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Donor-acceptor modulation of coordination polymers for effective photothermal conversion

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Science China Chemistry 2024年

作者： bo Zhang Xing-Wang Li Han Fang Chang-Tai Li si-Jia Yu Mei-Hui Yu Ze Chang Xian-He Bu School of Materials Science and Engineering Nankai University State Key Laboratory of Elemento-Organic Chemistry Nankai University

The targeted construction of donor-acceptor（D-A） materials featuring efficient photothermal（PT） conversion properties has been an attractive but challenging goal. Herein, a new series of coordination polymers（CPs） featuring different PT performances were constructed with flexible linker 1,1′-Ferrocenedicarboxylic acid（FCA） and 2,4,6-tri（pyridin-4-yl）-1,3,5-triazine（TPT） as acceptor and donor molecules including coronene and tetrathiafulvalene（TTF）. Based on the flexible configurations of FCA ligand and the directing of donor dependent D-A interactions, the structures of TF-1 to TF-3 featuring distinctive dimension were obtained based on Cd（II） ions for investigating the PT property in configurational perspectives. A systematic investigation of the PT properties of the CPs was performed. Notably, TF-3 exhibits the finest PT conversion effect under the irradiation of 560 nm laser, while TF-2 shows optimal PT conversion under 808 nm laser irradiation required for biological PT therapy,illustrating the correlation between the structural and component features of the CPs and their PT performances. Furthermore,Zn（II） as bio-friendly ion was utilized to construct hypotoxic TF-4 that reveals similar structure to that of TF-2 for potential application. Polydimethylsiloxane（PDMS） patches doped with TF-4 exhibits considerable NIR PT conversion effect under808 nm, represented by the nearly 80 °C temperature increased in 120 s for TF-4@PDMS patch（1.2 wt%） under 0.9 W cm-2irradiation, the results of which herein indicate the potential of D-A CPs as versatile platform for the modulation of PT materials.

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Changes in visual performance after implantation of different intraocular lenses

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1273-1282页

作者： bo-Wen Li Hao Huang Man-Sha Huang Shuang-Lin Guo Lu Gao Yu-Ying Zeng Lu Cheng si-Yang Yao Jian-Qiang Lin Lin Liu Ye Yang Xiao-Ming Lu Hao Cheng Department of Ophthalmology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Eye Center of Xiangya Hospital Hunan Key Laboratory of OphthalmologyCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Ophthalmology Zhuzhou Hospital Affiliated to Xiangya School of MedicineCentral South UniversityZhuzhou 412000Hunan ProvinceChina State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina Department of Ophthalmology Guangzhou Red Cross HospitalJinan UniversityGuangzhou 510000Guangdong ProvinceChina AIER Eye Hospital Jinan UniversityGuangzhou 510180Guangdong ProvinceChina

AIM:To evaluate the trending visual performance of different intraocular lenses(IOLs)over time after ***:Ninety-one patients received cataract surgery with implantations of monofocal(Mon)IOLs,segmental refractive(SegRef)IOLs,diffractive(Dif)IOLs,and extendeddepth-of-focus(EDoF)IOLs were *** aberrations and optical quality collected with iTrace and OQAS within postoperative 6mo were followed and ***:Most of the visual parameters improved over the postoperative *** postoperative visual acuity(POVA)of the Mon IOL,SegRef IOL,and EDoF IOL groups achieved relative stability in earlier states compared with the Dif IOL ***,the overall visual performance of the 3 IOLs continued to upturn in small extents within the postoperative *** optical quality initially improved in the EDoF IOL group,then in the Mon IOL,SegRef IOL,and Dif IOL *** and objective visual performance of the Mon IOL and EDoF IOL groups,as well as POVA and visual quality of the Dif IOL group,improved in the postoperative 1mo and *** the postoperative 6mo,gradual improvements were observed in the visual acuity and objective visual performance of the SegRef IOL group,as well as in the postoperative optical quality of the Dif IOL ***:The visual performance is different among eyes implanted with different *** findings of the current study provide a potential reference for ophthalmologists to choose suitable IOLs for cataract patients in a personalized solution.

关键词： intraocular lenses visual performance changing characteristics high-order wavefront aberration

CoMP下行传输系统的联合最优参考序列设计

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北京工业大学学报 2014年第10期40卷 1478-1483页

作者：贾国庆司鹏搏陈善继吴国庆陈超青海民族大学物理与电子信息工程学院西宁810007 北京工业大学电子信息与控制工程学院北京100124

针对多小区协作传输系统,首先给出了频偏估计和信道估计的Cramer-Rao bound(CRB),作为理论上最优的训练序列的设计准则;然而通过分析发现,基于CRB的最优参考序列设计准则中不仅包含了信道的因素,而且还包含了协作基站频偏值的影响.由于... 详细信息

针对多小区协作传输系统,首先给出了频偏估计和信道估计的Cramer-Rao bound(CRB),作为理论上最优的训练序列的设计准则;然而通过分析发现,基于CRB的最优参考序列设计准则中不仅包含了信道的因素,而且还包含了协作基站频偏值的影响.由于基于CRB的最优参考序列设计过于复杂,因此转向次优的基于最小均方误差(MSE)的参考序列设计准则,并通过分析得出该准则下的最优参考序列是高斯序列.最后通过仿真,验证了高斯序列在最大似然估计下的性能.仿真结果显示:高斯序列检测性能逼近理论最优值CRB;通过与其他序列的检测性能进行比较,验证了其性能增益.

关键词：协作多点传输下行参考序列设计

Review of advanced oxidation processes for treating hospital sewage to achieve decontamination and disinfection

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Chinese Chemical Letters 2024年第1期35卷 140-152页

作者： si-Ying Yu Zhi-Hui Xie Xiaoyu Wu Yun-Zhe Zheng Yang Shi Zhao-Kun Xiong peng Zhou Yang Liu Chuan-Shu He Zhi-Cheng Pan Kai-Jun Wang bo Lai State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China sino-German Centre for Water and Health Research Sichuan UniversityChengdu 610065China State Key Joint Laboratory of Environment simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Water Safety and Water Pollution Control Engineering Technology Research Center in sichuan Province Haitian Water GroupChengdu 610041China

Hospital sewage contains various harmful pharmaceutical contaminants(e.g.,antibiotics,anti-inflammatory agents,and painkillers)and pathogens(e.g.,bacteria,viruses,and parasites),whose direct discharge into the environment will induce diseases and pose a powerful threat to human health and safety,and environmental *** recent years,advanced oxidation processes(AOPs),particularly photocatalysis,electrocatalysis,and ozone catalysis have been developed as widespread and effective techniques for hospital sewage ***,there is a lack of systematic comparison and review of the prior studies on hospital sewage treatment using AOPs *** review elaborates on the mechanisms,removal efficiencies,and advantages/disadvantages of these AOPs systems for hospital wastewater decontamination and ***,some novel and potential technologies such as photo-electrocatalysis,electro-peroxone,Fenton/Fenton-like,and piezoelectric catalysis are also included and ***,we further summarize and compare the capacity of these AOPs to treat the actual hospital wastewater under the impact of the water matrix and pH,and estimate the economic cost of these technologies for practical ***,the future development directions of AOPs for hospital wastewater decontamination and disinfection have been ***,this study provides a comparison and overview of these AOP systems in an attempt to raise extensive concerns about hospital wastewater decontamination and disinfection technologies and guide researchers to discover the future directions of technologies optimization,which would be a crucial step forward in the field of hospital sewage treatment.

关键词： Hospital sewage treatment Advanced oxidation processes Pharmaceutical contaminants Disinfection Decontamination

Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

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World Journal of Diabetes 2024年第5期15卷 898-913页

作者： Su-Su Feng si-Jing Wang Lin Guo Pan-Pan Ma Xiao-Long Ye Ming-Lin Pan bo Hang Jian-Hua Mao Antoine M Snijders Yi-Bing Lu Da-Fa Ding Department of Endocrinology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720United States

BACKGROUND The understanding of bile acid(BA)and unsaturated fatty acid(UFA)profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2DM)coexisting with non-alcoholic fatty liver disease(NAFLD).Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in *** To identify potential metabolite biomarkers capable of distinguishing between NAFLD and *** A training model was developed involving 399 participants,comprising 113 healthy controls(HCs),134 individuals with T2DM without NAFLD,and 152 individuals with T2DM and *** validation encompassed 172 *** patients were divided based on liver fibrosis *** analytical approach employed univariate testing,orthogonal partial least squares-discriminant analysis,logistic regression,receiver operating characteristic curve analysis,and decision curve analysis to pinpoint and assess the diagnostic value of serum *** Compared to HCs,both T2DM and NAFLD groups exhibited diminished levels of specific *** UFAs,particular acids exhibited a positive correlation with NAFLD risk in T2DM,while theω-6:ω-3 UFA ratio demonstrated a negative *** ofα-linolenic acid andγ-linolenic acid were linked to significant liver fibrosis in *** validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM *** This study underscores the connection between altered BA and UFA profiles and the presence of NAFLD in individuals with T2DM,proposing their potential as biomarkers in the pathogenesis of NAFLD.

关键词： Bile acid Non-alcoholic fatty liver disease Type 2 diabetes mellitus Unsaturated fatty acid

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基于随机牛顿算法的离散系统自适应参数估计

控制与决策 2024年第6期39卷 1959-1966页

作者：陈思宇那靖黄英博昆明理工大学机电工程学院昆明650500 昆明理工大学云南省先进装备智能控制及应用国际联合实验室昆明650500

针对一类离散系统,提出一种基于随机牛顿算法的自适应参数估计新框架,相较于已有的参数估计算法,所提出方法仅要求系统满足有限激励条件,而非传统的持续激励条件.所提出算法的核心思想在于通过对原始代价函数的修正,在使用当前时刻误差... 详细信息

针对一类离散系统,提出一种基于随机牛顿算法的自适应参数估计新框架,相较于已有的参数估计算法,所提出方法仅要求系统满足有限激励条件,而非传统的持续激励条件.所提出算法的核心思想在于通过对原始代价函数的修正,在使用当前时刻误差信息的基础上融入历史误差信息,进而通过对历史信息和历史激励的复用使得持续激励条件转化为有限激励条件;然后,为了解决传统算法收敛速度慢的问题并避免潜在的病态问题,采用随机牛顿算法推导出参数自适应律,并引入含有历史信息的海森矩阵作为时变学习增益,保证参数估计误差指数收敛;最后,基于李雅普诺夫稳定性理论给出不同激励条件下所提出算法的收敛性结论和证明,并通过对比仿真验证所提出算法的有效性和优越性.

关键词：离散系统自适应参数估计随机牛顿算法递推最小二乘有限激励代价函数

Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with spleen Qi deficiency syndrome

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World Journal of Cardiology 2024年第7期16卷 422-435页

作者： si-Qi Li Dong-Yu Min Jun-Wen Jiang Xiao-Ying Li Xu-Na Yang Wen-bo Gu Jia-Hui Jiang Li-Hao Chen Han Nan Ze-Yu Chen Second Department of Cardiology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina

BACKGROUND Chronic heart failure is a complex clinical *** Chinese herbal compound preparation Jianpi Huatan Quyu recipe has been used to treat chronic heart failure;however,the underlying molecular mechanism is still not *** To identify the effective active ingredients of Jianpi Huatan Quyu recipe and explore its molecular mechanism in the treatment of chronic heart *** The effective active ingredients of eight herbs composing Jianpi Huatan Quyu recipe were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis *** target genes of chronic heart failure were searched in the Genecards *** target proteins of active ingredients were mapped to chronic heart failure target genes to obtain the common drugdisease targets,which were then used to construct a key chemical componenttarget network using Cytoscape 3.7.2 *** protein-protein interaction network was constructed using the String *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed through the Metascape ***,our previously published relevant articles were searched to verify the results obtained via network *** A total of 227 effective active ingredients for Jianpi Huatan Quyu recipe were identified,of which quercetin,kaempferol,7-methoxy-2-methyl isoflavone,formononetin,and isorhamnetin may be key active ingredients and involved in the therapeutic effects of TCM by acting on STAT3,MAPK3,AKT1,JUN,MAPK1,TP53,TNF,HSP90AA1,p65,MAPK8,MAPK14,IL6,EGFR,EDN1,FOS,and other *** pathways identified by KEGG enrichment analysis include pathways in cancer,IL-17 signaling pathway,PI3K-Akt signaling pathway,HIF-1 signaling pathway,calcium signaling pathway,cAMP signaling pathway,NF-kappaB signaling pathway,AMPK signaling pathway,*** studies on Jianpi Huatan Quyu recipe suggested that this Chinese compound preparation can regulate the TNF-α,IL-6,MAPK

关键词： Jianpi Huatan Quyu recipe Traditional Chinese medicine Chronic heart failure Data mining Network pharmacology Bioinformatics Spleen Qi deficiency syndrome

荧光探针四苯基-1,3-丁二烯在四环素检测上的应用

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光谱学与光谱分析 2024年第5期44卷 1321-1329页

作者：王瑞郑露莹胡博张新宇赵思思张航沈阳师范大学化学化工学院辽宁沈阳110034 中国科学院深圳先进技术研究院智能仿生中心广东深圳518055

抗生素具有抗菌活性强、成本低等优点,已广泛应用于生产生活中。然而,抗生素的滥用可能导致其在人体内或食物中的积累,造成公共卫生问题,如引起耳毒性、肾毒性、过敏反应和细菌耐药性。因此,选取具有灵敏度高、选择性好、制备简单、快... 详细信息

抗生素具有抗菌活性强、成本低等优点,已广泛应用于生产生活中。然而,抗生素的滥用可能导致其在人体内或食物中的积累,造成公共卫生问题,如引起耳毒性、肾毒性、过敏反应和细菌耐药性。因此,选取具有灵敏度高、选择性好、制备简单、快速、可用于实际样品检测等优点的荧光检测技术,对提高食品安全性和合理用药具有重要意义。基于荧光技术在检测抗生素方面的应用,选取具有AIE效应的典型代表四苯基-1,3-丁二烯(TPB),其具有化学性能稳定、发光性能好、不受溶液条件限制等优点,将其制成荧光探针用来探究TPB的光化学性质及抗生素对其猝灭效应的影响。研究结果表明,TPB的最大激发波长为365 nm,最大发射波长为435 nm,TPB固体有很强的荧光特性;在365 nm的激发波长下,TPB的量子产率为51.9%;在水体积分数为80%时,TPB的荧光效果最佳;荧光探针TPB对四环素类抗生素具有较高的选择性和较强的抗干扰能力,即四环素类抗生素对TPB高度猝灭,满足荧光内滤效应的条件,而磺胺类和喹诺酮类抗生素对TPB猝灭效果不佳;体系荧光强度随着盐酸四环素浓度增加而降低,存在较强的相关性,线性回归方程为y=-1.338x+984.20,检出限为0.0427 mmol·L^(-1);在pH≤7时,猝灭效果较好;加入盐酸四环素溶液后,湖水、海水、牛奶体系荧光强度均明显减弱,可以通过荧光强度的变化间接反映四环素类抗生素溶液浓度的变化。通过抗生素猝灭TPB的探究,在环境和食品中抗生素残留量的检测具有重大意义,为人类治理食品和环境中残留的抗生素提供参考。

关键词：荧光检测抗生素聚集诱导发光效应四苯基-1 3-丁二烯

3D-ASL的rCBF max值在儿童后颅窝肿瘤鉴别诊断中的价值

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放射学实践 2024年第4期39卷 523-527页

作者：盛思思邵剑波彭雪华郭豫朱百奇华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院)影像中心/武汉市儿童影像医学临床医学研究中心湖北武汉430016

目的:探讨三维动脉自旋标记成像(3D-ASL)参数rCBF_(max)对儿童后颅窝肿瘤的诊断价值。方法:回顾性分析2018年1月-2022年12月在本院经手术病理证实的52例后颅窝肿瘤患儿的临床和术前MRI资料(平扫、增强和3D-ASL)。其中,髓母细胞瘤28例,... 详细信息

目的:探讨三维动脉自旋标记成像(3D-ASL)参数rCBF_(max)对儿童后颅窝肿瘤的诊断价值。方法:回顾性分析2018年1月-2022年12月在本院经手术病理证实的52例后颅窝肿瘤患儿的临床和术前MRI资料(平扫、增强和3D-ASL)。其中,髓母细胞瘤28例,毛细胞星形细胞瘤11例,室管膜瘤13例。测量肿瘤实性区域的最大脑血流量(CBF_(max))值,并计算最大相对脑血流量(rCBF_(max)=CBF_(max)/CBF_(健侧正常脑灰质))。采用Kruskal-Wallis检验比较3组肿瘤的rCBF_(max)值,采用ROC曲线和约登指数来确定rCBF_(max)鉴别肿瘤病理类型的最佳阈值、敏感度、特异度和曲线下面积(AUC)。结果:室管膜瘤的rCBF_(max)值最高,为1.53(1.27,2.04),毛细胞星形细胞瘤的rCBF_(max)值最低,为0.69(0.56,0.76),髓母细胞瘤的rCBF_(max)值为0.90(0.84,1.00)。三组肿瘤的rCBF_(max)值比较,差异有统计学意义(P<0.001)。ROC曲线分析显示鉴别室管膜瘤与髓母细胞瘤的rCBF_(max)最佳阈值为1.13,相应的诊断敏感度为100%,特异度为82.1%,AUC为90.7%;鉴别髓母细胞瘤与毛细胞星形细胞瘤的rCBF_(max)最佳阈值为0.80,相应的诊断敏感度为85.7%,特异度为100%,AUC为97.1%。结论:3D-ASL定量参数rCBF_(max)对常见儿童后颅窝肿瘤的鉴别诊断具有较高的临床应用价值。

关键词：后颅窝肿瘤儿童动脉自旋标记成像脑血流量磁共振成像