed framework on MCS task optimal allocation.

关键词： mobile crowd sensing task allocation mobility regularity pattern matching