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检索条件"作者=SHU-MIN DUAN"

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Neuroscience Bulletin calls for papers

Neuroscience Bulletin calls for papers

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： shu-min duan Professor,Editor-in-Chief Editorial Office of Neuroscience Bulletin

＜正＞Neuroscience Bulletin is sponsored by the Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,the Chinese Neuroscience Society and the Second Military Medical University,and is published bimonthly by Science Press,*** Bulletin mainly publishes original research articles and reviews in English in the field of neuroscience. Neuroscience Bulletin is indexed/abstracted by Chemical Abstracts（CA）,MEDLINE/PubMed,Index Medicus （IM）,Excerpta Medica（EM）,Scopus,IndexCopernicus database outside *** is the source journal for Chinese

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Purine-mediated responses in microglia

Purine-mediated responses in microglia

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： shu-min duan Zhejiang University School of Medicine,Hangzhou 310058,China

＜正＞Microglia are resident immune cells in the central nervous system（CNS）.In response to injury or inflammatory stimuli,the resting microglia can be rapidly activated to participate in pathological responses,including migration to the affected site,release of various inflammatory molecules,and clearing of cellular *** released from damaged neural cells has been considered to be a major chemokine for inducing rapid process extension and migration of microglial ***,ATP leaking from the local injured cells may not be able to diffuse extensively to effectively induce migration of remote microglia,because extracellular nucleotides are rapidly degraded by ecto-ATPases in the *** found that ATP-indueed ATP release from microglial lysosomes contributed to the directional migration of remote *** addition,we found that ATP could function as a "drink" signal in microglia by triggering ***,we found that this purine-induced macropinocytosis is very efficient in clearing up extracellular soluble amyloid beta（Aβ）,an early and key intermediate in the pathogenesis Alzheimer’s disease.

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SNARE protein dependent exocytosis in microglia lysosomes

SNARE protein dependent exocytosis in microglia lysosomes

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Ying DOU,shu-min duan Institute of Neuroscience,CAS,Shanghai,200031

＜正＞As the major immunological cell in CNS,microglia is well studied in the field of cytokines release,but the release mechanism in microglia is largely *** is considered as a terminal degradative compartment of the endocytic pathway,into which transport is thought to be ***,specialized secretory vesicles regulated by calcium share characteristics with lysosomes,suggesting that lysosome exocytosis might be a generalized process present in most cell *** we showed that lysosome in microglia exhibits calcium and SNARE protein dependent *** of cultured microglia with FM dye specifically labels lysosomes,as identified by immunostaining with lysosome specific marker *** lapse imaging with confocal microscopy showed that application of ATP,glutamate,or ionomycin induced calcium-dependent exocytosis in lysosomes as revealed by the destaining of FM dye-labeled ***, treatment of cultures with tetanus toxin（TeNT） that cleaves vesicle protein VAMP2 significantly inhibits lysosome exocytosis. Our results indicate that SNARE protein-dependent lysosome exocytosis may play essential role in microglia functions.

关键词： microglia lysosome SNARE exocytosis

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The maturation of pre- and postsynaptic components of excitatory/inhibitory synapses

The maturation of pre- and postsynaptic components of excita...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： shu-min duan,Bei WU,Ye-Fei LI Lab of synaptic plasticity and development,Institute of Neuroscience,CAS,Shanghai 200031

＜正＞Neurons develop extensive axonal and dendritic arbors and form numerous *** heterochronic coculture method,we studied the sequential events of the pre- and postsynaptic *** data showed that functional synapses could be formed between young and old neurons within 24 h in culture *** using GAD-GFP mice,we found that in GABAergic synapses,the number of new neurons that function as postsynaptic parters is much more that new neurons act as presynaptic *** together,our results suggest that the postsynaptic components of GABAergic synapses maturate earlier than presynaptic *** sequential development of inhibitory and excitatory synapses may play important role in the circuit *** studies mainly focused on excitatory synapses development and rarely on inhibitory *** the difference between the development process of inhibitory and excitatory synapses and if they share the same developmental mechanism or not is still unclear *** using GAD-GFP mice and dual patch technique,we can clearly pick the GABAergic and Glutamatergic neurons to test if they for a functional synapse or not during the developmental *** far,our results suggest that functional GABAergic synapses appears earlier than Glutamatergic *** there’s a few evidence indicate that certain type of neurons tend to form synapses with a different type of neuron as a post-synaptic tarket.

关键词： GABAergic synapses maturation developmental process

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Different endocytosis and recycling mechanisms of synaptic vesicles in glutamatergic and GABAergic synapses

Different endocytosis and recycling mechanisms of synaptic v...

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中国神经科学学会第十届全国学术会议

作者： Ye-Fei LI Xiao-Xing ZHANG Xia LI Hao YU Ye RONG Hui-Fang LOU shu-min duan Institute of Neuroscience and Key Laboratory of Neurobiology Shanghai Institutes for Biological SciencesChinese Academy of Sciences Department of Neurobiology Key Laboratory of Medical Neurobiology of Ministry of Health of ChinaZhejiang Province Key Laboratory of NeurobiologyZhejiang University School of Medicine

Synaptic vesicle turnover is a critical process in shaping synaptic *** multiple modes of vesicle recycling have been proposed,it is not clear whether different recycle pathways are used by different synapses or by the same synapse under different *** the present study,we used electrophysiology,live neuron imaging and electron microscopy to compare presynaptic vesicle recycling property of two major hippocampal synapses,glutamatergic and GABAergic *** double-patch whole cell recording from cultured neurons,we found that glutamatergic synapses exhibit lower release probability,slower depletion and faster RRP recovery than GABAergic *** FM dye labeled micro-island GAD-GFP neuron,we managed to monitor vesicle release kinetics separately in glutamatergic and GABAergic synapses,showing glutamatergic recycled vesicles fill RRP slower than GABAergic *** Scanning Transmission Electron Microscopy- Electron Tomography and normal electron microscopy,our ultra-structural analysis showed dissimilar distribution of vesicle size and localization,especially different endocytosis mode of recycbng vesicles in glutamatergic and GABAergic *** study demonstrated that glutamatergic and GABAergic synapses have distinct mechanisms for the biogenesis,endocytosis and recycbng of synaptic *** fundamental differences may have differential physiological relevance.

关键词： Glutamatergic GABAergic synaptic vesicle recycling electrophysiology FM dye Electron microscopy Endosome-like vesicle

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The possible mechanism of Ca2+ induced Ca2+ release in astrocytes

The possible mechanism of Ca2+ induced Ca2+ release in astro...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jun-Hua YANG,Ke-Qing ZHU,shu-min duan~* Department of Neuroscience,School of Medicine Zhejiang University,Hangzhou 310058,China

Objective Astrocytes are the primary neuronal structural and trophic supportive *** like neurons which can generate action potential,however astrocytes exhibit diversity intracellur calcium activity and this is thought to play an important part in physiology and pathological *** calcium elevation has various forms,one important is Cainduced Ca release(CICR)which is thought to be mediated by 1,4,5-triphosphate receptor(IP3R)and ryanodine receptor(RyR)but the mechanism is not very *** our research,we want to explore the potential mechanism of CICR by a new *** We used laser scan confocol microscopy to monitor the intraculler calcium variation and used a special method triggering Cainflux in mouse *** inhibitors of different channels were use to investigate the possible role of participating in *** Astrocytes calcium elevation was significantly inhibited by some specificity *** Our primary datas showed that NCX may play an important role in astrocytes *** contrary to some papers which reported RyR relating to CICR,our study didn’t find this result.

关键词： astrocytes 1,4,5-triphosphate receptor ryanodine receptor Na+/Ca2+ exchangers

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Clathrin-dependent endocytosis is required for TrkB-dependent Akt-mediated neuronal protection and dendritic growth

Clathrin-dependent endocytosis is required for TrkB-dependen...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Jing ZHENG,Wan-Hua SHEN,Ting-Jia LU,Yang ZHOU,Qian CHEN,shu-min duan and Zhi-Qi XIONG

＜正＞Endocytosis of tyrosine receptor kinases（Trks） is involved in neurotrophin-dependent neuronal survival. However,the mechanisms governing the endocytosis of TrkB and its specific contribution to TrkB downstream signaling have not been *** this study,we found that blocking clathrin- and dynamin-dependent endocytosis in neurons of the central nervous system inhibited BDNF-induced activation of Akt but not Erk1/2,while the same blockade in PC 12 cells inhibited NGF-induced activation of Erk1/2 but not ***,clathrin- and dynamin-dependent endocytosis was required for BDNF-induced neuronal protection and dendritic growth,but not the up-regulation of NPY and ARC. Thus clathrin- and dynamin-dependent endocytosis of Trk receptors may be responsible for differential activation of specific downstream pathways upon neurotrophin binding,leading to regulation of specific neuronal functions.

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Self-organization of non-random mono-synaptic networks in cultured neurons

Self-organization of non-random mono-synaptic networks in cu...

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中国神经科学学会第十届全国学术会议

作者： Xiao-Xing ZHANG Ye-Fei LI Ye RONG Hao YU Hui-Fang LOU Cheng-Yu LI shu-min duan Lab of Synaptic Development and Plasticity Institute of NeuroscienceShanghai Institutes of Biological SciencesChinese Academy of Sciences Lab of Synaptic Development and Plasticity Institute of NeuroscienceMedical School of Zhejiang University

The comprehension and analysis of the complexity of neural networks are fundamental to our understanding of the dynamics and cognitive functions of the *** from cellular level to the whole brain have proved that structural connections in both micro- and macro-scale neural networks are not random but exhibit many complex-network ***,the conditions and mechanisms underlying the development of these non-random structural features,as well as their biological significances,are still not *** answers to these questions could benefit from a direct study of the non-random network features in early-developing neural *** this study,we cultured mice hippocampal neurons in vitro,and investigated non-random structural features in developing neural circuits independent of anatomical brain structures and behavioral *** multi-channel whole cell patch recordings and GAD-GFP transgenic mice whose GABAergic neurons are tagged by fluorescence,we were able to distinguish and detect both glutamatergic and GABAergic mono-synapse,and record *** found that,cultured neurons self-organized into non-random mono-synaptic neural networks that exhibited complex network features which were also found in neural networks in the brain but not in randomly connected *** example,the numbers of certain network motifs,as well as the numbers of neurons with multiple output connections exceeded expectations;synaptic connections clustered in local neuronal subgroups;synaptic weights positively correlated to the numbers of GABA connections in local *** on these findings,we proposed a rule that is capable of explaining the self-organizations of complex neural networks during early development:the probability of synapse formation between a pair of neurons depends on neuron types,and is negatively correlated to the distance between the neurons and positively correlated to the number of outgoing connections already formed on

关键词： neural network cultured neural network self-organize complex network non-random early development

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Physiological and pathological roles of glia-released ATP

Physiological and pathological roles of glia-released ATP

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： shu-min duan Institute of Neuroscience and State Key Laboratory of Neuroscience,Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,Shanghai 200031,China

Astrocytes can release signal molecules that mediate intercellular *** particular,ATP release from astrocytes is required for Ca wave propagation among *** found that repetitive neuronal activity induces extensive release of ATP/adenosine from astrocytes,which in turn causes both short-term and long-term hetero-synaptic *** studies showed that lysosomes in astrocytes contained abundant ATP and their partial exocytosis resulted in a low-level ATP release,whereas full exocytosis led to the release of a larger amount of ATP,together with lysosomal *** intracellular lysis of lysosomes abolished both ATP release and Ca wave propagation among *** physiological and pathological relevance of the regulated lysosome exocytosis from other types of glial cells will be also discussed.

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GABA-induced Ca2+ elevation in NG2 glial cells through activation of persistent Na+ channels and Na+/Ca2+ exchangers

GABA-induced Ca2+ elevation in NG2 glial cells through activ...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Xiao-Ping TONG,shu-min duan Institute of Neuroscience and Key Laboratory of Neurobiology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China

NG2 glial cells distribute extensively in the adult brain and receive direct glutamatergic and GABAergic synapticinnervations from *** cells express Nachannels,but fail to produce regenerative action *** physiological role of the Na channel in these cells is thus ***,voltage dependent Ca channels,an important Ca entry pathway in many types of cells,can not be detected in these *** the present study we found that perfusion of GAB A induced Ca elevation in cultured and acute dissociated NG2 cells increased intracellular Ca involving persistent Na+ channels and Na+/Ca exchangers,but not Ca channels,an effect that can be abolished by treatment with sodium channel antagonist TTX,extracellular sodium free solution,calcium free solution,or Na/Ca exchanger inhibitor KB-R7943,but not by Ca channel *** evidence indicates this unconventional pathway may be also important for Zn uptake known to be crucial for NG2 cell development and injury.

关键词： NG2 glial cell GABA persistent sodium channels Na+/Ca2+ exchangers calcium elevation

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