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Potassium dehydroandrographolide succinate regulates the MyD88/CDH13 signaling pathway to enhance vascular injuryinduced pathological vascular remodeling

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Chinese Journal of Natural Medicines 2024年第1期22卷 62-74页

作者： GUO Qiru LI Jiali WANG Zheng WU Xiao JIN Zhong ZHU Song LI Hongfei ZHANG Delai HU Wangming XU Huan YANG Lan shi liangqin WANG Yong College of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 610000China Chengdu University of Traditional Chinese Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610000China

Pathological vascular remodeling is a hallmark of various vascular *** research has established the significance of andrographolide in maintaining gastric vascular homeostasis and its pivotal role in modulating endothelial barrier dysfunction,which leads to pathological vascular *** dehydroandrographolide succinate(PDA),a derivative of andrographolide,has been clinically utilized in the treatment of inflammatory diseases precipitated by viral *** study investigates the potential of PDA in regulating pathological vascular *** effect of PDA on vascular remodeling was assessed through the complete ligation of the carotid artery in C57BL/6 *** approaches,including rat aortic primary smooth muscle cell culture,flow cytometry,bromodeoxyuridine(BrdU)incorporation assay,Boyden chamber cell migration assay,spheroid sprouting assay,and Matrigel-based tube formation assay,were employed to evaluate the influence of PDA on the proliferation and motility of smooth muscle cells(SMCs).Molecular docking simulations and co-immunoprecipitation assays were conducted to examine protein *** results revealed that PDA exacerbates vascular injury-induced pathological remodeling,as evidenced by enhanced neointima *** treatment significantly increased the proliferation and migration of *** mechanistic studies disclosed that PDA upregulated myeloid differentiation factor 88(MyD88)expression in SMCs and interacted with T-cadherin(CDH13).This interaction augmented proliferation,migration,and extracellular matrix deposition,culminating in pathological vascular *** findings underscore the critical role of PDA in the regulation of pathological vascular remodeling,mediated through the MyD88/CDH13 signaling pathway.

关键词： Potassium dehydroandrographolide succinate Smooth muscle cell Myeloid differentiation factor 88 T-cadherin Pathological vascular remodeling

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Critical role of mitochondrial aldehyde dehydrogenase 2 in acrolein sequestering in rat spinal cord injury

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Neural Regeneration Research 2022年第7期17卷 1505-1511页

作者： Seth A.Herr liangqin shi Thomas Gianaris Yucheng Jiao Siyuan Sun Nick Race Scott Shapiro Riyi shi Center for Paralysis Research&Department of Basic Medical Sciences College of Veterinary MedicinePurdue UniversityWest LafayetteINUSA Department of Orthopedics Ruijin HospitalSchool of MedicineShanghai Jiaotong UniversityInstitute of Trauma and OrthopedicsShanghaiChina Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA

Lipid peroxidation-derived aldehydes,such as acrolein,the most reactive aldehyde,have emerged as key culprits in sustaining post-spinal cord injury(SCI)secondary pathologies leading to functional *** evidence suggests that mitochondrial aldehyde dehydrogenase-2(ALDH2),a key oxidoreductase and powerful endogenous anti-aldehyde machinery,is likely important for protecting neurons from aldehydesmediated *** a rat model of spinal cord contusion injury and recently discovered ALDH2 activator(Alda-1),we planned to validate the aldehyde-clearing and neuroprotective role of *** an acute 2 day period post injury,we found that ALDH2 expression was significantly lowered post-SCI,but not so in rats given *** lower enzymatic expression may be linked to heightened acrolein-ALDH2 adduction,which was revealed in co-immunoprecipitation *** have also found that administration of Alda-1 to SCI rats significantly lowered acrolein in the spinal cord,and reduced cyst *** addition,Alda-1 treatment also resulted in significant improvement of motor function and attenuated post-SCI mechanical hypersensitivity up to 28 days ***,ALDH2 was found to play a critical role in in vitro protection of PC12 cells from acrolein *** is expected that the outcome of this study will broaden and enhance anti-aldehyde strategies in combating post-SCI neurodegeneration and potentially bring treatment to millions of SCI *** animal work was approved by Purdue Animal Care and Use Committee(approval No.1111000095)on January 1,2021.

关键词： acrolein acrolein-lysine adduct alda-1 enzymatic catalyst lipid peroxidation mitochondrial aldehyde dehydrogenase-2 neurotrauma oxidative stress reactive aldehydes spinal cord contusion

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Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson’s disease:implication of acrolein and TRPA1

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Translational Neurodegeneration 2021年第2期10卷 151-165页

作者： liangqin shi Yazhou Lin Yucheng Jiao Seth AHerr Jonathan Tang Edmond Rogers Zhengli Chen Riyi shi College of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 610075China Center for Paralysis Research&Department of Basic Medical Sciences College of Veterinary MedicinePurdue UniversityWest LafayetteIN 47907USA Laboratory of Animal Disease Model College of Veterinary MedicineSichuan Agricultural UniversityChengdu 625014China Department of Orthopedics Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityInstitute of Trauma and OrthopedicsShanghai 200025China Weldon School of Biomedical Engineering Purdue University West LafayetteWest LafayetteIN 47907USA

Background:The mechanisms underlying lesions of dopaminergic(DA)neurons,an essential pathology of Parkinson’s disease(PD),are largely unknown,although oxidative stress is recognized as a key *** have previously shown that the pro-oxidative aldehyde acrolein is a critical factor in PD pathology,and that acrolein scavenger hydralazine can reduce the elevated acrolein,mitigate DA neuron death,and alleviate motor deficits in a 6-hydroxydopamine(6-OHDA)rat *** such,we hypothesize that a structurally distinct acrolein scavenger,dimercaprol(DP),can also offer neuroprotection and behavioral ***:DP was used to lower the elevated levels of acrolein in the basal ganglia of 6-OHDA *** acrolein levels and related pathologies were measured by *** and behavioral effects of 6-OHDA injections and DP treatment were examined using the open field test and rotarod *** was assessed using mechanical allodynia,cold hypersensitivity,and plantar ***,the effects of DP were assessed in vitro on SK-N-SH dopaminergic cells exposed to ***:DP reduced acrolein and reversed the upregulation of pain-sensing transient receptor potential ankyrin 1(TRPA1)channels in the substantia nigra,striatum,and *** also mitigated both motor and sensory deficits typical of *** addition,DP lowered acrolein and protected DA-like cells in ***’s ability to upregulate TRPA1 was also verified in vitro using cell ***:These results further elucidated the acrolein-mediated pathogenesis and reinforced the critical role of acrolein in PD while providing strong arguments for anti-acrolein treatments as a novel and feasible strategy to combat neurodegeneration in *** the extensive involvement of acrolein in various nervous system illnesses and beyond,anti-acrolein strategies may have wide applications and broad impacts on human health.

关键词： Oxidative stress Parkinson’s disease Neuroinflammation Acrolein TRPA1 Dimercaprol

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全三维立体解释技术在周返地区的应用

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江汉石油职工大学学报 2019年第4期32卷 1-3页

作者：石良钦中石化江汉油田分公司勘探开发研究院

周矶油田自1989年投入勘探开发以来,构造油藏发现程度高,三小微幅构造圈闭成为滚动评价的重点方向。依托周返高精度开发地震资料,以精细地层对比统层为基础,综合运用相干体、蚂蚁追踪等结合可视化全三维立体解释技术,精细解剖工区构造,... 详细信息

周矶油田自1989年投入勘探开发以来,构造油藏发现程度高,三小微幅构造圈闭成为滚动评价的重点方向。依托周返高精度开发地震资料,以精细地层对比统层为基础,综合运用相干体、蚂蚁追踪等结合可视化全三维立体解释技术,精细解剖工区构造,结构构造特征再认识有明显提升,在潜江组地层精准落实多个“三小”构造圈闭,署的圈闭井位均获得较好效果,有效指导了周返地区油气勘探生产。

关键词：周矶油田高精度全三维立体解释技术油气勘探

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Changes of anti-oxidation enzymes levels in the blood of MPTP-induced PD monkeys

Changes of anti-oxidation enzymes levels in the blood of MPT...

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中国畜牧兽医学会动物解剖及组织胚胎学分会第十九次学术研讨会

作者： Like Li liangqin shi Heng Liu Qihui Luo Chao Huang Wentao Liu Xiaolin Chen Wen Zeng Zhengli Chen Laboratory of Animal Disease Model College of Veterinary MedicineSichuan Agricultural University Key Laboratory of Animal Disease and Human Health of Sichuan Province College of Veterinary MedicineSichuan Agricultural University

Parkinson’s disease(PD) is an age-related neurodegenerative *** its pathogenic mechanism is not understand,oxidative stress is believed to play a key role in this *** order to clarify its influence on PD progress,we performed study in eight rhesus monkeys treated with 1l-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) by intramuscular injection to develop a slow evolution of *** serum superoxide dismutase(SOD),malondialdehyde(MDA),glutathione(GSH),glutathione peroxidase(GPX),and glutathione-s-transferase(GST) were detected by *** whole blood gamma-glutamyl transpeptidase(GGT),gamma-glutamylcysteine synthetase(GCS),glutathione peroxidase 1(GPX-1),and glutathione-s-transferase pi(GST-pi) were measured by *** systemic administration,monkeys gradually developed typical symptoms of PD,while the susceptibility of individual monkeys to the MPTP differed,so the toxin damages of dopaminergic neurons in brain’s substantia nigra were dissimilar,and all the monkeys showed distinct clinical behavioral symptoms which lead to the behavioral scores were big difference in the early *** all the monkeys subsequently developed the major motor symptoms of PD when receiving an additional treatment with *** prolong treated MPTP,monkeys reached a state of stable parkinsonism,and no significant variation was observed *** the contents of GSH,MDA and the expression of GCS,GST-pi kept increasing,while the activity of GPX,GST,SOD and expression of GPX-1 kept decreasing,no change was observed in GGT *** work displayed the antioxidants changes in the blood of MPTP-treated monkeys accompanied with the progresses of PD,and these data suggested a potential identification or diagnosis of PD at different time point through the blood analysis.

关键词： anti-oxidation enzymes MPTP monkey

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我国高速公路改扩建方案研究及运用AHP模糊分析法进行方案优化

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武汉理工大学学报（交通科学与工程版） 2012年第5期36卷 1005-1008,1016页

作者：石良清袁春毅吴剑锋长安大学特殊地区公路工程教育部重点实验室西安710064 交通运输部规划研究院北京100029

通过对国内外现有高速公路改扩建现状及趋势的研究,依据改扩建方案的特点,分别从宏观的路网优化层面与微观的新建、扩容方案比较层面对我国高速公路的改扩建方案进行递进分析.再通过模糊综合评价法的应用,为高速公路改扩建方案的主观决... 详细信息

通过对国内外现有高速公路改扩建现状及趋势的研究,依据改扩建方案的特点,分别从宏观的路网优化层面与微观的新建、扩容方案比较层面对我国高速公路的改扩建方案进行递进分析.再通过模糊综合评价法的应用,为高速公路改扩建方案的主观决策提供量化的客观依据.

关键词：改扩建宏观微观量化

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An uncertainty investigation for liner impedance eduction methods

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Chinese Journal of Aeronautics 2024年第3期37卷 49-59页

作者： Weihao shi Xiaodong JING School of Energy and Power Engineering Beihang UniversityBeijing 100191China

Impedance eduction methods have been developed for decades to meet the increasing need for high-quality impedance data in the design and optimization of acoustic *** this end,it is important to fully investigate the uncertainty problem,to which only limited attention has been devoted so *** paper considers the possibility of acoustically-induced structural vibration as a nonnegligible uncertainty or error source in impedance eduction *** the frequency moves away from the resonant frequency,with the increase in the value of cavity reactance,the acoustic particle velocity inside liner orifices possibly decreases to the extent comparable to the vibration velocity of liner facing ***,the acoustically-induced vibration,although generally being weak except at the inherent structural frequencies,may considerably affect the impedance eduction results near the anti-resonant frequency where the liner has poor *** demonstrate the effect of structural vibration,the vibration velocity of liner facing sheet is estimated from the experimentally educed admittance of the liner samples whose orifices are sealed with ***,a three-dimensional numerical model is set up,in which normal particle velocity is introduced over the solid portion of liner facing sheet to imitate structural vibration,rather than directly solving the acoustic-structural coupling *** shown by the results,the vibration of liner facing sheet,whose velocity is as small as estimated by the experiment,can result in anomalous deviation of the educed impedance from the impedance model near the anti-resonant *** trend that the anomalous deviation varies with frequency is numerically captured.

关键词： Impedance eduction Uncertainty analysis Acoustically-induced structural vibration Anti-resonant frequency Perforated liner

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No Reference Image Sharpness Assessment Based on Global Color Difference Variation

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Chinese Journal of Electronics 2024年第1期33卷 293-302页

作者： Chenyang shi Yandan LIN School of Artificial Intelligence Anhui Polytechnic University School of Mechanical Engineering Anhui Polytechnic University Department of Light Sources and Illuminating Engineering Fudan University Academy for Engineering & Technology Fudan University

Image quality assessment(IQA) model is designed to measure the image quality in consistent with subjective ratings by computational models. In this research, a valid no reference IQA(NR-IQA) model for color image sharpness assessment is proposed based on local color difference map in a color space. In the proposed model, the absolute color difference variation and relative color difference variation are combined to evaluate sharpness in YIQ color space(a color coordinate system for the development of the United States color television system). The difference between sharpest and blurriest spot of an image is represented by the absolute color difference variation, and relative color difference variation expresses the variation in the image content. Extensive experiments are performed on five publicly available benchmark synthetic blur databases and two real blur databases, and the results prove that the proposed model work better than the other state-of-the-art and latest NR-IQA models for the prediction accuracy on blurry images. Besides, the model maintains the lowest computational complexity.

关键词： Image quality TV Image color analysis Databases Computational modeling Color Predictive models

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Adaptive Space Expansion for Fast Motion Planning

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1499-1514页

作者： Shenglei shi Jiankui Chen State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The sampling process is very inefficient for sam-pling-based motion planning algorithms that excess random sam-ples are generated in the planning *** this paper,we pro-pose an adaptive space expansion(ASE)approach which belongs to the informed sampling category to improve the sampling effi-ciency for quickly finding a feasible *** ASE method enlarges the search space gradually and restrains the sampling process in a sequence of small hyper-ellipsoid ring subsets to avoid exploring the unnecessary ***,for a con-structed small hyper-ellipsoid ring subset,if the algorithm cannot find a feasible path in it,then the subset is ***,the ASE method successively does space exploring and space expan-sion until the final path has been ***,we present a particular construction method of the hyper-ellipsoid ring that uniform random samples can be directly generated in *** last,we present a feasible motion planner BiASE and an asymptoti-cally optimal motion planner BiASE*using the bidirectional exploring method and the ASE *** demon-strate that the computation speed is much faster than that of the state-of-the-art *** source codes are available at https://***/shshlei/ompl.

关键词： Adaptive space expansion(ASE) hyper-ellipsoid ring informed sampling motion planning.

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Quantization and Event-Triggered Policy Design for Encrypted Networked Control

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 946-955页

作者： Yongxia shi Ehsan Nekouei the Department of Electrical Engineering City University of Hong KongHong KongChina

This paper proposes a novel event-driven encrypted control framework for linear networked control systems(NCSs),which relies on two modified uniform quantization policies,the Paillier cryptosystem,and an event-triggered *** to the fact that only integers can work in the Pailler cryptosystem,both the real-valued control gain and system state need to be first quantized before *** is dramatically different from the existing quantized control methods,where only the quantization of a single value,e.g.,the control input or the system state,is *** handle this issue,static and dynamic quantization policies are presented,which achieve the desired integer conversions and guarantee asymptotic convergence of the quantized system state to the ***,the quantized system state is encrypted and sent to the controller when the triggering condition,specified by a state-based event-triggered strategy,is *** doing so,not only the security and confidentiality of data transmitted over the communication network are protected,but also the ciphertext expansion phenomenon can be ***,by tactfully designing the quantization sensitivities and triggering error,the proposed event-driven encrypted control framework ensures the asymptotic stability of the overall closedloop ***,a simulation example of the secure motion control for an inverted pendulum cart system is presented to evaluate the effectiveness of the theoretical results.

关键词： Cyber-security encrypted control event-triggered control(ETC) networked control systems(NCSs) semi-homomorphic encryption

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