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In vitro effects of Salvia officinalis *** oil on Candida albicans

Asian p.cific Journal of Trop.cal Biomedicine 2013年第5期3卷 376-380页

作者： Tularat Sookto Theerathavaj Srithavaj Sroisiri Thaweboon Boonyanit Thaweboon Binit shrestha Maxillofacial p.osthetic Clinic Department of ProsthodonticsFaculty of DentistryMahidol University Dep.rtment of Oral Microbiology Faculty of DentistryMahidol University

Objective:To determine the anticandidal activities of Salvia officinalis L.(***)essential oil against Candida albicans(***)and the inhibitory effects on the adhesion of *** to p.lymethyl methacrylate(p.MA)resin ***:Disc diffusion method was first used to test the anticandidal activities of the *** *** oil against the reference strain(ATCC 90028)and 2 clinical strains of *** the minimal inhibitory concentration(MIC)and minimal lethal concentration(MLX)were determined by modified membrane *** adhesion of *** to p.MA resin surface was assessed after immersion with *** *** oil at various concentrations of 1XMIC.0.5XMIC and 0.25XMIC at room temp.rature for30 ***-way ANOVA was used to comp.re the Candida cell adhesion with the p.etreatment agents and Tukey's test was used for multip.e ***:*** *** oil exhibited anticandidal activity against all strains of *** with inhibition zone ranging from 40.5 mm to 19.5 *** MIC and MLC of the oil were determined as 2.780 g/L against all test *** to the effects on *** adhesion to p.MA resin surface,it was found that immersion in the essential oil at concentrations of 1XMIC(2.780 g/L).0.5XMIC(1.390 g/L)and0.25XMIC(0.695 g/L)for 30 min significantly reduced the adhesion of all 3 test strains to p.MA resin surface in a dose dep.ndent manner(p.0.05).Conclusions:*** *** oil exhibited anticandidal activities against *** and had inhibitory effects on the adhesion of the cells to p.MA resin *** further testing and develop.ent,*** essential oil may be used as an antifungal denture cleanser to p.event candidal adhesion and thus reduce the risk of candida-associated denture stomatitis.

关键词： Salvia officinalis L. Candida albicans Essential oil p.MA resin Adhesion

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Comp.rative analysis of different hep.ticojejunostomy techniques for treating adult typ. I choledochal cyst

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Gastroenterology Rep.rt 2018年第1期6卷 54-60,I0002页

作者： Wenjie Ma Yongqiong Tan Anuj shrestha Fuyu Li Rongxing Zhou Junke Wang Haijie Hu Qin Yang Dep.rtment of Biliary Surgery West China Hospital of Sichuan UniversityChengduChina Op.ration Room West China Hospital of Sichuan UniversityChengduChina Dep.rtment of General Surgery Andaki Medical CollegePokharaNepal

Objective:To comp.re Roux-en-Y hep.tico-jejunostomy with comp.ete resection of the cyst or incomp.ete resection with 1-cm remnant p.oximal cyst wall in treating adult typ. I choledochal cyst(CC).Methods:The medical records of 267 adult p.tients with typ. I CC from January 1998 to December 2015 were reviewed *** them,171 underwent Roux-en-Y hep.tico-jejunostomy with comp.ete resection(p.D 0-cm group.and 96 underwent Roux-en-Y hep.tico-jejunostomy with 1-cm p.oximal cyst wall left(p.D 1-cm group..The short-and long-termp.st-op.rative comp.ications were comp.red between the two ***:No significant difference was observed in op.rative time or anastomotic diameter between the two *** incidence of p.riop.rative comp.ications was significantly higher in the p.D 1-cm group.than that in the p.D 0-cm group.28.1%vs 14.0%,p.0.005),esp.cially p.st-op.rative cholangitis(7.3%vs 1.2%,p.0.021).The incidence of long-term p.st-op.rative comp.ications was not significantly different,including anastomotic stricture,reflux cholangitis,intra-hep.tic bile duct stones and bile leak(all p.0.05).p.st-op.rative intra-p.ncreatic biliary malignancy occurred in one p.tient in the p.D 0-cm group.at 25 months and one p.tient in the p.D 1-cm group.at 5 month,*** site malignancy was observed in one p.tient in the p.D 1-cm group.at 10 ***:Ease of p.rforming anastomosis does not justify retaining a segment of choledochal cyst in typ. I CC due to its higher risk of p.st-op.rative comp.ication and malignancy.A comp.ete excision of the CC with anastomosis to the healthy p.oximal bile duct is necessary in treatment of typ. I CC.

关键词： Choledochal cyst roux-en-Y hep.tico-jejunostomy biliary drainage adults

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Exp.ession of annexin II in gastric carcinoma and its role in gastric cancer metastasis

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World Journal of Gastroenterology 2017年第38期23卷 7009-7015页

作者： Feng Han Shikha shrestha Hua Huang Huang-Yong Lv Chuan Nie Ling Lin Ming-Liang Lu Dep.rtment of Gastroenterology the PLA No.59 Hospital Dep.rtment of Gastroenterology The Second Affiliated Hospital Kunming Medical University

AIM To investigate the exp.ession of annexin II in gastric carcinoma and its role in the metastasis of gastric *** The exp.ession of annexin II in 51 cases of gastric carcinoma and 24 cases of adjacent tissues was detected by immunohistochemistry. The relationship.between annexin II and clinical features of gastric cancer was analyzed. Annexin II sp.cific si RNA was used to inhibit the exp.ession of annexin II in gastric cancer HGC-27 cells, and the effects of annexin II on the migration and secretion of matrix metallop.oteinases(MMp.) were *** The p.sitive rate of annexin II p.otein was 82.4% in gastric cancer tissues and 37.5% in adjacent tissues. There was significant difference between the two group.(p.p.sitive exp.ession of annexin II was not related to the sex and age of the p.tients(p.> 0.05). The exp.ession of annexin IIp.otein was correlated with tumor size, histological differentiation, TNM stage, Lymp. node metastasis and other clinical features were significantly correlated, the difference was statistically significant(p.p.ession, gastric cancer HGC-27 cells migration and secretion of MMp. were significantly decreased, the difference was statistically significant(p.p.essed in gastric cancer tissues, annexin II p.otein exp.ession is related to tumor size, histological differentiation, TNM staging, lymp. node metastasis and other clinical features were significantly correlated. Annexin II high exp.ession can p.omote the invasion and metastasis of gastric cancer.

关键词： Gastric cancer Annexin II Metastasis Realtime quantitative p.R Human gastric cancer HGC-27 cells Matrix metallop.oteinases

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p.vement p.rformance model for road maintenance and rep.ir p.anning: a review of p.edictive techniques

Digital Transportation and Safety

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Digital Transp.rtation and Safety 2023年第4期2卷 253-267页

作者： Krishna Singh Basnet Jagat Kumar shrestha Rabindra Nath shrestha Dep.rtment of Civil Engineering Pulchowk CampusInstitute of EngineeringTribhuvan UniversityKathmanduP.O.Box 1915Nepal

This p.p.r p.ovides a review of p.edictive analytics for roads,identifying gap. and limitations in current *** exp.ores the imp.ications of these limitations on accuracy and ap.lication,while also discussing how advanced p.edictive analytics can address these *** article acknowledges the transformative shift brought about by technological advancements and increased comp.tational *** degradation of p.vement surfaces due to increased road users has resulted in safety and comfort *** have conducted studies to assess p.vement condition and p.edict future changes in p.vement *** Management Systems are crucial in develop.ng p.ediction p.rformance models that estimate p.vement condition and degradation severity over *** learning algorithms,artificial neural networks,and regression models have been used,with strengths and *** generally agree on their accuracy in estimating p.vement condition considering factors like traffic,p.vement age,and weather ***,it is imp.rtant to carefully select an ap.rop.iate p.ediction model to achieve a high-quality p.ediction p.rformance *** the strengths and weaknesses of each model enables informed decisions for imp.ementing p.ediction models that suit sp.cific *** advancement of p.ediction models,coup.ed with innovative technologies,will contribute to imp.oved p.vement management and the overall safety and comfort of road users.

关键词： Road Maintenance p.ediction Model Deterministic Model p.obabilistic Model Machine Learning Model

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New antiglycation and enzyme inhibitors from p.rmotrema coop.ri

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Science China Chemistry 2011年第12期54卷 1926-1931页

作者： M.Iqbal CHOUDHARY Meher ALI Atia-tul-WAHAB Ajmal KHAN Saima RASHEED Sajan Lal SHYAULA(shrestha) Atta-ur-RAHMAN H.E.J.Research Institute of Chemistry International Center for Chemical and Biological SciencesUniversity of Karachi Dr.p.njwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of Karachi Dep.rtment of Chemistry College of ScienceKing Saud University Nep.l Academy of Science and Technology

Lichens are unique individuals which have been widely used in traditional medicines. This study was focused on the bioassayguided p.ytochemical investigation, and bioactivity evaluation on a lichens sp.cies, p.rmotrema coop.ri. This first bioassaydirected chemical study on p. coop.ri has led to the isolation of ethyl heamatomate （1）, atraric acid （2）, ethyl orsellinate （3）, orsellinic acid （4）, lecanoric acid （5）, gyrop.oric acid （6）, and licanorin （7）. The structures of 1-7 were mainly elucidated from sp.ctroscop.c methods including 1D, and 2D NMR sp.ctroscop., and mass sp.ctrometry. These comp.unds were evaluated for their antiglycation, urease, a-chymotryp.in, and β-glucoronidase inhibitory activities. Few of the p.enolic comp.unds showed significant, while most of them showed good inhibition of p.otein glycation, and urease activities.

关键词： lichen p.rmotrema coop.d ethyl heamatomate atraric acid urease inhibition antiglycation

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Exp.essions of Long Non-Coding RNAs in Carcinogenesis of Cervix: A Review

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Op.n Journal of Obstetrics and Gynecology 2018年第2期8卷 130-145页

作者： shrestha Reshies Min-Min Yu Dep.rtment of Obstetrics and Gynaecology the Second Hospital of Nanjing Affiliated to Medical School of Southeast University Nanjing China Dep.rtment of Obstetrics and Gynecology the Second Affiliated Hospital of Nanjing Medical University Nanjing China

Long non-coding RNAs (lncRNAs) are transcrip.s longer than 200 nucleotides mostly transcribed by RNA which do not encode p.oteins. p.eviously, lncRNAs were considered transcrip.ional byp.oducts called “junk DNA” with no biological functions. There are many studies conducted on lncRNAs showing they are actively involved in regulation of ep.genetic, transcrip.ional, and p.st-transcrip.ional events. Exp.essions of lncRNAs are more different in many malignant tumors than in benign tumors and normal tissue. Aberration of lncRNAs is resp.nsible to p.omote or sup.ress tumorigenesis and cancer p.ogression. Under different circumstances, lncRNAs exhibit their roles in carcinogenesis such as MALAT1 is resp.nsible for intervening mRNA instability, HOTAIR, MALAT1, ANRIL, p.T1 links with miRNA and histonemodifying comp.exes, MEG3 associates with miRNA, CCAT2, MEG3, GAS5, UCA1 allies with c-Myc or p.3 causing sup.ression of tumor or oncogenesis. Abnormal exp.essions of lncRNAs are noticed in gynecological cancers, such as cervical cancer, ovarian cancer, and endometrial cancer. Identification of cervical cancer associated lncRNAs is necessary to understand the molecular biogenesis of cancers. In this review, we summarized the foundation and function of the lncRNAs in terms of tumor p.ogression, invasion, p.ognosis, ap.p.osis, metastasis, and chemo-resistance. This review will p.ovide references to determine the clinical ap.lications of lncRNAs as ideal diagnostic biomarkers or therap.utic targets in cervical cancers.

关键词： lncRNAs Long Non-Coding RNAs Cervical Cancer Hp. HOTAIR MALAT-1 GAS5 MEG3 p.T1 HULC ANRIL CCHE1 CCAT2 UCA1

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尼泊尔儿童弱视种类及治疗结果(英文)

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国际眼科杂志 2013年第1期13卷 14-17页

作者： Srijana Adhikari Ujjowala shrestha 迪甘佳眼科中心尼泊尔加德满都

目的:研究尼泊尔儿童弱视类型以及影响治疗结果的相关因素。方法:该研究为以医院为基础的回顾性研究。对 2009-06 /2011-06 注册登记的 257 名弱视儿童的诊断记录进行了回顾性分析。弱视的类型分为屈光参差性、双眼屈光不正性、斜视性... 详细信息

目的:研究尼泊尔儿童弱视类型以及影响治疗结果的相关因素。方法:该研究为以医院为基础的回顾性研究。对 2009-06 /2011-06 注册登记的 257 名弱视儿童的诊断记录进行了回顾性分析。弱视的类型分为屈光参差性、双眼屈光不正性、斜视性和混合性弱视。双眼屈光不正性弱视儿童单独给予戴镜治疗,斜视性弱视每天给予 6h 修补治疗,屈光参差性和混合性弱视根据需要给予修补和光学矫正。主要检测为术后视力,并分析就诊时的年龄、弱视类型、初始视力以及屈光不正的类型和严重程度对最终视力的影响。结果:儿童年龄范围为 3 ～ 15( 平均 7. 96±3. 09) 岁。双眼屈光不正性弱视为最常见类型( 35. 8%) ,其余依次为斜视性弱视( 31.9%) ,屈光参差性为 23. 0%,混合性弱视为9. 3% 。双眼屈光不正性弱视的平均最终视力 ( 0. 295 ±0. 25) 比其他类型的要好( logMAR 视力检测,p.= 0. 001) 。最终视力与就诊年龄、屈光不正的类型和严重程度没有显著的相关性( p.值分别为 0. 98,p.= 0. 12) ,但是最终视力与就诊时初始视力有显著相关性( p.0.00) 。结论:双眼屈光不正性弱视为最常见的,术后视力也是最好的、最初的视力是成功治疗弱视的最重要因素。

关键词：弱视双眼屈光不正性弱视尼泊尔

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Characterization of glucose isomerase-p.oducing bacteria and op.imization of fermentation conditions for p.oducing glucose isomerase using biomass

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Green Chemical Engineering 2023年第2期4卷 239-249页

作者： Aristide Laurel Mokale Kognou Chonlong Chio Janak Raj Khatiwada Sarita shrestha Xuantong Chen Hongwei Li Yuen Zhu Zi-Hua Jiang Chunbao(Charles)Xu Wensheng Qin Dep.rtment of Biology Lakehead UniversityThunder BayONP7B 5E1Canada Dep.rtment of Chemical and Biochemical Engineering Western UniversityLondonONN6A 5B9Canada School of Environment and Resources Shanxi UniversityTaiyuan030006China Dep.rtment of Chemistry Lakehead UniversityThunder BayONP7B 5E1Canada

Glucose isomerase(GI)is an enzyme with high p.tential *** of GI p.oducing bacteria with interesting p.op.rties from an industrial p.int of view is *** sp.,p.enarthrobacter sp.,Chryseobacterium sp.,Hymenobacter sp.,Mycobacterium sp.,and Stenotrop.omonas *** isolated from soil *** of enzyme p.oduction yield was investigated in various fermentation conditions using resp.nse surface *** isolates exhibited maximum GI activity at 40℃,p. 6–8 after 4 days of incubation.A mixture of p.p.one/yeast extract or tryp.one/p.p.one enhanced higher enzyme *** same trend was observed in fermentation medium containing 1%xylose or 2%–2.5%wheat *** study advanced the knowledge of these bacterial isolates in p.omoting wheat straw as feedstock for the bio-based industry.

关键词： Cellulolytic bacteria Glucose/xylose isomerase 16S rRNA Biomass conversion

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p.osp.ctive study of transsp.enoidal p.tuitary surgery： is tumor volume a p.edictor for the residual tumor？

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Chinese Medical Journal 2012年第14期125卷 2444-2448页

作者： Resha shrestha QI Lei BAO Gang WANG Mao-de Dep.rtment of Neurosurgery First Affiliated Hospital of MedicalSchool Xi'an Jiaotong University Xi'an Shaanxi 710061 China

Background The p.esence of residual tumor after surgery for p.tuitary adenoma may necessitate further treatment. The sup.asellar and p.rasellar extension of the tumor have been widely considered as the p.edictors for residual tumor. However there is scarcity of studies regarding the p.eop.rative tumor volume and residual tumor. This study was conducted to evaluate if tumor volume could p.edict the outcome of transsp.enoidal p.tuitary surgery. Methods A p.osp.ctive study was designed and 48 p.tients who underwent transsp.enoidal p.tuitary surgery within 1 year in the First Affiliated Hosp.tal of Xi＇an Jiaotong University were included in this study. The p.eop.rative tumor volume and immediate p.stop.rative tumor volume （within 4-7 days） were calculated in the contrast magnetic resonance imaging by using the formula of ellip.oid. All these volumes were divided into three subgroup., i.e. group.1, group.2 and group.3 with p.eop.rative volume of less than 4 cm3, 4-8 cm3, and more than 8 cm3 resp.ctively. The p.rasellar and sup.asellar extension of the tumor were also classified by Knosp.and modified Hardy＇s classifications. Results Baseline characteristics were comp.rable. The p.eop.rative tumor volume of more than 8 cm3 （group.3, （12.1±1.1） cm3） had increased risk on p.stop.rative tumor residue （p.〈0.01） than the other two group. （（2.1±0.3） cm3 and （6.1±0.3） cm3 in group. 1 and 2）. The mean p.stop.rative volume in group.3 p.tients （（2.2±0.1） cm3） was significantly higher than the other two group. （p.〈0.01）. Conclusion p.eop.rative volume of more than 8 cm3 can be considered as a p.edictor for p.stop.rative residual volume.

关键词： p.tuitary neop.asms, transsp.enoidal ap.roach, tumor volume, residual volume p.edictor

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IKBKE在宫颈病变组织中表达的研究

IKBKE在宫颈病变组织中表达的研究

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作者： RANJANA shrestha 大连医科大学

学位级别：硕士

目的:通过检测I KBKE在慢性宫颈炎、低级别上皮内瘤变、高级别上皮内瘤变及宫颈癌组织中的表达,探讨I KBKE在不同类型宫颈组织中表达的意义。方法:收集2011年01月~2013年12月间临床诊断为慢性宫颈炎,低级别上皮内瘤变、高级别上皮内瘤... 详细信息

目的:通过检测I KBKE在慢性宫颈炎、低级别上皮内瘤变、高级别上皮内瘤变及宫颈癌组织中的表达,探讨I KBKE在不同类型宫颈组织中表达的意义。方法:收集2011年01月~2013年12月间临床诊断为慢性宫颈炎,低级别上皮内瘤变、高级别上皮内瘤变及宫颈癌IA期,IB期,IIA期及IIB期患者石蜡标本共160例。所有患者均接受了手术治疗（宫颈锥切术或根治性子宫切除术）,术前接受化疗及放疗患者未纳入。慢性宫颈炎组作为对照。所有组织标本以抗IKKe/IKK-I抗体检测IKBKE表达,使用Sp.S17.0分析数据。结果:纳入实验组患者的平均年龄为49±9.2岁（31岁-78岁）。结果显示了IKBKE在各种类型宫颈组织胞浆中表达的差异。在慢性宫颈炎组,IKBKE均呈阴性表达,低级别上皮内瘤变组仅1例阳性表达,而在高级别上皮内瘤变组及宫颈癌IA期、IB期、IIA期及IIB期组中,IKBKE阳性表达率更高,且染色更深。41例高级别上皮内瘤变标本中,25例（60.9%）阳性表达;79例宫颈癌标本中,69例（87.3%）阳性表达。慢性宫颈炎组与低级别上皮内瘤变组的IKBKE表达无统计学差异p.0.694（p.0.05）;慢性宫颈炎组与高级别上皮内瘤变组中的IKBKE表达有统计学差异（p.0.05）;高级别上皮内瘤变组与宫颈癌组中的IKBKE表达有统计学差异（p.0.05）;我们发现恶性宫颈疾病（高级别上皮内瘤变和宫颈癌）与宫颈良性疾病（低级别上皮内瘤变、宫颈炎）相比,IKBKB表达水平更高。结论:免疫组化实验证实IKBKE在低级别上皮内瘤变、高级别上皮内瘤变及宫颈癌组织的胞浆中表达。IKBKE的表达与病理分级相关,高级别上皮内瘤变及宫颈癌组织较宫颈炎或低级别上皮内瘤变IKBKE的表达增加,因此我们推测IKBKE可能在宫颈癌发生和发展中起重要作用。

关键词：宫颈病变 IKBKE 肿瘤发生免疫组化

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