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Reconceptualization of immune checkpoint inhibitor-associated gastritis

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World Journal of Gastroenterology 2024年第36期30卷 4031-4035页

作者： Ying-Fang Deng Xian-shu Cui Liang Wang Department of Oncology Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Gastrointestinal Oncology Surgery Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina

In recent years,with the extensive application of immunotherapy in clinical practice,it has achieved encouraging therapeutic *** enhancing clinical efficacy,however,it can also cause autoimmune damage,triggering immunerelated adverse events(irAEs).Reports of immunotherapy-induced gastritis have been increasing annually,but due to its atypical clinical symptoms,early diagnosis poses a certain ***,it can lead to severe complications such as gastric bleeding,elevating the risk of adverse outcomes for solid tumor patients if immunotherapy is ***,gaining a thorough understanding of the pathogenesis,clinical manifestations,diagnostic criteria,and treatment of immune-related gastritis is of utmost importance for early identification,diagnosis,and ***,the treatment of immune-related gastritis should be personalized according to the specific condition of each *** patients with grade 2-3 irAEs,restarting immune checkpoint inhibitors(ICIs)therapy may be considered when symptoms subside to grade *** restarting ICIs therapy,it is often recommended to use different types of *** grade 4 irAEs,permanent discontinuation of the medication is necessary.

关键词： Programmed cell death receptor-1 Programmed cell death-ligand 1 Cytotoxic T lymphocyte-associated antigen 4 Immune-related adverse events Immune-related gastritis

Electroacupuncture Promotes Angiogenesis in Mice with Cerebral Ischemia by Inhibiting miR-7

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Chinese Journal of Integrative Medicine 2024年第6期30卷 543-550页

作者： YU Qian shu Shi JU Xin-yao PENG Wei REN Xue-qi SI shu-han SONG Shi-zhen XIE Xue-yun FANG Bang-jiang ZHOU shuang School of Acupuncture-Moxibustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai201203China College of Basic Medicine Shanghai University of Traditional Chinese MedicineShanghai201203China Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China

Objective To observe the angiogenesis effect of electroacupuncture(EA)at shuigou acupoint(GV 26)in the treatment of cerebral ischemia,and explore the value of miRNA-7(miR-7)in *** First,48 mice were randomly divided into sham operation,middle cerebral artery occlusion(MCAO)model,and EA treatment *** 9 mice were divided into carrier control group,miR-7 knockout group and miR-7 overexpression group(n=3 each group).Finally,20 mice were divided into model and carrier control group,model and miR-7 knockout group,EA treatment and carrier control group and EA treatment and miR-7 overexpression group,with 3–6 mice in each *** MCAO model was established in the MCAO and EA *** deficit score and 2,3,5-triphenyltetrazolium chloride(TTC)staining were used to evaluate the severity of cerebral ***-eosin staining was used to describe basic pathological *** was used to quantify cerebral microvessel ***-time PCR and Western blot were used to detect the expression of miR-7 and its downstream target genes Krüppel-like factor 4/vascular endothelial growth factor(KLF4/VEGF)and angiopoietin-2(ANG-2)in the ischemic cerebral *** After EA,neurological deficit scores and infarction volumes decreased,and the density of cerebral microvessels *** the MCAO group,miR-7 expression was higher than that in the sham group(P<0.01).After EA at GV 26,miR-7 expression decreased(P<0.01)and the expression of downstream target genes KLF4/VEGF and ANG-2 increased as compared with the MCAO group(P<0.01).After EA combined with overexpression of miR-7,the expression of downstream target genes KLF4/VEGF and ANG-2 decreased compared to the control EA group(P<0.01).After miR-7 knockdown,the expression of KLF4/VEGF and ANG-2 increased(P<0.05 or P<0.01).Conclusions EA could promote angiogenesis in MCAO mice likely by inhibiting the expression of miR-7 and relieving inhibition of downstream target genes KLF4/VEG

关键词： electroacupuncture cerebral ischemia miRNA-7 angiogenesis shuigou(GV 26) acupuncture points

Highly Red Emissive Conjugated Homopolymers Based on Double B←N Bridged Bipyridine Unit

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Chinese Journal of Polymer Science 2024年第8期42卷 1029-1037页

作者： Yu-Yue Gao Kai-Yuan Zhang shu-Meng Wang Hui Tong Jun Liu State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Conjugated homopolymers based on six-member rings,e.g.,polyfluorene,always exhibit blue emission and conjugated homopolymers based on five-member rings,e.g.,polythiophene,can give red emission with low *** this work,we report a series of new conjugated homopolymers based on six-member rings with high-efficiency deep-red *** repeating units of the red light emitting homopolymers are double B←N bridged bipyridine(BNBP)with the boron atoms functionalized with diphenyl,borafluorene,and 2,7-di-tert-butyl-borafluorene groups,*** relationship between the chemical structures and the opto-electronic properties of the monomers and the homopolymers has been systematically *** three polymers emit pure red light(λ_(max)=656 nm)or deep red light(λ_(max)=693 nm)with fluorescence quantum efficiency in solution higher than 60%.The polymers can be used as the emitters in solution-processed organic light-emitting diodes with red emission and decent device *** work indicates a new strategy to design highly efficient light emitting conjugated polymers.

关键词： Conjugated homopolymers Double B←N bridged bipyridine(BNBP) Deep-red emission High fluorescent efficiency

Testing the first law of black hole mechanics with gravitational waves

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 76-82页

作者： Chao-Wan-Zhen Wang Jin-Bao Zhu Guo-Qing Huang Fu-Wen shu Department of Physics Nanchang UniversityNanchang 330031China Center for Relativistic Astrophysics and High Energy Physics Nanchang UniversityNanchang 330031China GCAP-CASPER Physics DepartmentBaylor UniversityWaco 76798-7316USA

The successful observation of gravitational waves has provided humanity with an additional method to explore the universe,particularly black *** this study,we utilize data from LIGO and Virgo gravitational wave observations to test the first law of black hole mechanics,employing two different *** consider the secondary compact object as a perturbation to the primary black hole before the merger,and the remnant black hole as a stationary black hole after the *** the pre-merger and post-merger analysis,our results demonstrate consistency with the first law,with an error level of approximate 25%at a68%credibility level for *** the full inspiral-merger-ringdown analysis,our results show consistency with the first law of black hole mechanics,with an error level of about 6%at a 68%credibility level and 10%at a 95%credibility level for ***,we observe that the higher the mass ratio of the gravitational wave source,the more consistent our results are with the first law of black hole ***,our study sheds light on the nature of compact binary coalescence and their implications for black hole mechanics.

关键词： gravitational waves black hole mechanics data analysis ringdown

Non-contact and full-field online monitoring of curing temperature during the in-situ heating process based on deep learning

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Advances in Manufacturing 2024年第1期12卷 167-176页

作者： Qiang-Qiang Liu shu-Ting Liu Ying-Guang Li Xu Liu Xiao-Zhong Hao College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing210016People’s Republic of China School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing211816People’s Republic of China

Online monitoring of the curing temperature field is essential to improving the quality and efficiency of the manufacturing process of composite *** embedded sensor-based technologies have difficulty monitoring the full temperature field or have to introduce heterogeneous items that could have an undesired impact on the *** this paper,a non-contact,full-field monitoring method based on deep learning that predicts the internal temperature field of composite parts in real time using surface temperature measurements of auxiliary materials is *** the proposed method,an average temperature monitoring accuracy of 97%is achieved in various heating *** addition,this method also demonstrates satisfying feasibility when a stronger thermal barrier covers the *** method was experimentally validated during the self-resistance electric heating process,in which the monitoring accuracy reached 93.1%.This method can potentially be applied to automated manufacturing and process control in the composites industry.

关键词： Online monitoring Curing temperature field Deep learning(DL) In-situ heating

Elaborative collection of condensed combustion products of solid propellants:Towards a real Solid Rocket Motor(SRM)operational environment

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Chinese Journal of Aeronautics 2024年第1期37卷 77-88页

作者： Wenchao ZHANG Zhimin FAN Dongliang GOU Yao shu Peijin LIU Aimin PANG Wen AO National Key Laboratory of Solid Rocket Propulsion Northwestern Polytechnical UniversityXi’an 710072China Science and Technology on Aerospace Chemical Power Laboratory Xiangyang 441003China

A novel constant-pressure and constant-quenching distance Condensed Combustion Products(CCPs)collection system was developed,coupled with a timing control system,to collect the CCPs formed in the course of burning of aluminum-based composite *** effects of adiabatic graphite plating,collection zone,quenching distance,time series of collection,and propellant burning rate on the microscopic morphology,particle size distribution and unburned aluminum content of CCPs were *** was verified that the graphite plating can provide a high-fidelity high-temperature environment for propellant *** combustion efficiency is improved by 2.44% compared to the bare propellant *** time series of collection has a significant effect on the combustion efficiency of aluminum,and the combustion efficiency of aluminum in the thermal state(1.2-2.4 s)is 2.75% higher than that in the cold state(0-1.2 s).Similarly,the characteristics of the CCPs in different collection zones are *** the quenching distance of 5 mm,the combustion efficiency of aluminum in the core zone(85.39%)is much lower than that in the outer zone(92.07%),while the particle size of the CCPs in the core zone(172μm)is larger than that in the outer zone(41μm).This indicates that the core zone is more likely to produce large-sized and incompletely burned agglomerates during the propellant combustion *** burning rates also lead to a significant difference in particle size distribution and combustion *** burning rates result in higher combustion efficiency.A detailed sequence of the elaborative collection process of CCPs is proposed,mainly including the setting of ignition delay time,burning rate,working pressure,plating length and time series of *** findings of this study are expected to provide a reliable tool for the evaluation of the combustion efficiency of solid propellants.

关键词： Composite propellants Condensed combustion products Aluminum Combustion efficiency Particle size distribution

Kinetic study and DFT calculation on the tetracycline abatement by peracetic acid

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Chinese Chemical Letters 2024年第9期35卷 346-350页

作者： Dan-Ying Xing Xiao-Dan Zhao Chuan-shu He Bo Lai College of Chemical Engineering Huaqiao UniversityXiamen 361021China State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China

Water contamination by tetracycline(TC)has emerged as an environmental concern owing to its widespread use and antibiotic *** of peracetic acid(PAA)in the water and wastewater treatment has recently been proposed and demonstrated to be effective for TC abatement,yet the underlying reaction kinetics between the PAA and TC are not yet *** explore the reaction kinetics,the effect of solution pH on TC abatement by PAA is studied and the species-specific rate constants are *** ability to donate and accept electrons for different species of TC and PAA is evaluated via density functional theory(DFT)*** pH-dependent apparent second-order rate constants of TC abatement by PAA exhibits the parabolic shape with the maximum at p H 8.5(9.75 L mol^(-1)s^(-1)).This phenomenon is closely related to the speciation of TC and PAA,in which the reaction between PAAH and TTC^(2-)possesses the highest species-specific rate constants according to the kinetic *** DFT calculations suggest that the HOMO of TTCH^(+),TTC,TTC^(-),TTC^(2-)and the LUMO of PAAH and PAA-are–6.40,–6.26,–5.10,–4.94 e V and–0.24,0.60 e V,*** to the DFT calculations,deprotonation of TC and PAA leads to an increase of the HOMO value of TC and the LUMO value of ***,the HOMOTC–LUMOPAAvalues is in good agreement with the trend of species-specific rate constants,which can be used to evaluate the reactivity between PAA and TC with different *** study provides the kinetic data and theoretical basis for the reaction of PAA and TC,which is critical for the application of PAA in the treatment of water and wastewater.

关键词： Peracetic acid Tetracycline Kinetics Rate constants DFT calculation

Aerodynamic/stealth design of S-duct inlet based on discrete adjoint method

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 725-746页

作者： Jun DENG Ke ZHAO Lin ZHOU Wei ZHANG Bowen shu Jiangtao HUANG Zhenghong GAO School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Aerospace Technology Institute of China Aerodynamic Research and Development CenterMianyang 621000Sichuan ProvinceChina

It is a major challenge for the airframe-inlet design of modern combat aircrafts,as the flow and electromagnetic wave propagation in the inlet of stealth aircraft are very *** this study,an aerodynamic/stealth optimization design method for an S-duct inlet is *** upwind scheme is introduced to the aerodynamic adjoint equation to resolve the shock wave and flow *** multilevel fast multipole algorithm(MLFMA)is utilized for the stealth adjoint equation.A dorsal S-duct inlet of flying wing layout is optimized to improve the aerodynamic and stealth *** the aerodynamic and stealth characteristics of the inlet are effectively ***,the optimization results are analyzed,and it shows that the main contradiction between aerodynamic characteristics and stealth characteristics is the centerline and crosssectional *** S-duct is smoothed,and the cross-sectional area is increased to improve the aerodynamic characteristics,while it is completely opposite for the stealth *** radar cross section(RCS)is reduced by phase cancelation for low frequency *** method is suitable for the aerodynamic/stealth design of the aircraft airframe-inlet system.

关键词： S-duct inlet aerodynamic/stealth optimization design discrete adjoint upwind scheme multilevel fast multipole algorithm(MLFMA)

Joint Transmit and Reflective Beamforming Design for Active IRS-Aided SWIPT Systems

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Chinese Journal of Electronics 2024年第2期33卷 536-548页

作者： Weiping SHI Qingqing WU Di WU Feng shu Jiangzhou WANG School of Electronic and Optical Engineering Nanjing University of Science and Technology Department of Electronic Engineering Shanghai Jiao Tong University School of Information and Communication Engineering Hainan University Department of Automation Shanghai Jiao Tong University School of Engineering University of Kent

To further improve the performance of passive intelligent reflecting surface(IRS)-assisted communication systems and mitigate the serious path loss due to “double-fading ” of IRS-assisted links, an active IRS-aided simultaneous wireless information and power transfer(SWIPT) system is investigated. This paper jointly optimizes the transmit beamforming at the base station(BS) and the phase shifts at the active IRS in order to maximize the power collected by the energy harvesting receiver under both perfect and imperfect channel state information(CSI)states, subject to the signal-to-interference-noise ratio constraint of the information decoding receiver, and the power constraints of the BS/IRS. Under perfect CSI, the alternating optimization algorithm is utilized for obtaining the transmit beamforming at the BS and the phase shifts at the active IRS. For each subproblem, we first transform nonconvex objective function and constraints into convex ones by performing a first-order Taylor expansion. Then, each subproblem is solved by using the interior point method. Given that obtaining perfect CSI is impractical, two robust beamforming designs are proposed for imperfect CSI case. Under the bounded CSI error model, we first transform the non-convex optimization problem into two semidefinite programming subproblems, and then solve each subproblem based on S-procedure and sequential rank-one constraint relaxation(SROCR) techniques. Under the stochastic CSI error model, the alternating optimization method is applied in an iterative manner based on Bernstein-type inequality and SROCR technique. Simulation results show that both robust and non-robust schemes for active IRS-assisted SWIPT systems can achieve extremely superior performance over conventional passive IRS-assisted systems under the same overall power budget.

关键词： Wireless communication Semidefinite programming Array signal processing Simulation Stochastic processes Transforms Receivers