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Early-onset and later-onset cancer:trends,risk factors,and prevention in Northern China

Science China(Life Sciences) 2024年第9期67卷 1928-1940页

作者： Tong Liu Chen-An Liu Qing-Song Zhang Qi Zhang Yi-Ming Wang Meng-Meng Song Shi-Qi Lin Li Deng shou-ling wu Han-Ping Shi Department of Gastrointestinal Surgery Department of Clinical NutritionBeijing Shijitan HospitalCapital Medical UniversityBeijing 100038China National Clinical Research Center for Geriatric Diseases Xuanwu HospitalCapital Medical UniversityBeijing 100053China Key Laboratory of Cancer FSMP for State Market Regulation Beijing 100038China Laboratory for Clinical Medicine Capital Medical UniversityBeijing 100038China Department of General Surgery Kailuan General HospitalTangshan 063000China Department of Genetics Yale School of MedicineNew Haven 06510USA Department of Hepatobiliary Surgery Kailuan General HospitalTangshan 063000China Cardiovascular Research Institute University of CaliforniaSan Francisco 94158USA Department of Cardiology Kailuan General HospitalTangshan 063000China

The characteristics of early-onset(onset age<50 years)and later-onset(onset age≥50 years)cancers differ *** novel risk factors for both types of cancer is crucial for increasing awareness of cancer prevention and for reducing its *** study aimed to analyze the trends in incidence and risk factors for early-onset and late-onset *** conducted a prospective study by drawing data from the Kailuan *** study included 6,741 participants with cancer(624 with early-onset cancer and 6,117 with later-onset cancer)and 6,780 matched controls among the 186,249 participants who underwent Kailuan health examinations from 2006 to *** primary outcomes were cancer incidence rates,and associated risk factors for early-and later-onset *** Cox regression was used to calculate hazard ratios and 95% confidence intervals of each exposure factor for early-and later-onset cancer by cancer *** risk proportions were used to estimate the number of cases that could be prevented by eliminating a risk factor from the *** for liver cancer,incidence rates for nearly all types of cancer increased during the study ***,alcohol consumption,lipid metabolism disorders,hypertension,diabetes mellitus,fatty liver,and inflammation were associated with a significantly increased risk of cancer at multiple sites,but risk factors for cancer incidence differed by ***,alcohol consumption,inflammation,and hypertension were the major contributors to preventable *** incidence of several different types of cancer,including earlyonset cancer,is increasing in northeastern *** in risk factors between early-onset and later-onset malignancies may contribute to the divergence in the observed changes in incidence trends between these two specific types of cancer.

关键词： cancer early-onset later-onset trend risk factor prevention

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Retinal nerve fiber layer defects and chronic kidney disease:the Kailuan Eye Study

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1696-1706页

作者： Qian-Qian Wan Jin-Qiong Zhou Li-Jian Fang Ya-Xing Wang Ye-Nan Wang Qian Wang Yan-Ni Yan Xuan Yang shou-ling wu Shuo-Hua Chen Jost B Jonas Wen-Bin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology the Second Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of Ophthalmology Beijing Liangxiang HospitalCapital Medical UniversityBeijing 102400China Beijing Institute of Ophthalmology Beijing Key Laboratory of Ophthalmology and Visual SciencesBeijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Xuanwu HospitalCapital Medical UniversityBeijing 100730China Department of Cardiology Kailuan General HospitalTangshan 063000Hebei ProvinceChina Health Care Center Kailuan GroupTangshan 063000Hebei ProvinceChina Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University of HeidelbergHeidelberg 69117Germany

AIM:To investigate whether retinal nerve fiber layer defects(RNFLDs)is a potential risk factor for chronic kidney disease(CKD)in Chinese ***:The Kailuan Eye Study was a populationbased study that included 14440 *** participants underwent detailed assessments,RNFLDs were diagnosed using color fundus ***:Overall,12507 participants[8533 males(68.23%)]had complete systemic examination data and at least one evaluable fundus *** were found in 621 participants[5.0%;95%confidence interval(CI):4.6%-5.34%],and 70 cases of multiple RNFLDs were found(11.27%).After adjusting multiple factors,RNFLDs was significantly associated with CKD severity,the ORs of CKD stage 3,stage 4 and stage 5 were 1.698,4.167,and 9.512,*** RNFLDs were also associated with CKD severity after adjusting multiple factors,the ORs of CKD stage 3 and stage 5 were 4.465 and 11.833 ***,2294 participants had CKD(18.34%,95%CI:17.68%-18.99%).After adjusting for other factors,CKD presence was significantly correlated with the presence of ***:The strongest risk factors for RNFLDs are CKD and ***,RNFLDs can be an ocular feature in patients with *** can help detect systemic diseases,and assessment for RNFLDs should be considered in CKD patients.

关键词： chronic kidney disease retinal nerve fiber layer defects Kailuan Eye Study fundus examination

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Possible Association of ACE Gene I/D Polymorphism With Blood Pressure——Lowering Response to Hydrochlorothiazide

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Biomedical and Environmental Sciences 2007年第5期20卷 351-356页

作者： YONG ZHOU shou-ling wu JIAN-QING LIU WAN-NIAN LIANG GAI-FEN LIU Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Cardiology Affiliated Kailuan Hospital North China Coal Mining Medical College Tangshan 063000 Hebei China Capital Medical University Beijing 100069 China

Objective To explore the association between polymorphism in the ACE I/D gene and blood pressure-lowering response to hydrochlorothiazide （HCTZ） in 829 patients. Methods HCTZ 12.5 mg was taken once a day for six weeks. The blood pressure reduction and ratio reaching target blood pressure were compared in different ACE genotype groups. Results The reduction in SBP of patients carrying DD was greater than that in other groups carrying II or ID （12.2 mmHg versus 5.4 mmHg, 12.2 mmHg versus 4.4 mmHg, respectively, P〈0.05）. The reduction in MAP of patients carrying DD was also greater than that in other groups carrying II or ID （6.9 mmHg versus 3.9 mmHg, 6.9 mmHg versus 3.6 mmHg, respectively, P〈0.05）. The ratio reaching target blood pressure in DD groups was significantly higher than that in II or ID groups （P〈0.05）. The pre-treatment SBP, DD genotype, aldosterone levels entered the multi-linear regression model significantly and might affect the reduction of SBP. The pre-treatment DBP, aldosterone levels, DD genotype entered the multi-linear regression model significantly and might affect the reduction of DBP. The pre-treatment MAP, DD genotype, aldosterone levels entered the multi-linear regression model significantly and might affect the reduction of MAP. Conclusion ACE genotyping is associated with blood pressure-lowering response to HCTZ. Specific genotypes might be associated with the response to specific antihypertensive treatment.

关键词： Hypertension Peptidyl-dipeptidase A Genotype Treatment

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Changes in pulse pressure × heart rate, hs-CRP, and arterial stiffness progression in the Chinese general population: a cohort study involving 3978 employees of the Kailuan Company

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Journal of Geriatric Cardiology 2019年第9期16卷 710-716页

作者： Hao XUE Jun-Juan LI Jian-Li WANG Shuo-Hua CHEN Jing-Sheng GAO Yun-Dai CHEN shou-ling wu Department of Cardiology Chinese People’s Liberation Army General Hospital Beijing China Department of Cardiology Kailuan Hospital Hebei United University Tangshan China

Background Pulse wave velocity(PWV) is a marker of arterial stiffness, which represents sub-clinical atherosclerosis. Pulsatile stress and high-sensitivity C-reactive protein(hs-CRP) are associated with arteriosclerosis. However, there is no prospective data confirming whether changes in pulsatile stress and inflammatory markers affect the progression of arterial stiffness. The aim of this study was to investigate the relationships over time between the effects of changes in pulsatile stress and hs-CRP, and arterial stiffness progression during a 2-year follow-up. Methods We performed a longitudinal study involving 3978 participants. All participants underwent a physical examination in 2010–2011 and 2012–2013, during which we measured participants’ hs-CRP levels, brachial–ankle pulse wave velocity(ba PWV), and pulsatile stress. Results Baseline hs-CRP was correlated with ba PWV(r = 0.18, P = 0.000);however the correlation was weaker than that with systolic blood pressure(r = 0.65), pulsatile stress(r = 0.57), and rate-pressure product(r = 0.58). Multiple linear regression analysis demonstrated that changes in pulsatile stress, mean arterial pressure, and low-density lipoprotein-C(LDL-C) were positively correlated with changes in ba PWV, with correlation coefficients of 0.27, 0.25, and 0.07, respectively, but not with changes in hs-CRP. Moreover, each 100-a U increase in pulsatile stress, 1 mm Hg increase in mean blood pressure, and 1 mmol/L increase in LDL-C was associated with a 3 cm/s, 4.78 cm/s, and 17.37 cm/s increase in ba PWV, respectively. Conclusions Pulsatile stress increases are associated with arterial stiffness progression, but that changes in hs-CRP had no effect on arterial stiffness progression. Hs-CRP may simply be a marker of inflammation in arterial stiffness and has no association with arterial stiffness progression.

关键词： Atherosclerosis Blood vessels Brachial–ankle index C-reactive protein Pulse wave velocity

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Correlation of the history of stroke and the retinal artery occlusion: a nested case-control study

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International Journal of Ophthalmology(English edition) 2020年第3期13卷 431-437页

作者： Yue-Yan Xiao Wen-Bin Wei Ya-Xing Wang Ai-Dong Lu Shuo-Hua Chen Lu Song shou-ling wu Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Kailuan General HospitalTangshan 063000Hebei ProvinceChina Department of Cardiology Kailuan General HospitalTangshan 063000Hebei ProvinceChina

AIM:To analyze the systemic factors including stroke history related to the retinal artery occlusion(RAO).METHODS:Patients with an exact diagnosis of RAO in the medical database of the Kailuan Corporation were identified as the case *** patients without RAO were added for each case from the Kailuan Study and matched for sex and age(age±2)as the control *** Kailuan Study is a general population-based cohort study in northern China,in which a total of 101510 individuals(81110 men)aged 18-98 y were recruited to participate in the *** the participants were bi-annually *** database of both groups was from Kailuan study of 2010 *** the information,including the demographic characteristics,lifestyle behaviors,medical comorbidities,medical history,family medical history,drug usage,anthropometric measurements,blood pressure measurement,blood sample laboratory assessment,urine tests,and other physical examinations were all collected.A retrospective nested case-control method was used for this *** multivariate logistic regression was used to analyze the risk factors with SPSS 13.0 software and SAS 9.3 ***:A total of 45 patients were included as the case group,and the control group included 225 *** the case group,28 patients(62.2%)had a central retinal artery occlusion(CRAO),and 17 patients(37.8%)had a branch retinal artery occlusion(BRAO).A total of 18 patients(40.0%)had a stroke before the RAO(mean 4.04±3.88 y before the RAO),and 31 patients(81.6%)had infarctions or malacia identified by the cranial computed tomography(CT)*** basal ganglia and centrum semiovale were the most frequently involved *** in the common carotid artery were present in 32 patients(88.9%).Conditional multivariate logistic regression analysis showed that the RAO was found to be associated with the history of stroke(P=0.0023,OR=28.794;95%CI:3.322-249.586).CONCLUSION:A history of stroke can significantly increase the

关键词： retinal artery occlusion stroke risk factor embolic source carotid plaque

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Retinal nerve fiber layer thickness and retinal vascular caliber alterations in coal miners in northern China:a community-based observational study

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 135-140页

作者： Jing-Yan Yang Wen-Jia Zhou Qian Wang Yang Li Yan-Ni Yan Ya-Xing Wang shou-ling wu Wen-Bin Wei Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology and Visual Science Key LabBeijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentCapital Medical UniversityBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100730China Cardiology Department Kailuan General HospitalTangshan 063000Hebei ProvinceChina

AIM:To evaluate retinal nerve fiber layer thickness and retinal vascular caliber alterations in coal mine ***:The community-based observational crosssectional study included 4004 participants of a subpopulation of the Kailuan *** the study participants underwent structured interviews with a standardized questionnaire,fundus photography and spectral-domain optical coherence tomography(OCT)examinations performed by trained ***:The retinal nerve fiber layer thickness was significantly higher(P=0.006)and the central macular thickness was lower in coal miners(n=659,51.0±7.8 y)as compared to the control(working above the ground;n=477,51.8±7.5 y;P=0.032).Additionally,the downhole workers showed a significantly thicker retinal artery(P=0.012)and vein diameters(P<0.001).In multivariable regression,a thicker retinal nerve fiber layer was associated with a higher cumulative silica dust exposure(P=0.005)after adjusting for younger age and larger spherical *** a reverse pattern,a higher cumulative silica dust exposure(P=0.004)was significantly associated with a thicker retinal nerve fiber layer after adjusting for age,high-density lipoproteins and uric *** retinal vein diameters were associated with higher cumulative silica dust exposure(P=0.036)after adjusting for younger age and larger spherical ***:The retinal vessels diameters and retinal nerve fiber layer thickness are significantly thicker in long term of coal *** results of our study indicate that underground working environment may lead to retinal vessel dilation and ***,ocular examination might be needed within coal miners in order to monitor the occupational eye health as well as the incidence and progression of eye diseases.

关键词： retinal vessels diameter retinal nerve fiber layer thickness cumulative silica dust exposure

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Relationship of Retinal Nerve Fiber Layer Thickness and Retinal Vessel Calibers with Cognitive Impairment in the Asymptomatic Polyvascular Abnormalities Population

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Biomedical and Environmental Sciences 2024年第2期37卷 196-203页

作者： WANG Dan Dan WANG An Xin ZHANG Xiao Li WEI Wen Bin wu shou ling ZHAO Xing Quan Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China China National Clinical Research Center for Neurological Diseases Beijing 100070China Beijing Tongren Eye Center Beijing Key Laboratory of Ophthalmology and Visual ScienceBeijing Tongren HospitalCapital Medical UniversityBeijing 100005China Department of Cardiology Kailuan HospitalTangshan 063001HebeiChina

Objective Cognitive impairment(CI)in older individuals has a high morbidity rate worldwide,with poor diagnostic methods and susceptible population *** study aimed to investigate the relationship between different retinal metrics and CI in a particular population,emphasizing polyvascular *** We collected information from the Asymptomatic Polyvascular Abnormalities Community Study on retinal vessel calibers,retinal nerve fiber layer(RNFL)thickness,and cognitive function of 3,785participants,aged 40 years or *** regression was used to analyze the relationship between retinal metrics and cognitive *** stratified by different vascular statuses were also *** RNFL thickness was significantly thinner in the CI group(odds ratio:0.973,95%confidence interval:0.953–0.994).In the subgroup analysis,the difference still existed in the non-intracranial arterial stenosis,non-extracranial carotid arterial stenosis,and peripheral arterial disease subgroups(Pshould be investigated in the future.

关键词： Retinal nerve fiber layer Cognitive impairment Polyvascular abnormality

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The association between orthostatic blood pressure changes and subclinical target organ damage in subjects over 60 years old

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Journal of Geriatric Cardiology 2019年第5期16卷 387-394页

作者： Hong-Jie CHI Hai-Jun FENG Xiao-Jiao CHEN Xiao-Tao ZHAO En-Xiang ZHANG Yi-Fan FAN Xian-Chen MENG Jiu-Chang ZHONG shou-ling wu Jun CAI Heart Center&Beijing Key Laboratory of Hypertension Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Respiratory Department Beijing First Hospital of Integrated Chinese and Western MedicineBeijingChina Cardiology Department Beijing Liangxiang HospitalCapital Medical UniversityBeijingChina Department of Statistics Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of Cardiology Kailuan General HospitalHebei United UniversityTangshanChina Hypertension Center Fuwai HospitalState Key Laboratory of Cardiovascular Disease of ChinaNational Center for Cardiovascular Diseases of ChinaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background Although recent studies have indicated that both orthostatic hypotension and orthostatic hypertension independently predict cardiovascular events,the underlying mechanisms are still *** aim of the study was to investigate the relationships between orthostatic changes and organ damage in subjects over 60 years *** This is a prospective observational cohort *** thousand nine hundred and ninety-seven subjects over 60 years old were *** were grouped according to whether they had a drop>20 mmHg in systolic or>10 mmHg in diastolic BP(orthostatic hypotension),an increase in mean orthostatic systolic blood pressure>20 mm Hg(orthostatic hypertension),or normal changes within 3 min of *** regression modeling was used to investigate the relationship between orthostatic hypotension,orthostatic hypertension and subclinical organ damage with adjustment for *** Orthostatic hypotension and orthostatic hypertension were found in 461(23.1%)and 189(9.5%)participants,*** of carotid intima-media thickness(IMT),brachial-ankle pulse wave velocity(baPWV),clearance of creatinine,and microalbuminuria were associated with orthostatic hypotension;measurement of IMT and baPWV were associated with orthostatic hypertension in a cruse *** adjustment,IMT[odds ratio(OR),95%confidence interval(CI)per one-SD increment:1.385,1.052-1.823;P=0.02],baPWV(OR=1.627,95%CI:1.041-2.544;P=0.033)and microalbuminuria(OR=1.401,95%CI:1.002-1.958;P=0.049)were still associated with orthostatic hypotension,while orthostatic hypertension was only associated with IMT(OR=1.730,95%CI:1.143-2.618;P=0.009).Conclusions Orthostatic hypotension seems to be independently correlated with increased carotid atherosclerosis,arterial stiffness and renal damage in subjects over 60 years *** hypertension correlates with carotid atherosclerosis only.

关键词： Atherosclerosis Blood pressure Orthostatic Organ damage

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Phase-field lattice-Boltzmann study on fully coupled thermal-solute-convection dendrite growth of Al-Cu alloy

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China Foundry 2024年第2期21卷 125-136页

作者： Yin-qi Qiu Meng-wu wu Xun-peng Qin shou-mei Xiong Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Longzhong Laboratory Xiangyang 441000HubeiChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

Dendrite growth is a complex liquid-solid phase transition process involving multiple physical factors.A phase-field lattice-Boltzmann method was developed to simulate the two-and three-dimension dendrite growth of Al-Cu *** effect of fully coupled thermal-solute-convection interaction on the dendrite growth was investigated by incorporating a parallel-adaptive mesh refinement algorithm into the numerical *** accurately reproducing the latent heat release,solute diffusion and convective transport behaviors at the liquidsolid interface,the interaction mechanism among thermal-solute-convection transport as well as their coupling effects on the dendrite growth dynamics were *** simulation results show that the release of latent heat slows down the dendrite growth rate,and both natural and forced convection disrupt the symmetrical growth of *** combination makes the growth of dendrites more complex,capturing important physical aspects such as recalescence,dendrite tip splitting,dendrite tilting,dendrite remelting,and solute plume in the simulation *** on the robustness and powerful ability of the numerical model,the formation mechanisms of these physical aspects were revealed.

关键词： simulation phase field dendrite growth thermal-solute-convection interaction

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Recent Advances in the Synthesis of Zeolites from Solid Wastes

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Chemical Research in Chinese Universities 2024年第4期40卷 646-656页

作者： LIU Pei wu Qinming CHEN Zhenghai XIAO Feng-shou Key Laboratory of Biomass Chemical Engineering of Ministry of Education and College of Chemical and Biological Engineering Zhejiang UniversityHangzhou310028P.R.China Zhejiang Provincial Innovation Center of Green Petrochemical Technology Ningbo315048P.R.China Kente Catalysts Inc. Xianju317300P.R.China

With the rapid development of industrialization,it is inevitable to produce solid wastes in the fields of energy petrochemical ***,the storage and utilization of these solid wastes have become a considerable *** to the main element composition of these solid wastes including silicon and aluminum,it has attracted extensive attention for synthesizing *** review summarized the properties of major solid wastes including coal fly ash,coal gangue,spent fluid catalytic cracking(FCC)catalyst,lithium slag,bauxite residue,and waste ***,the preparation of LTA,FAU,ZSM-5,SSZ-13,Beta,and MOR zeolites from these solid wastes were ***,the current challenges and perspectives were discussed.

关键词： Solid waste Zeolite Utilization Sustainable route Application

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