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银屑病相关miRNA的研究进展

医学综述 2025年第1期31卷 13-17页

作者：舒心冉敏杨怡解放军总医院第三医学中心皮肤科北京100039 解放军总医院第三医学中心内分泌科北京100039

微RNA(miRNA)可通过改变靶信使RNA的翻译或稳定性在RNA沉默和转录后基因表达调控中发挥作用。此外,miRNA也是细胞生长、分化、凋亡、免疫反应等细胞过程的重要调节因子。miRNA可调节银屑病角质形成细胞的分化、增殖、凋亡和T细胞的激活... 详细信息

微RNA(miRNA)可通过改变靶信使RNA的翻译或稳定性在RNA沉默和转录后基因表达调控中发挥作用。此外,miRNA也是细胞生长、分化、凋亡、免疫反应等细胞过程的重要调节因子。miRNA可调节银屑病角质形成细胞的分化、增殖、凋亡和T细胞的激活、生存以及免疫细胞与角蛋白细胞之间的干扰,不同的miRNA及其靶基因可通过不同的信号转导通路参与银屑病的发生发展。银屑病中高表达的miRNA主要包括miR-31、miR-21、miR-203、miR-146a等,低表达的miRNA主要包括miR-125b、miR-205-5p等。因此,全面了解银屑病中异常表达的miRNA可以为阐明疾病的发病机制、寻找相关诊断标志物提供坚实的理论基础,同时也可为银屑病的临床治疗提供新思路。

关键词：银屑病发病机制微RNA

A feature-wise attention module based on the difference with surrounding features for convolutional neural networks

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Frontiers of Computer Science 2023年第6期17卷 77-86页

作者： shuo TAN Lei ZHANG xin shu Zizhou WANG Machine Intelligence Laboratory College of Computer ScienceSichuan UniversityChengdu 610065China

Attention mechanism has become a widely researched method to improve the performance of convolutional neural networks(CNNs).Most of the researches focus on designing channel-wise and spatial-wise attention modules but neglect the importance of unique information on each feature,which is critical for deciding both“what”and“where”to *** this paper,a feature-wise attention module is proposed,which can give each feature of the input feature map an attention ***,the module is based on the well-known surround suppression in the discipline of neuroscience,and it consists of two sub-modules,Minus-Square-Add(MSA)operation and a group of learnable non-linear mapping *** MSA imitates the surround suppression and defines an energy function which can be applied to each feature to measure its *** group of non-linear functions refines the energy calculated by the MSA to more reasonable *** these two sub-modules,feature-wise attention can be well ***,due to the simple structure and few parameters of the two sub-modules,the proposed module can easily be almost integrated into any *** verify the performance and effectiveness of the proposed module,several experiments were conducted on the Cifar10,Cifar100,Cinic10,and Tiny-ImageNet datasets,*** experimental results demonstrate that the proposed module is flexible and effective for CNNs to improve their performance.

关键词： feature-wise attention surround suppression image classification convolutional neural networks

Effect of CaO content on residual stress of CAS glass-ceramic

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中国有色金属学会会刊：英文版 2006年第B01期16卷 101-104页

作者： XIE Jun CHENG Jin-shu LONG xin-jiang YANG shu-zhen Key Laboratory of Silicate Materials Science and Engineering Wuhan University of Technology Wuhan 430070 China

The mismatch in thermal expansion coefficient between crystalline phase and glass phase can result in large thermal stresses during thermal processing, as well as the low thermal conductivity, which is the most troublesome in the production of the CaO-Al2O3-SiO2 glass-ceramic. CaO content may influence the residual stress in the system. Therefore X-ray diffraction (XRD) ‘sin2ψ’ method was used to calculate the residual stress in samples containing various contents of CaO. The relationship between CaO content and residual stress in CAS system was investigated. Finally reasons causing such residual stress were analyzed.

关键词： CAS玻璃陶瓷氧化钙含量残余应力晶相玻璃相

THE THIXOTROPY-LOOP BEHAVIORS OF AN LDPE MELT:EXPERIMENT AND SIMPLE ANALYSIS

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Journal of Hydrodynamics 2006年第6期18卷 666-675页

作者： HUANG shu-xin LU Chuan-jing Department of Engineering Mechanics Shanghai Jiaotong University Shanghai 200030 China

The time-dependent viscoelastic behaviors of an Low-Density-Pdyethyene（LDPE）（PE-FSB-23D022） melt were experimentally investigated using two types of thixotropy-loop test i.e., the triangular- and the trapezoidal-loop shear test. The shear strengthening was noted in the thixotropy-loop tests not only at high shear rate but also at low shear rate, and it was found that the dimensionless stress amplitude of shear strengthening at low shear rate is larger than that at high shear rate. Moreover, the shear strengthening is a time-dependent viscoelastic behavior that is observed during the initial stage of shearing, and it cannot be found when the time interval corresponding to the increase in shear rate is sufficiently long, The remarkable shear-weakening phenomenon was noticed at higher shear rate when shearing time is prolonged. Five types of the triangular thixotropy-loop results were marked in terms of the configurations of the stress-rate curves, which indicate the complex features of the time-dependent viscoelasticity. A simple model was used to describe the thixotropy-loop tests, and the fitted results showed good agreement with the experimental results.

关键词： thixotropy-loop test time-dependent viscoelasticity LDPE shear strengthening shear weakening

Proton Orbital[541]1/2 and Backbending in ^(178)W

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Communications in Theoretical Physics 2008年第9期50卷 715-718页

作者： WEI Zhi-Yuan LIU shu-xin School of Physics Peking University Beijing 100871 China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Collisions Lanzhou 730000 China

The microscopic mechanism of nine experimentally observed bands in ^178W is investigated using the particle-number conserving method of the cranked shell model with monopole and quadrupole paring interactions. The experimental results, including the moments of inertia and angular momentum alignments of nine bands in ^178W, are reproduced well by the particle-number conserving calculations, in which no free parameter is involved. Calculations demonstrate that occurrence of sharp backbending comes mainly from the contribution of high-j intruder orbitals vi13/2 or πh11/2 and their interference effect with orbitals near the Fermi surface. Theω variation of the occupation probability of each cranked orbital and the contribution to moment of inertia from each cranked orbital are analyzed.

关键词： backbending cranked shell model moment of inertia pairing interaction

Spin Assignment of the First Discovered Superdeformed Band 152Dy(1) and Some Superdeformed Bands in Neighboring Nuclei

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Chinese Physics Letters 1999年第9期16卷 632-634页

作者： LIU shu-xin xin Xiao-bin ZENG Jin-yan Department of Physics Peking Universityj Beijing 100871

By using various approaches to the spin assignment, including the best-fit-method, the variation of moment of inertia with angular momentum, the bandhead moment of inertia J0 systematics, and the signature systematics, the spin of the lowest level observed in the first discovered superdeformed band 152Dy(1)is definitely predicted to be I0 = 26(Eγ(I0 + 2 → I0) = 602.4 keV), rather than the previously predicted I0 = 22,24, or 25. The spin prediction and properties of some superdeformed bands in the A ~ 150 region are discussed.

关键词： inertia momentum signature

PREPARATION OF POLYMER MICROSPHERES WITH PYRIDYL GROUP AND THEIR STABILIZED GOLD METALLIC COLLOIDS

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Chinese Journal of Polymer Science 2007年第6期25卷 555-563页

作者： shu-ning Li xin-lin Yang Wen-qiang Huang Key Laboratory of Functional Polymer Materials the Ministry of Education Institute of Polymer Chemistry Nankai University Tianjin 300071 China

Narrow disperse poly（ethyleneglycol dimethacrylate-co-4-vinylpyridine）（poly（EGDMA-co-4-VPy）） microspheres were prepared by distillation-precipitation copolymerization of ethyleneglycol dimethacrylate （EGDMA） and 4-vinylpyridine （4-VPy） with 2,2＇-azobisisobutyronitrile （AIBN） as initiator in neat acetonitrile. The polymer microspheres containing pyridyl group were then utilized as stabilizer for gold metallic colloids with the diameter around 7 nm, which were prepared by the in situ reduction of gold chloride trihydrate with sodium borohydride through the coordination of the pyridyl group on the gel layer and surface of the microsphere with the gold metallic nano-particles. The catalytic properties of the pyridyl- functionalized microsphere-stabilized gold metallic colloids and the behavior of the stabilized-catalyst for the recycling were investigated with reduction of 4-nitrophenol to 4-aminophenol as a model reaction.

关键词： Polymer microsphere Distillation-precipitation polymerization Pyridyl group Gold metallic colloids Catalysis.

Application of Random Forest Regressions on Stellar Parameters of A-type Stars and Feature Extraction

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Research in Astronomy and Astrophysics 2022年第2期22卷 189-194页

作者： shu-xin Chen Wei-Min Sun Ying He Qiqihar University Qiqihar 161006China Key Lab of In-fiber Integrated Optics Ministry Education of ChinaHarbin Engineering UniversityHarbin 150009China Department of Computer Science and Technology Tianjin Ren'ai CollegeTianjin 301636China

Measuring the stellar parameters of A-type stars is more difficult than FGK stars because of the sparse features in their spectra and the degeneracy between effective temperature(T_(eff))and gravity(log g).Modeling the relationship between fundamental stellar parameters and features through machine learning is possible because we can employ the advantage of big data rather than sparse known *** soon as the model is successfully trained,it can be an efficient approach for predicting Teffand log g for A-type stars especially when there is large uncertainty in the continuum caused by flux calibration or *** this paper,A-type stars are selected from LAMOST DR7 with a signal-to-noise ratio greater than 50 and the Teffranging within 7000 to 10,000 *** perform the Random Forest(RF)algorithm,one of the most widely used machine learning algorithms to establish the regression relationship between the flux of all wavelengths and their corresponding stellar parameters(T_(eff))and(log g)*** trained RF model not only can regress the stellar parameters but also can obtain the rank of the wavelength based on their sensibility to *** to the rankings,we define line indices by merging adjacent *** objectively defined line indices in this work are amendments to Lick indices including some weak *** use the Support Vector Regression algorithm based on our new defined line indices to measure the temperature and gravity and use some common stars from Simbad to evaluate our *** addition,the Gaia Hertzsprung-Russell diagram is used for checking the accuracy of Teffand log g.

关键词： methods:data analysis surveys stars:early-type stars:abundances

Ablation-resistant Ir/Re coating on C/C composites at ultra-high temperatures

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Rare Metals 2022年第1期41卷 199-208页

作者： Hong Zhang Li-An Zhu shu-xin Bai Yi-Cong Ye Department of Materials Science and Engineering College of Aerospace Science and EngineeringNational University of Defense TechnologyChangsha 410073China

An iridium/rhenium(Ir/Re)double-layer coating was prepared on carbon/carbon(C/C)composites by chemical vapor deposition(CVD)and *** morphologies and bond strengths of the coatings on the C/C substrate were *** ablation resistance of the Ir/Re coating was studied at 1800℃in an oxyacetylene torch flame for 300 *** results show that Re interlayer increases the bond strength between Ir coating and C/C substrate by over 100%.During entire hightemperature ablation process,Ir/Re coating keeps intact without any signs of ablation *** coating gets smoother and the grain size becomes larger after ablation,with the preferred orientation changing from h311i to h220i:Although some voids are observed along the grain boundaries of the as-ablated Ir coating,Ir/Re coating keeps intact on C/C *** study indicates that Ir/Re coating can provide good ablation resistance up to 1800℃for C/C composites,especially for the continuous ablation applications.

关键词： Iridium Rhenium Carbon/carbon(C/C) Interlayer Ablation