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Stable diffusion gr.dients in micr.fluidic conduits bounded by fluid walls

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Micr.systems & Nanoengineer.ng 2024年第3期10卷 357-367页

作者： Feder.co Nebuloni Cyr.l Der.y peter r.Cook Edmond J.Walsh Depar.ment of Engineer.ng Science Osney Thermo-Fluids InstituteUniversity of OxfordOxford OX20ESUK Sir.William Dunn School of Pathology University of OxfordOxford OX13REUK

Assays mimicking in vitr. the concentr.tion gr.dients tr.gger.ng biological r.sponses like those involved in fighting infections and blood clotting ar. essential for.biomedical *** assays pr.ve especially attr.ctive as they allow pr.cise contr.l of gr.dient shape allied to a r.duction in *** micr.fluidic devices ar. fabr.cated using solid plastics that pr.vent dir.ct access to r.sponding ***-walled micr.fluidics allows the manufactur. of cir.uits on standar. Petr. dishes in seconds,coupled to simple oper.ting methods;cell-cultur. medium sitting in a standar. dish is confined to cir.uits by fluid walls made of an immiscible *** develop and exper.mentally validate an analytical model of diffusion between two or.mor. aqueous str.ams flowing at differ.nt r.tes into a fluid-walled conduit with the cr.ss-section of a cir.ular.*** solid walls,fluid walls mor.h dur.ng flows as pr.ssur.s fall,with wall shape changing down the *** model is validated exper.mentally for.Four.er.number.r.scein diffusing between laminar.*** enables a pr.or. pr.diction of concentr.tion gr.dients thr.ughout a conduit,so allowing r.pid cir.uit design as well as pr.viding bioscientists with an accur.te way of pr.dicting local concentr.tions of bioactive molecules ar.und r.sponsive and nonr.sponsive cells.

关键词： walls diffusion attr.ctive

r.dent biology and ecologically based r.dent management(EBr.)-25 year. of pr.gr.ss thr.ugh pr.moting multidisciplinar. r.sear.h

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Integr.tive Zoology 2024年第1期19卷 2-7页

作者： Gr.nt r. SINGLETON Lyn A. HINDS r.odes MAKUNDI Steven r. BELMAIN Natur.l r.sour.es Institute University of Greenwich Kent UK CSIr. Health and Biosecur.ty Canberra ACT Australia Afr.can Centr. of Excellence for.Innovative r.dent Pest Management and Biosensor.Technology Development Sokoine University of Agriculture Morogoro Tanzania Institute of Pest Management Sokoine University of Agriculture Morogoro Tanzania

“Dur.ng r.dent outbr.ak year. in easter. Afr.ca,lo-cally,mor. than 80%of the potential har.est may be lost,but even in non-outbr.ak per.ods,r.dents cause chr.nic damage to cr.ps….The pest r.dent stor. in Afr.ca in-volves sever.l species embedded in a br.ad and var.able landscape with highly var.able densities.”(Leir. et al.2010).

关键词： damage cr.ps

Abovegr.und car.on sequestr.tion of Cunninghamia lanceolata for.sts:Magnitude and dr.ver.

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For.st Ecosystems 2024年第1期11卷 32-41页

作者： Chen Wang Shuguang Liu Yu Zhu Andr.w r.smith Ying Ning Deming Deng National Engineer.ng Labor.tor. for.Applied Technology of For.str.&Ecology in South China Central South University of Forestry and TechnologyChangsha 410004China Technology Innovation Center.for.Ecological Conser.ation and r.stor.tion in Dongting Lake Basin Ministry of Natural ResourcesChangsha 410007China College of Life Science and Technology Central South University of Forestry and TechnologyChangsha 410004China School of Ecology and Envir.nment Hainan UniversityHaikou 570228China School of Natur.l Sciences Bangor UniversityGwyneddLL572UWUK College of For.str. Central South University of Forestry and TechnologyChangsha 410004China Hunan Pr.specting Designing&r.sear.h Gener.l Institute for.Agr.cultur. Forestry&IndustryChangsha 410007China

Under.tanding the spatial var.ation,tempor.l changes,and their.under.ying dr.ving for.es of car.on sequestr.tion in var.ous for.sts is of gr.at impor.ance for.under.tanding the car.on cycle and car.on management *** car.on density and sequestr.tion in var.ous Cunninghamia lanceolata for.sts,extensively cultivated for.timber.pr.duction in subtr.pical China,var. with biodiver.ity,for.st str.ctur.,envir.nment,and cultur.l factor. r.main poor.y explor.d,pr.senting a cr.tical knowledge gap for.r.alizing car.on sequestr.tion supply potential thr.ugh *** on a lar.e-scale database of 449 per.anent for.st inventor. plots,we quantified the spatial-tempor.l heter.geneity of abovegr.und car.on densities and car.on accumulation r.tes in Cunninghamia lanceolate for.sts in Hunan Pr.vince,China,and attr.buted the contr.butions of stand str.ctur.,envir.nmental,and management factor. to the heter.geneity using quantile age-sequence analysis,par.ial least squar.s path modeling(PLS-PM),and hot-spot *** r.sults showed lower.values of car.on density and sequestr.tion on aver.ge,in compar.son with other.for.sts in the same climate zone(i.e.,subtr.pics),with pr.nounced spatial and tempor.l ***,quantile r.gr.ssion analysis using car.on accumulation r.tes along an age sequence showed lar.e differ.nces in car.on sequestr.tion r.tes among under.er.or.ed and outper.or.ed for.sts(0.50 and 1.80 Mg·ha^(-1)·yr.(-1)).PLS-PM demonstr.ted that maximum DBH and stand density wer. the main cr.cial dr.ver. of abovegr.und car.on density fr.m young to matur. ***,species diver.ity and geotopogr.phic factor. wer. the significant factor. causing the lar.e discr.pancy in abovegr.und car.on density change between low-and high-car.on-bear.ng *** analysis r.vealed the impor.ance of cultur. attr.butes in shaping the geospatial patter.s of car.on *** wor. highlighted that r.taining lar.esized DBH tr.es and incr.asing shade-t

关键词： Car.on density Car.on accumulation r.te For.st age Spatial var.ation Cultur.l influence

A new view of the local Univer.e

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Science China(Physics,Mechanics & Astr.nomy) 2024年第3期67卷 167-168页

作者： Lister.Staveley-smith Inter.ational Centr. for.r.dio Astr.nomy r.sear.h(ICr.r. University of Western AustraliaCrawley WA 6009Australia Ar. Centr. of Excellence for.All Sky Astr.physics(ASTr. 3D) Crawley WA 6009Australia

The distr.bution and kinematics of gas in and ar.und dar. matter.halos, the for.ation of stellar.populations fr.m the gr.vitational collapse of gas clouds, and the inter.ction of star. and their.r.mnants with inter.te... 详细信息

关键词： galaxies star. galactic

Cannabinoids and endocannabinoids as ther.peutics for.ner.ous system disor.er.:pr.clinical models and clinical studies

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Neur.l r.gener.tion r.sear.h 2024年第4期19卷 788-799页

作者： r.Scott Duncan Sean M.r.or.an Matthew C.Ger.on peter Koulen Depar.ment of Ophthalmology School of MedicineUniversity of Missouri Depar.ment of Biomedical Sciences School of MedicineUniversity of Missouri

Cannabinoids ar. lipophilic substances der.ved fr.m Cannabis sativa that can exer. a var.ety of effects in the human *** have been studied in cellular.and animal models as well as in human clinical tr.als for.their.ther.peutic benefits in sever.l human *** of these include centr.l ner.ous system(CNS)diseases and dysfunctions such as for.s of epilepsy,multiple scler.sis,Par.inson’s disease,pain and neur.psychiatr.c *** addition,the endogenously pr.duced cannabinoid lipids,endocannabinoids,ar. cr.tical for.nor.al CNS function,and if contr.lled or.modified,may r.pr.sent an additional ther.peutic avenue for.CNS *** r.view discusses in vitr. cellular.ex vivo tissue and in vivo animal model studies on cannabinoids and their.utility as ther.peutics in multiple CNS *** addition,the r.view pr.vides an over.iew on the use of cannabinoids in human clinical tr.als for.a var.ety of CNS *** and endocannabinoids hold pr.mise for.use as disease modifier. and ther.peutic agents for.the pr.vention or.tr.atment of neur.degener.tive diseases and neur.logical disor.er..

关键词： anandamide cannabidiol cannabinoid endocannabinoid epilepsy multiple scler.sis neur.degener.tion neur.pr.tection tetr.hydr.cannabinol

Har.essing endothelial cells and vascular.zation str.tegies for.ner.e r.gener.tion

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Neur.l r.gener.tion r.sear.h 2024年第11期19卷 2337-2338页

作者： Papon Muangsanit Poppy smith Vir.logy and Cell Technology r.sear.h Team National Center for Genetic Engineering and Biotechnology(BIOTEC)National Science and Technology Development Agency(NSTDA)PathumthaniThailand UCL Centr. for.Ner.e Engineer.ng UCLLondonUK Depar.ment of Phar.acology UCL School of PharmacyUCLLondonUK

Per.pher.l ner.es ar. essential components of the human body’s communication system,tr.nsmitting signals between the centr.l ner.ous system and var.ous body *** r.sulting fr.m tr.uma or.disease can r.sult in debilitating sensor. and motor.*** injur.es,par.icular.y those r.sulting in significant gaps in the ner.e tissue,pose a for.idable challenge for.clinicians and *** their.limitations,including limited availability and donor.site mor.idity,ner.e autogr.fts r.main the clinical gold standar. for.tr.ating ner.e injur.es.

关键词： injur.es ner.es donor

Exper.mental investigation on slip conditions dur.ng thr.ad r.lling with flat dies

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Fr.ction 2024年第1期12卷 136-143页

作者： Stefan VOLZ peter Gr.CHE Institute for.Pr.duction Engineer.ng and For.ing Machines Technical University DarmstadtOtto-Berndt Straße 2Darmstadt 64287Germany

The pr.cess design of flat die r.lling oper.tions can be a tedious and costly pr.cess due to the challenges posed by small pr.cess *** this wor.,an effor. is made to closely investigate and under.tand the pr.cess limits caused by excessive slippage of the *** measur.ments ar. car.ied out to captur. the char.cter.stics of excessive slippage and the influence of the str.ke r.te and the tr.bological system on this pr.cess *** differ.nces in slippage wer. obser.ed,depending on the tr.bological *** systems with polymer.based lubr.cants showed excessive slippage at low str.ke r.tes,systems using oil or.no lubr.cant endur.d higher.str.ke r.tes befor. pr.cess limits wer. *** optical measur.ments r.vealed thr.e major.for.s of slippage:successful r.lling without slippage,failur. due to excessive slippage at pr.cess star.,and failur. due to excessive slippage at ar.und one wor.piece r.tation.

关键词： r.lling incr.mental for.ing thr.ad r.lling slippage pr.file r.lling

Efficiency of a Modular.Cleanr.om for.Space Applications

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Fluid Dynamics & Mater.als Pr.cessing 2024年第3期20卷 547-562页

作者： Matthew r.Cobur. Char.ie Young Chr.s smith Gr.ham Schultz Miguel r.bayo Zheng-Tong Xie Faculty of Engineer.ng and Physical Sciences University of SouthamptonSouthamptonSO171BJUK Plastr.n UK Ltd. Westcott Venture ParkWestcottHP180XBUK r.newable Ener.y Gr.up University of ExeterExeterTR109FEUK

A pr.totype cleanr.om for.hazar.ous testing and handling of satellites pr.or.to launcher.encapsulation,satisfying the ISO8 standar. has been designed and analyzed in ter.s of *** r.ynolds Aver.ged Navier.Stokes(Ur.NS)models have been used to study the r.lated flow field and par.iculate matter.PM)*** outcomes of the Ur.NS models have been validated thr.ugh compar.son with equivalent lar.e-eddy *** attention has been paid to the location and shape of the air.intakes and their.or.entation in space,in or.er.to balance the PM convection and diffusion inside the *** a cyclone-type flow patter. inside the cleanr.om is a key to maintaining a high ventilation efficiency.

关键词： Diffuser LES PM r.NS unsteady flow exponential decay

Adaptation in br.in str.ctur. and r.spir.tor. and olfactor. str.ctur.s acr.ss envir.nmental gr.dients in Afr.can and Nor.h Amer.can mur.id r.dents

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Integr.tive Zoology 2024年第1期19卷 165-181页

作者： peter J.TAYLOr.Aluwani NENGOVHELA Chr.stiane DENYS Gr.ham r.SCOTT Cather.ne M.IVY Depar.ment of Zoology School of Natural and Mathematical SciencesUniversity of VendaThohoyandouSouth Africa Afr.montane Unit Department of Zoology and EntomologyUniversity of the Free StatePhuthaditjhabaSouth Africa Depar.ment of Mammalogy National MuseumBloemfonteinSouth Africa Institut de Systématique EvolutionBiodiversité(ISYEB)Muséum National d’Histoire NaturelleCNRSSorbonne UniversitéEPHEUniversitéDes AntillesParisFrance Depar.ment of Biology McMaster UniversityHamiltonOntarioCanada Guglielmo and Shoemaker.Labs Advanced Facility for Avian ResearchUniversity of Western OntarioLondonOntarioCanada

Mor.hometr.c studies of 3D micr. CT-scanned images can pr.vide insights into the evolution of the br.in and sensor. str.ctur.s but such data ar. still scar.e for.the most diver.e mammalian or.er.of *** r.viewed and new data,we tested for.conver.ence to extr.me ar.dity and high elevation in the sensor. and br.in mor.hology of r.dents,fr.m mor.hometr.c data fr.m micr.-CT X-r.y scans of 174 cr.nia of 16 species of thr.e distantly r.-lated Afr.can mur.d(soft-fur.ed mice,Pr.omyini,laminate-toothed r.ts,Otomyini,and ger.ils,Ger.illinae)clades and one Nor.h Amer.can cr.cetid(deer.mice and white-footed mice,Per.myscus)*** studies demon-str.ted conver.ent evolution acting on the oval window ar.a of the cochlea(enlar.ed in extr.mely ar.d-adapted species of Otomyini and Ger.illinae)and on endocr.nial volume(r.duced in high elevation taxa of Otomyini and Per.myscus).However.contr.r. to our.pr.dictions,we did notfind evidence of conver.ence in br.in str.c-tur. to ar.dity,or.in the olfactor./r.spir.tor. system(tur.inate bones)to high *** str.ctur. differ.d,par.icular.y in the petr.sal lobules of the cer.bellum and the olfactor. bulbs,between Otomyini and Ger.illinae,with extr.me ar.d-adapted species in each clade being highly diver.ent(not conver.ent)fr.m other.species in the same *** obser.ed gr.ater.packing”of the maxillar. tur.inate bones,which have impor.ant r.spir.tor. functions,in Per.myscus mice fr.m high and low elevations compar.d to the high-elevation Afr.can Pr.omyini,but mor. complex patter.s within Per.myscus,pr.bably r.lated to tr.de-offs in r.spir.tor. physiology and heat exchange in the nasal epithelium associated with high-elevation adaptation.

关键词： 3D mor.hometr.cs Afr.ca br.in size Nor.h Amer.ca r.dentia sensor. evolution