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多模态超声在乳腺非肿块型病变鉴别诊断中的应用价值探析

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智慧健康 2024年第14期10卷 7-10页

作者：李春雨王艳宋文卿陈艳丽大庆龙南医院/齐齐哈尔医学院附属第五医院物理诊断科黑龙江大庆163453

目的探析多模态超声在乳腺非肿块型病变鉴别诊断中的应用价值。方法选择2022年3月—2023年3月本院收治的94例乳腺非肿块型病变患者为研究对象,对其进行常规超声、超声血流成像、超声弹性成像检查,以病理检查结果作为金标准,分析多模... 详细信息

目的探析多模态超声在乳腺非肿块型病变鉴别诊断中的应用价值。方法选择2022年3月—2023年3月本院收治的94例乳腺非肿块型病变患者为研究对象,对其进行常规超声、超声血流成像、超声弹性成像检查,以病理检查结果作为金标准,分析多模态超声(三者联合)在乳腺非肿块型病变鉴别诊断中的应用价值。结果 94例乳腺非肿块型病变患者经病理检查,其中41例确诊为乳腺癌,53例确诊为良性乳腺病变。常规超声、超声血流成像、超声弹性成像及多模态超声鉴别诊断乳腺非肿块型病变与病理检查的一致性kappa值分别为0.411、0.617、0.742、0.913。多模态超声检查鉴别诊断乳腺非肿块型病变的灵敏度为95.12%(39/41)、特异度为96.23%(51/53)、准确度为95.74%(90/94)、阳性预测值为95.12%(39/41)、阴性预测值为96.23%(51/53),高于单独的常规超声、超声血流成像、超声弹性成像的鉴别诊断结果,差异显著,具有统计学意义(P<0.05)。结论多模态超声在乳腺非肿块型病变鉴别诊断中的应用价值较高,与病理结果的一致性较高,可提升诊断准确性。

关键词：乳腺非肿块型病变多模态超声超声血流成像剪切波超声弹性成像

Effects of dynamical spanwise retraction and stretch on flapping-wing forward flights

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Chinese Journal of Aeronautics 2024年第4期37卷 181-202页

作者： Kang LIU Bifeng song Ang CHEN Zhihe WANG Dong XUE wenqing YANG School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Intelligent Aircraft Research Center Chengdu Technological UniversityChengdu 610031China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Harbin Institute of Technology Shenzhen 518055China

Birds and bats retract and stretch their wings dynamically during each flap in level flights, implying intriguing mechanisms for the aerodynamic performance improvement of flapping wings. A numerical investigation into the aerodynamic effects of such bio-inspired concept in forward flights has been performed based on a three-dimensional wing in plunging motion and a twosection wing in flapping motion. The currently considered Reynolds number and Strouhal number are Re=1.5×10^(5) and St=0.3, respectively. During the research, the mean angle of attack is varied in relatively wide ranges to achieve lift-thrust interconversion for the wings. The conclusive results show that dynamical spanwise retraction and stretch has induced three absolutely desirable scenarios for the oscillating wings in forward flights, namely producing more lift and consuming less power for a given thrust generation, producing more thrust and consuming less power for a given lift generation, and producing more lift and more thrust while consuming less power. Furthermore,the morphing wings have alleviated periodical aerodynamic load fluctuations compared with the non-morphing baseline. The mechanism of the aerodynamic effects of the bionic morphing mode is analyzed with the aid of field visualization. The current article is the first to reveal the absolute advantages of the bionic spanwise morphing. Hopefully, it may help comprehend the behaviors of natural fliers and provide inspirations for performance enhancement of micro artificial flappingwing vehicles.

关键词： Flapping wing Morphing wing Bionic Aerodynamics Vortex Flight

基于差分扰动HBO算法的巡检机器人路径规划

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无线电工程 2024年第9期54卷 2249-2257页

作者：宋文清赵奇陈玉李银广冀永臻冯朱建国能北电胜利能源有限公司内蒙古锡林浩特026002 广州博智林机器人有限公司广东广州511370

针对巡检机器人需在电站复杂环境下多任务点遍历巡检路径规划问题,提出一种多策略差分扰动机制改进的堆优化(Heap-Based Optimizer,HBO)算法。对不同个体实行差异化的扰动策略,增强新解的多样性。针对巡检任务起终点一致的特性,使用交... 详细信息

针对巡检机器人需在电站复杂环境下多任务点遍历巡检路径规划问题,提出一种多策略差分扰动机制改进的堆优化(Heap-Based Optimizer,HBO)算法。对不同个体实行差异化的扰动策略,增强新解的多样性。针对巡检任务起终点一致的特性,使用交错同步搜索策略,双种群各执行一半搜索任务,降低了搜索时间,提高了收敛速度。环境建模引入了无限邻域机制,可搜索邻域个数变为连续任意方向,减少了转折点数,使用四阶最小Snap平滑算法平滑整体路径,增大路径平顺度,满足机器人动力学特性。经仿真对比,改进后HBO算法在多任务点遍历巡检任务中性能提升明显,相对于改进前HBO算法和对比的混合粒子群灰狼(Hybrid Gray Wolf Optimizer with Particle Swarm Optimization,HGWOP)算法的步数最低,路径最平滑,最优路径分别缩短了11.1%和20.0%,平均迭代次数分别降低了25.78%和10.53%。

关键词：差分扰动堆优化算法巡检机器人路径规划

Alkyl dimethyl betaine activates the low-temperature collection capacity of sodium oleate for scheelite

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 71-80页

作者： Xu Wang Zhengquan Zhang Yanfang Cui Wei Li Congren Yang Hao song wenqing Qin Fen Jiao School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China College of Engineering Drexel UniversityPhiladelphiaPA 19102USA Luoyang Zhenbei Industry and Trade Co. Ltd.Luoyang 47100China

The impact of alkyl dimethyl betaine (ADB) on the collection capacity of sodium oleate (NaOl) at low temperatures was evaluated using flotation tests at various scales. The low-temperature synergistic mechanism of ADB and NaOl was explored by infrared spectroscopy, X-ray photoelectron spectroscopy, surface tension measurement, foam performance test, and flotation reagent size *** flotation tests revealed that the collector mixed with octadecyl dimethyl betaine (ODB) and NaOl in a mass ratio of 4:96 exhibited the highest collection capacity. The combined collector could increase the scheelite recovery by 3.48% at low temperatures of 8–12℃. This is particularly relevant in the Luanchuan area, which has the largest scheelite concentrate output in China. The results confirmed that ODB enhanced the collection capability of NaOl by improving the dispersion and foaming performance. Betaine can be introduced as an additive to NaOl to improve the recovery of scheelite at low temperatures.

关键词： scheelite betaine low temperature synergistic effect dispersion foamability

Knowledge,Attitude,and Practice Towards Mpox and Associated Factors Among HIV-Infected Individuals—Beijing Municipality,China,2023

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China CDC weekly 2024年第7期6卷 109-117,I0001,I0002页

作者： Yue Gu Ruiqi Ren Jing Han wenqing Bai Yuanyuan Zhang Haoliang Liu Zhaohe Li Chao Li Rui song Lei Zhou Chinese Center for Disease Control and Prevention BeijingChina National Center for Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijingChina Nanjing Medical University Nanjing CityJiangsu ProvinceChina

Summary What is already known about this topic?Approximately 50%of patients with mpox are human immunodeficiency virus(HIV)-infected *** have shown that individuals with advanced HIV infection tend to have more severe... 详细信息

关键词： mortality Infect clinical

Deleterious variants in RNF111 impair female fertility and induce premature ovarian insufficiency in humans and mice

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Science China(Life Sciences) 2024年第7期67卷 1325-1337页

作者： Chengcheng song Yingying Qin Yan Li Bingyi Yang Ting Guo wenqing Ma Dian Xu Keyan Xu Fangfang Fu Li Jin Yanhua Wu Shuyan Tang Xiaojun Chen Feng Zhang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic EngineeringInstitute of Medical Genetics and GenomicsFudan UniversityShanghai 200011China Human Phenome Institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan 250021China State Key Laboratory of Reproductive Medicine and Offspring Health Key Laboratory of Reproductive Endocrinology of Ministry of EducationNational Research Center for Assisted Reproductive Technology and Reproductive GeneticsShandong Key Laboratory of Reproductive MedicineShandong Provincial Clinical Research Center for Reproductive HealthShandong UniversityJinan 250021China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Demonstration Center for Experimental Biology Education School of Life SciencesFudan UniversityShanghai 200433China Department of Gynecology the Tenth People’s Hospital of Tongji UniversityShanghai 200072China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health Hospital of China Welfare InstituteShanghai 200030China

Premature ovarian insufficiency(POI)is a heterogeneous female disorder characterized by the loss of ovarian function before the age of *** represents a significant detriment to female ***,the known POI-causative genes currently account for only a fraction of *** elucidate the genetic factors underlying POI,we conducted whole-exome sequencing on a family with three fertile POI patients and identified a deleterious missense variant in *** a subsequent replication study involving 1,030 POI patients,this variant was not only confirmed but also accompanied by the discovery of three additional predicted deleterious RNF111 *** variants collectively account for eight cases,representing 0.78%of the study cohort.A further study involving 500 patients with diminished ovarian reserve also identified two additional RNF111 ***,RNF111 encodes an E3 ubiquitin ligase with a regulatory role in the TGF-β/BMP signaling *** analysis revealed that RNF111/RNF111 is predominantly expressed in the oocytes of mice,monkeys,and *** further investigate the functional implications of RNF111 variants,we generated two mouse models:one with a heterozygous missense mutation(Rnf111+/M)and another with a heterozygous null mutation(Rnf111^(+/-)).Both mouse models exhibited impaired female fertility,characterized by reduced litter sizes and small ovarian ***,RNA-seq and quantitative proteomics analysis unveiled that Rnf111 haploinsufficiency led to dysregulation in female gonad development and negative regulation of the BMP signaling pathway within mouse *** conclusion,our findings strongly suggest that monoallelic deleterious variants in RNF111 can impair female fertility and induce POI in both humans and mice.

关键词： POI RNF111 female fertility ovarian reserve

The Persistence and Zonal Scale of Atmospheric Dipolar Modes

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Advances in Atmospheric Sciences 2024年第3期41卷 478-492页

作者： Jie song State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric Physics(IAP)Chinese Academy of SciencesBeijing 100029China

This study investigates the relationship between the persistence and the zonal scale of atmospheric dipolar modes(DMs). Results from the daily data of ERA5 and the long-term output of an idealized atmospheric model show that the atmospheric DMs with a broader(narrower) zonal scale dipolar structure possess a longer(shorter) persistence. A detailed vorticity budget analysis indicates that the persistence of a hemispheric-scale DM(1/1 DM) and a regional or sectoral DM(1/8 DM) in the model both largely rely on the persistence of the nonlinear eddy forcing. Linear terms can indirectly reduce the persistence of the anomalous nonlinear eddy forcing in a 1/8 DM by modifying the baroclinicity via the arousal of anomalous vertical motions. Therefore, the atmospheric DMs with a broader(narrower) zonal scale possess a longer(shorter) persistence because the effects of the linear terms are less(more) pronounced when the atmospheric DMs have better(worse) zonal symmetry. Further analyses show that the positive eddy feedback effect is weak or even absent in a 1/8DM and the high-frequency eddy forcing acts more like a concomitant phenomenon rather than a leading driving factor for a 1/8 DM. Thus, the hemispheric-scale DM and the regional or sectoral DMs are different, not only in their persistence but also in their dynamics.

关键词： NAM NAO eddy feedback persistence linear term

Conservation and characterization of unique porcine interstitial telomeric sequences

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Science China(Life Sciences) 2012年第12期55卷 1029-1037页

作者： JI GuangZhen LIU Kai CHEN ChengBin RUAN WeiMin GLYTSOU Christina YANG Yang OKUKA Maja song wenqing GAGOS Sarantis LINing LIU Lin State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University Tianjin 300071 China" State Key Laboratory far Agrobiotechnology College of Biological Sciences China Agricultural Universi~ Beijing 100193 China" Genettcs Dtvlslon Center of Basic Research H Biomedical Research Foundation of the Academy of Athens Greece Athens 11527 Greece Department of Obstetrics and Gynecology University of South Florida College of Medicine Tampa FL 33612 USA

Telomeres are composed of TTAGGG repeats and located at the ends of chromosomes. Telomeres protect chromosomes from instability in mammals, including mice and humans. Repetitive TTAGGG sequences are also found at intrachromosomal sites, where they are named as interstitial telomeric sequences (ITSs). Aberrant ITSs are implicated in chromosomal instability and found in cancer cells. Interestingly, in pigs, vertebrate telomere sequences TTAGGG (vITSs) are also localized at the centromeric region of chromosome 6, in addition to the end of all chromosomes. Surprisingly, we found that botanic telomere sequences, TTTAGGG (bITSs), also localize with vITSs at the centromeric regions of pig chromosome 6 using telomere fluorescence in situ hybridization (FISH) and by comparisons between several species. Furthermore, the average lengths of vITSs are highly correlated with those of the terminal telomeres (TTS). Also, pig ITSs show a high incidence of telomere doublets, suggesting that pig ITSs might be unstable and dynamic. Together, our results show that pig cells maintain the conserved telomere sequences that are found at the ITSs from of plants and other vertebrates. Further understanding of the function and regulation of pig ITSs may provide new clues for evolution and chromosomal instability.

关键词：端粒序列保护间质常染色体猪不稳定性表征荧光原位杂交

Identification of Linear Systems Using Binary Sensors with Random Thresholds

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Journal of Systems Science & Complexity 2024年第3期37卷 907-923页

作者： HUANG Zhiyong song Qijiang School of Mathematics Renmin University of ChinaBeijing 100872China School of Mathematics Sino-French InstituteRenmin University of ChinaBeijing 100872China

In this paper,the problem of identifying autoregressive-moving-average systems under random threshold binary-valued output measurements is *** the help of stochastic approximation algorithms with expanding truncations,the authors give the recursive estimates for the parameters of both the linear system and the binary *** reasonable conditions,all constructed estimates are proved to be convergent to the true values with probability one,and the convergence rates are also established.A simulation example is provided to justify the theoretical results.

关键词： α-mixing binary sensor quantized system stochastic approximation stochastic thresh-old strongly consistent system identification