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Kinetics of thymocyte developmental process in fetal and neonatal mice

Cell Research 2003年第4期13卷 265-273页

作者： shi yun xiao, yan li, wei feng chendepartment of immunology,{3., Peking University health science center, 3. xueyuan road, beijing 100083, china 1Department of immunology School of Basic Medical Sciences Peking University Health Science Center 38 Xueyuan Road Beijing 100083 China 1Department of immunology School of Basic Medical Sciences Peking University Health Science Center 38 Xueyuan Road Beijing 100083 China 1Department of immunology School of Basic Medical Sciences Peking University Health Science Center 38 Xueyuan Road Beijing 100083 China

Kinetics of thymocyte development in vivo during embryogenesis was pursued. The early development of thymocytes in the fetal and neonatal BALB/c mice was discontinuous, with four waves of cell proliferation occurring at fetal day (Fd) 14 to 17, Fd 18 to day (D) 1 after birth, D 2 to D 5 and D6 thereafter. The first three proliferation waves coincided with the generation of CD4/"CD8/" (DP), TCR+CD4/hiCD8-/lo (CD4 SP), and TCR+CD4-/loCD8int/hi (CD8 SP) thymocytes, respectively. The transition from DN to DP cells was further investigated and it was found out that there were two differential pathways via immature single positive (ISP) cells in the BALB/c mice, each functioning at different fetal ages. One is via TCR-CD4-CD8+ cells, occurring between Fd 15 and Fd 17 and the other is via TCR-CD4+CD8- cells, occurring from Fd 17 until birth. In contrast, the TCR-CD4-CD8+ pathway dominated overwhelmingly in the C57BL/6 mice. These findings shed new light on the hypothesis that the differential pathway preferenc

关键词： fetal thymus neonatal mice thymocyte ontogeny.

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