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Intracellular Retention of Human Melanocortin-4 Receptor:A Molecular Mechanism Underlying Early-onset Obesity in F261S Pedigree of Chinese

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Biomedical and Environmental Sciences 2008年第4期21卷 280-285页

作者： QI-CHEN FANG WEI-PING JIA shu-bing cai XIN-YU SHAO RONG ZHANG CONG-RONG WANG YU-QIAN BAO KUN-SAN XIANG Department of Endocrinology and Metabolism Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong UniversityShanghai Diabetes InstituteShanghai Clinical Center of DiabetesShanghai 200233China

Objective To investigate how F261S mutation identified from Chinese obese patients affects the function of melanocorfin 4 receptor (MC4R) and to analyze the obesity-related phenotypes in subjects carrying the F261S mutation. Methods F261S mutant of MC4R was generated by site-directed mutagenesis. Plasmids encoding wild-type or F261S mutant of MC4R were transfected into HEK293 and COS-7 cells to examine their functional characteristics. Signaling properties of F261S MC4R were assessed by measuring intracellular cAMP levels in response to α-MSH stimulation. Cell surface expression of F261S MC4R was compared with that of wild-type MC4R. Clinical examinations were performed in subjects carrying F261S mutation and in non-mutated controls. Results The a-MSH-stimulated reporter gene activity was significantly reduced in cells expressing F261S MC4R, with a maximal response equal to 57% of wild-type MC4R. The F261S mutation also led to a significant change in the EC50 value compared with the wild-type receptor (P〈0.01). Immunofluorescent assay revealed a marked reduction in plasma membrane localization of the MC4R in cells expressing the F261S mutant receptor. The resting metabolic rate and fat composition of the mutant carriers were not significantly different from those of the non-mutated obese controls. Conclusions The decreased response to α-MSH due to the intracellular retention of MC4R may cause early-onset obesity in the F261S pedigree of Chinese.

关键词： Obesity Melanocortin 4 receptor Mutation Chinese

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支气管哮喘患者白细胞介素-33作用的临床研究

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中国现代医学杂志 2016年第4期26卷 64-66页

作者：蔡树冰广东省潮州市人民医院呼吸内科广东潮州521000

目的分析支气管哮喘(简称哮喘)患者血清白细胞介素-33(IL-33)水平变化及临床意义。方法回顾性分析该院2013年3月-2015年3月住院的120例未治疗的哮喘急性发作期及治疗后缓解期的患者作为观察组,另选择80例健康者(健康体检人群)为对照组,... 详细信息

目的分析支气管哮喘(简称哮喘)患者血清白细胞介素-33(IL-33)水平变化及临床意义。方法回顾性分析该院2013年3月-2015年3月住院的120例未治疗的哮喘急性发作期及治疗后缓解期的患者作为观察组,另选择80例健康者(健康体检人群)为对照组,分别对两组患者血清中IL-33的水平进行检测,并检测患者血清免疫球蛋白E(Ig E)及嗜酸性粒细胞(Eos)的水平,所有受试者均行肺功能检测(PTF)。结果与健康对照组比较,哮喘急性发作治疗前组血清中IL-33及IgE的水平、Eos的绝对数显著升高(P<0.05);哮喘治疗后缓解组IL-33的水平与IgE的水平、Eos绝对计数呈正相关(P<0.05),而与第1秒用力呼气容积(FEV1)、第1秒用力呼气量占用力肺活量比值(FEV1/FVC)、FEV1占预计值的百分比(FEV1%pre)均呈负相关(P<0.05)。结论 IL-33积极参与了机体的炎症反应;调节IL-33可以作为支气管哮喘的治疗方法。

关键词：支气管哮喘 IL-33 免疫球蛋白E 嗜酸性粒细胞

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Determination of minimum cover depth for shallow tunnel subjected to water pressure

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Journal of Central South University 2013年第8期20卷 2307-2313页

作者： HUANG Fu QIN Chang-bing LI shu-cai School of Civil Engineering and Architecture Changsha University of Science and Technology Changsha 410004 China School of Civil Engineering Central South University Changsha 410075 China Geotechnical and Structural Engineering Research Center Shandong University Jinan 250061 China

Prediction of the state of roof collapse is a big challenge in tunnel engineering, while the limit analysis theory makes it possible to derive the analytical solutions of the collapse mechanisms. In this work, an exact solution of collapsing shape in shallow underwater tunnel is obtained by using the variation principle and the upper bound theorem based on nonlinear failure criterion. Numerical results under the effect of river water and supporting pressure are derived and discussed. The maximum water depth above the river bottom surface is determined under a given buried depth of shallow cavities and the critical depth of roof collapse is obtained under a constant river depth. In comparison with the previous results, the present solution shows a good agreement with the practical results.

关键词： shallow underwater subway roof collapse nonlinear failure criterion

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夯扩桩的质量检测及事故分析

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土工基础 2004年第4期18卷 57-58页

作者：王树德刘丙才金耀军河南省周口市建设工程质量安全监督站河南周口466000

用低应变动测检测复合载体夯扩桩的桩身缺陷 ,随后采用开挖和静载试验进行验证 ,分析产生缺陷的原因。

关键词：复合载体夯扩桩承载力桩身缺陷事故分析静载试验开挖

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Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： Peng Li Meifeng cai Shengjun Miao Yuan Li Yu Wang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

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SensFL:Privacy-Preserving Vertical Federated Learning with Sensitive Regularization

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 385-404页

作者： Chongzhen Zhang Zhichen Liu Xiangrui Xu Fuqiang Hu Jiao Dai Baigen cai Wei Wang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing100044China shuohuang Railway Development Co. Ltd.National Energy GroupCangzhou062350China Beijing Key Laboratory of Security and Privacy in Intelligent Transportation School of Computer Science and TechnologyBeijing Jiaotong UniversityBeijing100044China

In the realm of Intelligent Railway Transportation Systems,effective multi-party collaboration is crucial due to concerns over privacy and data *** Federated Learning(VFL)has emerged as a promising approach to facilitate such collaboration,allowing diverse entities to collectively enhance machine learning models without the need to share sensitive training ***,existing works have highlighted VFL’s susceptibility to privacy inference attacks,where an honest but curious server could potentially reconstruct a client’s raw data from embeddings uploaded by the *** vulnerability poses a significant threat to VFL-based intelligent railway transportation *** this paper,we introduce SensFL,a novel privacy-enhancing method to against privacy inference attacks in ***,SensFL integrates regularization of the sensitivity of embeddings to the original data into the model training process,effectively limiting the information contained in shared *** reducing the sensitivity of embeddings to the original data,SensFL can effectively resist reverse privacy attacks and prevent the reconstruction of the original data from the *** experiments were conducted on four distinct datasets and three different models to demonstrate the efficacy of *** results show that SensFL can effectively mitigate privacy inference attacks while maintaining the accuracy of the primary learning *** results underscore SensFL’s potential to advance privacy protection technologies within VFL-based intelligent railway systems,addressing critical security concerns in collaborative learning environments.

关键词： Vertical federated learning privacy defenses

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Experimental investigation for temperature and emissivity by flame emission spectrum in a cavity of rocket based combined cycle combustor chamber

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Defence Technology（防务技术） 2024年第9期39卷 114-122页

作者： Weiguang cai shu Zheng Yan Wang bing Liu Shaohua Zhu Li Zhao Qiang Lu National Engineering Research Center of New Energy Power Generation North China Electric Power UniversityBeijing 102206China Science and Technology on Combustion Internal Flow and Thermal-structure LaboratoryNorthwestern Polytechnical UniversityXi'an 710072China

Flame temperature and spectral emissivity were the important parameters characterizing the sufficient degree of fuel combustion and the particle radiative characteristics in the Rocket Based Combined Cycle(RBCC)*** investigate the combustion characteristics of the complex supersonic flame in the RBCC combustor,a new radiation thermometry combined with Levenberg-Marquardt(LM)algorithm and the least squares method was proposed to measure the temperature,emissivity and spectral radiative properties based on the flame emission ***-situ measurements of the flame temperature,emissivity and spectral radiative properties were carried out in the RBCC direct-connected test bench with laser-induced plasma combustion enhancement(LIPCE)and without *** flame average temperatures at fuel global equivalence ratio(a)of 1.0b and 0.6 with LIPCE were 4.51%and 2.08%higher than those without *** flame combustion oscillation of kerosene tended to be stable in the recirculation zone of cavity with the thermal and chemical effects of laser induced *** differences of flame temperature at a=1.0b and 0.6 were 503 K and 523 K with LIPCE,which were 20.07%and42.64%lower than those without *** flame emissivity with methane assisted ignition was 80.46%lower than that without methane assisted ignition,due to the carbon-hydrogen ratio of kerosene was higher than that of *** spectral emissivities at 600 nm with LIPCE were 1.25%,22.2%,and 4.22%lower than those without LIPCE at a=1.0a(with methane assisted ignition),1.0b(without methane assisted ignition)and *** effect of concentration in the emissivity was removed by normalization to analyze the flame radiative properties in the RBCC combustor *** maximum differences of flame normalized emissivity were 50.91%without LIPCE and 27.53%with *** flame radiative properties were stabilized under the thermal and chemical effects of laser induced plasma at a=0.6.

关键词： Rocket-based combined-cycle Supersonic combustion Flame temperature measurement Emissivity Laser induced plasma combustion enhancement

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Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke cai Youluan Lu Fanpeng Cheng Lijuan Shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

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The study of Seyfert 2 galaxies with and without infrared broad lines

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Research in Astronomy and Astrophysics 2010年第5期10卷 427-437页

作者： Hong-bing cai Xin-Wen shu Zhen-Ya Zheng Jun-Xian Wang CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China Hefei 230026 China National Time Service Center CAS Xi＇an 710600 China

From the literature, we construct a sample of 25 Seyfert 2 galaxies （S2s）with a broad line region （BLR） detected in near infrared （NIR） spectroscopy and 29with NIR BLRs which were not detected. We find no significant difference betweenthe nuclei luminosity （extinction-corrected [OIII] 5007） and infrared color f 60/f25between the two populations, suggesting that the non-detections of NIR BLRs couldnot be due to low AGN luminosity or contamination from the host galaxy. As ex-pected, we find significantly lower X-ray obscurations in Seyfert 2s with NIR BLRdetection, supporting the unification scheme. However, such a scheme was challengedby the detection of NIR BLRs in heavily X-ray obscured sources, especially in sixof them with Compton-thick X-ray obscuration. The discrepancy could be solved bythe clumpy torus model and we propose a toy model demonstrating that IR-thin X-ray-thick S2s could be viewed at intermediate inclinations and compared with thoseIR-thick X-ray-thick S2s. We note that two of the IR-thin X-ray-thick S2s （NGC 1386and NGC 7674） experienced X-ray transitions, i.e. from Compton-thin to Compton-thick appearance or vice versa based on previous X-ray observations, suggesting thatX-ray transitions could be common in this special class of objects.

关键词： galaxies: active — galaxies: Seyfert — infrared: galaxies

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Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui cai Bo Sun Huijun Wang Yi Zheng Siyu Zhou Huixin Li Yanyan Huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(DBO)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-GRU).The models with DBO show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original DBO,the R and RPD of models with the improved DBO increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU Ningxia

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