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竞争环境下双目标零售平台销售模式选择

管理工程学报 2025年第1期39卷 227-242页

作者：张冲朱祎宋君南京邮电大学管理学院

电子商务行业发展迅速,具有“超越利润”战略导向以实现更广泛目标的组织正变得越来越普遍,兼顾消费者利益成为企业凸显竞争优势的方式。为此,本文构建由一个制造商和两个零售平台组成的两级供应链。其中,制造商和其中一个零售平台追求... 详细信息

电子商务行业发展迅速,具有“超越利润”战略导向以实现更广泛目标的组织正变得越来越普遍,兼顾消费者利益成为企业凸显竞争优势的方式。为此,本文构建由一个制造商和两个零售平台组成的两级供应链。其中,制造商和其中一个零售平台追求自身利润最大化,另外一个零售平台追求自身利润和消费者剩余的线性组合最大化,即考虑双目标最优。本文具体考虑两个零售平台分别选择转售模式或代理模式共四种情形,进而研究双目标零售平台销售模式选择问题,及其对供应链成员最优决策和供应链整体绩效的影响。结果表明:(1)在一定条件下,双目标零售平台能获得比竞争对手更高的利润;(2)当双目标零售平台选择转售模式时,无论其竞争对手选择哪种销售模式,其双目标策略都能使供应链总体利润得到优化;(3)当双目标零售平台的竞争对手选择代理模式时,其自身根据不同情况选择转售模式或者代理模式可以使两个零售平台的销售模式选择形成均衡。

关键词：双目标企业社会责任零售平台销售模式双渠道

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Rational design of lipid-activatable NIR-II probes for precisely imaging atherosclerotic plaque

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science China Chemistry 2025年

作者： Xinyu Xu yuan Ma Hui Cao Li Xu Haoming Chen sulai Liu Wei sun Guosheng song Xiaobing Zhang state Key Laboratory for Chemo/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan University Department of Hepatobiliary surgery/Central Laboratory Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University) Department of Cardiology the First Affiliated Hospital of Nanjing Medical University Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical University shenzhen Research Institute of Hunan University

Atherosclerosis(As) is a prevalent condition associated with cardiovascular and cerebrovascular diseases, featuring lipid-laden plaque; however, the insufficient resolution and low sensitivity of traditional medical imaging techniques limit their application in lipid imaging. Currently, the second near-infrared(NIR-II) fluorescence imaging offers promising sensitivity and convenience. However, existing probes have limitations in terms of signal-to-background ratio, penetration depth, and tissue scattering. Herein, we use a molecular regulatory strategy to design a lipid-activatable probe Rh-965 with high specificity and NIR-II emission for improved imaging potential in deep tissues. The potential of Rh-965 for imaging plaque lipids in mice with As is demonstrated by localizing carotid artery plaques using NIR-II imaging. The development of more stable lipid-activated NIR-II probes can significantly enhance atherosclerosis diagnosis and facilitate in vivo imaging in deeper tissues.

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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu yu shi Haoxue Wang Lijie Huang su Zhang Ruixin Zhang song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical school of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NsCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology research 2025年第1期33卷 133-148页

作者： Tao sun Qinghua song Hua Liu Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong University Medical School of Nantong University Nantong 226001 China. Department of Emergency The People's Hospital of Rugao Nantong 226500 China. Department of Haematology The People's Hospital of Rugao Nantong 226500 China.

Background:Lung cancer is a life-threatening disease that occurs worldwide, but is especially common in China. The crucial role of the tumour microenvironment (TME) in non-small cell lung cancer (NsCLC) has attracted recent attention. Cancer-associated fibroblasts (CAFs) are the main factors that contribute to the TME function, and CAF exosomes are closely linked to NsCLC.Methods:The expression levels of miR-3124-5p and Toll-interacting protein (TOLLIP) were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot detection. Fibroblasts were isolated and identified from clinical NsCLC tissues. Transmission electron microscopy and Western Blot were used to identify exosomes from these cells. Changes in proliferation (CCK-8 and clone formation), migration (wound healing), and invasion (transwell) of NsCLC cells were measured. The Luciferase reporter test was applied to clarify the binding of miR-3124-5p to TOLLIP. The TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot analysis.Results:MiR-3124-5p is overexpressed in clinical tissues and cells of NsCLC. MiR-3124-5p was dramatically enriched in CAF-derived exosomes. Cellular experiments revealed that CAFs delivered miR-3124-5p into NsCLC cells via exosomes, stimulating cancer cell progression. MiR-3124-5p acted as a sponge to negatively regulate TOLLIP expression, which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of NsCLC. Functional salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NsCLC by affecting the TOLLIP signalling pathway.Conclusions:These results provide an interesting direction for the diagnosis and therapy of NsCLC.

关键词： Cancer-associated fibroblasts (CAFs) Exosomes Non-small cell lung cancer (NsCLC) Toll-interacting protein (TOLLIP) miR-3124-5p

Plastic Effect on the sliding Inception Bet ween a Cylinder and a Rigid Flat

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Acta Mechanica solida sinica 2019年第1期32卷 1-16页

作者： s.Zhang J.Huan H.song X.Liu y.G.Wei LNM Institute of MechanicsChinese Academy of SciencesBeijing 100190China Department of Mechanical Engineering Johns Hopkins UniversityBaltimoreMD 21218USA College of Engineering Peking UniversityBeijing 100871China school of Engineering science University of Chinese Academy of SciencesBeijing 100049China

The effec ts of mat erial plasticity and local slip on the sliding inception of asperity are studied in the present ***,a semi-analytical solution is derived under the full-stick condition to analyze the effect of material plasticity on sliding ***,a friction model with contact stiffness criterion is proposed to study the cases from partial-slip condition to full-stick *** element simulations with the provided model are used to present the friction *** friction coefficient of full-s tick interface converges at a st able value,approxima tely *** saturation appears as the normalized contact interference u*is larger than 3.A transition mechanism from slip-dominated to yield-dominated takes place in the sliding *** simulation results are compared with the semi-analytical solution.

关键词： Mat erial yielding Local slip Contact stiffness criterion Finite element simulation

synchronous improvement of mechanical properties and stress corrosion resistance by stress-aging coupled with natural aging pre-treatment in an Al-Zn-Mg alloy with high recrystallization fraction

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Journal of Materials science & Technology 2022年第26期121卷 40-51页

作者： D.Zhang H.C.Jiang Z.J.Cui D.s.yan y.y.song L.J.Rong CAs Key Laboratory of Nuclear Materials and safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China school of Materials science and Engineering University of Science and Technology of ChinaShenyang 110016China shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China shandong Key Laboratory of Advanced Aluminum Materials and Technology Binzhou 256606China

Enhancing the strength of Al-Zn-Mg alloys is critical to the weight-lightening of structural components in the application of high-speed trains and aerospace industries,while high stress corrosion cracking(sCC)susceptibility of Al-Zn-Mg alloys(especially the alloy with high recrystallization fraction)with high strength makes it *** this study,the influence of tensile stress-aging coupled with natural aging pre-treatment on the mechanical properties and sCC resistance of Al-Zn-Mg alloy with high recrystallization fraction has been *** results show that tensile stress-aging at 160℃can inhibit the dissolution of clusters/Guinier-Preston(GP)zones formed during long-term natural aging pre-treatment,which increases the number density of matrix precipitates(MPts),narrow the width of precipitate free zone(PFZ),and dramatically improve the mechanical properties of the experimental Al-Zn-Mg ***,the precipitation of the high density of MPts within the matrix will assume a large number of solute atoms during artificial aging,which will reduce the supplement of solute atoms to grain *** a result,the volume of anodic active grain boundary precipitates(GBPs)and the content of free solute atoms at grain boundaries are reduced,which reduces the possibility of initial nucleation and propagation of sCC *** coupled treatment method proposed in this study proves efficient in resolving the contradiction between the strength and sCC resistance in Al-Zn-Mg alloy.

关键词： Al-Zn-Mg alloy Natural aging stress-aging Precipitates stress corrosion cracking

Variant selection in additively manufactured alpha-beta titanium alloys

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Journal of Materials science & Technology 2022年第18期113卷 14-21页

作者： s.L.Lu C.J.Todaro y.y.sun T.song M.Brandt M.Qian Centre for Additive Manufacturing School of Engineering RMIT University school of Mechanical and Aerospace Engineering Nanyang Technological University

Alpha-beta(α-β)titanium alloys such as Ti-6Al-4V(wt.%,here-after the same)and Ti-6Al-2sn-4Zr-2Mo fabricated by fusion-based additive manufacturing(AM)typically exhibit a strong columnar prior-βgrain *** columnar prior-βgrains with their001along the build direction not only lead to solidification tex-ture but also cause subsequentα-phase textures[1].The forma-tion of theseα-phase textures is a consequence of theβ→αtransformation obeying the Burgers orientation relationship(BOR)[1-5],which results in[0001]of theα-phase being orientated at about either 45°or 0°relative to the *** affect the deformation behaviour and mechanical properties[1,6].Defined by the BOR,a singleβ-phase grain can bring forth 12α-phase vari-ants[2,7],leading to significant microstructural ***α-phase variants do not form randomly in eachβ-phase ***,their formation displays specific crystallographic features,known asα-variant selection,which is common in Ti *** an extreme case,α-variant selection can lead to the formation of a singleα-phase crystal through anα→β→αtransformation cy-cle[8,9].

关键词： alloys grain transformation

Impact of thermostat on interfacial thermal conductance prediction from non-equilibrium molecular dynamics simulations

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Chinese Physics B 2022年第5期31卷 561-568页

作者： song Hu C y Zhao Xiaokun Gu Institute of Engineering Thermophysics School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The knowledge of interfacial thermal conductance(ITC)is key to understand thermal transport in *** non-equilibrium molecular dynamics(NEMD)simulation is a useful tool to calculate the *** this study,we investigate the impact of thermostat on the prediction of the *** Langevin thermostat is found to result in larger ITC than the Nose-Hoover *** addition,the results from NEMD simulations with the Nose-Hoover thermostat exhibit strong size effect of thermal *** spectral heat flux decomposition and modal temperature calculation reveal that the acoustic phonons in hot and cold thermal reservoirs are of smaller temperature difference than optical phonons when using the Nose-Hoover thermostat,while phonons in the Langevin thermostat are of identical *** a nonequilibrium state of phonons in the case of the Nose-Hoover thermostat reduces the heat flux of low-to-middle-frequency *** also discuss how enlarging the reservoirs or adding an epitaxial rough wall to the reservoirs affects the predicted ITC,and find that these attempts could help to thermalize the phonons,but still underestimate the heat flux from low-frequency phonons.

关键词： interfacial thermal conductance phonon transport molecular dynamics

Towards creep property improvement of selective laser melted Ni-based superalloy IN738LC

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Journal of Materials science & Technology 2022年第17期112卷 301-314页

作者： H.y.song M.C.Lam y.Chen s.Wu P.D.Hodgson X.H.Wu y.M.Zhu A.J.Huang Monash Centre for Additive Manufacturing 15-17 Normanby RdNotting HillVIC 3168Australia Department for of Materials science and Engineering Monash UniversityClaytonVIC 3800Australia Monash Centre for Electron Microscopy 10 Innovation WalkClaytonVIC 3800Australia Institute for Frontier Materials Deakin UniversityVIC 3216Australia

Nickel-based superalloy IN738LC produced by selective laser melting(sLM)exhibits inferior hightemperature creep properties than its cast counterparts due to relatively smaller grain size,particularly for the plane normal to the building *** work studied effects of post heating strategy on the microstructure and especially the grain size to improve the high temperature creep *** asbuilt microstructure exhibited a fine grain size and large quantities of MC carbides that could effectively hinder grain *** was found that unconventional two-step heat treatments could lead to substantial grain growth,and the effect is particularly prominent at a specific *** ease of grain growth was explained after classifying the microstructural evolution(boundary carbide transformation)during each heating step and related to the reduced grain boundary pinning force from MC *** tests validated the effect of the new heat treatment scheme on the sLM-processed IN738LC at 850℃.An extended creep fracture life(1.5 to 4 times improvement)and lower secondary creep rates were achieved with samples subjected to the newly optimized two-step heat *** complete creep curves are also firstly presented for sLM-IN738LC,confirming the effectiveness of grain growth and highlighting the importance of dedicated heat treatment for sLM superalloys.

关键词： selective laser melting IN738LC alloy Creep properties Heat treatments Grain structure