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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu kai Zhao Guoqiang Liu Youming Lu Xinyan Li kai shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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Investigations on Fluid Resonance Within A Narrow Gap Formed by Two Fixed Bodies with Varying Breadth Ratios

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China Ocean Engineering 2023年第6期37卷 962-974页

作者： GONG shu-kai GAO Jun-liang MAO Hong-fei School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300350China College of Ocean Engineering and Energy Guangdong Ocean UniversityZhanjiang 524000China Guangdong Provincial Key Laboratory of Intelligent Equipment for South China Sea Marine Ranching Guangdong Ocean UniversityZhanjiang 524088China

The resonant motion of the fluid inside a narrow gap between two fixed boxes induced by incident regular waves with various wave heights is investigated by adopting a two-dimensional numerical wave flume based on an opensourced CFD package,*** two boxes have identical draft and height,but the upstream box has a variable *** article focuses on the influences of the breadth ratio,defined as the ratio of the breadth of the upstream box to that of the downstream box,on the following three aspects of hydrodynamic characteristics of gap resonance:(1)the wave height amplifications inside the gap,and in front and at the rear of the structure system,(2)the reflection,transmission,and energy loss coefficients of the structure system,and(3)the response and damping time of the fluid *** is found that the fluid resonant frequency,the amplification factor of the resonant wave height inside the gap and the maximum energy loss coefficient of the structure system are shown to gradually decrease with the increase of the breadth *** response time of gap resonance is shown to first increase and then decrease with the breadth ratio overall,regardless of the incident wave height,and the configuration that the two boxes have the same breadth would bring the largest response time of gap resonance.

关键词： gap resonance wave amplification varying breadth ratios OpenFOAM

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Resource allocation for multiuser two-way OFDMA relay networks with user rate constraints

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The Journal of China Universities of Posts and Telecommunications 2011年第3期18卷 54-61页

作者： YANG Ding-cheng XU Ji-sheng HU shu-kai School of Electronic Information Wuhan University Wuhan 430079 China The State Key Lab of ISN Xidian University Xi'an 710126 China

This paper studies the resource allocation for a multi-user two-way amplify-and-forward （AF） relay network over orthogonal frequency-division multiplexing （OFDM） technology, where all users communicate with their pre-assigned partners. Using convex optimization techniques, an optimal solution to minimize the total transmit power while satisfy each user-pair＇s data rate requirements is proposed. We divide the resource allocation problem into two subproblems：（1） power optimization within user-pair and relay in each subcarrier. （2） optimal subcarrier allocation and sum power assignment among N parallel OFDM subcarriers. Closed-form expressions of the power among user-pair and relay can be obtained in subproblem （1）, and so the proposed algorithm decreases the variable dimensionality of the objective function to reduce the complexity of this optimization problem. To solve it, a three-step suboptimal approach is proposed to assign the resources to user-pairs： Firstly, decompose each user-pair into two sub user-pairs which have one-way and two-way relaying transmission modes. Secondly, allocate the subcarriers to the new mode user-pairs and assign the transmit power to each carrier. Thirdly, distribute the assigned power to three nodes allocated in the subcarrier. Simulation results demonstrate the significant power is saved with the proposed solutions, as compared to a fixed subcarrier allocation.

关键词： resource allocation convex optimization Two-way relay amplify and forward multiuser dual decomposition orthogonal frequency-division multiplexingaccess (OFDMA)

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Multifaceted Signaling Networks Mediated by Abscisic Acid Insensitive 4

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Plant Communications 2020年第3期1卷 20-29页

作者： Umashankar Chandrasekaran Xiaofeng Luo Wenguan Zhou kai shu School of Ecology and Environment Northwestern Polytechnical UniversityXi’an 710012China Institute of Ecological Agriculture Sichuan Agricultural UniversityChengdu 611130China

Although ABSCISIC ACID INSENSITIVE 4(ABI4)was initially demonstrated as a key positive regulator in the phytohormone abscisic acid(ABA)signaling cascade,multiple studies have now shown that it is actually involved in the regulation of several other cascades,including diverse phytohormone biogenesis and signaling pathways,various developmental processes(such as seed dormancy and germination,seedling establishment,and root development),disease resistance and lipid *** with its versatile biological functions,ABI4 either activates or represses transcription of its target *** upstream regulators of ABI4 at both the transcription and post-transcription levels have also been documented in recent ***,a complicated network consisting of the direct target genes and upstreamregulators of ABI4,through which ABI4 participates in several phytohormone crosstalk networks,has been *** this review,we summarize current understanding of the sophisticated ABI4-mediated molecular networks,mainly focusing on diverse phytohormone(including ABA,gibberellin,cytokinin,ethylene,auxin,and jasmonic acid)*** also discuss the potential mechanisms through which ABI4 receives the ABA signal,focusing on protein phosphorylation modification events.

关键词： ABI4 transcription factor target genes phytohormones crosstalk

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Two Faces of One Seed： Hormonal Regulation of Dormancy and Germination

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Molecular Plant 2016年第1期9卷 34-45页

作者： kai shu Xiao-dong Liu Qi Xie Zu-hua He State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai 200032 China Key Laboratory of Crop Ecophysiology and Farming System in Southwest China Institute of Ecological Agriculture Sichuan Agricultural UniversityChengdu 611130 China College of Agronomy Xinjiang Agricultural University Urumqi 830052 Xinjiang China These authors contributed equally to this article

Seed plants have evolved to maintain the dormancy of freshly matured seeds until the appropriate time for germination. Seed dormancy and germination are distinct physiological processes, and the transition from dormancy to germination is not only a critical developmental step in the life cycle of plants but is also impor- tant for agricultural production. These processes are precisely regulated by diverse endogenous hormones and environmental cues. Although ABA （abscisic acid） and GAs （gibberellins） are known to be the primary phytohormones that antagonistically regulate seed dormancy, recent findings demonstrate that another phytohormone, auxin, is also critical for inducing and maintaining seed dormancy, and therefore might act as a key protector of seed dormancy. In this review, we summarize our current understanding of the sophisticated molecular networks involving the critical roles of phytohormones in regulating seed dormancy and germination, in which AP2-domain-containing transcription factors play key roles. We also discuss the interactions （crosstalk） of diverse hormonal signals in seed dormancy and germination, focusing on the ABA/GA balance that constitutes the central node.

关键词： seed dormancy germination ABA GA auxin crosstalk

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Concurrent Deficiency of Gibberellins and Abscisic Acid Causes Plant Male Sterility

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Journal of Genetics and Genomics 2014年第11期41卷 601-604页

作者： kai shu Yaorong Wu Wenyu Yang Qi Xie Key Laboratory of Crop Ecophysiology and Farming System in Southwest China of Ministry of Agriculture Department of BiotechnologySichuan Agricultural University State Key Laboratory of Plant Genomics National Center for Plant Gene ResearchInstitute of Genetics and Developmental BiologyChinese Academy of Sciences

Plant fertility influences crop yield and quality, and thus is an important economic trait for agricultural production. There- fore, it is essential to understand the precise molecular mechanisms that control plant fertility. In the past decades, many studies demonstrated that the phytohormones gibberellin （GA） and abscisic acid （ABA） play key roles in the regulation of plant fertility （Kasembe, 1967; Stein, 1971; Jacobsen and Olszewski, 1991; Zhu et al., 2010）, but the detailed mecha- nisms largely remain unknown so far.

关键词： ABA Concurrent Deficiency of Gibberellins and Abscisic Acid Causes Plant Male Sterility

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Pulse coding off-chip learning algorithm for memristive artificial neural network

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Chinese Physics B 2022年第7期31卷 648-656页

作者： Ming-Jian Guo shu-kai Duan Li-Dan Wang College of Artificial Intelligence Southwest UniversityChongqing 400715China

Memristive neural network has attracted tremendous attention since the memristor array can perform parallel multiplyaccumulate calculation(MAC)operations and memory-computation operations as compared with digital CMOS hardware ***,owing to the variability of the memristor,the implementation of high-precision neural network in memristive computation units is still *** learning algorithms for memristive artificial neural network(ANN)is unable to achieve the performance comparable to high-precision by using CMOS-based ***,we propose an algorithm based on off-chip learning for memristive ANN in low *** the ANN in the high-precision in digital CPUs and then quantifying the weight of the network to low precision,the quantified weights are mapped to the memristor arrays based on VTEAM model through using the pulse coding weight-mapping *** this work,we execute the inference of trained 5-layers convolution neural network on the memristor arrays and achieve an accuracy close to the inference in the case of high precision(64-bit).Compared with other algorithms-based off-chip learning,the algorithm proposed in the present study can easily implement the mapping process and less influence of the device *** result provides an effective approach to implementing the ANN on the memristive hardware platform.

关键词： off-chip learning mapping memristor array artificial neural network

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Calculations of the 3-D neutronics for CH HCSB TBM with 3×3 sub-modules

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核聚变与等离子体物理 2006年第3期26卷 170-175页

作者： ZHANG Guo-shu FENG kai-ming CHEN Rong-guang YUAN Tao LI Zeng-qiang Southwestern Institute of Physics Chengdu 610041

Using three dimension MCNP code and FENDL2.0 data library, neutronics calculation for a HCSB (helium cooling solid breeder ) TBM ( test blanket module ) with 3×3 sub-modules has been performed. Local tritium breeding ratio (TBR) of 0.907, total tritium generation rate of 0.0175 g· d-1, peak power density of 9.27MW· m-3 and total power deposit of 0.422MW·m-3 are obtained under neutron wall loading of 0.78MW·m-2 and duty factor of 22%.

关键词：融化覆盖中子物理 TBR 再生区

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Experimental Researches on Milled Wood Lignin Pyrolysis Based on Analysis of Bio-oil

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Chemical Research in Chinese Universities 2011年第3期27卷 426-430页

作者： GUO Xiu-juan WANG shu-rong WANG kai-ge LUO Zhong-yang State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 P. R. China

The structure of milled wood lignin（MWL）, isolated via the Bjrkman procedure, was studied by means of 1H NMR spectroscopy and Fourier transform infrared spectroscopy, and then its pyrolytic product distribution was investigated on a pyrolysis device. MWL obtained from Manchurian Ash（MA） contained more methoxyl and free phenolic hydroxyl groups per C9 unit than MWL from Mongolian Pine（MP） due to the existence of both guaiacyl and syringyl units, which have a major influence on the pyrolysis behavior of lignin. The results of pyrolysis show that MWL from MA generated a higher yield of bio-oil, mainly composed of phenols, guaiacols, syringols and catechols, and a less yield of char, in addition to the gaseous products CO, CO2, methane and methanol, compared with MWL from MP. Guaiacol and syringol were the typical products from G-lignin and S-lignin, probably attributed to the easier cleavage of the aryl-alkyl linkage in the side chain compared with the C―OCH3 bond in the benzene ring. The degradation of MWL from MP was dominated by the demethylation reaction and the cleavage of aliphatic ―CH2OH at the γ-position, followed by the cracking of the Cα―Cβ and C4―Cα bonds.

关键词： Pyrolysis Milled wood lignin(MWL) Guaiacyl unit Syringyl unit

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Microsurgical Treatment of Epilepsy with Parenchymal Neurocysticercosis

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Current Medical Science 2019年第6期39卷 984-989页

作者： Yu-tang TAN Suo-jun ZHANG kai shu Ting LEI Hong-quan NIU Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Parenchymal neurocysticercosis is the most common form of neurocysticercosis in the central nervous system(CNS),which mainly causes epilepsy and usually responses well to routine ***,there are appreciable cases of relapses refractory to medical *** investigated microsurgical treatment of epilepsy with parenchymal *** cases of epilepsy caused by parenchymal neurocysticercosis from 2002 to 2018 were analyzed *** in 7 cases were completely *** case died of operation and no new dysfunction of the nervous system was observed after *** the other 9 cases,8 cases became seizure-free or controlled by medicine according to the postoperative followup for 6 months to 9 *** case was lost for *** was suggested that epilepsy with parenchymal neurocysticercosis can usually be controlled after routine ***,surgery is still indicated in some cases and careful microsurgery is associated with satisfactory clinical outcomes in appropriately selected cases.

关键词： epilepsy parenchymal cysticercosis neurocysticercosis microsurgery

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