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Ultrahigh strength and uniform corrosion in Zn-Li alloys through ultrahigh pressure supersaturated solid solution treatment for biodegradable orthopedic applications

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Rare Metals 2024年第10期43卷 5284-5304页

作者： Wan-Ying Li Yi-Long Dai Wen-Hao Cai si-Han Lin Lin guo De-Chuang Zhang Yuncang Li Cuie Wen School of Materials Science and Engineering Xiangtan University Department of Prosthodontics Shanghai Ninth People′s HospitalShanghai Jiao Tong University Key Laboratory of Low Dimensional Materials&Application Technology Ministry of EducationXiangtan University School of Engineering RMIT UniversityMelbourne

Zn-Li alloys are considered promising candidate materials for biodegradable orthopedic implant applications due to their high mechanical performance and good ***,the presence of a large number of second-phase particles in this class of Zn alloys can lead to severe localized degradation due to micro-galvanic corrosion,which is detrimental to the mechanical integrity of the alloys during tissue healing in the human *** this study we report ultrahigh strength,uniform corrosion,good cytocompatibility,and effective antibacterial ability in Zn-x Li（x=0.3,0.5,0.7;wt%） alloys achieved through supersaturated solid solution treatment （SSST） at 375℃ under ultrahigh pressure of 3 GPa.A high concentration of β-LiZn4phases coexisted with the-Zn matrix in the as-cast Zn-x Li alloys,whereas almost all the Li dissolved into the-Zn matrix of SSST *** yield strength was 437 MPa for SSST Zn-0.3Li,592 MPa for SSST Zn-0.5 Li and 686 MPa for SSST *** SSST Zn-Li alloys showed uniform degradation with remarkably reduced degradation rates compared to their as-cast *** 25% concentration extracts of the Zn-x Li alloys demonstrated no cytotoxicity toward MC3T3-E1 cells,and the alloys exhibited effective antibacterial ability agains methicillin-resistant staphylococcus aureus.

关键词： Corrosion behavior Mechanical property Supersaturated solid solution treatment (SSST) Ultrahigh pressure Zn-Li alloy

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Construction and validation of a pancreatic cancer prognostic model based on genes related to the hypoxic tumor microenvironment

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World Journal of Gastroenterology 2024年第36期30卷 4057-4070页

作者： Fan Yang Na Jiang Xiao-Yu Li Xing-si Qi Zi-Bin Tian Ying-Jie guo Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Pancreatic cancer is one of the most lethal malignancies,characterized by poor prognosis and low survival *** prognostic factors for pancreatic cancer offer inadequate predictive accuracy,often failing to capture the complexity of the *** hypoxic tumor microenvironment has been recognized as a significant factor influencing cancer progression and resistance to *** study aims to develop a prognostic model based on key hypoxia-related molecules to enhance prediction accuracy for patient outcomes and to guide more effective treatment strategies in pancreatic *** To develop and validate a prognostic model for predicting outcomes in patients with pancreatic cancer using key hypoxia-related *** This pancreatic cancer prognostic model was developed based on the expression levels of the hypoxia-associated genes CAPN2,PLAU,and *** results were validated in an independent *** study also examined the correlations between the model risk score and various clinical features,components of the immune microenvironment,chemotherapeutic drug sensitivity,and metabolism-related ***-time quantitative PCR verification was conducted to confirm the differential expression of the target genes in hypoxic and normal pancreatic cancer cell *** The prognostic model demonstrated significant predictive value,with the risk score showing a strong correlation with clinical features:It was significantly associated with tumor grade(G)(bPsignificantly correlated with residual tumor(R)status(bPsignificant negative correlation between the risk score and the half-maximal inhibitory concentration of some chemotherapeutic ***,the risk score was linked to the enrichment of metabolism-related pathways in pancreatic *** The prognostic model based on hypoxia-related genes effectively predicts pancreati

关键词： Pancreatic cancer Hypoxia Prognostic model Immune microenvironment Metabolism pathway

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Update understanding on diagnosis and histopathological examination of atrophic gastritis:A review

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4080-4091页

作者： Xiu-Zhen Ma Ni Zhou Xiu Luo si-Qi guo Ping Mai The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Gastroenterology Gansu Provincial People's HospitalLanzhou 730000Gansu ProvinceChina Department of Gastroenterology Xi'an International Medical CenterXi’an 710000Shaanxi ProvinceChina The First School of Clinical Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina

Chronic atrophic gastritis(CAG)is a complex syndrome in which long-term chronic inflammatory stimulation causes gland atrophy in the gastric mucosa,reducing the stomach's ability to secrete gastric juice and pepsin,and interfering with its normal physiological *** pathogenic factors contribute to CAG incidence,the most common being Helicobacter pylori infection and the immune reactions resulting from gastric ***,CAG has a broad spectrum of clinical manifestations,including gastroenterology and extraintestinal symptoms and signs,such as hematology,neurology,and ***,the initial CAG evaluation should involve the examination of clinical and serological indicators,as well as diagnosis confirmation via gastroscopy and histopathology if *** on the severity and scope of atrophy affecting the gastric mucosa,a histologic staging system(Operative Link for Gastritis Assessment or Operative Link on Gastritis intestinal metaplasia)could also be ***,chronic gastritis has a higher risk of progressing to gastric cancer(GC).In this regard,early diagnosis,treatment,and regular testing could reduce the risk of GC in CAG ***,the optimal interval for endoscopic monitoring in CAG patients remains uncertain,and it should ideally be tailored based on individual risk evaluations and shared decision-making *** there have been many reports on CAG,the precise etiology and histopathological features of the disease,as well as the diagnosis of CAG patients,are yet to be fully ***,this review offers a detailed account of CAG,including its key clinical aspects,aiming to enhance the overall understanding of the disease.

关键词： Atrophic gastritis Helicobacter pylori infection Autoimmune gastritis Diagnosis Operative link for gastritis assessment staging Gastric cancer risk

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Echinacoside attenuates glandular fibrosis in benign prostatic hyperplasia via inhibiting MKK6/MK2 signaling pathway

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Traditional Medicine Research 2024年第3期9卷 24-31页

作者： si Qin Jing-Lou Chen Xiao-Feng Zhou Cong-Yue Xu Jing guo Department of Pharmacy Jianghan UniversityWuhan 430056China Department of Clinical Medicine Jianghan UniversityWuhan 430056China Institutes of Biomedical Sciences Jianghan UniversityWuhan 430056China Department of Basic Medicine School of MedicineJianghan UniversityWuhan 430056China

Background:Lower urinary tract symptoms commonly occur in the elderly population and seriously constrain the quality of *** fibrosis is an important pathobiological process in benign prostatic hyperplasia and is also a main inducing factor for benign prostatic hyperplasia-associated lower urinary tract *** species is an important herbal medicine resource and is traditionally used in ameliorating renal and prostatic ***:This study was to investigate the potential protective function of echinacoside(a bioactive compound from Cistanches)against prostatic fibrosis in mice and human benign prostatic hyperplasia epithelial-1 cell ***:It was found that echinacoside attenuated testosterone-induced prostatic hyperplasia and collagen deposition in mice,relieved prostate local inflammation and oxidative damage,and ameliorated prostatic epithelial-mesenchymal ***,echinacoside inhibited the activation of the MKK6/MK2 signaling pathway both in vivo and in ***:This study added new evidence for the anti-fibrotic function of echinacoside on the prostate and provided new insights for understanding its possible pharmacological mechanisms.

关键词： benign prostatic hyperplasia echinacoside epithelial-mesenchymal transition fibrosis

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创制杀菌剂烯肟菌胺生物活性及应用(Ⅰ)──小麦白粉病

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农药 2008年第10期47卷 712-714页

作者：司乃国刘君丽陈亮兰杰沈阳化工研究院沈阳110021

室内试验结果表明:烯肟菌胺对小麦白粉病的盆栽杀菌活性(EC90值)为4.03mg/L;田间小区试验结果一致表明,烯肟菌胺在40～80ga.i./hm2的处理剂量下,施药1～2次,对小麦白粉病具有优异的防治效果,同时对小麦锈病、小麦赤霉病、小麦纹枯病也... 详细信息

室内试验结果表明:烯肟菌胺对小麦白粉病的盆栽杀菌活性(EC90值)为4.03mg/L;田间小区试验结果一致表明,烯肟菌胺在40～80ga.i./hm2的处理剂量下,施药1～2次,对小麦白粉病具有优异的防治效果,同时对小麦锈病、小麦赤霉病、小麦纹枯病也有良好的防治作用。

关键词：烯肟菌胺小麦白粉病生物活性

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烯肟菌酯防治苹果病害的混剂筛选

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农药 2020年第3期59卷 228-230页

作者：孙芹兰杰李志念司乃国沈阳中化农药化工研发有限公司新农药创制与开发国家重点实验室沈阳110021

[目的]明确烯肟菌酯与氟环唑、咪鲜胺对苹果树主要病害的协同增效作用。[方法]采用菌丝生长速率法和田间喷雾法。[结果]室内筛选试验发现:烯肟菌酯与氟环唑在1∶4、1∶2、1∶1、2∶1、4∶1配比下对苹果斑点落叶病增效作用明显,在1∶5、1... 详细信息

[目的]明确烯肟菌酯与氟环唑、咪鲜胺对苹果树主要病害的协同增效作用。[方法]采用菌丝生长速率法和田间喷雾法。[结果]室内筛选试验发现:烯肟菌酯与氟环唑在1∶4、1∶2、1∶1、2∶1、4∶1配比下对苹果斑点落叶病增效作用明显,在1∶5、1∶3、1∶1、3∶1、5∶1配比下对苹果树腐烂病增效作用明显;烯肟菌酯与咪鲜胺在3∶1、1∶1、1∶3、1∶5、1∶7配比下对苹果轮纹病增效作用明显。田间试验结果显示:18%烯肟菌酯·氟环唑悬浮剂对苹果斑点落叶病在120 mg a.i./kg剂量下,春梢防效达到88.71%,秋梢防效达到81.67%。[结论]烯肟菌酯与氟环唑、咪鲜胺等混配,多个比例下均对3种病害增效作用明显,有效降低了新杀菌剂抗性风险,为混剂开发提供了方向,为生产用药提供了指导。

关键词：烯肟菌酯氟环唑咪鲜胺苹果斑点落叶病苹果轮纹病苹果腐烂病

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灰葡萄孢菌对啶菌恶唑的抗药性研究初报

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农药 2005年第4期44卷 181-183页

作者：赵平司乃国刘君丽兰杰沈阳农业大学沈阳110161 沈阳化工研究院沈阳110021

以灰葡萄孢菌为试验耙标,通过室内药剂驯化、紫外灯诱变,获得抗性突变体,并对抗性突变体的适合度进行测定,以评价新型杀菌剂啶菌恶唑的抗性风险。结果表明,经药剂驯化10代,抗性突变体的EC50值与敏感菌株无明显差异。在诱导14代后,EC50... 详细信息

以灰葡萄孢菌为试验耙标,通过室内药剂驯化、紫外灯诱变,获得抗性突变体,并对抗性突变体的适合度进行测定,以评价新型杀菌剂啶菌恶唑的抗性风险。结果表明,经药剂驯化10代,抗性突变体的EC50值与敏感菌株无明显差异。在诱导14代后,EC50有所上升,但是抗性突变体的生长速率、产孢量等明显低于敏感菌株。因此,初步推断啶菌恶唑是一种抗性风险较低的杀菌剂。

关键词：灰葡萄孢菌,啶菌恶唑,抗药性

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Ischemic colitis induced by a platelet-raising capsule: A case report

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World Journal of Clinical Cases 2024年第3期12卷 607-615页

作者： Chen-Lu Wang Ze-Kun si guo-Hong Liu Chen Chen Hui Zhao Lei Li The Affiliated Hospital of Shandong Second Medical University School of Clinical MedicineShandong Second Medical UniversityWeifang 261000Shandong ProvinceChina Department of Gastroenterology The Affiliated Hospital of Shandong Second Medical UniversityWeifang 261000Shandong ProvinceChina

BACKGROUND Ischemic colitis(IC)is also known as colon ischemia and is caused by colon vascular occlusion or nonocclusion,which results in a reduced blood supply to the colon and is not significant enough to maintain the metabolic function of cells,leading to intestinal wall *** main symptoms include abdominal pain,diarrhea,and bloody *** severe cases,intestinal gangrene,peritonitis,intestinal stenosis and even intestinal obstruction may *** induced by long-term use of certain special drugs is relatively rare in clinical *** article describes the clinical diagnosis and treatment of a typical case and provides a new treatment idea for the treatment of *** SUMMARY The patient was admitted to the hospital with"abdominal pain for half a month and bloody stool with mucous and pus for 3 d"and was diagnosed with"IC".Symptomatic and supportive treatment,such as antibiotics(levofloxacin),acid inhibition and stomach protection,fluid replenishment,and intravenous nutrition,was *** patient's colonic ulcers were considered to be related to the oral administration of platelet(PLT)-raising capsules;the patient was asked to stop PLT-raising drugs for selective review via colonoscopy,and antibiotics and mesalazine enteric-coated tablets were *** the guidance of hematology consultation,60 mg of methylprednisolone was given in combination with PLT infusion to increase the *** treatment,the patient's condition stabilized,the patient’s stool turned yellow,the patient’s symptoms improved,and the patient was allowed to leave the *** PLT-raising capsules can lead to IC,so clinicians should have a full understanding of the application of these drugs in the treatment of various causes of thrombocyt-INTRODUCTION Ischemic colitis(IC)is also known as colon ischemia(CI)and is caused by colon vascular occlusion or nonocclusion,which results in a reduced blood supply to the colon;this process is not significant enough to maintai

关键词： Platelet-raising capsule Ischemic colitis Drug-related Colonic ulcer Case report

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新杀菌剂抗性风险评估及其在市场预测中的作用

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农药 2005年第10期44卷 477-479页

作者：单中刚刘君丽司乃国沈阳化工研究院沈阳110021

杀菌剂抗性风险是指病原菌抗药性发展使杀菌剂防效丧失或药效降低的可能性。一个农药新品种投入市场时,抗性风险评估、抗性检测技术和抗性治理策略也往往同时推出。通过药剂驯化、诱导、化学诱变、紫外线诱变等方法获得抗性菌株,并对抗... 详细信息

杀菌剂抗性风险是指病原菌抗药性发展使杀菌剂防效丧失或药效降低的可能性。一个农药新品种投入市场时,抗性风险评估、抗性检测技术和抗性治理策略也往往同时推出。通过药剂驯化、诱导、化学诱变、紫外线诱变等方法获得抗性菌株,并对抗性菌株的致病力和遗传稳定性进行研究,对新杀菌剂可能产生抗性的风险做出评估。植物病原菌对杀菌剂的抗药性风险的高低,是影响杀菌剂新品种在市场中使用时间长短和销量的关键因素,杀菌剂抗性风险评估是新品种市场预测和应用开发的重要依据。

关键词：杀菌剂抗性风险市场预测

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Measurement of the high energyγ-rays from heavy ion reactions usingČerenkov detector

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Nuclear Science and Techniques 2024年第2期35卷 123-130页

作者： Da-Wei si Yan Zhou Sheng Xiao Zhi Qin Dong guo Yu-Hao Qin Yi-Jie Wang Bo-Yuan Zhang Bai-Ting Tian Zhi-Gang Xiao Department of Physics Tsinghua UniversityBeijing 100084China

The energetic bremsstrahlung photons up to 100 MeV produced in heavy ion collisions can be used as a sensitive probe for short-range correlation in atomic nuclei. The energy of the γ-rays can be measured by collecting the Čerenkov light in the medium induced by the fast electrons generated in the Compton scattering or electromagnetic shower of the incident γray. Two types of detectors based on pure water and lead glass as sensitive materials were designed for this purpose. The γresponse and optical photon propagation in the detectors were simulated based on electromagnetic and optical processes in Geant4. The inherent energy resolutions of 0.022(4) + 0.51(2)∕E^(1/2)_(γ) for water and 0.0026(3) + 0.446(3)∕E^(1/2)_(γ) for lead glass were obtained. The geometry sizes of the lead glass and water were optimized to 30 cm × 30 cm × 30 cm and 60 cm × 60 cm ×120 cm, respectively, to detect high-energy γ-rays at 160 MeV. The Hough transform method was applied to reconstruct the direction of the incident γ-rays, providing the ability to experimentally distinguish the high-energy γ-rays produced in the reactions on the target from random background cosmic-ray muons.

关键词： Bremsstrahlungγ-rays Čerenkov Geant4 Energy resolution Direction reconstruction Hough transform

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