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High Power Laser Science and Engineering 2024年第1期12卷 60-73页

作者： shikha Bhadoria Mattias Marklund Christoph H.Keitel Max-Planck-Institut für Kernphysik HeidelbergGermany Department of Physics University of GothenburgGöteborgSweden

The impact of radiation reaction and Breit±Wheeler pair production on the acceleration of fully ionized carbon ions driven by an intense linearly polarized laser pulse has been investigated in the ultra-relativistic transparency *** initial expectations, the radiation reaction and pair production at ultra-high laser intensities are found to enhance the energy gained by the ions. The electrons lose most of their transverse momentum, and the additionally produced pair plasma of Breit±Wheeler electrons and positrons co-streams in the forward direction as opposed to the existing electrons streaming at an angle above zero degree. We discuss how these observations could be explained by the changes in the phase velocity of the Buneman instability, which is known to aid ion acceleration in the breakout afterburner regime, by tapping the free energy in the relative electron and ion streams. We present evidence that these non-classical effects can further improve the highest carbon ion energies in this transparency regime.

关键词： ion acceleration quantum electrodynamic effects

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Unveiling a new regulator: Vacuolar V-ATPase mediates brassinosteroid signaling in Arabidopsis

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Molecular Plant 2024年第2期17卷 227-229页

作者： shikha Malik Justin W.Walley Department of Plant Pathology Entomologyand Microbiologylowa State UniversityAmesIA 50011USA

Plant growth and development are intricately regulated by hormones such as auxins,gibberellins,jamonates,cytokinins,and brassinosteroids(BRs).BRs are a group of plant steroid hormones that play a vital role in plant growth and response to the *** regulate many biological processes including cell elongation,cell division,and male fertility,as well as abiotic and biotic stress responses.

关键词： media fertility brassinosteroid

A comprehensive review on pharmacognosy, phytochemistry and pharmacological activities of 8 potent Prunus species of southeast Asia

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Journal of Traditional Chinese Medicine 2024年第3期44卷 620-628页

作者： shikha Agrawal Adarsh Kumar Ankit Kumar Singh Harshwardhan Singh Suresh Thareja Pradeep Kumar Department of Pharmaceutical Sciences and Natural Products Central University of Punjab

Genus Prunus comprising around 430 species is a vast important genus of family Rosaceae, subfamily amygdalaoidae. Among all 430 species, around 19 important species are commonly found in Indian subcontinent due to their broad nutritional and economic importance. Some most common species of genus Prunus are Prunus amygdalus, Prunus persica, Prunus armeniaca, Prunus avium, Prunus cerasus, Prunus cerasoides, Prunus domestica, Prunus mahaleb, etc. A newly introduced species of Prunus i.e Prunus sunhangii is recently discovered which is morphologically very similar to Prunus cerasoides. Plants of Prunus species are short to medium-sized deciduous trees mainly found in the northern hemisphere. In India and its subcontinent,it extends from the Himalayas to Sikkim, Meghalaya,Bhutan, Myanmar etc. Different Prunus species have been extensively studied for their morphological,microscopic, pharmacological and phytoconstituents characteristics. Total phenolic content of Prunus species explains the presence of phenols in high quantity and pharmacological activity due to phenols. Phytochemical screening of species of genus Prunus shows the presence of wide phytoconstituents which contributes in their pharmacological significance and reveals the therapeutic potential and traditional medicinal significance of this genus. Genus Prunus showed a potent antioxidant activity analyzed by 1,1-diphenyl-2-picryl-hydrazyl radical assay. Plant species belonging to the genus Prunus is widely used traditionally for the treatment of various disorders. Some specific Prunus species possess potent anticancer, anti-inflammatory,hypoglycemic etc. activity which makes the genus more interesting for further research and findings. This review is an attempt to summarize the comprehensive study of Prunus species from its distribution, morphological characters to phytoconstituents, and pharmacological activity.

关键词： Prunus Rosaceae antineoplastic agents distribution hypoglycemic agents phytochemistry review

A case report on a rare case of primary tuberculous otitis media

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Journal of Otology 2024年第1期19卷 40-45页

作者： Dr Yadav Sagar Shyamlal Dr shikha Gianchand Dr Rahul Kurkure Dept of ENT and Head Neck Surgery 5 Air Force HospitalJorhatAssam785005India Dept of ENT and Head Neck Surgery Armed Forces Medical CollegePuneMaharashtra411040India

Although tuberculosis has become more common in recent years, it still accounts for just a small percentage of cases of chronic otitis media. Common symptoms of tuberculous otitis media(TOM) include otorrhoea, hearing loss, and multiple tympanic membrane perforations. Due to its rarity, the illness is frequently misdiagnosed. When a patient does not improve with standard antibacterial and antifungal treatment, this may be a possible diagnosis to explore. Complete healing is possible if the illness is diagnosed and treated timely to prevent consequences.

关键词： otitis healing diagnosis

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Diuretic Activity of Ethanol Extract of Piper attenuatum Leaves Might Be Due to the Inhibition of Carbonic Anhydrase Enzyme:An in vivo and in silico Investigation

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 62-68页

作者： shikha Sharma Gaurav Kumar Nitin Kumar Neeraj K.Sethiya Dheeraj Bisht Department of Pharmaceutical Sciences Lords UniversityAlwarRajasthan 301028India Navsahyadri Institute of Pharmacy NasrapurPuneMaharashtra 412213India Faculty of Pharmacy DIT UniversityMussoorie Diversion RoadDehradunUttarakhand 248009India Devsthali Vidyapeeth College of Pharmacy(Veer Madho Singh Bhandari Uttarakhand Technical University Dehradun)LalpurRudrapurUttarakhand 263148India

Background:Ayurvedic system of medicine is well established for prevention and treatment of renal *** are vast number of medicinal plants mentioned in Ayurvedic system of medicine,including Piper attenuatum Buch.-*** Miq.,which has been known to exhibit diuretic ***:To investigate possible mechanism and diuretic activity of ethanol extract of *** ***:Present study reports an in vivo diuretic activity of ethanol extracts of *** ***-four Sprague-Dawley male rats were deprived from food and water for 20 h,followed by being divided into four groups to receive normal saline,Furosemide,and two doses of the ethanol extract,***,the ethanol extract were subjected for prelimnary phytochemical screening test,and analytical investigation was performed via high-performance thin-layer chromatography(HPTLC),followed by effectiveness exploration of putative bioactive compounds from *** against human carbonic anhydrase(hCA)enzyme using molecular docking ***:During phytochemicals screening,several groups of compounds such as amides,terpenoids,proteins,flavonoids,and glycosides have been ***,HPTLC reveals presence of carbohydrates,proteins,amino acids,steroids,alkaloids,flavonoids,tannins,glycosides,and *** diuretic action was revealed for both 200 mg/kg bw and 400 mg/kg bw of ethanol extract of *** ***,molecular docking analysis demonstrated greater binding affinity of compounds such as Cepharadione A,Nor-cepharadione B,Galbelgin,Crotepoxide,and Pipoxide chlorohydrin out of total 23 studied compounds against hCA isoforms(a key biomarker for diuretic)and score is comparable with standard drug ***:It was concluded from the present studies that ethanol extract of *** leaves exhibits signifi-cant diuretic *** activity may be correlated due to the presence of Cepharadione A,Norcepharadion

关键词： Piper attenuatum Diuretic activity Phytochemicals In silico and molecular docking

An Adaptive Genetic Algorithm-Based Load Balancing-Aware Task Scheduling Technique for Cloud Computing

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Computers, Materials & Continua 2022年第12期73卷 6103-6119页

作者： Mohit Agarwal shikha Gupta Deptartment of Computer Science&Engineering School of Engineering&TechnologySharda UniversityGreater NoidaUttar Pradesh201319India Department of Information Technology Maharaja Agrasen Institute of TechnologyDelhi110086India

Task scheduling in highly elastic and dynamic processing environments such as cloud computing have become the most discussed problem among *** scheduling algorithms are responsible for the allocation of the tasks among the computing resources for their execution,and an inefficient task scheduling algorithm results in under-or over-utilization of the resources,which in turn leads to degradation of the ***,in the proposed work,load balancing is considered as an important criterion for task scheduling in a cloud computing environment as it can help in reducing the overhead in the critical decision-oriented *** this paper,we propose an adaptive genetic algorithm-based load balancing(GALB)-aware task scheduling technique that not only results in better utilization of resources but also helps in optimizing the values of key performance indicators such as makespan,performance improvement ratio,and degree of *** concept of adaptive crossover and mutation is used in this work which results in better adaptation for the fittest individual of the current generation and prevents them from the *** simulator has been used to carry out the simulations and obtained results establish that the proposed GALB algorithm performs better for all the key indicators and outperforms its peers which are taken into the consideration.

关键词： Cloud computing genetic algorithm(GA) load balancing makespan resource utilization task scheduling

Enhanced Deep Learning for Detecting Suspicious Fall Event in Video Data

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Intelligent Automation & Soft Computing 2023年第6期36卷 2653-2667页

作者： Madhuri Agrawal shikha Agrawal Department of CSE University Institute of TechnologyRajiv Gandhi Proudyogiki VishwavidyalayaBhopalIndia

Suspicious fall events are particularly significant hazards for the safety of patients and ***,suspicious fall event detection has become a robust research case in real-time *** paper aims to detect suspicious fall events during video monitoring of multiple people in different moving back-grounds in an indoor environment;it is further proposed to use a deep learning method known as Long Short Term Memory(LSTM)by introducing visual atten-tion-guided mechanism along with a bi-directional LSTM *** method contributes essential information on the temporal and spatial locations of‘suspi-cious fall’events in learning the video frame in both forward and backward *** effective“You only look once V4”(YOLO V4)–a real-time people detection system illustrates the detection of people in videos,followed by a track-ing module to get their *** Neural Network(CNN)fea-tures are extracted for each person tracked through bounding ***,a visual attention-guided Bi-directional LSTM model is proposed for the final suspicious fall event *** proposed method is demonstrated using two different datasets to illustrate the *** proposed method is evaluated by comparing it with other state-of-the-art methods,showing that it achieves 96.9%accuracy,good performance,and ***,it is accep-table to monitor and detect suspicious fall events.

关键词： Convolutional neural network(CNN) Bi-directional long short term memory(Bi-directional LSTM) you only look once v4(YOLO-V4) fall detection computer vision

Fate and toxicity of nanoparticles in aquatic systems

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Acta Geochimica 2023年第1期42卷 63-76页

作者： shikha Singh Sheo Mohan Prasad Gausiya Bashri Ranjan Plant Physiology and Biochemistry Laboratory Department of BotanyUniversity of Allahabad211002 AllahabadIndia Department of Botany Aligarh Muslim University202001 AligarhIndia

Nanotechnology is a ground-breaking multidisciplinary fi eld across a broad spectrum of basic and applied sciences for producing and applying nano-sized materials for innovative *** use of nanomaterials in industrial applications,medical products,and consumers has increased repeatedly over the last few years,and these applications will likely continue to *** an aquatic ecosystem,nanoparticles take entry through a direct route that includes industrial discharge,disposal of wastewater treatment e ffl uents,and indirect runof f from the *** reaching the aquatic environment,the nanomaterials are highly af fected by their backdrops and subsequently go through various conversions like agglomeration,aggregation,dissolution,sulfi dation,*** fate and the behavior of nanomaterials in the aquatic system not only depend on their physical-chemical properties but also on the pH,temperature,salinity,water hardness,and concentration of natural organic matter present in receiving *** this review,emphasis has been given to the toxicological properties and potential risks of nanomaterials in terms of factors contributing to their toxicology,bioavailability,and accumulation in aquatic organisms as well as the ***,we summarize the published data on engineered nanoparticles’ef fect on aquatic *** issues related to the accumulation and penetration of nanoparticles in the aquatic organism,their toxic ef fect,and biotransformation along with the food web are also *** nanomaterials are being increasingly released into aquatic bodies,it is important to pay greater attention to their toxicity and how it af fects the aquatic *** nanomaterials are bioavailable to plants,resulting in trophic transfer,and they impact other organisms through biomagnifi cation,as discussed in this *** close the enormous information gap,extensive research on the interactions and impacts of NPs on dif ferent species belonging to di

关键词： wastewater sized likely

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Electronic structure factors and the importance of adsorbate effects in chemisorption on surface alloys

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npj Computational Materials 2022年第1期8卷 1560-1571页

作者： shikha Saini Joakim Halldin Stenlid Frank Abild-Pedersen SUNCAT Center for Interface Science and Catalysis Department of Chemical EngineeringStanford University443 Via OrtegaStanfordCA94305USA SUNCAT Center for Interface Science and Catalysis SLAC National Accelerator Laboratory2575 Sand Hill RoadMenlo ParkCA94025USA

The chemisorption energy is an integral aspect of surface chemistry,central to numerous fields such as catalysis,corrosion,and ***-structure-based methods such as the Newns-Anderson model are therefore of great importance in guiding the engineering of material surfaces with optimal ***,existing methods are inadequate for interpreting complex,multi-metallic ***,we introduce a physics-based chemisorption model for alloyed transition metal surfaces employing primarily metal d-band properties that accounts for perturbations in both the substrate and adsorbate electronic states upon ***,we show that adsorbate-induced changes in the adsorption site interact with its chemical environment leading to a second-order response in chemisorption energy with the d-filling of the neighboring *** demonstrate the robustness of the model on a wide range of transition metal alloys with O,N,CH,and Li adsorbates yielding a mean absolute error of 0.13 eV versus density functional theory reference chemisorption energies.

关键词： alloys corrosion chemisorption

Pasteurella multocida bacteremia in a patient with septic arthritis

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Infectious Medicine 2022年第3期1卷 221-223页

作者： shikha Malhotra Tung Phan Department of Pathology University of PittsburghPittsburghPennsylvaniaUSA

Pasteurella multocida is a common commensal microorganism found in the nasopharynx of domestic and wild *** acquire P multocida infection primarily through contact with animals or their mucous secretions.P multocida is infrequently encountered in clinical settings,and it is considered as a zoonotic *** this study,we present an interesting case of septic arthritis and bacteremia caused by P multocida in a 62-year-old *** patient was treated with surgical procedures and antibiotic therapy,which made significant *** case study highlights the importance of P multocida in causing zoonotic infection in humans.

关键词： Bacteremia Arthritis Pasteurella mulocida Total knee replacement