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Prognostic significance of peritoneal metastasis from colorectal cancer treated with first-line triplet chemotherapy

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World Journal of Clinical Cases 2022年第8期10卷 2429-2438页

作者： shouki bazarbashi Abdulrahman Alghabban Mohamed Aseafan Ali H Aljubran Ahmed Alzahrani Tusneem AM Elhassan Oncology Center King Faisal Specialist Hospital&Research CenterRiyadh 11211RiyadhSaudi Arabia

BACKGROUND Peritoneal metastasis from colorectal cancer(CRC)carries a poor prognosis in most *** majority of those studies used either a single-agent or doublet chemotherapy regimen in the first-line *** To investigate the prognostic significance of peritoneal metastasis in a cohort of patients treated with triplet chemotherapy in the first-line *** We retrospectively evaluated progression-free survival(PFS)and overall survival(OS)in 51 patients with metastatic CRC treated in a prospective clinical trial with capecitabine,oxaliplatin,irinotecan,and bevacizumab in the first-line setting according to the presence and absence of peritoneal ***,univariate and multivariate analyses for PFS and OS were performed to assess the prognostic significance of peritoneal metastasis at the multivariate *** Fifty-one patients were treated with the above triplet *** had peritoneal *** patient characteristics of both groups showed a significant difference in the sidedness of the primary tumor(left-sided primary tumor in 60%of the peritoneal group vs 86%in the nonperitoneal group,P=0.03)and the presence of liver metastasis(40%for the peritoneal group vs 75%for the nonperitoneal group,P=0.01).Univariate analysis for PFS showed a statistically significant difference for age less than 65 years(P=0.034),presence of liver metastasis(P=0.046),lung metastasis(P=0.011),and those who underwent metastasectomy(P=0.001).Only liver metastasis and metastasectomy were statistically significant for OS,with P values of 0.001 and 0.002,*** analysis showed that age(less than 65 years)and metastasectomy were statistically significant for PFS,with P values of 0.002 and 0.001,*** the other hand,the absence of liver metastasis and metastasectomy were statistically significant for OS,with P values of 0.003 and 0.005,*** Peritoneal metastasis in patients with metastatic CRC tre

关键词： Colorectal cancer Peritoneal carcinomatosis Triplet chemotherapy Survival Prognostic factors Metastasectomy

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Calcium supplementation in colorectal cancer prevention:A systematic meta-analysis of adverse events

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BIOCELL 2022年第3期46卷 759-767页

作者： XUE MEI LUO SHAHANAVAJ KHAN ABDUL MALIK FAHAD M.ALDAKHEEL ANIS AHMAD CHAUDHARY shouki bazarbashi FATEMEH TABATABAIE Department of General Surgery Mianzhu People’s Hospital of SichuanMianzhuChina Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Biosciences Shri Ram Group of College(SRGC)MuzaffarnagarIndia Department of Health Sciences Novel Global Community Educational FoundationSydneyAustralia Department of Clinical Laboratory Sciences College of Applied Medical SciencesKing Saud UniversityRiyadhSaudi Arabia Department of Biology College of ScienceImam Mohammad Ibn Saud Islamic University(IMSUI)RiyadhSaudi Arabia Oncology Center King Faisal Specialist Hospital and Research CenterRiyadhSaudi Arabia Shiraz University of Medical Sciences ShirazIran

Despite the multiple systematic reviews and meta-analyses accumulating evidence on the preventive effect of calcium supplementation for colorectal cancer,most of the associated adverse effects are not systematically *** aim of the study is evaluating adverse events associated with calcium supplementation for colorectal cancer prevention through a systematic *** searched Medline,PubMed Central,EMBASE(Excerpta Medica database),Scopus,Cochrane Central Register of Controlled Trials,and Web of Science published in English from database inception up to 31 July *** the current systematic meta-analysis,we included human studies(including cohort studies,clinical trials,case-control studies)on supplementation of calcium in patients with or at risk of colorectal *** of the quality of included studies was performed by Jadad *** on the patient population,number of enrolled subjects in each group,dose of calcium supplementation,duration of calcium supplementation,and reported adverse events were *** data were pooled for incidence rates for any adverse event during the study period regardless of causality *** identified 6 studies,comprising 4583 participants that met the inclusion ***-analysis on pooled incidence rates for adverse event during study period showed no statistically significant increased risk for cancer(OR=0.92,95%CI:0.70–1.21,P=0.577;I^(2)=0.0%,P=0.731),coronary revascularization(OR=1.12,95%CI:0.79–1.59,P=0.492;I^(2)=0.0%,P=0.957),myocardial infarction(OR=0.81,95%CI:0.34–1.91,P=0.634;I^(2)=67.9%,P=0.047),stroke(OR=0.75,95%CI:0.42–1.33,P=0.332,I^(2)=0.00%,P=0.717),Transient Ischemic Attack(TIA)(OR=1.37,95%CI:0.28–6.51,P=0.692,I^(2)=81.9%,P=0.002),urolithiasis(OR=1.23,95%CI:0.75–2.01,P=0.410;I^(2)=0.0%,P=0.851),fracture(OR=0.98,95%CI:0.70–1.37,P=0.938;I^(2)=37.8%,P=0.152)and death(OR=1.05,95%CI:0.71–1.56,P=0.786,I^(2)=12.2%,P=0.317)in patients receiving calcium supplementation for colo

关键词： Colorectal cancer Calcium Supplement Adverse event Systematic reviewed Meta-analysis

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Hybrid Malware Variant Detection Model with Extreme Gradient Boosting and Artificial Neural Network Classifiers

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Computers, Materials & Continua 2023年第9期76卷 3483-3498页

作者： Asma A.Alhashmi Abdulbasit A.Darem Sultan M.Alanazi Abdullah M.Alashjaee Bader Aldughayfiq Fuad A.Ghaleb shouki A.Ebad Majed A.Alanazi Department of Computer Science Northern Border UniversityArar9280Saudi Arabia Department of Computer Sciences Faculty of Computing and Information TechnologyNorthern Border UniversityRafha91911Saudi Arabia Department of Information Systems College of Computer Science and InformationJouf UniversitySakakaAljoufSaudi Arabia School of Computing University Teknologi Malaysia81310 UTM Johor BahruJohor81310Malaysia Department of Computer and Electronic Engineering Sana’a Community CollegeSana’a5695Yemen

In an era marked by escalating cybersecurity threats,our study addresses the challenge of malware variant detection,a significant concern for amultitude of sectors including petroleum and mining *** paper presents an innovative Application Programmable Interface(API)-based hybrid model designed to enhance the detection performance of malware *** model integrates eXtreme Gradient Boosting(XGBoost)and an Artificial Neural Network(ANN)classifier,offering a potent response to the sophisticated evasion and obfuscation techniques frequently deployed by malware *** model’s design capitalizes on the benefits of both static and dynamic analysis to extract API-based features,providing a holistic and comprehensive view of malware *** these features,we construct two XGBoost predictors,each of which contributes a valuable perspective on the malicious activities under *** outputs of these predictors,interpreted as malicious scores,are then fed into an ANN-based classifier,which processes this data to derive a final *** strength of the proposed model lies in its capacity to leverage behavioral and signature-based features,and most importantly,in its ability to extract and analyze the hidden relations between these two types of *** efficacy of our proposed APIbased hybrid model is evident in its performance *** outperformed other models in our tests,achieving an impressive accuracy of 95%and an F-measure of 93%.This significantly improved the detection performance of malware variants,underscoring the value and potential of our approach in the challenging field of cybersecurity.

关键词： API-based hybrid malware detection model static and dynamic analysis malware detection

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Influence of an Uncontrolled Strength and Aerobic Exercise on Clinical and Echocardiographic Parameters in a Patient Following Anterior Myocardial Infarction

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Case Reports in Clinical Medicine 2017年第8期6卷 217-220页

作者： Adam Staron Najdat bazarbashi Bartlomiej Wojtasik Department of Cardiac Rehabilitation Murcki Hospital Katowice Poland Department of Cardiology Prince Sultan Cardiac Center Prince Sultan Military Medical City Riyadh Saudi Arabia

Cardiac rehabilitation has been strongly recommended as a major therapeutic measure for coronary artery disease. Exercises, including resistance training, Ti-chi and yoga surprisingly show various and promising outcomes. We present an unusual case which certain aerobic techniques over a period of 5 weeks have improved a patient’s myocardial contractility and overall function after sustaining an anterior myocardial infarction.

关键词： Anterior MI Strength Exercise Resistance Training Aerobic Training Cardiac Rehabilitation

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Extracorporeal Membrane Oxygenation for Post Cardiotomy Acute Right Ventricle Failure in Adults

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World Journal of Cardiovascular Surgery 2017年第6期7卷 73-78页

作者： Sohail Siddique Najdat bazarbashi Abdullah Ashmeg Asif Mahmood Abdul Aziz Alhosan Amro Saeed Department of Cardiac Surgery Prince Sultan Cardiac Center Prince Sultan Military Medical City Riyadh KSA

Myriad surgical and medical remedies including Extracorporeal Membrane Oxygenation (ECMO) are being employed for acute right ventricle with varying results. Very few cases have been documented in literature regarding the role of VA ECMO for right ventricular failure after open heart surgery. We retrospectively analyzed all cases eliciting VA ECMO for post-operative right heart failure over a period of 24 months. Data was completely delineated for demography, pre-operative patient status at length, brief venipuncture course, indications for VA ECMO and its outcome after institution.

关键词： Open Heart Surgery Right Ventricular Failure VA ECMO

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Metabolropic glutamale receptors negatively regulate melatonin synthesis in rat pinealocytes

Metabolropic glutamale receptors negatively regulate melaton...

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Third Congress of the Asian-Pacific Organization for Cell Biology

作者： Hiroshi Yamada shouki Yatsushiro Mitsuko Hayashi Akitsugu Yamamoto Akihito Yamaguchi Yoshinori Moriyama Institute of Scientific and Industrial Research (ISIR) Osaka UniversityIbarakiOsaka 567JAPAN Kansai Medical University MoriguchiOsaka 570JAPAN

Rat pinealocytes are neuroendocrine cells that synthesize and secrete melatonin. Besides melatonin, pinealocytes accumulate L-glutamate in microvesicles and secrete it through Ca2+ regulated exocytosis (1,2). Extracellular glutamate is sequestered through a GLT-1 type Na+-dependent glutamate transporter at the plasma membrane (3). Thus pinealocyte may also

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Propofol vs traditional sedatives for sedation in endoscopy:A systematic review and meta-analysis

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World Journal of Gastrointestinal Endoscopy 2019年第12期11卷 573-588页

作者： Aureo Augusto de Almeida Delgado Diogo Turiani Hourneaux de Moura Igor Braga Ribeiro Ahmad Najdat bazarbashi Marcos Eduardo Lera dos Santos Wanderley Marques Bernardo Eduardo Guimaraes Hourneaux de Moura Gastrointestinal Endoscopy Unit Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao PauloSao Paulo 05403000Brazil Division of Gastroenterology Hepatology and EndoscopyBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States

BACKGROUND Propofol is commonly used for sedation during endoscopic *** suggests its superiority to traditional sedatives used in endoscopy including benzodiazepines and opioids with more rapid onset of action and improved postprocedure recovery times for ***,Propofol requires administration by trained healthcare providers,has a narrow therapeutic index,lacks an antidote and increases risks of cardio-pulmonary *** To compare,through a systematic review of the literature and meta-analysis,sedation with propofol to traditional sedatives with or without propofol during endoscopic *** A literature search was performed using MEDLINE,Scopus,EMBASE,the Cochrane Library,Scopus,LILACS,BVS,Cochrane Central Register of Controlled Trials,and The Cumulative Index to Nursing and Allied Health Literature *** last search in the literature was performed on March,2019 with no restriction regarding the idiom or the year of *** randomized clinical trials with full texts published were *** divided sedation therapies to the following groups:(1)Propofol versus benzodiazepines and/or opiate sedatives;(2)Propofol versus Propofol with benzodiazepine and/or opioids;and(3)Propofol with adjunctive benzodiazepine and opioid versus benzodiazepine and *** following outcomes were addressed:Adverse events,patient satisfaction with type of sedation,endoscopists satisfaction with sedation administered,dose of propofol administered and time to recovery post ***-analysis was performed using RevMan5 software version *** A total of 23 clinical trials were included(n=3854)from the initial search of 6410 *** Group I(Propofol vs benzodiazepine and/or opioids):The incidence of bradycardia was not statistically different between both sedation arms(RD:-0.01,95%CI:-0.03–+0.01,I2:22%).In 10 studies,the incidence of hypotension was not statistically difference between sedation arms(RD:0.01,95%CI

关键词： Sedation Digestive endoscopy Propofol Benzodiazepines Opioids Adverse events

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Role of endoscopic vacuum therapy in the management of gastrointestinal transmural defects

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World Journal of Gastrointestinal Endoscopy 2019年第5期11卷 329-344页

作者： Diogo Turiani Hourneaux de Moura Bruna Furia Buzetti Hourneaux de Moura Michael A Manfredi Kelly E Hathorn Ahmad N bazarbashi Igor Braga Ribeiro Eduardo Guimaraes Hourneaux de Moura Christopher C Thompson Division of Gastroenterology Hepatology and EndoscopyBrigham and Women’s Hospital-Harvard Medical School Department of Endoscopy of Clinics Hospital of Sao Paulo University Esophageal and Airway Atresia Treatment Center Boston Children's Hospital-Harvard Medical School

A gastrointestinal(GI) transmural defect is defined as total rupture of the GI wall,and these defects can be divided into three categories: perforations,leaks,and fistulas. Surgical management of these defects is usually challenging and may be associated with high morbidity and mortality rates. Recently,several novel endoscopic techniques have been developed,and endoscopy has become a firstline approach for therapy of these conditions. The use of endoscopic vacuum therapy(EVT) is increasing with favorable results. This technique involves endoscopic placement of a sponge connected to a nasogastric tube into the defect cavity or lumen. This promotes healing via five mechanisms,including macrodeformation,microdeformation,changes in perfusion,exudate control,and bacterial clearance,which is similar to the mechanisms in which skin wounds are treated with commonly employed wound vacuums. EVT can be used in the upper GI tract,small bowel,biliopancreatic regions,and lower GI tract,with variable success rates and a satisfactory safety profile. In this article,we review and discuss the mechanism of action,materials,techniques,efficacy,and safety of EVT in the management of patients with GI transmural defects.

关键词： Gastrointestinal Endoscopy Endoscopic vacuum therapy Negative pressure therapy Fistula Leak Perforation Defect

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