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You get by with a little help:The effects of variable guidance degrees on performance and mental state

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Visual Informatics 2019年第4期3卷 177-191页

作者： Davide Ceneda Theresia Gschwandtner silvia Miksch TU Wien Faculty of InformaticsInstitute of Visual Computing&Human-Centered TechnologyFavoritenstrasse 9-11/193A-1040 ViennaAustria

Since it can be challenging for users to effectively utilize interactive visualizations,guidance is usually provided to assist users in solving *** is mentioned as an effective mean to overcome stall situations occurring during the ***,the effectiveness of a peculiar guidance solution usually varies for different analysis *** same guidance may have different effects on users with(1)different levels of *** choice of the appropriate(2)degree of guidance and the type of(3)task under consideration also affect the positive or negative outcome of providing *** these three factors,we conducted a user study to investigate the effectiveness of variable degrees of guidance with respect to the user’s previous knowledge in different analysis *** results shed light on the appropriateness of certain degrees of guidance in relation to different tasks,and the overall influence of guidance on the analysis outcome in terms of user’s mental state and analysis performance.

关键词： Guidance User study Knowledge Trust Mixed-initiative Visual data analysis

EQUIVALENT UNIFORM DOSE SENSITIVITY TO CHANGES IN ABSORBED DOSE DISTRIBUTION

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International Journal of Biomathematics 2013年第1期6卷 129-142页

作者： FRANCISCO CUTANDA-HENRIQUEZ silvia VARGAS-CASTRILLON Hospital General Universitario Gregorio Mara~Sn Calle Doctor Esquerdo 46 28007 Madrid Spain Universidad Politdcnica de Madrid Ciudad Universitaria s/n 28040 Madrid Spain

Treatment planning in external beam radiation therapy （EBRT） utilizes dose volume histograms （DVHs） as optimization and evaluation tools. They present the fraction of planning target volume （PTV） receiving more than a given absorbed dose, against the absorbed dose values, and a number of radiobiological indices can be computed with their help. Equivalent uniform dose （EUD） is the absorbed dose that, uniformly imparted, would yield the same biological effect on a tumor as the dose distribution described by the DVH. Uncertainty and missing information can affect the dose distribution, therefore DVHs can be modeled as samples from a set of possible outcomes. This work studies the sensitivity of the EUD index when a small change in absorbed dose distribution takes place. EUD is treated as a functional on the set of DVHs. Defining a Levy distance on this set and using a suitable expansion of the functional, a very simple expression for a bound on the variation of EUD when the dose distribution changes is found. This bound is easily interpreted in terms of standard treatment planning practice.

关键词： Equivalent uniform dose DVH von Mises differential.

A Learning-based Control Framework for Fast and Accurate Manipulation of a Flexible Object

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Journal of Bionic Engineering 2024年第4期21卷 1761-1774页

作者： Junyi Wang Xiaofeng Xiong silvia Tolu Stanislav N.Gorb Department of Electrical and Photonics Engineering Technical University of DenmarkAnker Engelunds Vej 101Kongens LyngbyZealand2800Denmark SDU Biorobotics Mærsk Mc-Kinney Møller InstituteUniversity of Southern Denmark(SDU)Campusvej 55Odense MFunen5230Denmark Department Functional Morphology and Biomechanics Zoological InstituteUniversity of KielAm Botanischen Garten 1–9D-24118KielSchleswig-HolsteinGermany

This paper presents a learning-based control framework for fast(3 times of others).Besides,motion tracking errors are greatly reduced to 13.29 and 22.36 of constant impedance control by the OIAC of the proposed *** addition,the trajectory similarity between simulated and physical whips is *** presented framework provides a new method integrating data-driven and physics-based algorithms for controlling fast and accurate arm manipulation of a flexible object.

关键词： Deep reinforcement learning Deformable object manipulation Variable impedance control Sim2real Visual tracking

Natural capital accounting perspectives:a pragmatic way forward

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Ecosystem Health and Sustainability 2019年第1期5卷 237-241,I0016页

作者： Kerry Turner Tomas Badura silvia Ferrini Centre for Social and Economic Research on the Global Environment(CSERGE) School of Environmental SciencesUniversity of East AngliaNorwichUK Global Change Research Institute Czech Academy of SciencesBrnoCzech Republic Department of Political and International Sciences University of SienaSienaItaly

Introduction:Recent debates surrounding the application of natural capital accounting(NCA)have produced several approaches to further develop this system,as well as highlighted a number of conceptual and methodological issues that need to be resolved before mainstreaming NCA into policy and decision *** argue that prolonged debate over the value concepts(i.e.,exchange versus other values)underpinning different modifications to NCA has slowed progress in experimentation and uptake by ***:Consequently we propose three broad approaches which can be progressed in parallel to reinvigorate experimentation with the NCA principles and practice,while at the same time generating policy relevant tools and evidence bases for decision *** three approaches are;extended SNA accounting anchored to the use of exchange values;a complementary accounts network(CAN)that utilizes plural values as supplementary accounts to the SNA system;and wealth accounting that focuses on measures of welfare and *** three approaches are complementary and data developed in any one can inform the other ***:We contend that CAN offers the most flexibility and opportunities to progress short term support for decision making on environmental issues which are now becoming urgent.

关键词： Natural capital accounting SEEA ecosystem accounting wealth accounting exchange values welfare values

Alcohol and hepatocellular carcinoma:A review and a point of view

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World Journal of Gastroenterology 2014年第43期20卷 15943-15954页

作者： Gianni Testino silvia Leone Paolo Borro Centro Alcologico Regionale-Regione Liguria Alcoholic UnitDepartment of General Internal and Specialist MedicineIRCCS AOU San Martino-National Institute for Cancer Research-IST Department of Internal Medicine Clinical Pharmacology and Toxicology UnitUniversity of Genoa

It is well recognized that one cause of chronic liver disease and hepatocellular carcinoma(HCC)is alcohol *** in Italy and the United States concludes that the most common cause of HCC(responsible for 32%to 45%of HCC)is *** has recently been shown that a significant relationship between alcohol intake,metabolic changes,and hepatitis virus infection does *** may be a factor in the development of HCC via direct(genotoxic)and indirect mechanisms(cirrhosis).There is only one way of diagnosing HCC,which is early identification through surveillance,when curative treatments become *** stopping alcohol intake the risk of liver cancer decreases by 6%to 7%a year,and an estimated time period of 23 years is also ***,surveillance is also important in former drinkers and,in our opinion,independently from the presence of compensated *** cases of very early stage(VES)and early stage with portal hypertension,liver transplantation is the optimal option;and in cases of associated disease,percutaneous ethanol injections,radiofrequency and microwave ablation are the ideal *** the possibility of detecting microvascular invasion with HR,several studies and some randomized controlled trials revealed that overall survival and DSF rates in patients with VES HCC are much the same after ablation and ***,ablation can be regarded as a firstline choice for patients with VES *** is important to emphasize that the choice of treatment should be weighed carefully in the context of a multidisciplinary cancer team.

关键词： Alcohol Alcoholic liver disease Hepatocellular carcinoma Percutaneous ablation

A topology-based bounded rationality day-to-day traffic assignment model

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Communications in Transportation Research 2022年第1期2卷 298-313页

作者： Enrico Siri silvia Siri Simona Sacone Department of Informatics BioengineeringRobotics and Systems EngineeringUniversity of GenovaGenova16145Italy

This paper analyzes the day-to-day adjustment process of users’behaviors in a transport network which is affected by relevant alterations such as disruptions due to critical events which cause the impossibility to use one or more *** representing the progressive adjustment of the flows on the network to reach a new equilibrium,a dayto-day discrete-time model is proposed,based on the idea that people are bounded rational in their choices,*** often do not behave according to the optimal solution but they accept solutions they consider ***,in their choice process,are influenced by the topological similarity between the route they are currently using and *** means that they tend to prefer the solutions that are more similar to the one they are already *** parallel,users exhibit a myopic behavior,i.e.,they tend to overestimate the goodness of a route if,when using it,they suddenly experience a significant reduction in travel time compared to what they are used *** the paper it is shown that such route choice behaviour implies that the steady state of the system corresponds to a Bounded Rational User Equilibrium,i.e.,a state that does not diverge from the user equilibrium more than a certain value which increases when the relative importance given to the topological similarity *** model also assumes that these biases vanish,at least with respect to those routes that are most frequently used by users,after a sufficient amount of *** certain conditions,it is then shown that the steady state can eventually collapse into a User *** effectiveness of the proposed model is assessed via simulation results in which two test networks are analyzed in detail to show the evolution of the users’behaviour in a transport network after a disruption.

关键词： Traffic Assignment Day-to-day traffic assignment Bounded rationality

Cellular and molecular mechanisms of intestinal fibrosis

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World Journal of Gastroenterology 2012年第28期18卷 3635-3661页

作者： silvia Speca Ilaria Giusti Florian Rieder Giovanni Latella Gastroenterology Unit Department of Internal Medicine and Public Health University of L'Aquila 67100 L'Aquila Italy Department of Gastroenterology and Hepatology Lerner Research Institute Cleveland Clinic Foundation Cleveland OH 73051 United States

Fibrosis is a chronic and progressive process characterized by an excessive accumulation of extracellular matrix (ECM) leading to stiffening and/or scarring of the involved tissue. Intestinal fibrosis may develop in several different enteropathies, including inflammatory bowel disease. It develops through complex cell, extracellular matrix, cytokine and growth factor interactions. Distinct cell types are involved in intestinal fibrosis, such as resident mesenchymal cells (fibroblasts, myofibroblasts and smooth muscle cells) but also ECM-producing cells derived from epithelial and endothelial cells (through a process termed epithelialand endothelial-mesenchymal transition), stellate cells, pericytes, local or bone marrow-derived stem cells. The most important soluble factors that regulate the activation of these cells include cytokines, chemokines, growth factors, components of the renin-angiotensin system, angiogenic factors, peroxisome proliferator-activated receptors, mammalian target of rapamycin, and products of oxidative stress. It soon becomes clear that although inflammation is responsible for triggering the onset of the fibrotic proc-ess, it only plays a minor role in the progression of this condition, as fibrosis may advance in a self-perpetuating fashion. Definition of the cellular and molecular mechanisms involved in intestinal fibrosis may provide the key to developing new therapeutic approaches.

关键词： Inflammatory bowel disease Intestinal fibrosis Extracellular matrix Molecular mediators Myofibroblasts Inflammatory cells Epithelial cells Mesenchymal cells Endothelial cells

A model-based approximate λ-policy iteration approach to online evasive path planning and the video game ***-Man

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控制理论与应用（英文版） 2011年第3期9卷 391-399页

作者： Greg FODERARO Vikram RAJU silvia FERRARI Department of Mechanical Engineering and Materials Science Duke University

This paper presents a model-based approximate λ-policy iteration approach using temporal differences for optimizing paths online for a pursuit-evasion problem,where an agent must visit several target positions within a region of interest while simultaneously avoiding one or more actively pursuing *** method is relevant to applications,such as robotic path planning,mobile-sensor applications,and path *** methodology described utilizes cell decomposition to construct a decision tree and implements a temporal difference-based approximate λ-policy iteration to combine online learning with prior knowledge through modeling to achieve the objectives of minimizing the risk of being caught by an adversary and maximizing a reward associated with visiting target *** learning and frequent decision tree updates allow the algorithm to quickly adapt to unexpected movements by the adversaries or dynamic *** approach is illustrated through a modified version of the video game ***-Man,which is shown to be a benchmark example of the pursuit-evasion *** results show that the approach presented in this paper outperforms several other methods as well as most human players.

关键词： Approximate dynamic programming Reinforcement learning Path planning Pursuit evasion games

Pancreatic adenocarcinoma:Beyond first line,where are we?

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World Journal of Gastroenterology 2021年第17期27卷 1847-1863页

作者： Sara Cherri silvia Noventa Alberto Zaniboni Department of Oncology Fondazione PoliambulanzaBrescia 25124Italy

Pancreatic cancer is considered one of the most aggressive cancers,with an increasing incidence in recent *** date,chemotherapy is still the standard of care for advanced metastatic disease,unfortunately providing only a slight advantage in terms of *** molecular and cellular characteristics of pancreatic cancer cells,as well as the cells that characterize the pancreatic tumour microenvironment,are the basis of the mechanisms of resistance to *** progression during first-line treatment,few patients are eligible for secondline treatment due to the loss of performance *** date,a clear survival advantage has not yet been demonstrated for second-line *** medicine could be the key to increasing responses to cancer treatment and finally impacting survival in this difficult-to-treat *** this review,we analyze current recommendations in the second-line setting and potential future prospects.

关键词： Pancreatic adenocarcinoma Second-line Chemotherapy Targeted therapy Immunotherapy