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Chemical Research in Chinese Universities 2006年第6期22卷 803-807页

作者： song li-ming ZHU Tao WANG Qiu-sheng ZHANG Xiao li Guo-wen Key Lab for Supramolecular Structure and Materials of Ministry of Education Jilin University Changchun 130012 P. R. China

A functional amphiphile, N^6 -myristoyl-9-[ 8-（ 1-trimethylamino） octyl ] adenine bromide （MTOAB）, was used to form coliposomes of phosphatidyleholine（PC）, PC/thymine, and PC/TOTB using sonication . The morphologies of the coliposomes were characterized using TEM （transmission electron microscopy）. The UV-Vis spectroscopic behavior of PC/MTOAB/thymine （molar ratio = 5： 1： 1 ） and PC/MTOAB/TOTB （molar ratio = 5： 1： 1 ） of coliposomal solutions showed that as a result of base pairing, absorption intensity showed a decrease at 263 nm with increase of time. The decrease of absorption intensity is ascribed to the hypochromic effect, which is because of the formation of hydrogen bonds between adenine and thymine in the coliposomes. The same effect was also observed for the mixture of aqueous PC/MTOAB liposomes and PC/TOTB liposomes after fusion, whereas the nocomplementary coliposomcs formed from PC/MTOAB and PC/TOTB did not show these spectroscopic changes. The molecular recognition through hydrogen interactions between adenine and thymine is very slow because of the possible occurrence of molecular lateral diffusion and exchange of amphiphile before recognition progresses in coliposomes. These results provide useful information for the design of supramolecular devices such as vesicles and liposomes,which can be used to mimic primitive recognition processes observed in biological systems.

关键词： Coliposomes Nueleobase Molecular recognition Amphiphile

MiR-181a-5p调控乳头状甲状腺癌细胞增殖和侵袭的作用及分子机制研究

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循证医学 2024年第4期24卷 234-242页

作者：郝俊文黄伟鋆黎颂铭广州医科大学附属番禺中心医院乳腺甲状腺外科广州511486

目的探讨miR-181a-5p对乳头状甲状腺癌(papillary thyroid cancer,PTC)细胞的作用及调控机制。方法利用生物信息学工具分析miR-181a-5p和促甲状腺激素受体(thyrotropin receptor,TSHR)在PTC组织中的表达以及两者的靶向关系,并使用双荧... 详细信息

目的探讨miR-181a-5p对乳头状甲状腺癌(papillary thyroid cancer,PTC)细胞的作用及调控机制。方法利用生物信息学工具分析miR-181a-5p和促甲状腺激素受体(thyrotropin receptor,TSHR)在PTC组织中的表达以及两者的靶向关系,并使用双荧光素酶报告基因实验验证两者的靶向关系。TPC-1细胞转染miR-181a-5p抑制物和shTSHR后,使用定量逆转录聚合酶链反应或免疫印迹实验检测TPC-1细胞中miR-181a-5p、TSHR、E-cadherin、N-cadherin和Vimentin的表达水平。通过MTT和Transwell实验检测miR-181a-5p和TSHR对TPC-1细胞活性、侵袭的作用。结果在PTC组织和细胞中miR-181a-5p表达上调(P<0.001),在甲状腺癌组织中TSHR低表达,且miR-181a-5p可直接靶向TSHR。下调miR-181a-5p抑制了TPC-1细胞活性、侵袭以及N-cadherin和Vimentin的表达(P<0.01),但促进了E-cadherin的表达(P<0.001)。TSHR敲减产生了相反的结果(P<0.01),并部分逆转了miR-181a-5p下调对TPC-1细胞的影响(P<0.01)。反之,miR-181a-5p下调可以逆转TSHR敲减产生的影响(P<0.05)。结论下调miR-181a-5p可通过促进TSHR的表达来抑制PTC细胞的恶性进展。

关键词：乳头状甲状腺癌 miR-181a-5p 促甲状腺激素受体增殖侵袭

低温对红耳龟血液指标及植物血凝素反应的影响

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水生态学杂志 2024年第4期45卷 148-154页

作者：张一帆林涵语李崧铭伍亮刁迎珠张志强安徽农业大学动物科技学院安徽合肥230036

探究低温对红耳龟(Trachemys scripta elegans)免疫功能和应激反应能力的影响,揭示红耳龟适应低温环境的生理学和免疫学基础,为深入了解其入侵生物学提供基础资料。采用活体背甲下静脉窦采血技术,测定了6℃、17℃和26℃条件下处理1、5和... 详细信息

探究低温对红耳龟(Trachemys scripta elegans)免疫功能和应激反应能力的影响,揭示红耳龟适应低温环境的生理学和免疫学基础,为深入了解其入侵生物学提供基础资料。采用活体背甲下静脉窦采血技术,测定了6℃、17℃和26℃条件下处理1、5和10 d时血液中各型白细胞百分比及嗜异性粒细胞与淋巴细胞的比值(ratio of heterophils to lymphocytes,H/L),以及第10天采血后植物血凝素(phytohemagglutinin-P,PHA-P)反应的变化。结果显示:(1)随着温度下降,第1天只有嗜碱性粒细胞的百分比显著升高(P0.05);第5天,嗜酸性粒细胞的百分比和H/L先升后降,淋巴细胞的百分比先降后升,单核细胞的百分比下降(P0.05),其他类型白细胞的百分比及H/L都有组内差异(P0.05)。红耳龟通过调整血液中嗜酸性粒细胞等不同类型白细胞的百分比、下降的应激反应能力和提前发生反应的免疫应答来适应低温的短期胁迫。

关键词：红耳龟低温淋巴细胞嗜酸性粒细胞植物血凝素应激

维普期刊数据库博看期刊

Compressed Data Separation via ℓ_(q)-Split Analysis with ℓ_(∞)-Constraint

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1655-1673页

作者： ming Yang Gu song li Jun Hong lin School of Mathematical Science Zhejiang UniversityHangzhou310027P.R.China Center for Data Science Zhejiang UniversityHangzhou310027P.R.China

In this paper,we study compressed data separation(CDS)problem,i.e.,sparse data separation from a few linear random *** propose the nonconvex ℓ_(q)-split analysis with ℓ_(∞)-constraint and 0lit-analysis Dantzig selector(ℓ_(q)-split-analysis DS).We show that the two distinct subcomponents that are approximately sparse in terms of two different dictionaries could be stably approximated via the ℓ_(q)-split-analysis DS,provided that the measurement matrix satisfies either a classical D-RIP(Restricted Isometry Property with respect to Dictionaries and ℓ_(2) norm)or a relatively new(D,q)-RIP(RIP with respect to Dictionaries and ℓ_(q)-quasi norm)condition and the two different dictionaries satisfy a mutual coherence condition between *** the Gaussian random measurements,the measurement number needed for the(D,q)-RIP condition is far less than those needed for the D-RIP condition and the(D,1)-RIP condition when q is small enough.

关键词： Data separation ℓ_(q)-split analysis Dantzig selector frames restricted isometry property compressed sensing

Strategic Study on the Development of Space Science in China and Proposals for Future Missions

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空间科学学报 2024年第4期44卷 699-703页

作者： WANG Chi song Tingting li ming CAO song National Space Science Center Chinese Academy of SciencesBeijing 100190

Since 2011,the Chinese Academy of Sciences(CAS)has implemented the Strategic Priority Program on Space Science(SPP).A series of scientific satellites have been developed and launched,such as Dark Matter Particle Explorer(DAMPE),Quantum Experiments at Space Scale(QUESS),Advanced Space-based Solar Observatory(ASO-S),Einstein Probe(EP),and significant scientific outcomes have been *** order to plan the future space science missions in China,CAS has organized the Chinese space science community to conduct medium and long-term development strategy studies,and summarized the major scientific frontiers of space science as“One Black,Two Dark,Three Origins and Five Characterizations”.Five main scientific themes have been identified for China’s future breakthroughs,including the Extreme Universe,Space-Time Ripples,the Panoramic View of the Sun and Earth,the Habitable Planets,and Biological&Physical Science in *** science satellite missions to be implemented before 2030 are proposed accordingly.

关键词： Space science Space missions Space exploration

Establishing the Harmonious Society in P.R. China under Intensifying Government Function in Public Administration

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Establishing the Harmonious Society in P.R. China under Inte...

Buried interface management via bifunctional NH_(4)BF_(4)towards efficient CsPbI_(2)Br solar cells with a V_(oc)over 1.4 V

2006 International Conference on Public Administration

作者： song li-ming ZHONG Ying-feng School of Marxism Renmin University of China School of Management UESTC

ISBN: (纸本)7811142686

The harmonious society is the one that is steady, well-administrant, sustainable developing and with the key social values which are acceptable by people. It is very important to intensify government function on public administration for establishing the harmonious socialist society, which is the mechanisms engineering and needs great efforts by the government and our people. As the public administrator, the government needs to perform the following functions:1. Consummate the harmonizing and safeguarding mechanism for people’s benefit. 2. Reconstruct the society benefit expression mechanism. 3. Building the new society floating mechanism. 4. Building the scientific and effective mechanism for public crisis forecast and disposal. 5. Establishing collaboration network for public administration.

关键词： Harmonious society Public Administration government functions

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Journal of Energy Chemistry 2024年第2期89卷 364-370,I0009页

作者： Fazheng Qiu ming-Hua li Jinpeng Wu Jin-song Hu School of Materials Science and Engineering NingboTech UniversityNingbo 315100ZhejiangChina Beijing National Laboratory for Molecular Sciences(BNLMS) Institute of ChemistryChinese Academy of SciencesBeijing 100190China College of Chemical Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China

CsPbI_(2)Br perovskite solar cells(PSCs)have drawn tremendous attention due to their suitable bandgap,excellent photothermal stability,and great potential as an ideal candidate for top cells in tandem solar ***,the abundant defects at the buried interface and perovskite layer induce severe charge recombination,resulting in the open-circuit voltage(V_(oc))output and stability much lower than ***,a novel buried interface management strategy is developed to regulate interfacial carrier dynamics and CsPbI_(2)Br defects by introducing ammonium tetrafluoroborate(NH_(4)BF_(4)),thereby resulting in both high CsPbI_(2)Br crystallization and minimized interfacial energy ***,NH_(4)^(+)ions could preferentially heal hydroxyl groups on the SnO_(2)surface and balance energy level alignment between SnO_(2)and CsPbI_(2)Br,enhancing charge transport efficiency,while BF_(4)^(-)anions as a quasi-halogen regulate crystal growth of CsPbI_(2)Br,thus reducing perovskite ***,it is proved that eliminating hydroxyl groups at the buried interface enhances the iodide migration activation energy of CsPbI_(2)Br for strengthening the phase *** a result,the optimized CsPbI_(2)Br PSCs realize a remarkable efficiency of 17.09%and an ultrahigh V_(oc)output of 1.43 V,which is one of the highest values for CsPbI_(2)Br PSCs.

关键词： Inorganic perovskite Buried interface Defect Stability Open-circuit voltage loss

Topology optimization of modular structures with multiple assemblies and applications to airborne shelves

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Chinese Journal of Aeronautics 2024年第4期37卷 321-332页

作者： Jie WANG Tong GAO ming li Jihong ZHU Longlong song Weihong ZHANG State IJR Center of Aerospace Design and Additive Manufacturing Northwestern Polytechnical UniversityXi’an 710072China Beijing Specialized Machinery Institute Beijing 100143China

This work is devoted to the aeronautical application of topology optimization for modular structures with multiple assemblies that consist of repeated standard modules and optional *** kinds of structures are widely used owing to their transportability,reconfigurability,low manufacturing and service *** this work,the design of airborne shelves with modular structures characterized by the standard module configuration is formulated for the first time as a topology optimization problem of multiple assemblies and multiple load cases subjected to the volume *** is shown that the weighted compliance design of multiple assemblies is a compromising solution compared to the optimization result of each individual assembly of standard ***,the performance of optimized airborne shelves with the modular structures can effectively be ameliorated with the help of reinforcements.

关键词： Topology optimization Modular structures Multiple assemblies Standard modules Airborne shelves

Interfacial friction effects on sealing performances of elastomer packer

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Petroleum Science 2024年第3期21卷 2037-2047页

作者： Peng-Cheng Wang ming-Hui Chen Jim Jenkinson Yong-Xin song li Sun Department of Mechanical Engineering University of HoustonHoustonTX77024USA Guren Nanomaterials Suzhou215127JiangsuChina Department of Marine Engineering Dalian Maritime UniversityDalian116026LiaoningChina

Elastomer sealing performance is of critical importance for downhole tools application including the use of fracturing(Frac)plugs during multi-stage hydraulic *** practice sealing performances of such plugs are normally evaluated through pressure tests,and in numerical simulation studies,maximum contact stress,average contact stress and contact length data are used to determine sealing quality between a packer and *** previous studies,the impact of friction forces on sealing performance is often *** work aims to fill this knowledge gap in determining the influence of friction forces on elastomer packer sealing *** first determined the most appropriate constitutive hyperelastic model for the elastomers used in frac *** we compared analytical calculation results with Finite Element Analysis simulation using a simplified tubular geometry and showed the significant influences on interfacial friction on elastomer packer stress distribution,deformation,and contact stress after *** the demonstration of validity of FEA method,we conducted systematic numerical simulation studies to show how the interfacial friction coefficients can affect the maximum contact stress,average contact stress,contact stress distribution,and maximum mises stress for an actual packer used in plug *** addition,we also demonstrated how the groove in a packer can affect packer deformation and evolvement during setting with the consideration of interfacial *** study underscores the critical role that friction forces play in Frac plug performance and provides a new dimension for optimizing packer design by controlling interfacial interactions at the packer contact surfaces.

关键词： Elastomer seal Friction Sealing performance Contact stress

New Benthic Fossils from the Late Ediacaran Strata of Southwestern China

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 311-323页

作者： liU Junping li ming TANG Feng ZHAO Jiangtai song Sicun ZHOU Ying song Xiaohan REN liudong School of Earth Science and Resources China University of GeosciencesBeijing 10083China Yunnan Institute of Geological Survey Kunming 650216China Chinese Academy of Geological Sciences Beijing 10037China Key Laboratory for Stratigraphy and Paleontology MNRCBeijing 10037China School of Earth Science and Engineering Nanjing UniversityNanjing 210093China Department of Earth Sciences University College LondonLondon WC1E 6BTU.K. CAS and Shandong Province Key Laboratory of Experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdaoShandong 266071China Institute of Geology Chinese Academy of Geological SciencesBeijing 10037China

The Jiangchuan Biota from the Jiucheng Member(Mb.)of the Dengying Formation(Fm.),discovered in Jiangchuan,eastern Yunnan,China,is marked by copious macrofossils at the apex of the Ediacaran *** fauna features benthic algae with varied holdfasts and other fossils of indeterminate taxonomic affinity and is compositionally unique compared to the Shibantan and Gaojiashan biotas of the Dengying *** the Miaohe and Wenghui biotas of the Doushantuo Fm.,elsewhere in *** novel benthic saccular macroalgal fossil,named here Houjiashania yuxiensis *** ***.,from the Jiangchuan Biota is based on fossils that are sausage-shaped,elongate,tubular,ranging from 0.3 to 4 cm in length,and up to 0.8 cm in *** terminus is blunt and rounded to an obtuse angle,the other is bent with a spread-out surface resembling a holdfast,suggesting a three-dimensional ***,stipe-shaped outgrowths,likely vestiges of sessile saccular life forms,are prevalent in macroalgal fossils of analogous size and shape,as well as present brown algae Scytosiphonaceae,such as Colpomenia and *** new findings augment the diversity of benthic algae,such as those known from the Early Neoproterozoic Longfengshan Biota in North *** benthic algal macrofossils in the Jiucheng *** to knowledge of Late Ediacaran metaphyte diversification and offer more clues about the evolutionary positioning of primitive *** co-occurrence of numerous planktonic and benthic multicellular algae and planktonic microbes might have facilitated ecologically the more extensive later Cambrian explosion evidenced by the Chengjiang Biota in Yunnan.

关键词： paleophytology benthic saccular algae algal evolution Neoproterozoic Jiucheng Member Jiangchuan Biota Yunnan Province