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Rapid discovery of two unprecedented meroterpenoids from Daphne altaica *** molecular networking integrated with MolNetEnhancer and Network Annotation Propagation

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Chinese Chemical Letters 2024年第8期35卷 294-298页

作者： Wei-Yu Zhou Zi-Han xi Ning-Ning Du Li Ye Ming-Hao Jiang Jin-Le Hao Bin Lin Guo-Dong Yao xiao-xiao Huang Shao-Jiang song Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning ProvinceEngineering Research Center of Natural Medicine Active Molecule Research&DevelopmentLiaoning ProvinceKey Laboratory of Natural Bioactive Compounds Discovery&ModificationShenyangSchool of Traditional Chinese Materia Medic1Shenyang Pharmaceutical UniversityShenyang 110016China Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China

Under the guidance of the approach which integrates molecular networking,MolNetEnhancer and Net-work Annotation Propagation(NAP),daphnaltaicanoids A and B(1 and 2)with unprecedented 9-oxa-tetracyclo[6.***.1.0^(2,6).0^(8,13)]pentadecane and tetracyclo[5.***.0.1^(2,5).2^(4,11)]tridecane central frameworks were iso-lated from Daphne altaica Pall.,representing two types of unparalleled meroterpenoid *** struc-tures were elucidated by extensive spectroscopic analysis,nuclear magnetic resonance(NMR)calcula-tions,DP4+analysis and electronic circular dichroism(ECD)*** plausible biosynthetic path-ways for 1 and 2 were ***,2 exerted potent neuroprotective activities which were su-perior to trolox at 12.5 and 25μmol/***,1 and 2 exhibited more noticeable acetylcholinesterase inhibitory activities than *** docking simulations were performed to explore the inter-molecular interaction of compounds 1 and 2 with *** bioactivity evaluation results highlight the prospects of 1 and 2 as a novel category of neurological agents.

关键词： Daphne altaica Pall. Molecular networking MolNetEnhancer NAP Unprecedented meroterpenoid frameworks Neuroprotective activities Acetylcholinesterase inhibitors

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早期气管插管在重型脑出血急救中的应用

中国医疗器械信息 2020年第24期26卷 130-131页

作者：宋希希天津市泰达医院天津300457

目的:分析早期气管插管在重型脑出血急救中的应用效果。方法:研究对象为本院2018年2月~2019年7月收治的46例重型脑出血患者,随机分组之后分别给予研究组和对照组患者气管插管治疗和气管切开治疗,观察两组患者治疗前后的格拉斯哥评分和... 详细信息

目的:分析早期气管插管在重型脑出血急救中的应用效果。方法:研究对象为本院2018年2月~2019年7月收治的46例重型脑出血患者,随机分组之后分别给予研究组和对照组患者气管插管治疗和气管切开治疗,观察两组患者治疗前后的格拉斯哥评分和神经功能缺损评分,观察两组患者的手术时间以及院内获得性肺炎发生率。结果:研究组和对照组患者在治疗前的格拉斯哥评分和神经功能缺损评分差异均不显著(P>0.05),治疗后研究组患者的格拉斯哥评分和神经功能缺损评分分别为(11.65±1.63)和(5.35±1.61),均优于对照组患者的(10.19±1.54)和(6.76±1.67),P<0.05。研究组患者的手术时间为(3.52±1.23)min,显著短于对照组患者的(10.84±3.62)min,P<0.05。研究组患者的院内获得性肺炎发生率为17.39%(4/23),显著低于对照组患者的39.13%(9/23),P<0.05。结论:对重型脑出血患者应用早期气管插管可以有效改善患者的神经功能,缩短手术时间,降低院内获得性肺炎发生率,效果显著。

关键词：早期气管插管重型脑出血急救

Trade-offs between the accumulation of cuticular wax and jasmonic acid-mediated herbivory resistance in maize

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Journal of Integrative Plant Biology 2024年第1期66卷 143-159页

作者： Jiong Liu Lu Li Zhilong xiong Christelle AMRobert Baozhu Li Shan He Wenjie Chen Jiasheng Bi Guanqing Zhai Siyi Guo Hui Zhang Jieping Li Shutang Zhou xi Zhang Chun‐Peng song School of Life Sciences Henan UniversityKaifeng 475004China State Key Laboratory of Crop Stress Adaptation and Improvement Henan UniversityKaifeng 475004China State Key Laboratory of Cotton Bio‐Breeding and Integrated Utilization Henan UniversityKaifeng 475004China Sanya Institute of Henan University Sanya 572025China Institute of Plant Sciences University of BernBern 3013Switzerland

Plants have evolved complex physical and chemical defense systems that allow them to withstand herbivory *** of a complex mixture of very-long-chain fatty acids(VLCFAs)and their derivatives,cuticular wax constitutes the first physical line of defense against ***,we report the function of Glossy 8(ZmGL8),which encodes a 3-ketoacyl reductase belonging to the fatty acid elongase complex,in orchestrating wax production and jasmonic acid(JA)-mediated defenses against herbivores in maize(Zea mays).The mutation of GL8 enhanced chemical defenses by activating the JA-dependent *** observed a trade-off between wax accumulation and JA levels across maize glossy mutants and 24 globally collected maize inbred *** addition,we demonstrated that mutants defective in cuticular wax biosynthesis in Arabidopsis thaliana and maize exhibit enhanced chemical *** transcriptomic and lipidomic analyses indicated that the gl8 mutant confers chemical resistance to herbivores by remodeling VLCFA-related lipid metabolism and subsequent JA biosynthesis and *** results suggest that VLCFA-related lipid metabolism has a critical role in regulating the trade-offs between cuticular wax and JA-mediated chemical defenses.

关键词： cuticular wax fall armyworm herbivore resistance jasmonic acid maize plant-herbivore interactions

Compound extreme inundation risk of coastal wetlands caused by climate change and anthropogenic activities in the Yellow River Delta,China

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Advances in Climate Change Research 2024年第1期15卷 134-147页

作者： xiao-Li WANG Ai-Qing FENG xi-Yong HOU Qing-Chen CHAO Bai-Yuan song Yu-Bin LIU Qi-Guang WANG He XU Yu-xin ZHANG Dong Li Li-Jie DONG Yu GUO CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Tongji Urban Planning Design Research Institute Shanghai 200092China School of Geography and Tourism Qilu Normal UniversityJinan 250200China China Meteorological Administration Training Centre China Meteorological AdministrationBeijing 10008China University of Chinese Academy of Sciences Beijing 100049China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316022China

The coastal wetlands of the Yellow River Delta(YRD)in China are crucial for their valuable resources,environmental significance,and economic ***,these wetlands are also vulnerable to the dual threats of climate change and human *** substantial attention to the historical shifts in YRD's coastal wetlands,uncertainties remain regarding their future trajectory in the face of compound risks from climate change and anthropogenic *** on a range of remote sensing data sources,this study undertakes a comprehensive investigation into the evolution of YRD's coastal wetlands between 2000 and ***,the potential fate of coastal wetlands is thoroughly analyzed through the Land Use/Cover Change(LUCC)simulation using System Dynamic-Future Land Use Simulation(SD-FLUS)model and the extreme water levels projection integrated future sea-level rise,storm surge,and astronomical high tide in 2030,2050,and 2100 under scenarios of SSP1-2.6,SSP2-4.5,and *** revealed that YRD's coastal wetlands underwent a marked reduction,shrinking by 1688.72 km²from 2000 to *** decline was mostly attributed to the substantial expansion in the areas of artificial wetlands(increasing by 823.78 km2),construction land(increasing by 767.71 km²),and shallow water(increasing by 274.58 km²).Looking ahead to 2030-2100,the fate of coastal wetlands appears to diverge based on different *** the SSP1-2.6 scenario,the area of coastal wetland is projected to experience considerable *** contrast,the SSP5-8.5 scenario anticipates a notable decrease in coastal *** to the inundated area suffered from the current extreme water levels,the study projects a decrease of 6.8%-10.6%in submerged coastal wetlands by 2030 and 9.4%-18.2%by 2050 across all *** 2100,these percentages are projected to decrease by 0.4%(SSP2-4.5)and 27.1%(SSP5-8.5),but increase by 35.7%(SSP1-2.6).Results suggest that coastal wetlands in th

关键词： Climate change Anthropogenic activities Compound extreme risk Coastal wetlands Yellow River Delta

Novel berberine derivatives as adjuvants in the battle against Acinetobacter baumannii: A promising strategy for combating multi-drug resistance

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Chinese Chemical Letters 2024年第10期35卷 334-340页

作者： Liping Zhao xixi Guo Zhimeng Zhang xi Lu Qingxuan Zeng Tianyun Fan xintong Zhang Fenbei Chen Mengyi Xu Min Yuan Zhenjun Li Jiandong Jiang Jing Pang Xuefu You Yanxiang Wang Danqing song Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China State Key Laboratory for Infectious Diseases Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

The development of resistance against most of the available antibiotics has made Acinetobacter baumannii(***)a pathogen of high *** this study,thirty novel berberine derivatives are rationally designed,synthesized,and evaluated for their synergistic antibacterial activities against *** them,compound 2d shows the most potent synergetic effect to aztreonam against ***,including carbapenem-resistant and extended-spectrumβ-lactamases-producing ***,synergistic effects were observed for the combinations of 2d and different antibacterial used in clinical practices,indicating its potent broad-spectrum antibiotic-sensitizing effects against *** combination of 2d and aztreonam significantly improves the survival rates of *** larvae compared with aztreonam treatment *** studies indicate that 2d inhibits the drug efflux and iron acquisition of the bacteria by targeting the AdeB transporter protein,thus achieving a synergistic antimicrobial efficacy with different antibacterial ***,berberine derivatives represent a new family of antimicrobial adjuvants against ***,with the advantage of dual-function antibacterial effect,and are worthy of further investigation.

关键词： Acinetobacter baumannii Berberine derivatives Rational design Synergistic effect Eflux Ironacquisition

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积雪草中五种微量元素的形态分析

分析科学学报 2012年第2期28卷 261-264页

作者：李瑞芬叶明德宋茜茜温州大学化学与材料工程学院浙江温州325035

按照传统煎煮法对积雪草中铁、锰、锌、铜和锶5种元素进行提取,用微孔滤膜分离提取液中的可溶态与悬浮态,利用阳离子交换树脂柱、大孔吸附树脂柱和螯合树脂柱对可溶态中的游离态和非游离态、有机态和无机态、稳定态和不稳定态进行分离后... 详细信息

按照传统煎煮法对积雪草中铁、锰、锌、铜和锶5种元素进行提取,用微孔滤膜分离提取液中的可溶态与悬浮态,利用阳离子交换树脂柱、大孔吸附树脂柱和螯合树脂柱对可溶态中的游离态和非游离态、有机态和无机态、稳定态和不稳定态进行分离后,采用火焰原子吸收光谱法(FAAS)对各种形态中的上述5种元素进行测定。结果显示,积雪草中5种元素的提取率为11.88%～22.86%,浸留比为14.04%～31.44%。该法测定各元素的回收率为95.6%～104.3%,相对标准偏差在0.37%～1.14%之间,具有较好的精密度和准确度。

关键词：积雪草金属元素火焰原子吸收光谱法形态分析

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《枕草子》与《浮生六记》中“趣”之比较

华北水利水电学院学报（社会科学版） 2013年第1期29卷 152-154页

作者：宋茜茜河南大学外语学院河南开封475001

《枕草子》是日本平安时代的一部随笔集,记录了宫廷生活的种种趣事。《浮生六记》是中国清代的一部自传体的散文,作者以夫妇生活为主线,描述了日常生活的趣味场景。虽然两部作品诞生的环境迥异,但不论是甜蜜的爱情生活以及妙趣横生的诗... 详细信息

《枕草子》是日本平安时代的一部随笔集,记录了宫廷生活的种种趣事。《浮生六记》是中国清代的一部自传体的散文,作者以夫妇生活为主线,描述了日常生活的趣味场景。虽然两部作品诞生的环境迥异,但不论是甜蜜的爱情生活以及妙趣横生的诗词应答,还是让人愉悦的自然景物和积极乐观的人生态度,两者都有相似之处。

关键词：《枕草子》《浮生六记》趣

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中小企业供应链协同知识转移模式研究

物流科技 2013年第1期36卷 84-87页

作者：宋茜茜北京物资学院北京101149

在分析供应链协同中中小企业进行知识转移的重要性及知识转移对中小企业的作用的基础上,了解到中小企业供应链协同知识转移的动机,进而提出了中小企业供应链协同的知识转移模式,随后从显性与隐性两种知识方面分别提出具体的知识转移方式... 详细信息

在分析供应链协同中中小企业进行知识转移的重要性及知识转移对中小企业的作用的基础上,了解到中小企业供应链协同知识转移的动机,进而提出了中小企业供应链协同的知识转移模式,随后从显性与隐性两种知识方面分别提出具体的知识转移方式,最后通过对供应链协同知识转移的效果分析,以完善中小企业供应链协同知识转移模式的研究。

关键词：中小企业供应链协同知识转移模式

Phage-displayed heptapeptide sequence conjugation significantly improves the specific targeting ability of antimicrobial peptides against Staphylococcus aureus

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mLife 2024年第2期3卷 251-268页

作者： Tao Wang Peng Tan Qi Tang Chenlong Zhou Yakun Ding Shenrui Xu Mengda song Huiyang Fu Yucheng Zhang xiaohui Zhang Yueyu Bai Zhihong Sun xi Ma State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijingChina Luoyang Key Laboratory of Animal Genetic and Breeding College of Animal ScienceHenan University of Science and TechnologyLuoyangChina Key Laboratory of Innovative Utilization of Indigenous Cattle and Sheep Germplasm Resources(Co‐construction by Ministry and Province) Ministry of Agriculture and Rural AffairsZhengzhou UniversityZhengzhouChina Animal Health Supervision in Henan Province ZhengzhouChina Laboratory for Bio‐Feed and Molecular Nutrition Department of Animal Science and TechnologySouthwest UniversityChongqingChina

Broad-spectrum antibacterial drugs often lack specificity,leading to indiscriminate bactericidal activity,which can disrupt the normal microbial balance of the host flora and cause unnecessary cytotoxicity during systemic *** this study,we constructed a specifically targeted antimicrobial peptide against Staphylococcus aureus by introducing a phage-displayed peptide onto a broad-spectrum antimicrobial peptide and explored its structure–function relationship through one-factor ***2 obtained by screening based on the selectivity index and the targeting index showed specific killing ability against ***,SFK2 showed excellent biocompatibility in mice and piglet,and demonstrated significant therapeutic efficacy against *** *** conclusion,our screening of phage-derived heptapeptides effectively enhances the specific bactericidal ability of the antimicrobial peptides against ***,providing a theoretical basis for developing targeted antimicrobial peptides.

关键词： antimicrobial peptides membrane disruption mechanism microbial infection phage display technology Staphylococcus aureus