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Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1:a mini-review

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Frontiers of Chemical Science and Engineering 2023年第2期17卷 123-138页

作者： Xuewen Mu yun Xu Zheng Wang Dunyun shi School of Pharmaceutical Science&Technology Tianjin UniversityTianjin 300072China Central Lab Shenzhen Second People’s Hospital/the First Affiliated Hospital of Shenzhen UniversityShenzhen 518035China Institute of Hematology Shenzhen Second People’s Hospital/the First Affiliated Hospital of Shenzhen UniversityShenzhen 518035China

The two-electron cytoplasmic reductase NAD(P)H:quinone oxidoreductase 1 is expressed in many ***(P)H:quinone oxidoreductase 1 is well-known for being highly expressed in most ***,it could be a target for cancer *** it is a quinone reductase,many bioimaging probes based on quinone structures target NAD(P)H:quinone oxidoreductase 1 to diagnose *** expression is higher in tumours than in normal tissues,and using target drugs such asβ-lapachone to reduce side effects in normal tissues can ***,the physicochemical properties ofβlapachone limit its *** problem can be solved by using nanosystems to deliverβ-*** minireview summarizes quinone-based fluorescent,nearinfrared and two-photon fluorescent probes,as well as nanosystems for delivering the NAD(P)H:quinone oxidoreductase 1-activating drugβ-*** review provides valuable information for the future development of probes and nano-delivery systems that target NAD(P)H:quinone oxidoreductase 1.

关键词： NAD(P)H:quinone oxidoreductase 1 cancer therapy target probe nanosystem

Analytical solution to one-dimensional mathematical model of flow and morphological evolution in open channels

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Science China(Technological Sciences) 2020年第12期63卷 2606-2616页

作者： DING yun LI ZuiSen shi YongZhong ZHONG DeYu State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China Zhejiang Institute of Hydraulics and Estuary Hangzhou 310008China Zhejiang Provincial Key Laboratory of Hydraulic Disaster Prevention and Mitigation Hangzhou 310008China Joint-Sponsored State Key Laboratory of Plateau Ecology and Agriculture Qinghai UniversityXining 810016China State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing 100084China

The evolution of open-channel flow and morphology can be simulated by one-dimensional(1D) mathematical models. These models are typically solved by numerical or analytical methods. Because the behavior of variables can be explained by explicit mathematical determinations,compared to numerical solutions,analytical solutions provide fundamental and physical insights into flow and sediment transport mechanisms. The singular perturbation technique derives a hierarchical equation of waves and describes the evolutionary nature of disturbances in hyperbolic systems. The wave hierarchy consists of dynamic,diffusion,and kinetic waves. These three types of waves interact with each other in the process of propagation. Moreover,the Laplace transform is implemented to transform partial differential equations into ordinary differential equations. Analytical expressions in the wave front are subtracted by the approximation of kinetic and diffusion models. Moreover,an analytical solution consists of a linear combination of the kinetic wave front and the diffusion wave front expressions,pursuing to describe the physical mechanism of motion in open channels as completely as possible. Analytical solutions are presented as a combination of exponential functions,hyperbolic functions,and infinite series. The obtained analytical solution was further applied to the simulation of flood path and morphological evolution in the Lower Yellow River. The phenomenon of increased peak discharge in the downstream reach was successfully simulated. It was encouraging that the results were in good agreement with the observed data.

关键词： open channel mathematical model analytical solution Laplace transform morphological evolution

Variational method based robust adaptive control for a guided spinning rocket

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Chinese Journal of Aeronautics 2021年第3期34卷 164-175页

作者： Zhongjiao shi Liangyu zhao Zhijie Liu School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing 100083China

In this paper,a robust adaptive controller is designed for a guided spinning rocket,whose dynamics presents the characteristics of pitch-yaw cross coupling,fast time-varying aerodynamics parameters and wide flight ***,a coupled nonlinear six-degree-of-freedom equation of motion for a guided spinning rocket is developed,and the lateral acceleration motion is modeled as a control plant with time-varying matched uncertainties and unmodeled ***,a robust adaptive control method is proposed by combining Bregman divergence and variational method to achieve fast adaption and maintain bounded *** stability of the resulting closed-loop system is proved,and the ultimate bound and convergence rate are also ***,numerical simulations are performed for a single operating point and the whole flight trajectory to show the robustness and adaptability of the proposed method with respect to timevarying uncertainties and unmodeled dynamics.

关键词： Autopilot design Guided spinning rockets Robust adaptive control Second-order adaptive law Variational method

Properties and strengthening mechanism of brush plated nanoparticle reinforced composite coatings

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 182-185页

作者： DONG shi-yun XU Bin-shi MA shi-ning TU Wei-yi National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China National Key Laboratory for RemanufacturingAcademy of Armored Force Engineering Beijing 100072 China National Key Laboratory for RemanufacturingAcademy of Armored Force Engineering Beijing 100072 China National Key Laboratory for RemanufacturingAcademy of Armored Force Engineering Beijing 100072 China

Nanoparticle reinforced nickel matrix composite coatings, such as n-Al2O3/Ni, n-SiO2/Ni, n-SiC/Ni and n-TiO2/Ni, were fabricated by brush plating technique. Hardness, wear resistance and contact-fatigue resistance of the composite coatings were determined, and strengthening mechanism of the composite coatings was discussed. Results show that the composite coatings have superior properties to the Ni metal coating. Compared with properties of brush plated Ni metal coating, the composite coatings have hardness over 1.5 times and wear resistance capability of about 2.5 times. The strengthening mechanism of the composite coatings mainly includes fine-crystal grain effect, nanoparticle dispersion effect and dislocation effect.

关键词： nanoparticles brush plated coatings strengthening mechanism

Agent-based effectiveness evaluation method and impact analysis of airborne laser weapon system in cooperation combat

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Chinese Journal of Aeronautics 2023年第4期36卷 442-454页

作者： Likuan shi Yang PEI Qijia yun Yuxue GE School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Beijing Institute of Astronautical Systems Engineering Beijing 100076China

The laser weapons will play a special role in the future high-tech *** study the impact of airborne laser weapon on the System-of-System(SoS)effectiveness in cooperative com-bat,this paper proposes an indicator construction method based on the combination of the weapon capability indicator system and the combat *** indicator system of capability is divided into 4 layers by the bottom-to-up generation mechanism of *** can describe the logical relationship between the indicator layers from a qualitative *** with the 4 layers capability indicator system,a hierarchical framework of airborne laser weapon is established by the agent-based modeling and *** analyses show that the SoS effectiveness improves with the increase of the laser weapon output power,the laser launcher diameter,and the photoelectric sensor *** the SoS effectiveness promotion brought by the photoelectric sensor pixel is *** results can be used for the development of tactical airborne laser weapon.

关键词： Agent modelling Effectiveness evaluation Hierarchical modularization Laser weapon System of system

General Mean-Field BDSDEs with Continuous and Stochastic Linear Growth Coefficients

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Journal of Systems Science & Complexity 2024年第5期37卷 1887-1906页

作者： WANG Jinghan shi Yufeng zhao Nana Institute for Financial Studies Shandong UniversityJinan 250100China Zhiyuan School of Liberal Arts Beijing Institute of Petrochemical TechnologyBeijing 102617China

In this paper,the authors study a class of general mean-field BDSDEs whose coefficients satisfy some stochastic ***,the authors prove the existence and uniqueness theorem of solution under stochastic Lipschitz condition and obtain the related comparison ***,the authors further relax the conditions and deduce the existence theorem of solutions under stochastic linear growth and continuous conditions,and the authors also prove the associated comparison ***,an asset pricing problem is discussed,which demonstrates the application of the general meanfield BDSDEs in finance.

关键词： Backward doubly stochastic differential equations comparison theorem mean-field stochastic conditions Wasserstein metric

Visible-light-driven photocatalysis degradation of antibiotic pollutants by La-doped CeO_(2) nanorods:synergy of La doping and oxygen vacancy

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Rare Metals 2024年第7期43卷 3134-3145页

作者： shi-Hai Cao Jing-Ru Qu Yu-Qi zhao yun-Tong Sun Wen-Tong Gao Bing Han Yao Lu College of Environmental Engineering Nanjing Institute of TechnologyNanjing 211167China School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167China School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637459Singapore Institute of Environmental Health and Ecological Security School of Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment Suzhou University of Science and TechnologySuzhou215009China

Elemental doping is an effective strategy to enhance photocatalytic activity and extend the light absorption range of single-component *** this work,a series of La-doped CeO_(2) nanorods(La-CeO_(2)-x) with La content of 1 wt%-15 wt% are synthesized by a simple hydrothermal method and further used as photocatalyst for sulfamerazine(SMR) *** prepared La-CeO_(2)-x nanorods exhibit a great improvement in electron-hole pair migration and visible-light response due to the synergistic effect of abundant oxygen vacancies and heterogeneous elements(La).Consequently,La-CeO_(2)-x exhibited excellent visible-light photocatalytic performances and chemical stability for SMR degradation,the La-CeO_(2)-5 sample achieved the highest SMR degradation rate of 81%,which was 3.4 times higher than that of the original CeO_(2).Furthermore,three possible degradation pathways of SMR in La-CeO_(2) photocatalytic reactions were proposed by liquid chromatography-mass spectrometry ***,density functional theory calculations were carried out to provide an in-depth understanding of the structure-performance *** its excellent properties and better photocatalytic performance,this study demonstrates that La doping in CeO_(2) is an effective way to increase oxygen vacancy and improve the photochemical properties of photocatalysts.

关键词： CeO_(2)nanorod La-doped Photocatalysis Oxygen vacancy Sulfamerazine

EVOLUTION OF SINGLE ELLIPTIC VORTEX RING

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Journal of Hydrodynamics 1998年第1期10卷 23-29页

作者： zhao, Yao shi, Xungang Peking Univ Beijing China

Evolution of single elliptic vortex ring for initial aspect ratio (AR)=2,4,6, has been studied. The incompressible Navier-Stokes equations were solved by a dealiased pseudo-spectral method with 643 grid points in a period cube. It can find that there are three kinds of vortex motion as AR increases and the vortex bifurcation occurs at a certain AR. The processes of advection, interaction and decay of vortex ring were analysed. Numerical results coincide with the experiments and other numerical simulation.

关键词： Computer simulation Flow interactions Flow of water Hydrodynamics Numerical analysis Turbulent flow

Early Neoarchean Magmatic and Paleoproterozoic Metamorphic Events in the Northern North China Craton:SHRIMP Zircon Dating and Hf Isotopes of Archean Rocks from the Miyun Area,Beijing

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Acta Geologica Sinica(English Edition) 2017年第3期91卷 988-1002页

作者： shi Yuruo zhao Xitao Beijing SHRIMP Center Institute of GeologyChinese Academy of Geological Sciences Institute of Geology and Geophysics Chinese Academy of Sciences

The Miyun area of Beijing is located in the northern part of the North China Craton （NCC） and includes a variety of Archean granitoids and metamorphic rocks. Magmatic domains in zircon from a tonalite reveal Early Neoarchean （2752±7 Ma） ages show a small range in εHf（t） from 3.1 to 7.4 and tDM1（Hf） from 2742 to 2823 Ma, similar to their U-Pb ages, indicating derivation from a depleted mantle source only a short time prior to crystallization. SHRIMP zircon ages of granite, gneiss, amphibolite and hornblendite in the Miyun area reveal restricted emplacement ages from 2594 to 2496 Ma. They also record metamorphic events at ca. 2.50 Ga, 2.44 Ga and 1.82 Ga, showing a similar evolutionary history to the widely distributed Late Neoarchean rocks in the NCC. Positive eHf（t） values of 1.5 to 5.9, with model ages younger than 3.0 Ga for magmatic zircon domains from these Late Neoarchean intrusive rocks indicate that they are predominantly derived from juvenile crustal sources and suggest that significant crustal growth occurred in the northern NCC during the Neoarchean. Late Paleoproterozoic metamorphism developed widely in the NCC, not only in the Trans-North China Orogen, but also in areas of Eastern and Western Blocks, which suggest that the late Paleoproterozoic was the assembly of different micro-continents, which resulted in the final consolidation to form the NCC, and related to the development of the Paleo-Mesoproterozoic Columbia or Nuna supercontinent.

关键词： SHRIMP zircon dating Neoarchean Miyun North China Craton Hf isotopes