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Functional protein microarray： an ideal platform for investigating protein binding property

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Frontiers in Biology 2012年第4期7卷 336-349页

作者： shu-min ZHOU Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine (Ministry of Education) Shanghai Jiao Tong University Shanghai 200240 China StateKey Laboratory of Oncogenes and Related Genes Shanghai 200240 China Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine Baltimore MD 21205 USA The High-Throughput Biology Center Johns Hopkins University School of Medicine Baltimore MD 21205 USA

Functional protein microarray is an important tool for high-throughput and large-scale systems biology studies. Besides the progresses that have been made for protein microarray fabrication, significant advancements have also been achieved for applying protein microarrays on determining a variety of protein biochemical activities. Among these applications, detection of protein binding properties, such as protein-protein interactions （PPIs）, protein-DNA interactions （PDIs）, protein-RNA interactions, and antigen-antibody interactions, are straightforward and have substantial impacts on many research fields. In this review, we will focus on the recent progresses in protein-protein, protein-DNA, protein-RNA, protein-small molecule, protein-lipid, protein-glycan, and antigen-antibody interactions. We will also discuss the challenges and future directions of protein microarray technologies. We strongly believe that protein microarrays will soon become an indispensible tool for both basic research and clinical applications.

关键词： lectin microarray protein microarray protein-cell interaction protein-DNA interaction (PDI) protein-proteininteraction (PPI)

Numerical Simulation of a Class of Nonlinear Wave Equations by Lattice Boltzmann Method

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Communications in Mathematics and Statistics 2017年第1期5卷 13-35页

作者： Yali duan Linghua Kong min Guo School of Mathematical sciences University of Science and Technology of ChinaHefei 230026.AnhuiPeople's Republic of China School of Mathematics and Information Science Jiangxi Normal UniversityNanchang 330022JiangxiPeople's Republic of China Department of Basic North China College of Mechanics and ElectricsChangzhi 046000ShanxiPeople's Republic of China

In this paper,we develop a lattice Boltzmann model for a class ofone-dimensional nonlinear wave equations,including the second-order hyperbolictelegraph equation,the nonlinear Klein-Gordon equation,the damped and undampedsine-Gordon equation and double sine-Gordon *** choosing properly theconservation condition between the macroscopic quantity u,and the distributionfunctions and applying the Chapman-Enskog expansion,the governing equation isrecovered correctly from the lattice Boltzmann ***,the local equilib-rium distribution function is *** results of numerical examples have beencompared with the analytical solutions to confirm the good accuracy and the applica-bility of our scheme.

关键词： Lattice Boltzmann method Second-order hyperbolic telegraph equation Klein-Gordon equation Sine-Gordon equation Chapman-Enskog expansion

Medical Knowledge Graph:Data Sources,Construction,Reasoning,and Applications

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Big Data mining and Analytics 2023年第2期6卷 201-217页

作者： Xuehong Wu Junwen duan Yi Pan min Li Computer Science and Engineering Central South UniversityChangsha 410083China School of Computer Science Hunan First Normal UniversityChangsha 410006China School of Computer Science and Engineering Central South UniversityChangsha 410083China Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518000China

Medical knowledge graphs(MKGs)are the basis for intelligent health care,and they have been in use in a variety of intelligent medical ***,understanding the research and application development of MKGs will be crucial for future relevant research in the biomedical *** this end,we offer an in-depth review of MKG in this *** research begins with the examination of four types of medical information sources,knowledge graph creation methodologies,and six major themes for MKG ***,three popular models of reasoning from the viewpoint of knowledge reasoning are discussed.A reasoning implementation path(RIP)is proposed as a means of expressing the reasoning procedures for *** addition,we explore intelligent medical applications based on RIP and MKG and classify them into nine major ***,we summarize the current state of MKG research based on more than 130 publications and future challenges and opportunities.

关键词： medical knowledge graph knowledge graph construction knowledge reasoning intelligent medical applications intelligent healthcare

Quantum properties of fermionic fields in multi-event horizon spacetime

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Science China(Physics,Mechanics & Astronomy) 2023年第12期66卷 56-62页

作者： Qianqian Liu shu-min Wu Cuihong Wen Jieci Wang Department of Physics Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of EducationSynergetic Innovation Center for Quantum Effects and ApplicationHunan Normal UniversityChangsha 410081China Department of Physics Liaoning Normal UniversityDalian 116029China

We investigated the properties of quantum entanglement and mutual information in the multi-event horizon Schwarzschild-de Sitter(Sd S)spacetime for massless Dirac *** the first time,we obtained the expression for the evolutions of the quantum state near the black hole event horizon(BEH)and cosmological event horizon(CEH)in the Sd S *** the Nariai limit,the physically accessible entanglement and mutual information are maximized,and the physically inaccessible correlations are *** the increase in temperature of either horizon,the physically accessible correlations experience ***,the initial state remains entangled and can be utilized in entanglement-based quantum information processing tasks,which differs from the scalar field ***,the degradation of physically accessible correlations is more pronounced for small-mass black *** contrast,the physically inaccessible correlations separated by the CEH monotonically increase with the radiation temperature,and such correlations are not decisively influenced by the effect of particle creation at the ***,a similar phenomenon is observed for the inaccessible correlations separated by the *** result differs from the single event spacetime,in which the physically inaccessible entanglement is a monotonic function of the Hawking temperature.

关键词： multi-event horizon spacetime Dirac field SdS spacetime quantum entanglement

Distinction of self-synchronous scrambled linear blockcodes based on multi-fractal spectrum

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Journal of Systems Engineering and Electronics 2016年第5期27卷 968-978页

作者： xinhao li min zhang shu'nan han quan yuan electronic engineering institute Hefei 230037China key laboratory of anhui electronic restricting technique Hefei 230037China

This study proposes a novel multi-fractal spectrumbasedapproach to distinguish linear block codes from its selfsynchronousscrambled codes. Given that the linear block codeand self-synchronous scrambled linear block code share the propertyof linear correlation, the existing linear correlation-basedidentification method is invalid for this case. This drawback can becircumvented by introducing a novel multi-fractal spectrum-basedmethod. Simulation results show that the new method has highrobustness and under the same conditions of bit error, the lowerthe code rate, the higher the recognition rate. Thus, the methodhas significant potential for future application in engineering.

关键词： linear block code self-synchronous scrambled code,multi-fractal spectrum statistical physics algorithm.

A Differential Optical Absorption Spectroscopy Method for X_(CO_2) Retrieval from Ground-Based Fourier Transform Spectrometers Measurements of the Direct Solar Beam

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Advances in Atmospheric Sciences 2015年第8期32卷 1119-1128页

作者： HUO Yanfeng duan minzheng TIAN Wenshou min Qilong Key Laboratory for Semi-Arid Climate Change of the ministry of Education College of Atmospheric Sciences Lanzhou University Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric Physics Chinese Academy of Sciences Wuhan University Atmospheric Science Research Center State University of New York

A differential optical absorption spectroscopy （DOAS）-like algorithm is developed to retrieve the column-averaged dry- air mole fraction of carbon dioxide from ground-based hyper-spectral measurements of the direct solar beam. Different to the spectral fitting method, which minimizes the difference between the observed and simulated spectra, the ratios of multiple channel-pairs--one weak and one strong absorption channel--are used to retrieve Xc02 from measurements of the shortwave infrared （SWIR） band. Based on sensitivity tests, a super channel-pair is carefully selected to reduce the effects of solar lines, water vapor, air temperature, pressure, instrument noise, and frequency shift on retrieval errors. The new algorithm reduces computational cost and the retrievals are le^s sensitive to temperature and H20 uncertainty than the spectral fitting method. Multi-day Total Carbon Column Observing Network （TCCON） measurements under clear-sky conditions at two sites （Tsukuba and Bremen） are used to derive Xc02 for the algorithm evaluation and validation. The DOAS-like results agree very well with those of the TCCON algorithm after correction of an airmass-dependent bias.

关键词： CO2 Retrieval ground-based measurement hyper-spectrum shortwave infrared band

Impact of atrazine and nitrogen fertilizers on the sorption of chlorotoluron in soil and model sorbents

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Journal of Environmental Sciences 2007年第3期19卷 327-331页

作者： GAO min-ling DAI shu-gui MA Yong-min ZHANG Ping College of Environmental Science and Engineering Nankai University Tianjin 300071 China Center of Disease Control and Prevention Tianjin 300011 China

Sorption of chlorotoluron in ammonium sulfate, urea and atrazine multi-solutes system was investigated by batch experiments. The results showed application of nitrogen fertilizers to the soil could affect the behavior of chlorotoluron. At the same concentration of N, sorption of chlorotoluron decreased as the concentration of atrazine increased on the day 0 and 6 in soil, respectively. The sorption of chlorotoluron increased from 0 to 6 d when soils were preincubated with deionized water, ammonium sulfate and urea solution for 6 d. That indicated incubation time was one of the most important factors for the sorption of chlorotoluron in nitrogen fertilizers treatments. The individual sorption isotherms of chlorotoluron in rubbery polymer and silica were strictly linear in single solute system, but there were competition sorption between pesticides or between pesticides and nitrogen fertilizers. That indicated the sorption taken place by concurrent solid-phase dissolution mechanism and sorption on the interface of water-organic matter or water-mineral matter.

关键词： sorption chlorotoluron atrazine nitrogen fertilizer competitive

Towards total protection from impact:a viability study using EPE foam to protect falling eggs

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Transportation Safety and Environment 2019年第2期1卷 154-163页

作者： Gui-Rong Liu Guang Chen shu-Yong duan Department of Aerospace Engineering and Engineering Mechanics University of Cincinnati2600 Clifton AveCincinnatiOhio45221 USA State Key Laboratory of Reliability and Intelligence of Electrical Equipment HeBei University of TechnologyTianjin City300401 China School of Mechanical Engineering HeBei University of TechnologyTianjin City300401 China

Total protection of fragile goods and equipment during transport has become critically important as fast delivery systems are growing rapidly due to the rise of mass online commerce *** paper therefore studies the protection of falling eggs—one of the most fragile goods—through *** experiments are first conducted to obtain the critical stress at which the eggshell is damaged by falling *** are first conducted of unpackaged eggs dropping onto a granite platform from various *** element method(FEM)models of unpackaged eggs are then built to simulate the behaviour of eggs and compute their stress *** experimental data is compared with the results of FEM simulations to determine the critical stress at which the eggshell is damaged.A series of tests and numerical simulations are then carried out for eggs wrapped in expanded polyethylene(EPE)*** stress distribution of both a single egg and multiple eggs in packaging are *** empirical formula between the drop speed(or height)and the bottom thickness of the EPE foam packaging is obtained,which can be useful in the design of packaging for the total protection of eggs that may fall during usual transport and delivery *** experimental and numerical results from this study show that it is viable to protect fragile goods,as long as the EPE form packaging has sufficient *** proposed study and design procedure are helpful for the selection of key parameters of foam packaging to protect fragile industry products from impact.

关键词： impact protection critical stress EPE foam packaging egg drop test FEM simulation

Modulation of the Intensity of Nascent Tibetan Plateau Vortices by Atmospheric Quasi-Biweekly Oscillation

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Advances in Atmospheric Sciences 2018年第11期35卷 1347-1361页

作者： Lun LI Renhe ZHANG min WEN Jianping duan State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Institute of Atmospheric Sciences Fudan UniversityShanghai 200433China Chinese Academy Science Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China Institute of Atmospheric Physics Chinese Academy ScienceBeijing 100029China

The modulation of the intensity of nascent Tibetan Plateau vortices(ITPV) by atmospheric quasi-biweekly oscillation(QBWO) is investigated based on final operational global analysis data from the National Centers for Environmental Prediction. The spatial and temporal distributions of the ITPV show distinct features of 10–20-day QBWO. The average ITPV is much higher in the positive phases than in the negative phases, and the number of strong TPVs is much larger in the former,with a peak that appears in phase 3. In addition, the maximum centers of the ITPV stretch eastward in the positive phases,indicating periodic variations in the locations where strong TPVs are generated. The large-scale circulations and related thermodynamic fields are discussed to investigate the mechanism by which the 10–20-day QBWO modulates the ITPV. The atmospheric circulations and heating fields of the 10–20-day QBWO have a major impact on the ITPV. In the positive QBWO phases, the anomalous convergence at 500 hPa and divergence at 200 hPa are conducive to ascending motion. In addition, the convergence centers of the water vapor and the atmospheric unstable stratification are found in the positive QBWO phases and move eastward. Correspondingly, condensational latent heat is released and shifts eastward with the heating centers located at 400 hPa, which favors a higher ITPV by depressing the isobaric surface at 500 hPa. All of the dynamic and thermodynamic conditions in the positive QBWO phases are conducive to the generation of stronger TPVs and their eastward expansion.

关键词： quasi-biweekly oscillation Tibetan Plateau vortex modulation