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Transmembrane serine protease 4 expression in the prognosis of radical resection for biliary tract cancer

World Journal of Gastrointestinal Surgery 2024年第8期16卷 2555-2564页

作者： Yoshiyuki Shibata Takeshi Sudo Sho Tazuma Naoki Tanimine Takashi Onoe Yosuke Shimizu Atsushi Yamaguchi Kazuya Kuraoka shinya takahashi Hirotaka Tashiro Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Diagnostic Pathology National Hospital Organization Kure Medical Centerand Chugoku Cancer CenterHiroshima 737-0023Japan Department of Surgery Graduate School of Biochemical and Health ScienceHiroshima UniversityHiroshima 734-8551Japan

BACKGROUND Recent advancements in biliary tract cancer(BTC)treatment have expanded beyond surgery to include adjuvant therapy,yet the prognosis remains *** prognostic biomarkers could enhance the assessment of patients who have undergone radical resection for *** To determine transmembrane serine protease 4(TMPRSS4)utility as a prognostic biomarker of radical resection for *** Medical records of patients who underwent radical resection for BTC,excluding intrahepatic cholangiocarcinoma,were retrospectively *** associations between TMPRSS4 expression and clinicopathological factors,overall survival,and recurrence-free survival were *** Among the 85 patients undergoing radical resection for BTC,46(54%)were *** TMPRSS4-positive group exhibited significantly higher preoperative carbohydrate antigen 19-9(CA19-9)values and greater lymphatic invasion than the TMPRSS4-negative group(P=0.019 and 0.039,respectively).Postoperative overall survival and recurrence-free survival were significantly worse in the TMPRSS4-positive group(median survival time:25.3 months vs not reached,P<0.001;median survival time:28.7 months vs not reached,P=0.043,respectively).Multivariate overall survival analysis indicated TMPRSS4 positivity,pT3/T4,and resection status R1 were independently associated with poor prognosis(P=0.032,0.035 and 0.030,respectively).TMPRSS4 positivity correlated with preoperative CA19-9 values≥37 U/mL and pathological tumor size≥30 mm(P=0.016 and 0.038,respectively).CONCLUSION TMPRSS4 is a potential prognostic biomarker of radical resection for BTC.

关键词： Biliary tract cancer Biomarker Prognosis Radical resection Transmembrane serine protease 4

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Solitary peritoneal metastasis of gastrointestinal stromal tumor: A case report

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World Journal of Gastroenterology 2020年第36期26卷 5527-5533页

作者： Yoichi Sugiyama Kensuke Shimbara Masaru Sasaki Mohei Kouyama Tatsuya Tazaki shinya takahashi Atsushi Nakamitsu Department of Gastrointestinal Surgery JA Hiroshima General HospitalHatsukaichi 738-8503Japan Department of Surgery Institute of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8551Japan

BACKGROUND A gastrointestinal stromal tumor(GIST)is a mesenchymal tumor of the gastrointestinal tract that is most commonly found in the *** of GISTs mostly occurs in the liver or peritoneum,and in most cases,multiple metastases *** a solitary peritoneal metastasis is rare,an appropriate treatment strategy has not been ***,we report a case of solitary peritoneal metastasis after complete resection of gastric *** SUMMARY A 76-year-old woman was diagnosed with stomach GIST and underwent laparoscopic local resection using the CLEAN-NET *** the recurrence risk was intermediate,adjuvant imatinib therapy was not *** years after surgery,routine computed tomography revealed an abdominal mass between the dorsal side of the right hepatic lobe and right *** imaging tests did not reveal any *** observation showed that the tumor was located at the retroperitoneum,and intraperitoneal dissemination was not ***,we performed laparoscopic tumor ***,the tumor was positive for c-kit and CD34 and had a relatively high mitotic index and MIB-1 Labeling *** administered adjuvant imatinib *** was no evidence of recurrence 3 years after the *** This is the first reported case of a solitary recurrence of GIST in the peritoneum treated with complete laparoscopic resection.

关键词： Gastrointestinal stromal tumor Peritoneal metastasis Laparoscopic resection Solitary metastasis Imatinib Case report

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Block Copolymer Composed of Caprolactone and Methylacrylate as a Compatibilizer to Blend Poly（lactic acid） with Oly（caprolactone）

Block Copolymer Composed of Caprolactone and Methylacrylate ...

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2006中日纺织学术交流会

作者： Tomoyuki Kasemura shinya takahashi Naohisa Tamura Faculty of Engineering Department of Applied Chemistry Gifu University1-1 YanagidoGifu City 501-1193 Japan Faculty of Engineering Department of Applied Chemistry Gifu University1-1 YanagidoGifu City 501-1193 Japan Faculty of Engineering Department of Applied Chemistry Gifu University1-1 YanagidoGifu City 501-1193 Japan

＜正＞1 Introduction Aliphatic polyesters such as poly（L-lactic acid）（PLLA）, poly（ε-caprolactone）（PCL）, poly（butylenesuccinate）（PBS） and so on have been noticed because of their bio-degradability. However, these polymers do not have enough properties for practical application. For example, PLLA is too rigid and brittle, PCL has too low melting temperature and PBS is too flexible. Therefore, many

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Current treatment strategies and future perspectives for gastrointestinal stromal tumors

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World Journal of Gastrointestinal Pathophysiology 2022年第1期13卷 15-33页

作者： Yoichi Sugiyama Masaru Sasaki Mohei Kouyama Tatsuya Tazaki shinya takahashi Atsushi Nakamitsu Department of Gastrointestinal Surgery JA Hiroshima General HospitalHatsukaichi 738-8503HiroshimaJapan Department of Surgery Institute of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8551Japan

Gastrointestinal stromal tumors(GISTs)are mesenchymal tumors that originate from the gastrointestinal tract,mostly from the *** are derived from the myenteric interstitial cells of Cajal and are caused by several mutations in the c-kit and platelet-derived growth factor receptor ***,GISTs are detected by endoscopic and imaging findings and are diagnosed by *** is the first line of treatment,and if the tumor is relatively small,minimally invasive surgery such as laparoscopy is *** recent years,neoadjuvant therapy has been administered to patients with GISTs that are suspected of having a large size or infiltration to other *** adjuvant imatinib is the standard therapy for high-risk *** is important to assess the risk of recurrence after GIST ***,the effect of tyrosine kinase inhibitor use will vary by the mutation of c-kit genes and the site of ***,information regarding gene mutation is indispensable when considering the treatment policy for recurrent *** article reviews the clinicopathological characteristics of GISTs along with the minimally invasive and multidisciplinary treatment options available for these *** future perspectives for diagnostic and treatment approaches for these tumors have also been discussed.

关键词： Gastrointestinal stromal tumor Minimally invasive surgery Laparoscopic surgery Imatinib Neoadjuvant therapy Risk assessment

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Morphologies and Properties of Cured Epoxy/Brominated-phenoxy Blends

Morphologies and Properties of Cured Epoxy/Brominated-phenox...

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第三届世界粘接及相关现象大会暨北京粘接学会第十五届学术年会

作者： NAOKI YOKOYAMA SHUNSUKE SAKAI shinya takahashi TOMOYUKI KASEMURA Nippon Steel Chemical Co. Ltd.and Epoxy Resin Development Center of Tohto Kasei Co.Ltd. Department of Applied Chemistry Faculty of EngineeringGifu University1-1 YanagidoGifu-shiGifu 501-1112Japan

The morphologies and properties of epoxy/brominated-phenoxy blends cured with novolac phenolic resin have been *** the brominated-phenoxy content for epoxy was less than 30%with a weight,the continuous phase was formed by the cured ***,when the brominated-phenoxy content was more than 40%with a weight, a phase-inverted morphology was observed by scanning transmission electron microscopy(STEM).In all these cured blends,two discrete T’s were found by dynamic mechanical analysis(DMA).Since the higher T was found at 155℃, the phase could be attributed to cured epoxy ***,since the lower Tg was found at 128℃,the phase could be attributed to *** brominated-phenoxy contents were in 40%～50%with a weight,although brominated -phenoxy of thermoplastics formed a continuous phase,rubbery plateaus of storage modulus(E’) were still found, i.e.,it was found that both properties of thermoplastics and thermoset could exist together in these cured *** the tensile elongation and the tensile strength could be increased together,and the T-peel adhesion strength and the lapshear adhesion strength also could be increased together.

关键词： epoxy phenoxy morphology polymer blends adhesives flexible printed circuit

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Visible Light-Induced Photocatalysis on Carbon Nitride Deposited Titanium Dioxide： Hydrogen Production from Sacrificial Aqueous Solutions

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Chinese Journal of Chemistry 2017年第2期35卷 165-172页

作者： shinya Higashimoto Kohji Hikita Masashi Azuma Mari Yamamoto Masanari takahashi Yoshihisa sakata Masaya Matsuoka Hisayoshi Kobayashi Department of Applied Chemistry College of Engineering Osaka Institute of Technology 5-16-10miya Asahi-ku Osaka 535-8585 Japan Osaka Municipal Technical Research Institute 1-6-50 Morinomiya Joto-ku Osaka 536-8553 Japan Graduate School of Science andEngineering Yamaguchi University 2-16-1 Tokiwadai Ube 755-8611 Japan Department of Applied Chemistry Graduate School of Engineering Osaka Prefecture University 1-1 Gakuen-cho Naka-ku Sakai Osaka 599-8531 Japan Department of Chemistry and Materials Technology Kyoto Institute of Technology Matsugasaki Sakyo-ku Kyoto 606-8585 Japan

Carbon and nitrogen species-involved TiO2 （CN-TiO2） were systematically synthesized by thermal condensa- tion of cyanuric acid on the TiO2 surface. And the photocatalytic reactions for H2 production from sacrificial aque- ous solutions were performed on several CN-TiO2 photocatalyst under visible-light irradiation. The photocatalytic activity of the CN-TiO2 was influenced by total amounts of carbon and nitrogen species, and the preferable activity was ten times higher than that of pristine carbon nitride. Here, the states of the CN-TiO2 photocatalyst were charac- terized by XPS, FT-IR and UV-Vis spectroscopy as well as DFT calculations. The photo-electrochemical measure- ments confirmed that the enhancement of H2 production is associated with effective charge separation under photo- excitation of highly dispersed carbon nitride on the TiO2 surface.

关键词： carbon nitride TiO2 visible light photo-electrochemistry DFT calculation sacrificial H2 production

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Comparison of fecal calprotectin levels and endoscopic scores for predicting relapse in patients with ulcerative colitis in remission

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World Journal of Gastroenterology 2023年第47期29卷 6111-6121页

作者： Natsuki Ishida Tatsuhiro Ito Kenichi takahashi Yusuke Asai Takahiro Miyazu Tomohiro Higuchi Satoshi Tamura shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Satoshi Osawa Ken Sugimoto Department of Endoscopic and Photodynamic Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan First Department of Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan Department of Laboratory Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan

BACKGROUND Although the usefulness of endoscopic scores,such as the Mayo Endoscopic Subscore(MES),Ulcerative Colitis Endoscopic Index of Severity(UCEIS),and Ulcerative Colitis Colonoscopic Index of Severity(UCCIS),and biomarkers such as fecal calprotectin(FC)for predicting relapse in ulcerative colitis(UC)has been reported,few studies have included endoscopic scores for evaluating the entire *** To compare the usefulness of FC value and MES,UCEIS,and UCCIS for predicting relapse in patients with UC in clinical *** In total,75 patients with UC in clinical and endoscopic remission who visited our institution between February 2019 and March 2022 were *** diagnosis of UC was confirmed based on the clinical presentation,endoscopic findings,and histology,according to the current established criteria for *** samples were collected the day before or after the colonoscopy for measurement of *** evaluations were performed using MES,UCEIS,and *** primary outcome measure of this study was the assessment of the association between relapse within 12 mo and MES,UCEIS,UCCIS,and *** secondary outcome was the comparison between endoscopic scores and biomarkers in en-rolled patients with UC with mucosal *** and UCCIS showed a significant correlation with UCEIS (r = 0.537, P < 0.001 and r = 0.957, P < 0.001, respectively).Receiver-operating characteristic analysis for predicting MES 0 showed that the area under the curve ofUCCIS was significantly higher than that of FC (P < 0.01). During the 1-year observation period, 18 (24%) patientsexperienced a relapse, and both the FC and UCCIS of the relapse group were significantly higher than that of theremission group. The cut-off values for predicting relapse were set at FC = 323 mg/kg and UCCIS = 10.2. The areaunder the curve of the receiver-operating characteristic analysis for predicting relapse did not show a significantdifference between FC and UCCIS. The accuracy of the

关键词： Ulcerative colitis Mayo Endoscopic Subscore Ulcerative Colitis Endoscopic Index of Severity Ulcerative Colitis Colonoscopic Index of Severity Fecal calprotectin Relapse

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Head Position of Patients with Right Hemisphere Damage during a Visual Search Task in a Large Field

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World Journal of Neuroscience 2018年第2期8卷 190-202页

作者： Ken Nakatani Shusuke takahashi Daisuke Kimura Masako Notoya Nobuyuki Sunahara Takashi Fujita Minoru Toyama shinya Fukunaga Naoe Mori Kiyoe Sakai shinya Fuwa Department of Rehabilitation Sciences Kansai University of Welfare Sciences Osaka Japan Department of Living and Welfare Faculty of Home Economics Kyoto Women’s University Kyoto Japan Department of Speech and Hearing Sciences and Disorders Kyoto Gakuen University Kyoto Japan School of Health Sciences College of Medical Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan Division of Occupational Therapy Faculty of Care and Rehabilitation Seijoh University Tōkai Japan Department of Sensory Science Faculty of Health Science and Technology Kawasaki University of Medical Welfare Kurashiki Japan

Spatial neglect syndrome with cerebral lesions is characterized by the ina-bility to orient, report, or respond to relevant visual stimuli contralateral to the lesions. In this study, we investigated the pattern of horizontal visual search in a large space;this search was performed by patients with right hemisphere damage caused by cerebrovascular disease. The neck rotation angle and search time in each increment were continuously recorded during the task, and quantitative data of the measurements were collected. Head position during the visual search task in a large space (%) was then calculated. We set angular bands in increments of 5 degrees from the midline on the left and right sides, and calculated the total search time in each angular band. In patients with unilateral spatial neglect (USN), the search time in the angular band of 5 - 9 on the right side was significantly longer (with USN 16.7%, without USN 4.5%, t = 2.52, df = 16, p < 0.05). Furthermore, in patients with neglect in the leftmost end area in a large space, the search time was significantly shorter in the angular band of 1 - 4 degrees to the left (with neglect 13.1%, without neglect 23.7%, t = 2.13, df = 16, p < 0.05), and tended to be long in the angular band of 5 - 9 to the right. The neck rotation angle and pattern during the search task in a large field deviated slightly to the right, and the search time slightly to the left was short. We believe that these results support the rightward deviation of the search pattern and frame of USN patients.

关键词： Head Position Neck Rotation Angle Unilateral Spatial Neglect Visual Exploration

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A Case of Relapsing Polychondritis Successfully Treated with Combination of a Glucocorticoid and Cyclosporine

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International Journal of Clinical Medicine 2015年第7期6卷 439-443页

作者： Koichiro takahashi Hiroshi Inoue Hironori Sadamatsu Hitomi Umeguchi Naoko Sueoka-Aragane shinya Kimura Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan

Relapsing polychondritis is a rare cartilaginous inflammatory disease affecting the external ear, nose, peripheral joints and tracheobronchial tree. It is characterized by recurrent inflammation and degeneration of cartilage and connective tissue. A 72-year-old man complained of dyspnea, cough and wheezing for 2 months. Diffuse wall thickening and narrowing from the trachea to segmental bronchus were seen on chest CT. Tracheostomy was performed in order to avoid as-phyxia, and he was diagnosed as relapsing polychondritis on the basis of pathology evaluation of a tracheal biopsy specimen. He was treated with high doses of a glucocorticoid, with which his symptoms improved. However, the cough and wheezing recurred after tapering of the glucocorticoid. His symptoms thereafter were improved by combination of the glucocorticoid with cyclosporine. The immunosuppressive agent provided effective treatment for glucocorticoid-resistant relapsing polychondritis.

关键词： Relapsing Polychondritis Trachea Cyclosporine

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Evaluation of preferable insertion routes for esophagogastroduodenoscopy using ultrathin endoscopes

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World Journal of Gastroenterology 2014年第17期20卷 5045-5050页

作者： Satoshi Ono Keiko Niimi Mitsuhiro Fujishiro Yu takahashi Yoshiki Sakaguchi Chiemi Nakayama Chihiro Minatsuki Rie Matsuda Itsuko Hirayama-Asada Yosuke Tsuji Satoshi Mochizuki shinya Kodashima Nobutake Yamamichi Atsuko Ozeki Lumine Matsumoto Yumiko Ohike Tsutomu Yamazaki Kazuhiko Koike Center for Epidemiology and Preventive Medicine Graduate School of MedicineUniversity of TokyoTokyo 113-8655Japan Department of Gastroenterology Graduate School of MedicineUniversity of TokyoTokyo 113-8655Japan Department of Endoscopy and Endoscopic Surgery Graduate School of MedicineUniversity of TokyoTokyo 113-8655Japan

AIM: To evaluate the discomfort associated with esophagogastroduodenoscopy (EGD) using an ultrathin endoscope through different insertion routes.

关键词： Esophagogastroduodenoscopy Ultrathin endoscope Visual analog scale

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