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生物医学与环境科学:英文版 2023年第9期36卷 892-896页

作者： LIU Xue Kui si shan wen YE Yan LI Jia Yi LYU He He MA Ya Mei ZOU Cai Yan SUN Hao Jie XUE Lei XU Wei GENG Hou Fa LIANG Jun Department of Endocrinology Xuzhou Central hospitalXuzhou 221009JiangsuChina Xuzhou Medical University Affiliated Xuzhou Clinical College of Xuzhou Medical UniversityXuzhou 221009JiangsuChina Graduate School of Bengbu Medical College Bengbu 233000AnhuiChina Department of Emergency Xuzhou Central HospitalXuzhou 221009JiangsuChina

Insulin resistance is closely associated with metabolic disorders and the pathogenesis of type 2 diabetes mellitus(T2DM).Accumulating evidence suggests that excess fatty acids due to inappropriate lipolysis increase the risk of insulin resistance,which,in turn,stimulates hyperinsulinemia,worsens metabolism,and leads to insulin resistance due to impairedβ-cell function.

关键词： metabolism impaired function.

Ferrihydrite transformation impacted by coprecipitation of lignin:Inhibition or facilitation?

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Journal of Environmental Sciences 2024年第5期139卷 23-33页

作者： Lin Liu Zhihui Yang Weichun Yang wen Jiang Qi Liao Mengying si Feiping Zhao School of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research Center for Control&Treatment of Heavy Metal Pollution(CNERC-CTHMP) Changsha 410083China

Lignin is a common soil organic matter that is present in soils,but its effect on the transformation of ferrihydrite(Fh)remains unclear.Organic matter is generally assumed to inhibit Fh transformation.However,lignin can reduce Fh to Fe(Ⅱ),in which Fe(Ⅱ)-catalyzed Fh transformation occurs.Herein,the effects of lignin on Fh transformation were investigated at 75℃ as a function of the lignin/Fh mass ratio(0-0.2),pH(4-8)and aging time(0-96 hr).The results of Fh-lignin samples(mass ratios=0.1)aged at different pH values showed that for Fh-lignin the time of Fh transformation into secondary crystalline minerals was significantly shortened at pH 6 when compared with pure Fh,and the Fe(Ⅱ)-accelerated transformation of Fh was strongly dependent on pH.Under pH 6,at low lignin/Fh mass ratios(0.05-0.1),the time of secondary mineral formation decreased with increasing lignin content.For high lignosulfonate-content material(lignin:Fh=0.2),Fh did not transform into secondary minerals,indicating that lignin content plays a major role in Fh transformation.In addition,lignin affected the pathway of Fh transformation by inhibiting goethite formation and facilitating hematite formation.The effect of coprecipitation of lignin on Fh transformation should be useful in understanding the complex iron and carbon cycles in a soil environment.

关键词： Ferrihydrite transformation Lignin Hematite Goethite Fe(Ⅱ)-catalyzed Reactive Fe(Ⅲ)species

How mesenchymal stem cells transform into adipocytes:Overview of the current understanding of adipogenic differentiation

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World Journal of Stem Cells 2024年第3期16卷 245-256页

作者： shan-shan Liu Xiang Fang Xin wen Ji-shan Liu Miribangvl Alip Tian Sun Yuan-Yuan Wang Hong-Wei Chen Department of Reumatology and Immunology Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Emergency Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China Anhui Key Laboratory of Infection and Immunity Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

Mesenchymal stem cells(MSCs)are stem/progenitor cells capable of self-renewal and differentiation into osteoblasts,chondrocytes and adipocytes.The transformation of multipotent MSCs to adipocytes mainly involves two subsequent steps from MSCs to preadipocytes and further preadipocytes into adipocytes,in which the process MSCs are precisely controlled to commit to the adipogenic lineage and then mature into adipocytes.Previous studies have shown that the master transcription factors C/enhancer-binding protein alpha and peroxisome proliferation activator receptor gamma play vital roles in adipogenesis.However,the mechanism underlying the adipogenic differentiation of MSCs is not fully understood.Here,the current knowledge of adipogenic differentiation in MSCs is reviewed,focusing on signaling pathways,noncoding RNAs and epigenetic effects on DNA methylation and acetylation during MSC differentiation.Finally,the relationship between maladipogenic differentiation and diseases is briefly discussed.We hope that this review can broaden and deepen our understanding of how MSCs turn into adipocytes.

关键词： Mesenchymal stem cell Adipogenic differentiation signaling pathway Noncoding RNA Epigenetic regulation

dECM restores macrophage immune homeostasis and alleviates iron overload to promote DTPI healing

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Regenerative Biomaterials 2024年第2期3卷 100-113页

作者： Ju Zhang Ruijuan si Yu Gao Hui shan Qi Su Zujian Feng Pingsheng Huang Deling Kong Weiwei Wang Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China School of Nursing Qingdao UniversityNingde RoadShinan DistrictQingdaoShandong266071China Cancer Hospital of Tianjin Medical University North Huanhu West RoadTianjinChina The Affliated Hospital of Qingdao University 16 Jjiangsu RoadShinan DistrictQingdaoChina 5NankaiUniver aniin300071.China

Due to its highly insidious and rapid progression,deep tissue pressure injury(DTPI)is a clinical challenge.Our previous study found that DTPI may be a skeletal muscle injury dominated by macrophage immune dysfunction due to excessive iron accu-mulation.Decellularized extracellular matrix(dECM)hydrogel promotes skeletal muscle injury repair.However,its role in po-larizing macrophages and regulating iron metabolism in DTPI remains unclear.Here,porcine dECM hydrogel was prepared,and its therapeutic function and mechanism in repairing DTPI were investigated.The stimulus of dECM hydrogel toward RAW264.7 cells resulted in a significantly higher percentage of CD2o6+macrophages and notably decreased intracellular divalent iron levels.In mice DTPI model,dECM hydrogel treatment promoted M1 to M2 macrophage conversion,improved iron metabolism and reduced oxidative stress in the early stage of DTPI.In the remodeling phase,the dECM hydrogel remarkably enhanced revascularization and accelerated skeletal muscle repair.Furthermore,the immunomodulation of dEcM hydrogels in vivo was mainly involved in the P13k/Akt signaling pathway,as revealed by GO and KEGG pathway analysis,which may ameliorate the iron deposition and promote the healing of DTPI.Our findings indicate that dECM hydrogel is promising in skeletal muscle repair,inflammation resolution and tissue injury healing by effectively restoring macrophage immune homeostasis and normalizing iron metabolism.

关键词： Deep tissue pressure injury hydrogel immunomodulation tissue repair

Research on Bast Fiber Extracted from the White Bark of Three Species in the Genus Broussonetia

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Chinese Journal of Polymer Science 2024年第6期42卷 729-738页

作者： shan-shan Jin si-Nong Wang Yan-Yan Huang Jing-Yu Zhang Peng Liu Hui Yu Hong-Dong Zhang Yu-Liang Yang Institute for Preservation and Conservation of Chinese Ancient Books Fudan University LibraryFudan UniversityShanghai200433China State key laboratory of Molecular Engineering of polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China

Against the backdrop of a global paper resource shortage,there is a growing need to identify fast-growing tree species capable of producing long-lasting paper.Three plant species namely Broussonetia kazinoki,Broussonetia papyrifera and hybrid paper mulberry,belong to the Broussonetia genus,were collected from China to study their white bark suitability for pulp and papermaking.Their chemical composition revealed that the holocellulose content in Broussonetia kazinoki and Broussonetia papyrifera was more than 80%.The molecular weight distribution of several holocellulose/α-cellulose is observed by GPC,which allows us to better observe the changes of various components on the molecular weight.The yield,lignin,whiteness,and molecular weight of the pulps obtained by NaOH treatment were determined.Optical microscope was used to characterize the fiber length-width ratio and rigidity.Finally,the improvement of the fiber rigidity method based on the Kratky-Porod chain model makes it more theoretical and further reveals the influencing factors of fiber rigidity.This study demonstrates the high potentiality of these three species for papermaking applications.

关键词： Broussonetia genus Cellulose Alkaline pulping Kratky-Porod chain model Fiber rigidity

Metallothionein 1E Alleviates Cadmium-induced Renal Cytotoxicity through Promoting Mitochondrial Functional Recovery

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Biomedical and Environmental Sciences 2024年第1期37卷 117-121页

作者： wen si Hui LI Lu Bei HUANG Hui Dan XIE Ying LUO Lei Key Laboratory of Molecular Epidemiology of Hunan Province School of MedicineHunan Normal UniversityChangsha 410081HunanChina Department of Occupational Health Changsha Centre for Disease Control and PreventionChangsha 410004HunanChina The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province Hunan Normal University School of MedicineChangsha 410013HunanChina

The pervasive utilization of industrial substances has escalated human exposure to cadmium(Cd),a metal associated with long-term negative health outcomes such as renal dysfunction,neurological disorders,and various cancers^([1]).Once ingested by humans,Cd interacts with cysteine-rich metallothioneins(MTs)which have metal-binding and antioxidant properties and is subsequently transported to the kidney^([2]).

关键词： Renal kidney cadmium

Optimal Shape Factor and Fictitious Radius in the MQ-RBF:Solving Ill-Posed Laplacian Problems

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3189-3208页

作者： Chein-shan Liu Chung-Lun Kuo Chih-wen Chang Center of Excellence for Ocean Engineering Taiwan Ocean UniversityKeelung202301TaiwanChina Department of Mechanical Engineering National United UniversityMiaoli36063TaiwanChina

To solve the Laplacian problems,we adopt a meshless method with the multiquadric radial basis function(MQRBF)as a basis whose center is distributed inside a circle with a fictitious radius.A maximal projection technique is developed to identify the optimal shape factor and fictitious radius by minimizing a merit function.A sample function is interpolated by theMQ-RBF to provide a trial coefficient vector to compute the merit function.We can quickly determine the optimal values of the parameters within a preferred rage using the golden section search algorithm.The novel method provides the optimal values of parameters and,hence,an optimal MQ-RBF;the performance of the method is validated in numerical examples.Moreover,nonharmonic problems are transformed to the Poisson equation endowed with a homogeneous boundary condition;this can overcome the problem of these problems being ill-posed.The optimal MQ-RBF is extremely accurate.We further propose a novel optimal polynomial method to solve the nonharmonic problems,which achieves high precision up to an order of 10^(−11).

关键词： Laplace equation nonharmonic boundary value problem Ill-posed problem maximal projection optimal shape factor and fictitious radius optimal MQ-RBF optimal polynomial method

Thermal-force control ability under variation of electromagnetic stick structure parameters in RPECT

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Journal of Iron and Steel Research(International) 2024年第1期31卷 224-236页

作者： Ting-song Yang wen-quan Sun Feng-shan Du An-rui He Quan Yang National Engineering Research Center of Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing100083China Institute of Engineering and Technology University of Science and Technology BeijingBeijing100083China College of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiChina

Thermal-force driving of roll profile electromagnetic control technology(RPECT),which can be used to adjust the roll profile,can be affected by the sequential temperature rise between the electromagnetic stick(ES)and electromagnetic control roll.Due to the limited space of ES and induction coil,the cross-sectional area of induction coil can be inevitably affected by changing the size of the ES induction zone,which can further change the energy input under the same electromagnetic parameters,the temperature rising effect and the bulging ability.To investigate this phenomenon,the effects of the radius of the induction zone on the thermal-force contribution ratio,the heating ability of ES and the temperature distribution were analyzed through an electromagnetic-thermal-structural finite element model.To ensure that the results are applicable to RPECT,the thermal energy conversion ability and thermal-force roll crown control ability under different lengths of the induction zone were analyzed.It was found that whether the current density regulation mode or the current frequency regulation mode is adopted,the cases with 20 or 25 mm radius of the induction zone have the great thermal energy conversion ability and the good thermal-force roll crown control ability.The reasonable adjustment of the length of the induction zone can reduce the radius required for the maximum energy efficiency regulation.Combined with the results of the simulation analysis,the optimization of ES based on the control ability maximization requirement is achieved,which provides the base for the design and configuration of ES in RPECT.

关键词： Roll profile electromagnetic control technology Electromagnetic stick Electromagnetic control roll Induction area Thermal-force driving

Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2

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Science China(Life Sciences) 2024年第6期67卷 1305-1307页

作者： Songlin Gan wen-si Yang Liting Wei Zhiguo Zhang Rui-Ming Xu Key Laboratory of Epigenetic Regulation and Intervention Institute of BiophysicsChinese Academy of SciencesBeijing 100101China School of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Institute for Cancer Genetics Department of Pediatrics and Department of Genetics and DevelopmentColumbia University Irving Medical CenterNew York 10032USA School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Dear Editor,The passage of DNA replication forks during eukaryotic cell division disrupts the nucleosomes they encounter,and de novo assembly of nucleosomes onto replicated DNA must take place to restore chromatin str... 详细信息

关键词： structure. nucleosome passage

Metabolic disorders in prediabetes:From mechanisms to therapeutic management

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World Journal of Diabetes 2024年第3期15卷 361-377页

作者： wen-Xin Ping shan Hu Jing-Qian Su Song-Ying Ouyang Biomedical Research Center of South China College of Life SciencesFujian Normal UniversityFuzhou 350117Fujian ProvinceChina

Diabetes,one of the world's top ten diseases,is known for its high mortality and complication rates and low cure rate.Prediabetes precedes the onset of diabetes,during which effective treatment can reduce diabetes risk.Prediabetes risk factors include high-calorie and high-fat diets,sedentary lifestyles,and stress.Consequences may include considerable damage to vital organs,including the retina,liver,and kidneys.Interventions for treating prediabetes include a healthy lifestyle diet and pharmacological treatments.However,while these options are effective in the short term,they may fail due to the difficulty of long-term implementation.Medications may also be used to treat prediabetes.This review examines prediabetic treatments,particularly metformin,glucagon-like peptide-1 receptor agonists,sodium glucose cotransporter 2 inhibitors,vitamin D,and herbal medicines.Given the remarkable impact of prediabetes on the progression of diabetes mellitus,it is crucial to intervene promptly and effectively to regulate prediabetes.However,the current body of research on prediabetes is limited,and there is considerable confusion surrounding clinically relevant medications.This paper aims to provide a comprehensive summary of the pathogenesis of prediabetes mellitus and its associated therapeutic drugs.The ultimate goal is to facilitate the clinical utilization of medications and achieve efficient and timely control of diabetes mellitus.

关键词： Prediabetes Glucagon-like peptide agonists Sodium–glucose cotransporter 2 inhibitors Vitamin D Chinese herbal medicines