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Altered serotonin metabolism in Takeda G protein-coupled receptor 5 knockout mice protects against diet-induced hepatic fibrosis

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liver Research 2022年第4期6卷 214-226页

作者： Jessica M.Ferrell Matthew Dilts Zachary Stahl Shannon Boehme Sabita Pokhrel Xinwen Wang john y.l.Chiang Department of Integrative Medical Sciences Northeast Ohio Medical UniversityRootstownOHUSA Department of Pharmaceutical Sciences Northeast Ohio Medical UniversityRootstownOHUSA

Background and aims:Diet-induced obesity and metabolic syndrome can trigger the progression of fatty liver disease to non-alcoholic steatohepatitis and fibrosis,which is a major public health *** acids regulate metabolic homeostasis and inflammation in the liver and gut via the activation of nuclear farnesoid X receptor(Fxr)and the membrane receptor Takeda G protein-coupled receptor 5(Tgr5).Tgr5 is highly expressed in the gut and skeletal muscle,and in cholangiocytes and Kupffer cells of the ***5 is implicated in the mediation of liver and gut inflammation,as well as the maintenance of energy ***,we used a high fat,high fructose,and high sucrose(HFS)diet to determine how bile acid signaling through Tgr5 may regulate metabolism during the progression from fatty liver to non-alcoholic steatohepatitis and *** and methods:Female C57Bl/6J control wild type(WT)and Tgr5 knockout(Tgr5^(-/-))mice were fed HFS(high fat(40%kcal),high fructose,and 20%sucrose water)diet for 20 *** phe-notypes were characterized through examination of bile acid synthesis pathways,lipid and cholesterol metabolism pathways,and fibrosis and inflammation ***:Tgr5^(-/-)mice were more glucose intolerant when fed HFS diet,despite gaining the same amount of weight as WT ***5^(-/-)mice accumulated significantly more hepatic cholesterol and triglycerides on HFS diet compared to WT mice,and gene expression of lipogenic genes was significantly *** cholesterol 7alpha-hydroxylase(Cyp7a1)gene expression was consistently elevated in Tgr5^(-/-)mice,while oxysterol 7alpha-hydroxylase(Cyp7b1),sterol 27-hydroxylase(Cyp27a1),Fxr,and small heterodimer partner(Shp)were downregulated by HFS ***,hepatic inflammation and fibrosis were also significantly reduced in Tgr5^(-/-)mice fed HFS diet,which may be due to altered se-rotonin signaling in the ***:Tgr5^(-/-)mice may be protected from high fat,high sugar-

关键词： Non-alcoholic fatty liver disease(NAFlD) liver fibrosis Takeda G protein-coupled receptor 5(TGR5) Serotonin(5-HT) High fat,high fructose,and high sucrose (HFS)

Analytical Mechanics Of Space Systems

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Momentum Transport in DIII-D Discharges with and Without Magnetohydrodynamics （MHD） Activity

丛书名： AIAA Education Series

2003年

作者： Hanspeter Schaub john l. Junkins

ISBN: (数字)9781600861550

ISBN: (纸本)9781563475634

This book provides a comprehensive treatment of dynamics of space systems starting with the basic fundamentals. This single source contains topics ranging from basic kinematics and dynamics to more advanced celestial mechanics; yet all material is presented in a consistent manner. The reader is guided through the various derivations and proofs in a tutorial way. The use of "cookbook" formulas is avoided. Instead, the reader is led to understand the underlying principle of the involved equations and shown how to apply them to various dynamical *** book is divided into two parts. Part I covers analytical treatment of topics such as basic dynamic principles up to advanced energy concept. Special attention is paid to the use of rotating reference frames that often occur in aerospace systems. Part II covers basic celestial mechanics treating the two-body problem, restricted three-body problem, gravity field modeling, perturbation methods, spacecraft formation flying, and orbit transfers.A Matlab® kinematics toolbox provides routines which are developed in the rigid body kinematics chapter. A solutions manual is also available for professors. Matlab® is a registered trademark of The MathWorks, Inc.

关键词： Differentiable dynamical systems.

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Plasma Science and Technology 2009年第1期11卷 127-130页

作者：任启龙 M. S. CHU l. l. lAO H. St. john R. lAHAyE y. M. JEON 张澄周登李国强 J. M. PARK J. S. DEGRASSIE Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China General Atomics San Diego CA USA Oak Ridge Institute for Science and Education Oak Ridge TN USA Oak Ridge National laboratory Oak Ridge TN USA

Two phases of a DIII-D discharge with and without magnetohydrodynamics （MHD） activity are analysed using ONETWO code. The toroidal momentum flux is extracted from experimental data and compared with the predictions by neoclassical theory, Gyro-landau fluid transport model （GlF23） and Multi-Mode model （MMM95）. It is found that without MHD activities GlF23 and MMM95 provide a reasonable description while with MHD activity no model alone can fully describe the experimental momentum flux. For the phase with MHD activity a simple model of resonant magnetic drag is tested and it cannot fully explain the plasma slowing down observed in experiment.

关键词： toroidal rotation MHD activity magnetic drag

The Soft X-ray Imager(SXI)on the SMIlE Mission

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Earth and Planetary Physics 2024年第1期8卷 5-14页

作者： S.Sembay A.l.Alme D.Agnolon T.Arnold A.Beardmore A.Belén Balado Margeli C.Bicknell C.Bouldin G.Branduardi-Raymont T.Crawford J.P.Breuer T.Buggey G.Butcher R.Canchal J.A.Carter A.Cheney y.Collado-Vega H.Connor T.Crawford N.Eaton C.Feldman C.Forsyth T.Frantzen G.Galgóczi J.Garcia G.y.Genov C.Gordillo H-P.Gröbelbauer M.Guedel y.Guo M.Hailey D.Hall R.Hampson J.Hasiba O.Hetherington A.Holland S-y.Hsieh M.W.J.Hubbard H.Jeszenszky M.Jones T.Kennedy K.Koch-Mehrin S.Kögl S.Krucker K.D.Kuntz C.lakin G.laky O.lylund A.Martindale J.Miguel Mas Hesse R.Nakamura K.Oksavik N.Østgaard H.Ottacher R.Ottensamer C.Pagani S.Parsons P.Patel J.Pearson G.Peikert F.S.Porter T.Pouliantis B.H.Qureshi W.Raab G.Randal A.M.Read N.M.M.Roque M.E.Rostad C.Runciman S.Sachdev A.Samsonov M.Soman D.Sibeck S.Smit J.Søndergaard R.Speight S.Stavland M.Steller TianRan Sun J.Thornhill W.Thomas K.Ullaland B.Walsh D.Walton C.Wang S.yang School of Physics and Astronomy University of LeicesterLeicesterLE17RHUK Space Park leicester University of LeicesterLeicesterLE17RHUK Mullard Space Science laboratory University College LondonDorkingRH56NTUK Centre for Electronic Imaging Open UniversityMilton KeynesMK76 AAUK Birkeland Centre for Space Science Department of Physics and TechnologyUniv.of BergenN-5007 BergenNorway University of Vienna A-1010 ViennaAustria Space Research Institute Austrian Academy of SciencesA-8042 GrazAustria National Institute of Aerospace Technology MadridSpain ESTEC European Space Agency2201 AZ NoordwijkNetherlands State Key laboratory of Space Weather National Space Science CentreBeijing 100190China University of Applied Sciences and Arts Northwestern Switzerland CH-5210 WindischSwitzerland Koegl Space GmbH CH-8157 DielsdorfSwitzerland Space Acoustics GmbH CH-8157 DielsdorfSwitzerland Zurich University of Applied Sciences 8400 WinterhurSwitzerland Genov Solutions N-5172 LoddefjordNorway STM Engineering N-5165 LaksevagNorway john Hopkins University Applied Physics laboratory MD 20723USA NASA/Goddard Space Flight Centre MD 20771USA Center for Space Physics Boston UniversityBostonMA 02215USA Department of Theoretical Physics and Astrophysics Masaryk University60177 BrnoCzech Republic Institute of Physics E¨otvo¨s Lor´and University1053 BudapestHungary Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100045China Centro de Astrobiologia(CAB) CSIC-INTAMadridSpain

The Soft X-ray Imager(SXI)is part of the scientific payload of the Solar wind Magnetosphere Ionosphere link Explorer(SMIlE)*** is a joint science mission between the European Space Agency(ESA)and the Chinese Academy of Sciences(CAS)and is due for launch in *** is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the SMIlE *** is sensitive to the soft X-rays produced by the Solar Wind Charge eXchange(SWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s *** provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field *** sensitivity of the SXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of SMIlE will enable such movements to be tracked for segments lasting many *** is led by the University of leicester in the United Kingdom(UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United States.

关键词： Soft X-ray Imaging micropore optics large area CCD

基于GIS的农业面源硝酸盐地下水污染动态风险评价(英文)

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吉林大学学报（地球科学版） 2007年第2期37卷 311-318页

作者：杨悦所 Wang john l 卡迪夫大学地球科学学院

地下水中的硝酸盐污染具有全球性,这不仅是一个环境问题,也是一个经济和人类健康问题。DRASTIC方法可以进行地下水污染的脆弱性评价,但是却没有涵盖风险的概念,也忽视了污染物随地表水流运动的动态特性。因此,所得结果可能有碍于“欧洲... 详细信息

地下水中的硝酸盐污染具有全球性,这不仅是一个环境问题,也是一个经济和人类健康问题。DRASTIC方法可以进行地下水污染的脆弱性评价,但是却没有涵盖风险的概念,也忽视了污染物随地表水流运动的动态特性。因此,所得结果可能有碍于“欧洲水管理框架指南”在地下水水质管理中的执行。笔者基于DRASTIC方法开发了一个动态风险评价方法,并将其运用于英国北爱尔兰Upper Bann流域中的一个小流域。研究区地下水硝酸盐污染风险评价结果表明,此方法将有效地帮助决策者在流域范围内开展农业面源地下水污染预防措施。“非常高风险”和“高风险”区分别占研究区面积的5.1%和10.5%。此结果可帮助当地政府针对流域内这些“非常高风险”和“高风险”区的特点制订地下水质保护政策。此方法同样适用于任何面源可溶性污染物的地下水污染动态风险评价。

关键词：地下水污染风险评价 DRASTIC 脆弱性面源污染 GIS

Association between axial length and toric intraocular lens rotation according to an online toric back-calculator

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 420-425页

作者： Jennifer l.Patnaik Malik y.Kahook john P.Berdahl David R.Hardten Brandie D.Wagner leonard K.Seibold Brent A.Kramer Department of Ophthalmology University of Colorado School of MedicineAuroraColorado 80045USA Vance Thompson Vision Sioux FallsSouth Dakota 57108USA Minnesota Eye Consultants MinneapolisMinnesota 55404USA Department of Biostatistics Colorado School of Public HealthAuroraColorado 80045USA Department of Ophthalmology University of North CarolinaChapel HillNorth Carolina 27517USA

AIM: To assess the relationship between axial length(Al) and intraocular lens(IOl) rotation among eyes receiving a toric IOl and subsequently entered into an online toric back-calculator ***: Retrospective analysis of data collected online via ***, a freely available online toric back-calculator where surgeons enter pre-and postoperative information to help manage residual postoperative *** records were deemed valid with entry of Al and IOl orientation between January 2017 and March *** was determined by a difference of ≥5° between pre-operative intended IOl orientation and actual post-operative IOl *** and magnitude of rotation are presented with means and associated standard deviation(SD).linear regression models of this association are ***: Records of 6752 eyes were included in the analysis, of which 74.8% were determined to have a rotated *** magnitude of rotation increased with each millimeter(mm) increase in Al with a mean rotation of 13.3°(SD: 12.8°) for eyes with Al 20-20.9 mm and a maximum mean rotation of 30.6°(SD: 30.3°) among eyes with Al 29-29.9 *** linear modeling demonstrated a significant association(Plysis from an online database indicates that toric IOls inserted into eyes with longer Al are more likely to rotate and to rotate more degrees from the target *** findings from this study are clinically relevant for surgeons implanting toric IOls.

关键词： cataract surgery toric lens axial length rotation

Seismic considerations for spent nuclear fuel storage in dry casks

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Engineering Sciences 2013年第3期11卷 20-30页

作者： john l Bignell Jeffrey A Smith Christopher A Jones Susan y Pickering Sandia National laboratories Albuquerque

To aid the United States Nuclear Regulatory Commission,Sandia National laboratories (SNl) was contracted to investigate the seismic behavior of typical dry cask storage systems. Parametric evaluations characterized the sensitivity of calculated cask response characteristics to input parameters. The parametric evaluation investigated two generic cask designs (cylindrical and rectangular),three different foundation types (soft soil,hard soil,and rock),and three different casks to pad coefficients of friction (0.2,0.55,0.8) for earthquakes with peak ground accelerations of 0.25g,0.6g,1.0g and 1.25g. A total of 1 165 analyses were completed,with regression analyses being performed on the resulting cask response data to determine relationships relating the mean (16 % and 84 % confidence intervals on the mean) to peak ground acceleration,peak ground velocity,and pseudo-spectral acceleration at 1 Hz and 5 % damping. In general,the cylindrical casks experienced significantly larger responses in comparison to the rectangular cask. The cylindrical cask experienced larger top of cask displacements,larger cask rotations (rocking),and more occurrences of cask toppling (the rectangular cask never toppled over). The cylindrical cask was also susceptible to rolling once rocking had been initiated,a behavior not observed in the rectangular cask. Cask response was not overly sensitive to foundation type,but was significantly dependent on the response spectrum employed.

关键词： dry cask storage spent nuclear fuel seismic analysis

Dual histologic variants of schwannomas in orbital schwannomatosis

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1563-1565页

作者： Gary john V.Mercado leandro Victor l.Arcena Elaine yatco-Omańa Elizabeth y.Arcellana-Nuqui Roland Joseph D.Tan The Medical City Eye and Vision Institute Pasig 1600Philipines Department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philppines College of Medicine University of the Philippines ManilaManila 1000Philippines

Dear Editor,We present an extremely rare case of orbital schwannomatosis with dual histologic *** are tumors resulting from the slow proliferation of Schwann cells located in peripheral nerve sheaths[1].They are commo... 详细信息

关键词： orbital sch patients

Surgical outcomes and quality of life following exercise-based prehabilitation for hepato-pancreatico-biliary surgery:A systematic review and meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2022年第3期21卷 207-217页

作者： Andy Deprato Kevin Verhoeff Kieran Purich Janice y Kung David l Bigam Khaled Z Dajani University of Alberta 116 St&85 AveEdmontonAlberta T6G 2R3Canada Department of Surgery University of Alberta Hospital8440112 Street NWEdmontonAlberta T6G 2B7Canada john W.Scott Health Sciences library University of Alberta Hospital8440112 Street NWEdmontonAlberta T6G 2B7Canada Department of Surgery Division of General SurgeryHPB Transplant and OncologyUniversity of Alberta Hospital8440112 Street NWEdmontonAlberta T6G 2B7Canada

Background:Hepato-pancreatico-biliary(HPB)patients experience significant risk of preoperative *** assessing preventative prehabilitation in HPB populations are *** systematic review and meta-analysis evaluates outcomes for HPB patients treated with exercise *** sources:A comprehensive search of MEDlINE(via Ovid),Embase(Ovid),Scopus,Web of Science Core Collection,Cochrane library(Wiley),Pro Quest Dissertations,Theses Global,and Google Scholar was conducted with review and extraction following PRISMA *** studies evaluated more than 5 adult HPB patients undergoing≥7-day exercise *** primary outcome was postoperative length of stay(lOS);secondary outcomes included complications,mortality,physical performance,and quality of ***:We evaluated 1778 titles and abstracts and selected 6(randomized controlled trial,n=3;prospective cohort,n=1;retrospective cohort,n=2)that included 957 *** those,536 patients(56.0%)underwent exercise prehabilitation and 421(44.0%)received standard *** in both groups were similar with regards to important demographic *** was associated with a 5.20-day lOS reduction(P=0.03);when outliers were removed,lOS reduction decreased to 1.85 days and was non-statistically significant(P=0.34).Postoperative complications(OR=0.70;95%CI:0.39 to 1.26;P=0.23),major complications(OR=0.83;95%CI:0.60 to 1.14;P=0.24),and mortality(OR=0.67;95%CI:0.17 to 2.70;P=0.57)were *** was associated with improved strength,cardiopulmonary function,quality of life,and alleviated ***:Exercise prehabilitation may reduce lOS and morbidity following HPB *** with well-defined exercise regimens are needed to optimize exercise prehabilitation outcomes.

关键词： Exercise-based prehabilitation Preoperative exercise Hepatobiliary Pancreaticoduodenectomy Hepatic resection Pancreatectomy