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Simulation of Reductive Dechlorination Processes in a Lab-Scale Anaerobic Biobarrier with Enriched TCP Dechlorinating Consortium

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Transactions of Tianjin University 2012年第6期18卷 441-449页

作者： LI Zhiling INOUE Yasushi MIZOGUCHI Takuya simizu yohei YOSHIDA Naoko KATAYAMA Arata EcoTopia Science Institute Nagoya University Nagoya 464-8603 Japan Department of Civil Engineering Graduate School of Engineering Nagoya University Nagoya 464-8603 Japan Electronics-Inspired Interdisciplinary Research Institute Toyohashi University of Technology Toyohashi 441-8580 Japan

In order to design and predict the dechlorination processes for remediating the halogenated aromatic compounds in the biobarrier system applied in situ,an anaerobic continuous-flow column was set up with the introduction of an enriched 2,4,6-trichlorophenol(TCP) reductive dechlorinating *** fates of TCP and its metabolites were simulated according to the first-order sequential dechlorination kinetic *** enriched TCP anaerobic dechlorinating consortium dechlorinated 100 μmol/L TCP to 4-chlorophenol(4-CP) via 2,4-dichlorophenol(DCP) in 10 *** consortium was predominated with the phylum of Firmicutes and Bacteroidetes,based on the PCRdenaturing gradient gel electrophoresis(DGGE) *** the consortium was applied to the column,the experimental data in the steady state were fitted by the least square method,and the first-order dechlorination kinetic constants from TCP to 2,4-DCP,from 2,4-DCP to 4-CP and from 4-CP to phenol,were 1.58 d-1,2.23 d-1 and 0.206 d-1,*** to the fitting results,the required biobarrier width for the complete remediation of TCP,2,4DCP and 4-CP were 126 cm,130 cm and 689 cm,*** dechlorination/degradation of 4-CP must be increased when the technology is applied to the real site.

关键词：还原脱氯生物系统 TCP 实验室规模厌氧模拟联盟变性梯度凝胶电泳

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DPY19L3 promotes vasculogenicmimicry by its C-mannosyltransferase activity

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Oncology Research 2024年第4期32卷 607-614页

作者： HASSAN BAYDOUN YUJI KATO HIROKI KAMO ANNA HÜSCH HAYATO MIZUTA RYOTA KAWAHARA SIRO simizu Department of Applied Chemistry Faculty of Science and TechnologyKeio UniversityYokohama223-8522Japan Department of Pharmacy and Biochemistry Faculty of ScienceUniversity of TübingenTübingen72074Germany

C-mannosylation is a post-translational modification that occurs intracellularly in the endoplasmic *** humans,biosynthesis of C-mannosylation in proteins containing thrombospondin type 1 repeat is catalyzed by the DPY19 family;nonetheless,biological functions of protein C-mannosylation are not yet fully understood,especially in tumor *** mimicry(VM)is the formation of fluid-conducting channels by highly invasive and genetically deregulated tumor cells,enabling the tumors to form matrix-embedded vasculogenic structures,containing plasma and blood cells to meet the metabolic demands of rapidly growing *** this study,we focused on DPY19L3,a C-mannosyltransferase,and aimed to unravel its role in *** of DPY19L3 inhibited the formation of VM in HT1080 human fibrosarcoma ***-expression of wild-type DPY19L3 recovered VM formation;however,DPY19L3 isoform2,an enzymatic activity-defect mutant,did not restore it,suggesting that the C-mannosyltransferase activity of DPY19L3 is crucial to its ***,the knockdown of DPY19L3 in MDA-MB-231 breast cancer cells hindered its network formation ***,our findings suggest that DPY19L3 is required for VM formation and stipulate the relevance of C-mannosylation in oncogenesis.

关键词： C-mannosylation Vasculogenic mimicry DPY19L3

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Magnetic Properties and Thermal Stability of Pr_(1-x)La_xCo_(5-y)Alloys

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Journal of Materials Science & Technology 1995年第6期11卷 463-465页

作者： Fazeng LIAN (Dept. of Materials Science and Engineering, Northeastern University, Shenyang, 110006, China)Meiqing HUANG, S.simizu and W.E.Wallace (Carnegie Mellon Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA) Northeastern Univ Shanghai China

Pr1-xLaxCo5-y (x=0, 0.15. 0.25, 0.35,1.0, y=0.5, 0.7, 0.9, 1.0) alloys were investigated. The effect of the variation of x and y on magnetic properties and thermal stability of the alloys were studied. The magnetic properties for the Pr0.85La0.15Co4.3 and Pr0.75La0.25Co4.1 magnets are iHc=368 kA/m, Br=0.91 T, (BH)max=145.6 kJ/m3, αBr=-0.03%/℃ and iHc=568 kA/m,Br=0.8 T, (BH)max=127.2 kJ/m3,αBr,=-0.06%/℃, respectively The phase structures of as-cast alloys and magnets were investigated

关键词： La x)La_xCo Magnetic Properties and Thermal Stability of Pr y)Alloys

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Diagnosis of IgG4-related sclerosing cholangitis

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World Journal of Gastroenterology 2013年第43期19卷 7661-7670页

作者： Takahiro Nakazawa Itaru Naitoh Kazuki Hayashi Katsuyuki Miyabe Shuya simizu Takashi Joh Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical SciencesNagoya 467-8601Japan

IgG4-related sclerosing cholangitis(IgG4-SC)is often associated with autoimmune ***,the diffuse cholangiographic abnormalities observed in IgG4-SC may resemble those observed in primary sclerosing cholangitis(PSC),and the presence of segmental stenosis suggests cholangiocarcinoma(CC).IgG4-SC responds well to steroid therapy,whereas PSC is only effectively treated with liver transplantation and CC requires surgical *** IgG4-SC was first described,it has become a third distinct clinical entity of sclerosing *** aim of this review was to introduce the diagnostic methods for ***4-SC should be carefully diagnosed based on a combination of characteristic clinical,serological,morphological,and histopathological features after cholangiographic classification and targeting of a disease for differential *** intrapancreatic stenosis is detected,pancreatic cancer or CC should be ruled *** multiple intrahepatic stenoses are evident,PSC should be distinguished on the basis of cholangiographic findings and liver biopsy with IgG4 *** inflammatory bowel disease is suggestive of *** stenosis is demonstrated in the hepatic hilar region,CC should be discriminated by ultrasonography,intraductal ultrasonography,bile duct biopsy,and a higher cutoff serum IgG4 level of 182 mg/dL.

关键词： IgG4-related sclerosing cholangitis Primary sclerosing cholangitis IgG4 Sclerosing cholangitis

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激光雷达在沙尘观测中的应用——2004年春季北京和呼和浩特沙尘天气的解析

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中国沙漠 2006年第6期26卷 942-947,I0011页

作者：董旭辉杉本伸夫白雪椿祁辉任立军王雁鹏狄一安陈岩赵淑莉松井一郎清水厚中日友好环境保护中心北京100029 日本国立环境研究所内蒙古环境监测中心站内蒙古呼和浩特010010 中国环境监测总站北京100029

2004年春季（2003年12月至2004年5月）利用激光雷达在北京和呼和浩特对沙尘天气进行了连续观测。利用激光雷达的数据导出了沙尘和大气污染物气溶胶消光系数的关系，对两个地点的沙尘天气特征和大气污染特征进行了探讨。该期间在呼和浩... 详细信息

2004年春季（2003年12月至2004年5月）利用激光雷达在北京和呼和浩特对沙尘天气进行了连续观测。利用激光雷达的数据导出了沙尘和大气污染物气溶胶消光系数的关系，对两个地点的沙尘天气特征和大气污染特征进行了探讨。该期间在呼和浩特观测到较大型的沙尘事件（消光系数大于0．3·km^-1）有9次，这些起源于蒙古国/内蒙古的沙尘事件晚于呼和浩特6～10h在北京被观测到。在呼和浩特观测到的沙尘云块的高度普遍较低（由地表至高空1～2km），而在北京较高一般可达到2～4km，同一沙尘事件的最高浓度（消光系数）是呼和浩特高于北京。在北京观测到的沙尘天气共有17次，其中包括数次小规模的沙尘事件在呼和浩特未观测到。从北京及呼和浩特的观测结果可以看出，北京地区3～5月沙尘的背景浓度高于呼和浩特，北京地区具有明显的区域规模大气污染特征，而呼和浩特只具有局部规模的大气污染特征。

关键词：激光雷达沙尘天气消光系数气溶胶北京

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