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Pharmacological effects of Schisandra Chinensis Fructus polysaccharide on intestinal protection

中国药理学与毒理学杂志 2021年第10期35卷 766-767页

作者： LI Ming-song ZHANG Dan-shen JING yong-shuai College of Chemistry and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018China

Schisandra Chinensis Fructus(SCF)is the fruit of Schisandra chinensis(Turcz.)Baill.,a perennial *** was first recorded in Shen Nong′s herbal classic and has a long application *** have shown that SCF has anti-inflammatory,protective liver,antioxidant,antibacterial and other pharmacological *** prescriptions are commonly used in the treatment of chronic diarrhea and other intestinal diseases and *** clinical pharmacology features of SCF polysaccharide(SCFP)in diabetes,liver diseases,enteritis and other aspects have achieved excellent *** is an important digestive organ of human body,but intestinal diseases are varied,including Crohn′s disease,ulcerative colitis,intestinal flora imbalance,etc..It is a chronic and non-specific inflammatory *** disease is persisted for a long time and the incidence rate is expected to *** of the symptoms are recurrent diarrhea,bloody stool and abdominal *** is considered by the World Health Organization as a refractory *** present,there is little possibility of complete cure,which is closely related to complex environmental factors,eating habits and *** recent years,clinical studies have found that SCFP has a variety of pharmacological effects on intestinal protection.①Reduce inflammatory factors:intestinal mucositis is a common adverse reaction in patients with *** development of mucositis is related to pro-inflammatory factors such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),IL^(-1)β,Interferon-γ(IFN-γ).SCFP can significantly reduce IL-6 TNF-α,IL^(-1)β,and IL-8,as well as the accumulation of T cells in the process of resisting apoptosis,reduce the inflammatory reaction and protect the damage to villi and crypts,improve the symptoms of small intestinal mucositis caused by weight loss and diarrhea.②Promote immunoglobulin A secretion:intestinal mucosal immunity is the first line of defense of the body′s immune *** main antibody

关键词： Schisandra Chinensis Fructus polysaccharide intestinal diseases inflammatory factor

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Vibration-assisted vat photopolymerization for pixelated-aliasing-free surface fabrication

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International Journal of Extreme Manufacturing 2024年第3期6卷 440-456页

作者： Han Xu Renzhi Hu shuai Chen Junhong Zhu Chi Zhou yong Chen Center for Advanced Manufacturing University of Southern CaliforniaLos AngelesCA 90007United States of America Daniel J.Epstein Department of Industrial and Systems Engineering University of Southern CaliforniaLos AngelesCA 90089United States of America Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089United States of America Department of Industrial and Systems Engineering University of BuffaloBuffaloNY 14260United States of America

Mask image projection-based vat photopolymerization(MIP-VPP)offers advantages like low cost,high resolution,and a wide material range,making it popular in industry and ***,MIP-VPP employing liquid crystal displays(LCDs)has gained traction,increasingly replacing digital micromirror devices,particularly among hobbyists and in educational settings,and is now beginning to be used in industrial ***,LCD-based MIP-VPPsuffers from pronounced pixelated aliasing arising from LCD’s discrete image pixels and itsdirect-contact configuration in MIP-VPP machines,leading to rough surfaces on the 3D-printed ***,we propose a vibration-assisted MIP-VPP method that utilizes a microscalevibration to uniformize the light intensity distribution of the LCD-based mask image on VPP’s building *** maintaining the same fabrication speed,our technique generates asmoother,non-pixelated mask image,reducing the roughness on flat surfaces and boundary segments of 3D-printed *** light intensity modeling and simulation,we derived an optimal vibration pattern for LCD mask images,subsequently validated by *** assessed the surface texture,boundary integrity,and dimensional accuracy of componentsproduced using the vibration-assisted *** notably smoother surfaces and improved boundary roughness enhance the printing quality of MIP-VPP,enabling its promisingapplications in sectors like the production of 3D-printed optical devices and others.

关键词： additive manufacturing vat photopolymerization piezo vibration sub-pixel resolution aliasing

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Research progress in mechanism of curcumin in treatment of Parkinson disease

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中国药理学与毒理学杂志 2021年第10期35卷 776-777页

作者： YUAN Xin-ru JING yong-shuai ZHANG Dan-shen College of Chemistry and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018China

Curcumin(Cur)is an important bioactive component of polyphenols in the rhizomes of Curcuma longa L.,Tulipa gesneriana *** other Curcuma *** has a wide range of pharmacological effects such as anti-tumor,anti-atherosclerosis,anti-inflammatory,and *** disease(PD)is a neurodegenerative disease that often occurs in the *** main pathological characteristics are the characteristic loss of substantia nigra dopaminergic neurons,the decrease of dopamine content in the striatum,and the formation of Lewy *** present,the main methods of clinical treatment of PD include drug therapy and surgical operation,but due to its complicated pathogenesis,they can only play a role in relieving,but cannot be completely *** pharmacological studies have shown that Cur has certain effects in the treatment of PD.①Anti-oxidative stress:oxidative stress is closely related to the degeneration of dopaminergic *** have found that Cur can increase the activity of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px),reduce malondialdehyde(MDA)content,thereby reducing oxidative stress damage and protecting dopaminergic neuron.②Reduce inflammation in brain tissue:neuroinflammation plays an important role in the development of *** the level of inflammatory factors can have a certain therapeutic effect on *** have shown that high-dose Cur can reduce the levels of interleukin-6(IL-6),IL^(-1)β,and tumor necrosis factor-α(TNF-α)in brain tissue,reduce inflammation,inhibit further neuronal damage,improve learning and memory,and exert neuroprotective effects.③Activation of autophagy:the abnormal accumulation ofα-Synuclein(α-Syn)in Lewy bodies is closely related to PD,and autophagy dysfunction leads toα-Syn clearance obstacles and an important factor of abnormal *** can increase the expression of microtubule-associated protein 1 light chain 3(LC3-Ⅱ)and lysosome-associated membrane protein 2A(LAMP2A),and reduce the

关键词： curcumin Parkinson disease mechanism of action

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Inducing opto-electronic and spintronic trends in bilayer h-BN through TMO3 clusters incorporation: Ab-initio study

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Chinese Physics B 2019年第11期28卷 284-294页

作者： Irfan Ahmed Muhammad Rafique Mukhtiar Ahmed Mahar Abdul Sattar Larik Mohsin Ali Tunio yong shuai Mehran University of Engineering and Technology SZABCampusKhairpur Mirs’Pakistan School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Mehran University of Engineering and Technology JamshoroSindhPakistan

The band structure, magnetism, charge distribution, and optics parameters of TMO3–h-BN hybrid systems are investigated by adopting first-principles study(FPS) calculations. It is observed that the TMO3 clusters add finite magnetic moments to bilayer h-BN(BL/h-BN), thereby making it a magnetic two-dimensional(2D) material. Spin-polarized band structures for various TMO3–BL/h-BN hybrid models are calculated. After the incorporation of TMO3, BL/h-BN is converted into semimetal or conducting material in spin up/down bands, depending on the type of impurity cluster present in BL/h-BN lattice. Optics parameters are also investigated for the TMO3–BL/h-BN complex systems. The incorporation of TMO3 clusters modifies the absorption and extinction coefficient in visible range, while static reflectivity and refraction parameter increase. It can be surmised that the TMO3 substitution in BL/h-BN is a suitable technique to modify its physical parameters thus making it functional for nano/opto-electronic applications, and an experimental approach can be adapted to reinforce the outcomes of this study.

关键词： bilayer h-BN band structure density of states magnetic moments optics

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Bound-State Soliton Solutions of the Nonlinear Schr?dinger Equation and Their Asymmetric Decompositions

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Chinese Physics Letters 2019年第3期36卷 5-8页

作者： yong-shuai Zhang Jing-Song He School of Science Zhejiang University of Science and Technology Institute for Advanced Study Shenzhen University

We study the asymmetric decompositions of bound-state(BS) soliton solutions to the nonlinear Schr?dinger equation. Assuming that the BS solitons are split into multiple solitons with different displacements, we obtain more accurate decompositions compared to the symmetric decompositions. Through graphical techniques, the asymmetric decompositions are shown to overlap very well with the real trajectories of the BS soliton solutions.

关键词： Solutions Nonlinear Equation

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临沂市罗庄区浅层地热能资源研究与评价——以地埋管地源热泵系统为例

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地下水 2024年第3期46卷 31-33,82页

作者：石林张永帅周亮宇郭雷刘孝峰荣玉伟河北地质大学地球科学学院河北石家庄050031 山东省地质矿产勘查开发局第七地质大队山东临沂276002

本研究旨在评估临沂市罗庄区浅层地热能资源量和开发利用潜力。在分析临沂市罗庄区区域地质、地热地质等基础资料的基础上,结合岩土体样品测试和现场热响应试验,采用指标法和层次分析法对临沂市罗庄区进行地埋管地源热泵系统进行适宜性... 详细信息

本研究旨在评估临沂市罗庄区浅层地热能资源量和开发利用潜力。在分析临沂市罗庄区区域地质、地热地质等基础资料的基础上,结合岩土体样品测试和现场热响应试验,采用指标法和层次分析法对临沂市罗庄区进行地埋管地源热泵系统进行适宜性区划并进行了潜力计算。结果表明:罗庄区内浅层地热能开发利用适宜性中等区面积68.97 km^(2),占97.17%;适宜区内,0~120 m浅层地热能储存量1.882×10^(13)kJ/℃。研究区采取地埋管地源热泵方式开采浅层地热能,冬季可供取暖面积2.56×10^(7)m^(2),夏季供可制冷面积1.56×10^(7)m^(2)。

关键词：浅层地热能地埋管地源热泵系统资源评价临沂市罗庄区

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Progress in protective effect and mechanism of 6-gingerol on myocardial ischemia/reperfusion injury

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中国药理学与毒理学杂志 2021年第10期35卷 769-770页

作者： MA Yun-feng PAN Fei-bing ZHANG Dan-shen JING yong-shuai College of Chemistry and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018China Huachuang Institute of Areca Research-Hainan Haikou 570125China

The morbidity and mortality of cardiovascular diseases are very high,which has attracted more and more attention all over the *** treatment methods for clinical treatment of acute myocardial infarction include direct percutaneous coronary intervention and coronary artery bypass grafting,which can quickly restore blocked coronary blood flow and reduce the infarct ***,the inevitable ischemia/reperfusion injury will occur during the recovery of coronary blood flow,its pathological mechanism is complicated,and the Western medicine countermeasures are very *** the current drugs for the treatment of cardiovascular diseases,traditional Chinese medicine has become a research hotspot due to its multiple targets,safety,and low side *** is the fresh rhizome of Zingiber officinale Rosc.,a perennial herbaceous plant in the ginger *** is a dual-purpose resource of medicine and *** has the functions of relieving the appearance and dispelling cold,warming up and relieving vomiting,resolving phlegm and relieving cough,and relieving fish and crab *** chemical components of ginger mainly include volatile oil,gingerol,diphenylheptane,etc..Among them,6-gingerol,as the main active component of gingerols,has obvious pharmacological effects in myocardial protection,anti-oxidation,anti-inflammatory,etc..Studies have shown that 6-gingerol protects myocardium mainly through anti-oxidative stress,anti-inflammatory,inhibiting cell apoptosis,and preventing calcium influx.①Anti-oxidative stress:oxidative stress is a state where oxidation and anti-oxidation in the body are out of balance,and it is also an important factor leading to myocardial *** studies have confirmed that 6-gingerol has an antioxidant effect,and it is considered a natural antioxidant.6-gingerol can significantly reduce the degree of oxidative stress and the level of reactive oxygen species caused by cardiomyocyte damage,and has a significant cardioprotective ef

关键词： 6-gingerol myocardial ischemia/reperfusion injury

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新型乳腺癌靶向小分子多肽性能初探

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解剖学研究 2024年第3期46卷 193-199页

作者：陈光锋谢艳萍帅永康陈裕环邹琼焦举中山大学附属第三医院核医学科广东广州510630

目的本研究经固相合成法设计并合成一种新的多肽分子(AR),探讨其乳腺癌靶向性及生物安全性。方法以多种乳腺细胞为模型,通过共聚焦和流式试验探究该荧光多肽分子探针的细胞摄取特异性并检测其对细胞周期的影响;通过CCK8法探讨其细胞毒性... 详细信息

目的本研究经固相合成法设计并合成一种新的多肽分子(AR),探讨其乳腺癌靶向性及生物安全性。方法以多种乳腺细胞为模型,通过共聚焦和流式试验探究该荧光多肽分子探针的细胞摄取特异性并检测其对细胞周期的影响;通过CCK8法探讨其细胞毒性,明确其生物安全性。结果共聚焦荧光成像和流式细胞分析结果显示MCF-7细胞的荧光强度明显高于正常乳腺上皮细胞MCF-10A以及其它类型乳腺癌细胞,验证了该探针具有良好的MCF-7细胞靶向特异性;CCK8结果显示,不同浓度AR-FITC处理后的MCF-7细胞存活率仍高于80%,表明该多肽探针具有较低的细胞毒性;细胞周期试验结果显示实验组和对照组MCF-7细胞的S期细胞分别为(12.45±0.75)%、(15.35±0.35)%,该细胞占比差异无统计学意义(P>0.05),表明AR对MCF-7细胞周期没有明显的影响。结论该新型多肽分子具有良好的肿瘤细胞靶向性及生物安全性,是一种较有潜力的乳腺癌靶向分子探针。

关键词：乳腺癌多肽分子探针靶向性

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Synthesis of nanofluids composed of deep eutectic solvents and metal-modified MCM-41 particles as multifunctional promoters for fuel oil desulfurization

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Frontiers of Chemical Science and Engineering 2023年第11期17卷 1776-1787页

作者： Jing-Xuan Zhang Xuan Wang Yan-Ru Feng Jia-Yu An Yu-Xuan Chi Ya-Tai Liu Ling-Fei Zhang Yun-Bo Zhao Xiang-Feng Zeng Zi-Bo Wang Jia-shuai Liu Yi-Fan Wang shuai-yong Dou Er-Hong Duan Tao Meng School of Environmental Science and Engineering Hebei University of Science and TechnologyShijiazhuang 050018China National Joint Local Engineering Research Center for Volatile Organic Compounds and Odorous Pollution Control Shijiazhuang 050018China College of Science Hebei Agricultural UniversityBaoding 071001China

Compared with traditional hydrodesulfurization,new nonhydrodesulfurization methods have the advantage of a high removal efficiency for thiophene compounds under mild ***,independent nonhydrodesulfurization technologies are faced with their own shortcomings,such as limitations of the desulfurization performance and regeneration of *** overcome these limitations,four nanofluids were prepared by dispersing different metal-modified MCM-41 particles in deep eutectic solvent as multifunctional promoters to develop a comprehensive desulfurization *** on the excellent adsorbability and high catalytic activity of the dispersed particles and the outstanding extractability of deep eutectic solvent in nanofluids,a high sulfur removal of 99.33%was achieved for model oil under mild conditions in 15 *** nanofluids also showed excellent reusability due to their high structural *** addition,NF@Cu/Al-MCM-41-2.5%exhibited the best desulfurization performance among the prepared *** result was obtained because the introduction of Al ions increased the number of acid sites and defect sites to improve the catalytic activity and adsorbability,and the best affinity of Cu/Al-MCM-41 for the deep eutectic solvent favored the reaction mass *** work opens the door to the development of a comprehensive nonhydrodesulfurization method based on the design of nanofluid materials.

关键词： fuel oil desulfurization nanofluids catalytic ozonation

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Phase evolution,hydrogen storage thermodynamics,and kinetics of ternary Mg_(98)Ho_(1.5)Fe_(0.5) alloy

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Journal of Rare Earths 2024年第9期42卷 1800-1808,I0006页

作者： Jinming Liu Hui yong Yang Zhao shuai Wang Yiwan Chen Baosheng Liu Jifan Hu Yanghuan Zhang College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan030024China China Institute of Ocean Engineering(Tsing Tao) Qingdao266000China Key Laboratory of Integrated Exploitation of Baiyun Obo Multi-Metal Resources Inner Mongolia University of Science and TechnologyBaotou014010China

Rare earth elements and transition metals have been found to improve the hydrogen storage characteristics of magnesium-based *** study investigated the Mg-Ho-Fe(MHF) ternary alloy prepared using the vacuum induction melting technique.X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),pressure-composition-temperature(PCT),and differential scanning calorimetry(DSC) were used to analyze the alloy's phase transitions,microstructure,thermodynamics,and kinetic *** results reveal that the Mg_(98)Ho_(1.5)Fe_(0.5) alloy forms a solid solution with Ho and Fe in the magnesium *** hydrogen absorption,the activated alloy transforms into a mixture of Mg/MgH_(2) phases and nanoscale HoH_(2) ***,only the MgH_(2) phase decomposes during hydrogen desorption,while the HoH_(2) phase remains unchanged,exhibiting a positive catalytic *** alloy demonstrates excellent hydrogen absorption kinetics,achieving a capacity of 5.56 wt% H_(2) within 10 min at 360℃,owing to the combined catalytic effects of Ho and *** activation energy for hydrogen desorption is found to be 135.87 kJ/mol,which is lower than that of the activation energies of pure MgH_(2) and MgFe alloys,indicating an enhancement in desorption ***,the enthalpy and entropy changes for hydrogen absorption and desorption are determined to be-70.51 kJ/mol H_(2),-125.62 J/(K·mol) H_(2),72.83 kJ/mol H_(2),and 128.95 J/(K·mol) H_(2),***,it is worth noting that the thermodynamic properties of the alloy are improved due to the catalytic effect of Ho and Fe.

关键词： Rare earths Magnesium-based hydrogen storage Hydrogen storage thermodynamics Hydrogen storage kinetics

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