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A review on re-emerging bacteriophage therapy in the era of XDR

生物细胞(英文) 2023年第9期47卷 1915-1930页

作者： POOJA BHADORIYA RICHA SHARMA REKHA MEHROTRA simran kaur ISHA SRIVASTAVA MUKUL JAIN PRASHANT KAUSHIK Department of Microbiology Shaheed Rajguru College of Applied Sciences for WomenUniversity of DelhiVasundhara EnclaveNew Delhi110096India Lab-209 Cell&Developmental biology labCenter of Research for DevelopmentParul UniversityVadodara391760GujaratIndia Instituto de Conservacióny Mejora de la Agrodiversidad Valenciana Universitat Politècnica de ValènciaValencia46022Spain

In the present medicine world antibiotic resistance is one of the key threats to universal health *** continue to work hard to combat this global health *** therapy,an age-old practice during the early twentieth century,was outshined by the discovery of *** the advent of widespread antibiotic resistance,phage therapy has again redeemed itself as a potential alternative owing to its adeptness to target bacteria *** side effects,the ability to migrate to different body organs,a distinct mode of action,and proliferation at the infection site,make phages a profitable candidate to replace conventional *** progressive outcome of numerous in vitro studies and case reports has validated the clinical efficacy of phage *** bright perspective of using phages to treat bacterial infections has fueled enormous medical research to exploit their potential as *** gaps in the information about phages and the lack of consent for clinical trials is major hurdle for consideration of phage *** phage therapy as a reality in medicine requires a coordinated effort from different *** this review,we aim to emphasize the importance of phage therapy in modern *** review explains their historical journey,basic phage biology,cross-talk with the host immunity,obstacles with phage therapy,and their possible *** data on the various significant clinical trials of phage therapy has been *** evaluated the efficacy of antibiotics and phage therapy in part and in combination,along with recent progress and future perspectives of phage therapy.

关键词： Bacteriophages Antibiotic resistance Phage biology Phage therapy Phage therapy clinical trials Phage therapy in India

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Viscous cosmology in holographic dark energy with Granda–Oliveros cut-off

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Communications in Theoretical Physics 2023年第2期75卷 144-156页

作者： simran kaur C P Singh Department of Applied Mathematics Delhi Technological UniversityBawana RoadDelhi-110042India

We study the effect of bulk viscosity on holographic dark energy(HDE)with Granda–Oliveros infra-red *** focus on a generalized form of the bulk viscous coefficient which successfully describes the present-day evolution of the *** observe that the model with bulk viscosity provides an elegant description of the early and late-time evolution of the *** constrain the model through the combined observational data of the Strong Lensing System(SLS),measurements of Hubble parameter,Type Ia supernova data of Pantheon sample and local H_(0)measured by *** best-fit values obtained from two different combinations of data,we estimate the present value of Hubble’s constant H_(0)=71.567-0.848+1.448and H_(0)=69.197-1.924+1.563,the deceleration parameter q_(0)=-0.535-0.016+0.016and q_(0)=-0.536-0.016+0.016,and the equation of state w_(0)=-0.690-0.010+0.010and w_(0)=-0.691-0.011+0.011,*** HDE model with bulk viscosity exhibits the phase transition from decelerated epoch to accelerated epoch.A comparison of the model with the standardΛCDM model is discussed with the statefinder and cosmographic parameters.

关键词： viscosity holographic dark energy cosmology

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Data mining-based algorithm for assortment planning

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Journal of Management Analytics 2020年第3期7卷 443-457页

作者： Praveen Ranjan Srivastava Satyendra Sharma simran kaur Information Technology Indian Institute of Management(IIM)RohatakRohtakIndia Operation and Supply Chain Birla Institute of Technology and Science(BITS)PilaniPilaniRajasthanIndia Computer Science Birla Institute of Technology and Science(BITS)PilaniPilaniRajasthanIndia

With increasing varieties and products,management of limited shelf space becomes quite difficult for ***,an efficient product assortment,which in turn helps to plan the organization of various products across limited shelf space,is extremely important for *** can be distinguished based on quality,price,brand,and other attributes,and decision needs to be made about an assortment of the products based on these *** efficient assortment planning improves the financial performance of the retailer by increasing profits and reducing operational *** techniques can be very effective in grouping products,stores,*** help managers solve the problem of assortment *** paper proposes data mining approaches for assortment planning for profit maximization with space,and cost constraints by mapping it into well-known knapsack problem.

关键词： Retail assortment SKU rationalization data mining

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Study on Snake Venom Protein-Antibody Interaction by Surface Plasmon Resonance Spectroscopy

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Photonic Sensors 2018年第3期8卷 193-202页

作者： Subhankar N. CHOUDHURY Barlina KONWAR simran kaur Robin DOLEY Biplob MONDAL Department of Electronics and Communication Engineering Tezpur University Tezpur 784028 Assam India Deptment of Molecular Biology and Biotechnology Tezpur University Tezpur 784028 Assam India

The development of a portable and inexpensive surface plasmon resonance （SPR） measurement device with the integrated biosensor for the detection of snake venom protein is presented in this paper. For the construction of the sensing element, amine coupling chemistry is used to bio-functionalize silver coated glass slide with antibodies like immunoglobulin （IgG）. The immobilization of the antibody is confirmed by spectroscopic measurements like ultraviolet-visible spectroscopy （UV-Vis） and Fourier-transforms infrared spectroscopy （FTIR）. The device is calibrated with the standard solution of sodium chloride and ethanol before testing venom protein samples. To investigate the bio-molecular interactions, crude venom of Indian cobra （concentration range： 0.1 mg/ml - 1.0mg/ml） in the phosphate buffer solution （PBS） are exposed to the biosensor. The experimentally measured data indicate the shift in the plasmon resonance angle from its initial value （52°） to 54° for 0.1 mg/ml and 60° for 1.0mg/ml protein solution.

关键词： Surface plasmon resonance biosensor venom protein

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Stem cell therapy: A paradigm shift in breast cancer treatment

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World Journal of Stem Cells 2021年第7期13卷 841-860页

作者： Sabiha Khan Moushumi Suryavanshi Jasamrit kaur Debadatta Nayak Anil Khurana Raj Kumar Manchanda Chanderdeep Tandon simran Tandon Amity Institute of Molecular Medicine and Stem Cell Research Amity UniversityNoida 201313Uttar PradeshIndia Department of Pathology Rajiv Gandhi Cancer Institute and Research CentreNew Delhi 110085India Department of Chemistry Goswami Ganesh Dutta Sanatan Dharma CollegeChandigarh 160030India Central Council for Research in Homeopathy New Delhi 110058India Department of AYUSH Karol BaghNew Delhi 110011India Amity Institute of Biotechnology Amity UniversityNoida 201313Uttar PradeshIndia

As per the latest Globocan statistics,the high prevalence rate of breast cancer in low-and middle-income countries has led to it becoming the most common cancer to be diagnosed,hence posing a major public health *** per this data,more than 11.7%of the estimated new cancer cases in 2020 were due to breast cancer.A small but significant subpopulation of cells with self-renewing ability are present in the tumor stroma and have been given the nomenclature of cancer stem cells(CSCs).These cells display a high degree of plasticity owing to their ability to transition from the slowly cycling quiescent phase to the actively proliferating *** attribute of CSCs allows them to differentiate into various cell types having diverse *** CSCs have a pivotal role in development,metastasis,treatment resistance and relapse of breast *** review focuses on the pathways regulating breast CSC maintenance and the current strategies that are being explored for directing the development of novel,targeted,therapeutic approaches for limiting and eradicating this aberrant stem cell population.

关键词： Molecular genomics Breast cancer stem cells Tumor microenvironment Molecular pathways Targeted therapy Inhibitors

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