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Association between Gene Polymorphisms and SNP-SNP Interactions of the Matrix Metalloproteinase 2 Signaling Pathway and the Risk of Vascular Senescence

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Biomedical and Environmental Sciences 2024年第2期37卷 146-156页

作者： LIAO Zhen Yu YANG shuo HU Song LIU Jia mao Yong Jun SUN shu qin Department of Geriatrics the Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina Department of Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina

Objective This study aimed to explore the association of single nucleotide polymorphisms(SNP)in the matrix metalloproteinase 2(MMP-2)signaling pathway and the risk of vascular senescence(VS).Methods In this cross-sectional study,between May and November 2022,peripheral venous blood of151 VS patients(case group)and 233 volunteers(control group)were *** SNPs were identified in five genes encoding the components of the MMP-2 signaling pathway,assessed through carotid-femoral pulse wave velocity(cf PWV),and analyzed using multivariate logistic *** multigene influence on the risk of VS was assessed using multifactor dimensionality reduction(MDR)and generalized multifactor dimensionality regression(GMDR)*** Within the multivariate logistic regression models,four SNPs were screened to have significant associations with VS:chemokine(C-C motif)ligand 2(CCL2)rs4586,MMP2 rs14070,MMP2rs7201,and MMP2 *** of the T/C genotype of MMP2 rs14070 had a 2.17-fold increased risk of developing VS compared with those of the C/C genotype,and those of the T/T genotype had a19.375-fold increased ***2 rs4586 and MMP-2 rs14070 exhibited the most significant *** CCL2 rs4586,MMP-2 rs14070,MMP-2 rs7201,and MMP-2 rs1053605 polymorphisms were significantly associated with the risk of VS.

关键词： Vascular senescence Pulse wave velocity(PWV) Single nucleotide polymorphism(SNP) Matrix metalloproteinase 2(MMP-2) Extracellular matrix(ECM) Structural degradation Multifactor dimensionality reduction(MDR)

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Survey on Interactive Theorem Proving Based Concurrent Program Verification

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Ruan Jian Xue Bao/Journal of Software 2024年第9期35卷

作者： Wang, Zhong-Ye Wu, shu-shu Cao, qin-Xiang School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai 200240 China

Concurrent programs and systems are usually highly efficient and respond faster than serial systems, making them widely used in practice. However, concurrent programs and systems are often prone to error, which could bring fatal consequences in real world applications. Moreover, the non-determinism brought by concurrency is a major difficulty in the verification of concurrent programs. With formal verification, people could use interactive theorem provers to rigorously prove the correctness of a concurrent program. This study presents several correctness criteria for concurrent programs, which can be verified by interactive theorem proof techniques. The criteria include Hoare triple, linearizability, contextual refinement, and logical atomicity. Researchers usually use program logic to verify programs in an interactive theorem prover. This study summarizes the usage of concurrent separation logic, rely-guarantee-based logic, and relational Hoare logic in concurrent program verifications. It also surveys existing foundational verification tools and verification results by these techniques. © 2024 Chinese Academy of Sciences. All rights reserved.

关键词： Formal verification

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On self-affine tiles that are homeomorphic to a ball

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Science China Mathematics 2024年第1期67卷 45-76页

作者： Jorg M.Thuswaldner shu-qin Zhang Mathematics and Statistics University of LeobenLeoben 8700Austria School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China

Let M be a 3×3 integer matrix which is expanding in the sense that each of its eigenvalues is greater than 1 in modulus and let D?Z^(3)be a digit set containing|det M|*** the unique nonempty compact set T=T(M,D)defined by the set equation MT=T+D is called an integral self-affine tile if its interior is *** D is of the form D={0,v,...,(|det M|-1)v},we say that T has a collinear digit *** present paper is devoted to the topology of integral self-affine tiles with collinear digit *** particular,we prove that a large class of these tiles is homeomorphic to a closed 3-dimensional ***,we show that in this case,T carries a natural CW complex structure that is defined in terms of the intersections of T with its neighbors in the lattice tiling{T+z:z∈Z^(3)}induced by *** CW complex structure is isomorphic to the CW complex defined by the truncated octahedron.

关键词： self-afine sets tiles and tilings low-dimensional topology truncated octahedron

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SAR regional all-azimuth observation orbit design for target 3D reconstruction

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Journal of Systems Engineering and Electronics 2024年第3期35卷 609-618页

作者： WANG Yanan ZHOU Chaowei LIU Aifang mao qin Beijing Institute of Tracking and Communication Technology Beijing 100094China Nanjing Research Institute of Electronics Technology Nanjing 210012China Shanghai Aerospace Electronic Technology Institute Shanghai 201109China

Three-dimensional(3D) synthetic aperture radar(SAR)extends the conventional 2D images into 3D features by several acquisitions in different aspects. Compared with 3D techniques via multiple observations in elevation, e.g. SAR interferometry(InSAR) and SAR tomography(TomoSAR), holographic SAR can retrieve 3D structure by observations in azimuth. This paper focuses on designing a novel type of orbit to achieve SAR regional all-azimuth observation(AAO) for embedded targets detection and holographic 3D reconstruction. The ground tracks of the AAO orbit separate the earth surface into grids. Target in these grids can be accessed with an azimuth angle span of360°, which is similar to the flight path of airborne circular SAR(CSAR). Inspired from the successive coverage orbits of optical sensors, several optimizations are made in the proposed method to ensure favorable grazing angles, the performance of 3D reconstruction, and long-term supervision for SAR sensors. Simulation experiments show the regional AAO can be completed within five hours. In addition, a second AAO of the same area can be duplicated in two days. Finally, an airborne SAR data process result is presented to illustrate the significance of AAO in 3D reconstruction.

关键词： synthetic aperture radar(SAR) orbit design all-azimuth observation(AAO) three-dimensional(3D)reconstruction successive coverage

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A novel method for determining the resistivity of compressed superconducting materials

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Matter and Radiation at Extremes 2024年第4期9卷 1-3页

作者： Liling Sun Qi Wu shu Cai Yang Ding Ho-kwang mao Center for High Pressure Science and Technology Advanced Research Beijing 100094China Institute of Physics Chinese Academy of SciencesBeijing 100190China

The measurement of resistivity in a compressed material within a diamond anvil cell presents significant *** high-pressure exper-imental setup makes it difficult to directly measure the size changes induced by pressure in the three crystallographic directions of the *** this study,we introduce a novel and effective method that addresses these technical *** method is anticipated to offer a valuable foundation for high-pressure investigations on quantum materials,particularly those with anisotropic layered structures.

关键词： resistivity method foundation

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Network pharmacology and molecular dynamics study of the effect of the Astragalus-Coptis drug pair on diabetic kidney disease

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World Journal of Diabetes 2024年第7期15卷 1562-1588页

作者： Mo-Yan Zhang shu-qin Zheng Liaoning University of Traditional Chinese Medicine Liaoning University of Traditional Chinese MedicineShenyang 110847Liaoning ProvinceChina Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110032Liaoning ProvinceChina

BACKGROUND Diabetic kidney disease(DKD)is the primary cause of end-stage renal *** Astragalus-Coptis drug pair is frequently employed in the management of ***,the precise molecular mechanism underlying its therapeutic effect remains *** To investigate the synergistic effects of multiple active ingredients in the Astragalus-Coptis drug pair on DKD through multiple targets and *** The ingredients of the Astragalus-Coptis drug pair were collected and screened using the TCMSP database and the SwissADME *** targets were predicted using the SwissTargetPrediction database,while the DKD differential gene expression analysis was obtained from the Gene Expression Omnibus *** targets were acquired from the GeneCards,Online Mendelian Inheritance in Man database,and DisGeNET databases,with common targets identified through the Venny *** protein-protein interaction network and the“disease-active ingredient-target”network of the common targets were constructed utilizing the STRING database and Cytoscape software,followed by the analysis of the interaction relationships and further screening of key targets and core active *** Ontology(GO)function and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichments were performed using the DAVID *** tissue and organ distributions of key targets were *** and AutoDock software validate the molecular docking between the core ingredients and key ***,molecular dynamics(MD)simulations were conducted to simulate the optimal complex formed by interactions between core ingredients and key target *** A total of 27 active ingredients and 512 potential targets of the Astragalus-Coptis drug pair were *** were 273 common targets between DKD and the Astragalus-Coptis drug *** protein-protein interaction network topology analysis,we identified 9 core active ingredients and 10 key *** and KEGG pathwa

关键词： Astragalus membranaceus Coptis chinensis Franch Diabetic kidney disease Network pharmacology Molecular docking Molecular dynamics simulation

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Long non-coding RNA MALAT1 in hematological malignancies and its clinical applications

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Chinese Medical Journal 2024年第10期137卷 1151-1159页

作者： Chunlan Zhang Yun qin Yu Wu Heng Xu Yang shu Department of Hematology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Radiology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Laboratory Medicine/Research Center of Clinical Laboratory Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Biotherapy State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041China Institute of General Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of General Surgery Gastric Cancer Center and Laboratory of Gastric CancerWest China HospitalSichuan UniversityChengduSichuan 610041China

Metastasis-associated lung adenocarcinoma transcript 1(MALAT1)is a well-established oncogenic long non-coding RNA,the higher expression of which is strongly correlated with cancer events such as tumorigenesis,progression,metastasis,drug resistance,and treatment outcome in solid ***,a series of studies has highlighted its potential role in hematological malignancies in terms of these *** to solid cancers,MALAT1 can regulate various target genes via sponging and epigenetic mechanisms,but the miRNAs sponged by MALAT1 differ from those identified in solid *** this review,we systematically describe the role and underlying mechanisms of MALAT1 in multiple types of hematological malignancies,including regulation of cell proliferation,metastasis,stress response,and ***,MALAT1 expression is related to poor treatment outcome and drug resistance,therefore exhibiting potential prognostic value in multiple myeloma,lymphoma,and ***,we discuss the evaluation of MALAT1 as a novel therapeutic target against cancer in preclinical studies.

关键词： Long non-coding RNA Hematological malignancies Tumorigenesis Metastasis Drug resistance Prognostic biomarker

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Numerical Simulation on Production Trials by Using Depressurization for Typical Marine Hydrate Reservoirs:Well Type and Formation Dip

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Journal of Ocean University of China 2024年第3期23卷 661-675页

作者： qin Fanfan SUN Jiaxin GU Yuhang CAO Xinxin mao Peixiao NING Fulong JIANG Guosheng National Center for International Research on Deep Earth Drilling and Resource Development Faculty of EngineeringChina University of GeosciencesWuhan 430074China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

Natural gas hydrate has huge reserves and is widely distributed in marine *** commercial development is of great significance for alleviating the contradiction between energy supply and *** an efficient research method,numerical simulation can provide valuable insights for the design and optimization of hydrate ***,most of the current production models simplify the reservoir as a two-dimensional(2D)horizontal layered model,often ignoring the impact of formation dip *** improve the accuracy of production prediction and provide theoretical support for the optimization of production well design,two three-dimensional(3D)geological models with different dip angles based on the geological data from two typical sites are *** vertical well,horizontal well and multilateral wells are deployed in these reservoirs with different permeabilities to perform production trial,and the sensitivity analysis of dip angles is also carried *** short-term production behaviors in high and low permeability reservoirs with different dip angles are *** simulation results show that 1)the gas and water production behaviors for different well types in the two typical reservoirs show obviously different variation laws when the short-term depressurization is conducted in the inclined formation;2)the inclined formation will reduce the gas production and increase the water extraction,and the phenomena becomes pronounced as the dip angle increases,particularly in the low-permeability reservoirs;3)and the impact of formation dip on hydrate recovery does not change significantly with the variation of well type.

关键词： natural gas hydrate inclined formation depressurization production well type

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Biomimetic chitin hydrogel via chemical transformation

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Nano Research 2024年第2期17卷 771-777页

作者： Rui-Rui Liu Qian-Qian Shi Yu-Feng Meng Yong Zhou Li-Bo mao shu-Hong Yu Division of Nanomaterials&Chemistry Hefei National Research Center for Physical Sciences at the MicroscaleDepartment of ChemistryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsUniversity of Science and Technology of ChinaHefei 230026China College&Hospital of Stomatology Key Laboratory of Oral Diseases Research of Anhui ProvinceAnhui Medical UniversityHefei 230032China Department of Dental Implantology College&Hospital of StomatologyAnhui Medical UniversityHefei 230032China

Chitin hydrogel has been recognized as a promising material for various biomedical applications because of its biocompatibility and ***,the fabrication of strong chitin hydrogel remains a big challenge because of the insolubility of chitin in many solvents and the reduced chain length of chitin regenerated from *** herein introduce the fabrication of chitin hydrogel with biomimetic structure through the chemical transformation of chitosan,which is a water-soluble deacetylated derivative of *** reacetylation of the amino group in chitosan endows the obtained chitin hydrogel with outstanding resistance to swelling,degradation,extreme temperature and pH conditions,and organic *** chitin hydrogel has excellent mechanical properties while retaining a high water content(more than 95 wt.%).It also shows excellent antifouling performance that it resists the adhesion of proteins,bacteria,blood,and ***,as the initial chitosan solution can be feasibly frozen and templated by ice crystals,the chitin hydrogel structure can be either nacre-like or wood-like depending on the freezing method of the precursory chitosan *** to these anisotropic structures,such chitin hydrogel can exhibit anisotropic mechanics and mass transfer *** current work provides a rational strategy to fabricate chitin hydrogels and paves the way for its practical applications as a superior biomedical material.

关键词： chitin hydrogel biomimetic structure chemical stability mechanical strength antifouling

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Pillar effect induced by ultrahigh phosphorous/nitrogen doping enables graphene/MXene film with excellent cycling stability for alkali metal ion storage

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Journal of Energy Chemistry 2024年第6期93卷 146-156,I0004页

作者： Meng qin Yiwei Yao Junjie mao Chi Chen Kai Zhu Guiling Wang Dianxue Cao Jun Yan Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001HeilongjiangChina Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials and Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen 361021FujianChina

Graphene's large theoretical surface area and high conductivity make it an attractive anode material for potassium-ion batteries(PIBs).However,its practical application is hindered by small interlayer distance and long ion transfer ***,this paper aims to address the issue by introducing MXene through a simple and scalable method for assembling graphene and realizing ultrahigh P doping *** findings reveal that MXene and P-C bonds have a "pillar effect" on the structure of graphene,and the P-C bond plays a primary *** addition,N/P co-doping introduces abundant defects,providing more active sites for K^(+) storage and facilitating K^(+) *** expected,the developed ultrahigh phosphorous/nitrogen co-doped flexible reduced graphene oxide/MXene(NPrGM) electrode exhibits remarkable reversible discharge capacity(554 mA hg^(-1) at 0.05 A g^(-1)),impressive rate capability(178 mA h g^(-1) at 2 A g^(-1)),and robust cyclic stability(0.0005% decay per cycle after 10,000 cycles at 2 A g^(-1)).Furthermore,the assembled activated carbon‖NPrGM potassium-ion hybrid capacitor(PIHC) can deliver an impressive energy density of 131 W h kg^(-1) and stable cycling performance with 98.1% capacitance retention after5000 cycles at 1 A g^(-1).Such a new strategy will effectively promote the practical application of graphene materials in PIBs/PIHCs and open new avenues for the scalable development of flexible films based on two-dimensional materials for potential applications in energy storage,thermal interface,and electromagnetic shielding.

关键词： Graphene MXene Phosphorous doping Pillar effect Potassium-ion batteries

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