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Glutamatergic Neurons in the Caudal Zona Incerta Regulate Parkinsonian Motor Symptoms in Mice

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Neuroscience Bulletin 2022年第1期38卷 1-15页

作者： Li-Xuan Li Yu-Lan Li jin-Tao wu ji-Zhou song Xiao-Ming Li Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou310003China NHC and CAMS Key Laboratory of Medical Neurobiology Ministry of Education Frontier Science Center for Brain Research and Brain-Machine IntegrationSchool of Brain Science and Brain MedicineZhejiang University School of MedicineHangzhou310030China Department of Engineering Mechanics Soft Matter Research Centerand Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang UniversityHangzhou310063China

Parkinson’s disease(PD)is the second most common and fastest-growing neurodegenerative *** recent years,it has been recognized that neurotransmitters other than dopamine and neuronal systems outside the basal ganglia are also related to PD ***,little is known about whether and how the caudal zona incerta(ZIc)regulates parkinsonian motor ***,we showed that specific glutamatergic but not GABAergic ZIc^(VgluT2) neurons regulated these ***^(VgluT2) neuronal activation induced time-locked parkinsonian motor *** mouse models of PD,the ZIc^(VgluT2) neurons were hyperactive and inhibition of their activity ameliorated the motor ***^(VgluT2) neurons monosynaptically projected to the substantia nigra pars ***-nigral circuit activation induced parkinsonian motor ***,our findings provide a direct link between the ZIc,its glutamatergic neurons,and parkinsonian motor symptoms for the first time,help to better understand the mechanisms of PD,and supply a new important potential therapeutic target for PD.

关键词： Parkinson's disease Caudal zona incerta Glutamate Substantia nigra pars reticulata Parkinsonian motor symptoms

Identification of a novel emaravirus infecting lilac through next-generation sequencing

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Journal of Integrative Agriculture 2020年第8期19卷 2064-2071页

作者： WANG Ya-qin song Yu CAO Meng-ji CHENG Qi wu jian-xiang HU Tao State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058P.R.China National Citrus Engineering and Technology Research Center Citrus Research InstituteSouthwest UniversityChongqing 400712P.R.China

Emaraviruses are multipartite negative-sense single-stranded viruses that usually infect flowering *** unbiased next-generation sequencing(NGS)approach,a novel virus from lilac leaves with yellow mottle symptom was *** viral genomic RNA segments were detected and completely *** molecular characteristics of the viral RNAs and proteins resemble those of members of the genus *** virus was found to be mechanically transmissible to Nicotiana *** alignment and phylogenetic analyses of the virus support the proposal of creating a new species in the genus Emaravirus for which the name lilac chlorotic ringspot-associated virus(LiCRaV)is proposed.

关键词： LiCRaV lilac Fimoviridae Emaravirus

Numerical simulation for the comparison of thermal and plastic material flow behavior between symmetrical and asymmetrical boundary conditions during friction stir welding

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Advances in Manufacturing 2023年第1期11卷 143-157页

作者： Hao Su Chuan-song wu MOE Key Lab for Liquid-Solid Structure Evolution and Materials Processing Institute of Materials JoiningShandong UniversityJinan250061People’s Republic of China

An accurate description of the contact condition between the tool and the workpiece material is one of the most important issues for expounding the underlying multi-physics coupled mechanism during friction stir welding(FSW)*** the present study,a novel asymmetrical boundary condition around the tool-workpiece contact interface is proposed for the FSW of AA2024-T4 alloy.A three-dimensional computational fluid dynamics model is employed for the comparison of the coupled thermal and plastic material flow behavior between asymmetrical and symmetrical boundary *** results of heat generation,temperature distribution,tunnel defect formation and material flow streamline during the welding process are quantitatively ***,various experimental measuring methods are utilized to obtain information about temperature,thermal cycle,tool torque and horizontal cross-section around the exiting *** is revealed that the modeling results of heat flux density and temperature distribution around the pin,as well as material flow characteristics all change significantly for the two models with different boundary ***,the asymmetrical boundary condition is more capable of predicting temperature fluctuation,plastic material flow along the vertical direction,as well as tunnel defect formation during ***,the superiority of the model with asymmetrical boundary condition over the symmetrical one during the numerical simulation of FSW is elucidated.

关键词： Friction stir welding(FSW) Numerical simulation Heat generation Plastic material flow Asymmetrical boundary condition

Power Efficient Sub-Array in Reconfigurable VLSI Meshes

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Journal of Computer Science & Technology 2005年第5期20卷 647-653页

作者： ji-Gang wu Thambipillai Srikanthan Centre for High Performance Embedded Systems School of Computer Engineering Nanyang Technological University Singapore 639798

Given an m × n mesh-connected VLSI array with some faulty elements, the reconfiguration problem is to find a maximum-sized fault-free sub-array under the row and column rerouting scheme. This problem has already been shown to be NP-complete. In this paper, new techniques are proposed, based on heuristic strategy, to minimize the number of switches required for the power efficient sub-array. Our algorithm shows that notable improvements in the reduction of the number of long interconnects could be realized in linear time and without sacrificing on the size of the sub-array. Simulations based on several random and clustered fault scenarios clearly reveal the superiority of the proposed techniques.

关键词： degradable VLSI mesh reconfiguration heuristic algorithm fault-tolerance NP-complete

Metal@Silica Yolk-Shell Nanostructures as Versatile Bifunctional Nanocatalysts

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Nano Research 2011年第1期4卷 33-49页

作者： ji Chan Park Hyunjoon song Department of Chemistry Korea Advanced Institute of Science and Technology （KAIST） Daejeon 305-701 Republic of Korea

Recent developments in nanochemistry offer precise morphology control of nanomaterials, which has significant impacts in the field of heterogeneous catalysis. Rational design of bifunctional catalysts can influence various aspects of catalytic properties. In this review, a new class of bifunctional catalysts with a metal@silica yolk-shell nanostructure is introduced. This structure has many advantages as a heterogeneous catalyst since it ensures a homogeneous environment around each metal core, and particle sintering is effectively eliminated during high temperature reactions. The catalysts exhibit high activity and recyclability in gas- and solution-phase reactions. It is anticipated that appropriate selection of bifunctional components and optimal structural control will significantly further enhance the catalytic properties, and enable target reaction-oriented development of new catalysts.

关键词： Yolk-shell nanostructure nanocatalyst bifunctionality metal nanoparticles heterogeneous catalytic reactions

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基于图重构和子图挖掘的僵尸网络检测方法

郑州大学学报（工学版） 2025年第1期46卷 34-41页

作者：景永俊吴悔陈旭宋吉飞合肥工业大学计算机与信息学院安徽合肥230601 北方民族大学计算机科学与工程学院宁夏银川750021 国家(中卫)新型互联网交换中心宁夏中卫755000

针对伪装后僵尸网络主机难以检测的问题,提出一种基于图重构和子图挖掘的僵尸网络检测方法(GR-SGM)。首先,将网络数据转化为图数据,并对其进行重构以此增强主机节点特征表示;其次,基于重构图中拓扑结构、节点的特征和位置变化设计僵尸... 详细信息

针对伪装后僵尸网络主机难以检测的问题,提出一种基于图重构和子图挖掘的僵尸网络检测方法(GR-SGM)。首先,将网络数据转化为图数据,并对其进行重构以此增强主机节点特征表示;其次,基于重构图中拓扑结构、节点的特征和位置变化设计僵尸网络子图评分函数,以此捕捉伪装后的特征,提取出僵尸网络子图,并对原始图和重构图进行预检测,以提高检测的准确率和效率,减少重构误差;最后,对预检测结果和僵尸网络子图进行综合评分,以获取完整的僵尸网络信息。在ISCX2014僵尸网络数据集和CICIDS2017僵尸网络数据集上的实验结果表明:GR-SGM的检测准确率分别达到99.98%和99.91%,F 1分别达到99.94%和99.65%,相较于其他僵尸网络检测模型,GR-SGM能更加高效准确地识别僵尸网络节点,同时具有更低的误报率。

关键词：僵尸网络子图挖掘图重构网络安全预检测

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A Free Surface Sharpening Strategy Using Optimization Method

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Journal of Thermal Science 2015年第6期24卷 544-548页

作者： song Hongchao ji Lucheng TU Shuangzhang School of Aerospace Engineering Beijing Institute of Technology Department of Computer Engineering Jackson State University

VOF method which consists in transporting a discontinuous marker variable is widely used to capture the free surface in computational fluid *** is numerical dissipation in simulations involving the transport of the *** dissipation makes the free surface lose its physical nature.A free surface sharpening strategy based on optimization method is presented in the *** strategy can keep the location of the free surface and local mass conservation at both time,and can also keep free surface in a constant *** is independent on the types of solvers and *** famous cases were chosen for verifying the free surface sharpening strategy *** show that the strategy has a very good performance on keeping local mass *** efficiency of prediction of the free surface is improved by applying the *** modeling of flow details such as drops can also be captured by this method.

关键词： VOF free surface sharpening optimization method local mass conservation

Influences of the Texture Characteristic and Interdendritic LPSO Phase Distribution on the Tensile Properties of Mg–Gd–Y–Zn–Zr Sheets Through Hot Rolling

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Acta Metallurgica Sinica(English Letters) 2021年第8期34卷 1051-1064页

作者： Bing Li ji wu Bugang Teng School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China

The Mg–Gd–Y–Zn–Zr alloy sheets with different texture characteristics and distribution of the interdendritic long periodstacking ordered(LPSO) phases were fabricated through altering the final rolling reduction(FRR). The results showed that the texture characteristic was closely related to FRR and affected the tensile properties of the resulted sheets to some extent. The Schmid factor(SF) of the basal 〈a〉 slip improved with further FRR, which was ascribed to that the dynamic recrystallization(DRX) grains expand into the deformed grains with basal texture. However, the improvement of the tensile yield strength(TYS) with further FRR indicates that the strengthening effect from DRX grains surpasses the weakening effect from the elevated SF. The formation of the line-distributed interdendritic 14 H-LPSO phases can also affect the tensile properties of the resulted sheets. The line-distributed interdendritic 14 H-LPSO phases along rolling direction(RD) can act as reinforcing fiber and contribute to the higher TYS along RD and 45° to some extent, which resulted in the higher TYS along 45° compared with that along transverse direction(TD) for each resulted sheet under the circumstance of approximate basal 〈a〉 and pyramid 〈c + a〉 friction stress. Thus, the tensile yield strength is not only related to the texture, but also depends on the grain size and line-distributed interdendritic LPSO phases. The micro-cracks spread perpendicular to the tension direction, and thus, the larger cracks form within the line-distributed 14 H-LPSO phases during tension along TD, which accounts for the lower fracture elongation along TD.

关键词： Final rolling reduction Texture characteristic Interdendritic 14H-LPSO phases distribution Tensile property

Calculation Methods of Added Resistance and Ship Motion Response Based on Potential Flow and Viscous Flow Theory

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China Ocean Engineering 2022年第3期36卷 488-499页

作者： wu Qi-ming ZHANG Bao-ji Shanghai Maritime University College of Ocean Science and EngineeringShanghai 201306China

To improve the energy efficiency of ships and to predict ship motion response under actual sea conditions,the far-field theory,strip theory,and Fujii and Takahashi’s modified semi-empirical method are based and studied to calculate the wave-induced added ***,a new modified formula based on the Maruo method is presented to calculate the radiation added resistance for the ship with a complex ***,some calculation details such as the Green function,the shape of the sections(shape below the still water level or shape below the wave level)in the strip theory,and so on are ***,the CFD method is used to simulate the motions of the hull and the added resistance,and the results of the CFD method and those of other numerical methods are analyzed and compared with the experiment *** modified method in the paper can predict the added resistance in waves for the complex-hull-surface ships well and quickly.

关键词： wave-induced added resistance strip theory computation fluid dynamics motion response