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Protective Effect of Silibinin on Lipopolysaccharide-Induced Endotoxemia by Inhibiting Caspase-11-Dependent Cell Pyroptosis

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Chinese Journal of Integrative Medicine 2024年第10期30卷 917-926页

作者： OU Jin-ying LIU Shan-hong TANG Dong-kai shi ling-zhu YAN Li-jun HUANG Jing-yan ZOU Li-fang QUAN Jing-yu YOU Yan-ting CHEN Yu-yao YU Lin-zhong LU Zi-bin Third Level Research Laboratory of State Administration of Traditional Chinese Medicine School of Traditional Chinese Medicine Southern Medical University Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics School of Traditional Chinese Medicine Southern Medical University

Objective: To explore the protective effect and the underlying mechanism of silibinin(SIB), one of the active compounds from Silybum marianum(L.) Gaertn in endotoxemia. Methods: Mouse peritoneal macrophage were isolated via intraperitoneally injection of BALB/c mice with thioglycolate medium. Cell viability was assessed using the cell counting kit-8, while cytotoxicity was determined through lactate dehydrogenase cytotoxicity assay. The protein expressions of interleukin(IL)-1α, IL-1β, and IL-18 were determined by enzyme-linked immunosorbent assay. Intracellular lipopolysaccharide(LPS) levels were measured by employing both the limulus amoebocyte lysate assay and flow cytometry. Additionally, proximity ligation assay was employed for the LPS and caspase-11 interaction. Mice were divided into 4 groups: the control, LPS, high-dose-SIB(100 mg/kg), and low-dose-SIB(100 mg/kg) groups(n=8). Zebrafish were divided into 4 groups: the control, LPS, high-dose-SIB(200 μmol/L), and low-dose-SIB(100 μmol/L) groups(n=30 for survival experiment and n=10 for gene expression analysis). The expression of caspase-11, gasdermin D(GSDMD), and N-GSDMD was determined by Western blot and the expressions of caspy2, gsdmeb, and IL-1β were detected using quantitative real-time PCR. Histopathological observation was performed through hematoxylineosin staining, and protein levels in bronchoalveolar lavage fluid were quantified using the bicinchoninicacid protein assay. Results: SIB noticeably decreased caspase-11 and GSDMD-mediated pyroptosis and suppressed the secretion of IL-1α, IL-1β, and IL-18 induced by LPS(P<0.05). Moreover, SIB inhibited the translocation of LPS into the cytoplasm and the binding of caspase-11 and intracellular LPS(P<0.05). SIB also attenuated the expression of caspase-11 and N-terminal fragments of GSDMD, inhibited the relative cytokines, prolonged the survival time, and up-regulated the survival rate in the endotoxemia models(P<0.05). Conclusions: SIB can inhibit pyrop

关键词： caspase-11 endotoxemia inflammation pyroptosis silibinin

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Novel milestones for early esophageal carcinoma:From bench to bed

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1104-1118页

作者： Ji-Han Qi shi-ling Huang shi-zhu Jin Department of Gastroenterology and Hepatology The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086Heilongjiang ProvinceChina

Esophageal cancer(EC)is the seventh most common cancer worldwide,and esophageal squamous cell carcinoma(ESCC)accounts for the majority of cases of *** effectively diagnose and treat ESCC and improve patient prognosis,timely diagnosis in the initial phase of the illness is *** article offers a detailed summary of the latest advancements and emerging technologies in the timely identification of *** biology and epigenetics approaches involve the use of molecular mechanisms combined with fluorescence quanti-tative polymerase chain reaction(qPCR),high-throughput sequencing technology(next-generation sequencing),and digital PCR technology to study endogenous or exogenous biomolecular changes in the human body and provide a decision-making basis for the diagnosis,treatment,and prognosis of *** invest-igation of the microbiome is a swiftly progressing area in human cancer research,and microorganisms with complex functions are potential components of the tumor *** intratumoral microbiota was also found to be connected to tumor *** application of endoscopy as a crucial technique for the early identification of ESCC has been essential,and with ongoing advancements in technology,endoscopy has continuously *** the advancement of artificial intelligence(AI)technology,the utilization of AI in the detection of gastrointestinal tumors has become increasingly *** implementation of AI can effectively resolve the discrepancies among observers,improve the detection rate,assist in predicting the depth of invasion and differentiation status,guide the pericancerous margins,and aid in a more accurate diagnosis of ESCC.

关键词： Early esophageal squamous cell carcinoma Epidemiology and risk factors Molecular biology Epigenetic Microbiology Endoscopy and artificial intelligence

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Optimal AP Deployment in Cell-Free Massive MIMO Systems with LoS/NLoS Transmissions:A Stochastic Geometry Approach

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China Communications 2024年第9期21卷 146-158页

作者： Jiang ling Zhang Qi zhu Hongbo Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and TelecommunicationsNanjing 210003China

Cell-free massive multiple-input multipleoutput(MIMO)is a promising technology for future wireless communications,where a large number of distributed access points(APs)simultaneously serve all users over the same time-frequency *** users and APs may locate close to each other,the line-of-sight(Lo S)transmission occurs more frequently in cell-free massive MIMO ***,in this paper,we investigate the cell-free massive MIMO system with Lo S and non-line-of-sight(NLo S)transmissions,where APs and users are both distributed according to Poisson point *** tools from stochastic geometry,we derive a tight lower bound for the user downlink achievable rate and we further obtain the energy efficiency(EE)by considering the power consumption on downlink payload transmissions and circuitry *** on the analysis,the optimal AP density and AP antenna number that maximize the EE are *** is found that compared with the previous work that only considers NLo S transmissions,the actual optimal AP density should be much smaller,and the maximized EE is actually much higher.

关键词： cell-free massive MIMO energy efficiency LoS/NLoS transmissions stochastic geometry

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Design strategies and recent advancements of solid-state supercapacitor operating in wide temperature range

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Carbon Energy 2024年第6期6卷 248-281页

作者： Jie Zhou Zhengfeng zhu Wenhui shi Xiangyu shi zhuoyuan Zheng Ye Xiong Yusong zhu School of Energy Science and Engineering Nanjing Tech UniversityNanjingJiangsuChina Kucap Smart Technology(Nanjing)Co. Ltd.NanjingJiangsuChina

Solid-state supercapacitors(SSCs)are emerging as one of the promising energy storage devices due to their high safety,superior power density,and excellent cycling ***,performance degradation and safety issues under extreme conditions are the main challenges for the practical *** the expansion of human activities,such as space missions,polar exploration,and so on,the investigation of SSC with wide temperature tolerance,high energy density,power density,and sustainability is highly *** this review,the effects of temperature on SSC are systematically illustrated and clarified,including the properties of the electrolyte,ion diffusion,and reaction dynamics of the ***,we summarize the recent advances in wide-temperature-range SSCs from the aspect of electrolyte modification,electrode design,and interface adjustment between electrode and electrolyte,especially with critical concerns on ionic conductivity and cycling *** the end,a perspective is presented,expecting to promote the practical application of the SSC in harsh conditions.

关键词： electrode interface solid-state electrolyte solid-state supercapacitor wide temperature

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Online Pareto optimal control of mean-field stochastic multi-player systems using policy iteration

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Science China(Information Sciences) 2024年第4期67卷 21-37页

作者： Xiushan JIANG Yanshuang WANG Dongya ZHAO ling shi College of New Energy China University of Petroleum(East China) Department of Electronic and Computer Engineering Hong Kong University of Science and Technology

In this study, the Pareto optimal strategy problem was investigated for multi-player mean-field stochastic systems governed by It? differential equations using the reinforcement learning(RL) method.A partially model-free solution for Pareto-optimal control was derived. First, by applying the convexity of cost functions, the Pareto optimal control problem was solved using a weighted-sum optimal control problem. Subsequently, using on-policy RL, we present a novel policy iteration(PI) algorithm based on the Hrepresentation technique. In particular, by alternating between the policy evaluation and policy update steps,the Pareto optimal control policy is obtained when no further improvement occurs in system performance,which eliminates directly solving complicated cross-coupled generalized algebraic Riccati equations(GAREs).Practical numerical examples are presented to demonstrate the effectiveness of the proposed algorithm.

关键词： mean-field stochastic systems Pareto optimal control policy iteration scheme $\mathcal{H}$-representation

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Mastering air combat game with deep reinforcement learning

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Defence Technology（防务技术） 2024年第4期34卷 295-312页

作者： Jingyu zhu Minchi Kuang Wenqing Zhou Heng shi Jihong zhu Xu Han Department of Precision Instruments Tsinghua UniversityBeijing 100084China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China Chengdu Aircraft Design&Research Institute Aviation Industry Corporation of ChinaChengdu 610000China

Reinforcement learning has been applied to air combat problems in recent years,and the idea of curriculum learning is often used for reinforcement learning,but traditional curriculum learning suffers from the problem of plasticity loss in neural *** loss is the difficulty of learning new knowledge after the network has *** this end,we propose a motivational curriculum learning distributed proximal policy optimization(MCLDPPO)algorithm,through which trained agents can significantly outperform the predictive game tree and mainstream reinforcement learning *** motivational curriculum learning is designed to help the agent gradually improve its combat ability by observing the agent's unsatisfactory performance and providing appropriate rewards as a ***,a complete tactical maneuver is encapsulated based on the existing air combat knowledge,and through the flexible use of these maneuvers,some tactics beyond human knowledge can be *** addition,we designed an interruption mechanism for the agent to increase the frequency of decisionmaking when the agent faces an *** the number of threats received by the agent changes,the current action is interrupted in order to reacquire observations and make decisions *** the interruption mechanism can significantly improve the performance of the *** simulate actual air combat better,we use digital twin technology to simulate real air battles and propose a parallel battlefield mechanism that can run multiple simulation environments simultaneously,effectively improving data *** experimental results demonstrate that the agent can fully utilize the situational information to make reasonable decisions and provide tactical adaptation in the air combat,verifying the effectiveness of the algorithmic framework proposed in this paper.

关键词： Air combat MCLDPPO Interruption mechanism Digital twin Distributed system

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On the Application of Mixed Models of Probability and Convex Set for Time-Variant Reliability Analysis

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1981-1999页

作者： Fangyi Li Dachang zhu Huimin shi Center for Research on Leading Technology of Special Equipment School of Mechanical and Electric EngineeringGuangzhou UniversityGuangzhou510006China

In time-variant reliability problems,there are a lot of uncertain variables from different ***,it is important to consider these uncertainties in *** addition,time-variant reliability problems typically involve a complexmultilevel nested optimization problem,which can result in an enormous amount of *** this end,this paper studies the time-variant reliability evaluation of structures with stochastic and bounded uncertainties using a mixed probability and convex set *** this method,the stochastic process of a limit-state function with mixed uncertain parameters is first discretized and then converted into a timeindependent reliability ***,to solve the double nested optimization problem in hybrid reliability calculation,an efficient iterative scheme is designed in standard uncertainty space to determine the most probable point(MPP).The limit state function is linearized at these points,and an innovative random variable is defined to solve the equivalent static reliability analysis *** effectiveness of the proposed method is verified by two benchmark numerical examples and a practical engineering problem.

关键词： Mixed uncertainty probability model convex model time-variant reliability analysis

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Stabilizing zinc anode using zeolite imidazole framework functionalized separator for durable aqueous zinc-ion batteries

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Journal of Energy Chemistry 2024年第3期90卷 23-31,I0003页

作者： Weisong Zhang Xinyan zhu ling Kang Ziyu Peng Jing zhu Liang Pan Lei Dai Shude Liu ling Wang Yongguang Liu Zhangxing He School of Chemical Engineering North China University of Science and TechnologyTangshan 063009HebeiChina Shanghai Key Laboratory of Multidimensional Information Processing East China Normal UniversityShanghai 201620China College of Textiles Donghua UniversityShanghai 201620China

Aqueous zinc-ion batteries(AZIBs) hold great promise as a viable alternative to lithium-ion batteries owing to their high energy density and environmental ***,AZIBs are consistently plagued by the formation of zinc dendrites and concurrent side reactions,which significantly diminish their overall service life,In this study,the glass fiber separator(GF) is modified using zeolite imidazole salt framework-8(ZIF-8),enabling the development of efficient ***-8,which is abundant in nitrogen content,efficiently regulates the desolvation of [Zn(H_(2)O)_(6)]^(2+) to inhibit hydrogen ***,it possesses abundant nanochannels that facilitate the uniform deposition of Zn~(2+) via a localized action,thereby hindering the formation of *** insulating properties of ZIF-8 help prevent Zn^(2+) and water from trapping electron reduction at the layer surface,which reduces corrosion of the zinc ***,ZIF-8-GF achieves the even transport of Zn^(2+) and regulates the homogeneous deposition along the Zn(002) crystal surface,thus significantly enhancing the electrochemical performance of the AZIBs,In particular,the Zn|Zn symmetric cell with the ZIF-8-GF separator delivers a stable cycle life at0.5 mA cm^(-2) of 2300 *** Zn|ZIF-8-GF|MnO_(2) cell exhibits reduced voltage polarization while maintaining a capacity retention rate(93.4%) after 1200 cycles at 1.2 A g^(-1) The unique design of the modified diaphragm provides a new approach to realizing high-performance AZIBs.

关键词： Aqueous zinc-ion batteries Separators modifications ZIF-8 Zn deposition Dendrite-free

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Privacy-Preserving Frank-Wolfe on Shuffle Model

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Acta Mathematicae Applicatae Sinica 2024年第4期40卷 887-907页

作者： ling-jie ZHANG shi-song WU Hai ZHANG School of Mathematics Northwest UniversityXi’an 710127China School of Mathematics and Information Science Baoji University of Arts and SciencesBaoji 721013China China Southern Power Grid Artificial Intelligence Technology Company Limited Guangzhou 510700China

In this paper,we design the differentially private variants of the classical Frank-Wolfe algorithm with shuffle model in the optimization of machine *** weak assumptions and the generalized linear loss(GLL)structure,we propose a noisy Frank-Wolfe with shuffle model algorithm(NoisyFWS)and a noisy variance-reduced Frank-Wolfe with the shuffle model algorithm(NoisyVRFWS)by adding calibrated laplace noise under shuffling scheme in thel_(p)(p∈[1,2])-case,and study their privacy as well as utility guarantees for the H?lder smoothness *** particular,the privacy guarantees are mainly achieved by using advanced composition and privacy amplification by *** utility bounds of the Noisy FWS and NoisyVRFWS are analyzed and obtained the optimal excess population risksO(n-(1+α/4α+log(d)√log(1/δ)/n∈and O(n-1+α/4α+log(d)√log1(+δ)/n^(2)∈with gradient complexity O(n(1+α)^(2)/4α^(2)forα∈[1/√3,1].It turns out that the risk rates under shuffling scheme are a nearly-dimension independent rate,which is consistent with the previous work in some *** addition,there is a vital tradeoff between(α,L)-Holder smoothness GLL and the gradient *** linear gradient complexity O(n)is showed by the parameterα=1.

关键词： differential privacy Frank-Wolfe algorithm privacy amplification shuffle model

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Regulation and application of supramolecular gel with circularly polarized luminescence

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Science China Chemistry 2024年第6期67卷 1865-1880页

作者： Shen Song Yulong shi Liangliang zhu Bingbing Yue School of Materials and Chemistry&Institute of Bismuth and Rhenium University of Shanghai for Science and TechnologyShanghai200093China State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai200438China

Supermolecular gel is a three-dimensional network structure assembled by small molecules or polymers in solvents through noncovalent *** emergence of system complexity occurs spontaneously during the molecular self-assembly process.A multitude of chiral molecular self-assembly systems have been engineered,facilitating the achievement of circularly polarized luminescence(CPL)through the amalgamation of chiral entities with *** bonding,π-πstacking,and noncovalent forces,such as host-guest interactions and Van der Waals'forces,confer upon supramolecular gels the capacity to react to diverse *** to the flexibility of supramolecular assembly,the CPL properties of supramolecular gels have rich controllability and can be used in various *** this review,we summarized the examples of CPL-active supramolecular gel assembly,and further summarized the assembly environment factors and external ***,the versatility of CPL applications in supramolecular gels is demonstrated,ranging from optical devices,information encryption,biosensing and chemical sensing,and other practical *** conclusion,the study provides insights into the multicultural factors influencing CPL in supramolecular gels,describes their applications in various domains,and presents future perspectives in the field.

关键词： supramolecular gels circularly polarized luminescence self-assembly chirality stimuli-response

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